CN101815784A - 植物系统中外来核酸和多肽的产生 - Google Patents

植物系统中外来核酸和多肽的产生 Download PDF

Info

Publication number
CN101815784A
CN101815784A CN200780007805A CN200780007805A CN101815784A CN 101815784 A CN101815784 A CN 101815784A CN 200780007805 A CN200780007805 A CN 200780007805A CN 200780007805 A CN200780007805 A CN 200780007805A CN 101815784 A CN101815784 A CN 101815784A
Authority
CN
China
Prior art keywords
protein
plant
polypeptide
virus
agrobacterium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200780007805A
Other languages
English (en)
Chinese (zh)
Inventor
维达季·尤西波夫
瓦季姆·梅特
莎伊拉贾·拉宾德拉
穆奈姆·沙劳尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer USA Inc
Original Assignee
Fraunhofer USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/353,905 external-priority patent/US7692063B2/en
Application filed by Fraunhofer USA Inc filed Critical Fraunhofer USA Inc
Publication of CN101815784A publication Critical patent/CN101815784A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
    • C12N15/8203—Virus mediated transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/14—Plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200780007805A 2006-02-13 2007-02-13 植物系统中外来核酸和多肽的产生 Pending CN101815784A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US77337406P 2006-02-13 2006-02-13
US77325506P 2006-02-13 2006-02-13
US77337806P 2006-02-13 2006-02-13
US60/773,374 2006-02-13
US11/353,905 US7692063B2 (en) 2002-11-12 2006-02-13 Production of foreign nucleic acids and polypeptides in sprout systems
US11/353,905 2006-02-13
US60/773,255 2006-02-13
US60/773,378 2006-02-13
US87945007P 2007-01-09 2007-01-09
US60/879,450 2007-01-09
PCT/US2007/003942 WO2007095304A2 (fr) 2006-02-13 2007-02-13 Production d'acides nucleiques et de polypeptides etrangers dans des systemes vegetaux

Publications (1)

Publication Number Publication Date
CN101815784A true CN101815784A (zh) 2010-08-25

Family

ID=38372119

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200780007805A Pending CN101815784A (zh) 2006-02-13 2007-02-13 植物系统中外来核酸和多肽的产生

Country Status (8)

Country Link
EP (1) EP1984509A4 (fr)
JP (1) JP2009528025A (fr)
KR (1) KR20080113372A (fr)
CN (1) CN101815784A (fr)
AU (1) AU2007215066A1 (fr)
BR (1) BRPI0707785A2 (fr)
CA (1) CA2642138A1 (fr)
WO (1) WO2007095304A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103146736A (zh) * 2013-03-28 2013-06-12 福建农林大学 一种植物表达载体pGⅡ0229-GUS的构建及应用
CN110423746A (zh) * 2019-07-16 2019-11-08 北京林业大学 编码小肽pfer的基因序列、小肽pfer和应用及诱导植物生根的方法
CN114736920A (zh) * 2022-03-01 2022-07-12 中国计量大学 农杆菌侵染菜豆叶片实现目的基因瞬时过表达或瞬时沉默的方法

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1594956A4 (fr) 2003-02-03 2007-08-01 Fraunhofer Usa Inc Systeme d'expression de genes dans des plantes
CA2526720C (fr) 2003-05-22 2013-10-22 Fraunhofer Usa, Inc. Molecule support recombinee pour l'expression, l'administration et la purification de polypeptides cibles
EP1919504B1 (fr) 2005-08-03 2013-10-16 iBio, Inc. Anticorps diriges contre l'antigene protecteur de bacillus anthracis
CA2692933C (fr) 2007-07-11 2016-10-18 Fraunhofer Usa, Inc. Antigenes yersinia pestis, compositions de vaccins, et methodes associees
EP2306807A1 (fr) * 2008-06-30 2011-04-13 ORF Liftaekni HF. Production industrielle, à base de plantes, de protéines recombinantes non animales dans un environnement défini
WO2010037063A2 (fr) * 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Vaccins au plasmodium, antigènes, compositions et procédés
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
WO2011041391A1 (fr) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Anticorps dirigés contre l'hémagglutinine du virus de la grippe, compositions, et procédés associés
JP6358257B2 (ja) 2013-09-06 2018-07-18 三菱ケミカル株式会社 植物を用いたタンパク質の製造方法
CA2944422A1 (fr) * 2014-04-10 2015-10-15 Mitsubishi Chemical Corporation Methode de production d'une proteine utile au moyen d'une plante
ES2876036T3 (es) * 2015-01-30 2021-11-11 Univ Tokyo Composición que contiene una bacteria láctica, composición farmacéutica oral para su uso en el tratamiento de infecciones por VPH y/o tumores asociados a VPH y agente inductor de inmunidad de la mucosa para su uso en dotar de inmunidad mucosal contra la infección por VPH
JP6578681B2 (ja) * 2015-03-11 2019-09-25 三菱ケミカル株式会社 植物栽培方法及びそれを用いる有用タンパク質の製造
US20190352659A1 (en) * 2016-11-30 2019-11-21 Kirin Company, Limited Method for Producing Useful Protein by Means of Plant
US11098320B2 (en) 2017-02-03 2021-08-24 Arizona Board Of Regents On Behalf Of The University Of Arizona Engineering high-protein-content soybeans
US20200115718A1 (en) * 2017-06-16 2020-04-16 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods, systems, and compositions for legume-based production of therapeutic proteins and therapeutic medical materials
US10889826B2 (en) 2017-06-16 2021-01-12 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and compositions for producing epidermal growth factor (EGF) in soybeans
WO2020074704A1 (fr) * 2018-10-11 2020-04-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Moyens et procédés de détection d'allergènes de soja

