CN101810843A - Medicament for treating nerve system diseases such as cerebrovascular accident, spinal cord injury and senile dementia - Google Patents
Medicament for treating nerve system diseases such as cerebrovascular accident, spinal cord injury and senile dementia Download PDFInfo
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Abstract
The invention relates to a medicament for treating nerve system diseases such as cerebrovascular accident, spinal cord injury and senile dementia. The medicament takes conventional Chinese medicinal herbs having simple preparation method and low cost as a base of the medicaments and mainly adopts the Chinese medicinal materials such as raw rehmannia glutinosa, medicinal indianmulberry root, dogwood, quilled cinnamon bark, liriope, thinleaf milkwort root-bark and Chinese magnoliavine fruit and the like. The medicament is prepared by adopting water extraction and ethamol extraction methods to obtain extract concentrated solution of the medicament finally. The medicinal extract obtained by the processing method can ensure quality and treatment effect of the preparation, can facilitate the carrying and administration of patients, has therapeutical effects on apoplexia and spinal cord injury, can meet the requirements of clinical treatment and assistance of functional recovery of the patients, and has obvious characteristics and advantages of Chinese medicine, convenient administration, and wide market application prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of medicine for the treatment of nervous system disease such as cerebrovascular accident, spinal cord injury and senile dementia.
Background technology
Over nearly 20 years, along with clinical and progress basic research, the case fatality rate of most countries apoplexy descends to some extent, and survival rate obviously improves, but its serious high disability rate also becomes the outstanding problem of present clinical treatment and rehabilitation thus.Primary disease is the at present human topmost reason that disables, and losing has handicaps such as hemiplegia, aphasia, brings heavy financial burden and psychologic damage for patient, family, society.How to utilize various measures, reduce disease the disabled body, the heart, social function disorder, to bring into play the high potential of its health, make disease the disabled can reintegrate into society, improve the quality of living, be the problem of showing great attention in the world always.Estimate that according to data in recent years the annual New Development apoplexy of China is about 1,500,000～1,800,000, existing patient is about 3,000,000, and its heavy disability rate, 5 years relapse rates are up to 50%; Spinal cord injury is owing to the develop rapidly of economy, traffic, building, and sickness rate is sustainable growth, increases nearly 10 times before 10 years.
Prior treatment method generally is the physical restoration therapy, just the trouble limb to the patient carries out functional rehabilitation under the effect of external force, though this method can play better auxiliary function to rehabilitation of patients, but get to the bottom of sb.'s illness, this mode still can't fundamentally be improved patient's the patient's condition, need be aided with Drug therapy and just can obtain best curative effect; The Chinese medicine of motherland's traditional medicine is as a kind of effective method for treatment, be widely used in the clinical treatment of multiple disease, especially at determined curative effect, with a high credibility aspect the improving of cerebrovascular disease, in rationale and clinical practice, all do a lot of work, its unique therapeutical effect is arranged.
Summary of the invention
In order better to help the patient to get well, can reduce simultaneously the cost of patient treatment again, the invention provides a kind of treatment cerebrovascular accident, the medicine of nervous system disease such as spinal cord injury and senile dementia, the employing manufacture method is simple, traditional Chinese herbal medicine with low cost is as the host of medicine, the main employing given birth to Radix Rehmanniae Preparata, Radix Morindae Officinalis, Fructus Corni, Cortex Cinnamomi, Radix Ophiopogonis, Radix Polygalae, Chinese crude drugs such as Fructus Schisandrae Chinensis, adopt water to carry the extract concentrated solution that is prepared and finally obtains this medicine with the method for alcohol extraction, the drug extract that this processing method obtains, make things convenient for carrying and taking of patient, to apoplexy, spinal cord injury all has therapeutical effect, can satisfy clinical treatment, the needs of assisting patients functional rehabilitation, striking features and advantage with traditional Chinese medical science, taking convenience, market application foreground is wide.
Treatment mechanism of the present invention is: by theory of Chinese medical science, by nourishing kidney-yin, kidney-replenishing with tonifying vital QI, by removing arthralgia due to stagnation of blood, curing mainly that limb is useless can not be with, stiff tongue unable to speak, thereby fundamentally sufferer is being treated, and can have simultaneously and have defying age, effect of prolonging life.