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693506A (en) * 1993-11-16 1997-12-02 The Regents Of The University Of California Process for protein production in plants
US6700040B2 (en) * 1998-01-16 2004-03-02 Large Scale Biology Corporation Cytoplasmic gene inhibition or gene expression in transfected plants by a tobraviral vector
US7683238B2 (en) * 2002-11-12 2010-03-23 iBio, Inc. and Fraunhofer USA, Inc. Production of pharmaceutically active proteins in sprouted seedlings
CA2526720C (fr) * 2003-05-22 2013-10-22 Fraunhofer Usa, Inc. Molecule support recombinee pour l'expression, l'administration et la purification de polypeptides cibles
ATE469231T1 (de) * 2003-11-10 2010-06-15 Icon Genetics Gmbh Von rna-virus abgeleitetes pflanzenexpressionssystem
WO2005081905A2 (fr) * 2004-02-20 2005-09-09 Fraunhofer Usa Inc. Systemes et methodes d'expression clonale dans des plantes
EP1616959A1 (fr) * 2004-07-07 2006-01-18 Icon Genetics AG Procédé d'expression transitoire de protéines dans les plantes biologiquement sur

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103146736A (zh) * 2013-03-28 2013-06-12 福建农林大学 一种植物表达载体pGⅡ0229-GUS的构建及应用
CN110423746A (zh) * 2019-07-16 2019-11-08 北京林业大学 编码小肽pfer的基因序列、小肽pfer和应用及诱导植物生根的方法
CN110423746B (zh) * 2019-07-16 2021-03-12 北京林业大学 编码小肽pfer的基因序列、小肽pfer和应用及诱导植物生根的方法
CN114736920A (zh) * 2022-03-01 2022-07-12 中国计量大学 农杆菌侵染菜豆叶片实现目的基因瞬时过表达或瞬时沉默的方法

Also Published As

Publication number Publication date
BRPI0707785A2 (pt) 2011-05-10
EP1984509A4 (fr) 2010-07-14
WO2007095304A2 (fr) 2007-08-23
JP2009528025A (ja) 2009-08-06
WO2007095304A3 (fr) 2010-01-21
CA2642138A1 (fr) 2007-08-23
KR20080113372A (ko) 2008-12-30
AU2007215066A1 (en) 2007-08-23
EP1984509A2 (fr) 2008-10-29

Similar Documents

Publication Publication Date Title
CN101815784A (zh) 植物系统中外来核酸和多肽的产生
US7683238B2 (en) Production of pharmaceutically active proteins in sprouted seedlings
DE69929073T2 (de) Verfahren und Zusammensetzungen für die Transformation von Pflanzen
CN1922306B (zh) 用于植物中克隆表达的系统和方法
CN101454347A (zh) 流感抗原、疫苗组合物和相关方法
JP2002501755A (ja) 植物及び植物の部分からポリペプチドを回収するための方法
US20080115243A1 (en) Transgenic Plants Expressing Intein Modified Proteins and Associated Processes for Bio-Pharmaceutical Production
US20110070609A1 (en) Production of Foreign Nucleic Acids and Polypeptides in Sprout Systems
KR20010085901A (ko) 식물에서의 치료학적 활성 단백질
KR102444024B1 (ko) 아프리카 돼지열병의 진단을 위한 항원 생산용 재조합 벡터 및 이의 용도
CN103403170A (zh) 植物中的蛋白质表达
KR102053009B1 (ko) 돼지 열병 백신용 조성물 및 이의 제조 방법
TW200914611A (en) Pig edema disease vaccine
Kim et al. Assembly of cholera toxin B subunit full-length rotavirus NSP4 fusion protein oligomers in transgenic potato
CN102851306B (zh) 用于生产蛋白的转基因芦荟植物及其相关的方法
US20070178148A1 (en) Preparations of growth hormone
CA2509678A1 (fr) Immunisation de poissons a l'aide de proteines recombinantes exprimees dans des plantes
KR102200773B1 (ko) 돼지의 Fc 단편과 융합된 항원 및 이를 포함하는 백신 조성물
CN100540666C (zh) 利用转基因生菜、番茄和烟草生产人胰岛素的方法
KR102155449B1 (ko) 식물에서 LysP11의 대량생산방법 및 이를 포함하는 돼지 단독증 예방 또는 치료용 약학적 조성물
KR20030096319A (ko) 안정한 유전자 전이 식물 제약 조성물들 및 이들의 제조방법들 및 피임약으로서의 이들의 용도
Cheung et al. Expression and subcellular targeting of human insulin-like growth factor binding protein-3 in transgenic tobacco plants
KR101428843B1 (ko) 로타바이러스에 대한 백신효과를 유도하는 형질전환체 및 이를 포함하는 백신 조성물
CN104561040B (zh) 植物抗热基因htt3及其应用
JP4228072B2 (ja) アビジンをコードする人工合成遺伝子

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20100825