According to above treatment mechanism, the each component of this medicine is according to the weight portion meter, and its proportioning is: give birth to each 25 parts of Radix Rehmanniae Preparata, 12 parts of Radix Morindae Officinaliss, 12 parts of Fructus Corni, 12 parts of Herba Dendrobiis, 9 parts of Herba Cistanches, 9 parts of Fructus Schisandrae Chinensis, 18 parts of Cortex Cinnamomi, 12 parts in Poria, 12 parts of Radix Ophiopogonis, 9 parts of Radix Polygalaes, 12 parts of Rhizoma Acori Gramineis, 9 parts of Herba Menthaes, 12 parts of Radix Dipsaci, 15 parts of Radix Achyranthis Bidentataes, 15 parts of Herba Lycopodiis, 12 parts of Sanguis Draxonis, 30 parts of the Radixs Astragali.
In order to improve the drug effect of said medicine, generally adopt the form of the form of extracting solution as administration.
Give birth to Radix Rehmanniae Preparata, Sanguis Draxonis, Fructus Corni nourishing kidney yin in the above-mentioned component, pursue arthralgia due to stagnation of blood; Herba Cistanches, crust halberd warming and recuperating the kidney-YANG; Cortex Cinnamomi kidney-replenishing and receive floating sun; Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis YIN nourishing are held back liquid; Rhizoma Acori Graminei, Radix Polygalae, Poria, Herba Menthae restoring normal coordination between the heart and kidney are to strengthen the merit of the kidney invigorating; Radix Dipsaci, Radix Achyranthis Bidentatae, Herba Lycopodii has bone and muscle strengthening, thereby improves the resistance of sufferer, in the resume speed that fundamentally improves the patient; Radix Astragali QI invigorating helps the blood operation, to increase by the merit of removing arthralgia due to stagnation of blood; Giving birth to Radix Rehmanniae Preparata is the top principal agent, and Radix Rehmanniae also has by the merit of removing arthralgia due to stagnation of blood except the effect of nourishing kidney yin is arranged, be aided with the effect of Radix Rehmanniae Preparata nourishing kidney yin again, after the integrated application, arthralgia due to stagnation of blood one is removed, blood must fill, muscle gets by force, bone must be strengthened, muscle must be supported, the brain mansion must replenish, and group's medicine gets each most its duty; Cortex Cinnamomi promotes cloudy medicine, and drug effect is satisfied work.
Compare with existing some Chinese medicine, mainly added the Radix Astragali, this two flavors principal agent of Sanguis Draxonis in the pharmaceutical formulation of the present invention.The Radix Astragali is given birth to reusing in this prescription, and giving birth to invigorating middle warmer has the logical power of a surname, reuses the justice that the Radix Astragali has Yin grows while yang is generating.No matter the Radix Astragali is got its property or is got its flavor, and not from the merit of Radix Astragali QI invigorating, the gas of right human body is given birth to being beneficial to the property of being apt to away to pass unimpeded plentifully.For the power that improves Radix Astragali QI invigorating is reused, be beneficial to the Radix Astragali and be apt to away give birth to usefulness, therefore, the Radix Astragali give birth to, the power of reusing then is special and be apt to away, all row whole bodies, to the human righteousness replenish and mechanism of qi pass unimpeded usefully, can take into account in many ways, with give birth to all medicines of Radix Rehmanniae Preparata share increase its QI invigorating, help the blood operation, by the merit of removing arthralgia due to stagnation of blood, relieving dizziness, high fever, infantile convulsions, epilepsy, etc.The sweet one-tenth of Sanguis Draxonis nature and flavor, flat, go into the heart, Liver Channel.Function blood circulation promoting and blood stasis dispelling, hemostasis are nourished blood, the diffusing blood that stagnates of tonify deficiency, and all disorders of blood stasis of bloods long-pending person be suitable for.Zoopery proves that this product can significantly shorten the plasma in rabbit recalcification time, thereby increases its Blood clotting.Influence to hemorheological property: continuous 3 weeks of Sanguis Draxonis water decoction-alcohol sedimentation liquid (1: 1) 0.5ml/kg intramuscular injection, the Sanguis Leporis seu oryctolagi packed cell volume is reduced, erythrocyte and platelet electrophoresis time shorten, but whole blood viscosity ratio and plasma viscosity ratio are not had obvious influence.Influence to platelet aggregation: Sanguis Draxonis water decoction-alcohol sedimentation liquid (1: 1) 0.1ml in vitro tests, be added in the 0.5ml platelet rich plasma, the inductive platelet aggregation of ADP there is inhibitory action.So this product promptly has anastalsis that the anti-platelet aggregation effect is arranged again, adopt the former powder of Sanguis Draxonis to be used as medicine among the present invention, reduced of the loss of other purification modes for its effective ingredient, can obviously increase this product drug effect.
For the various prescriptions of the present invention can better play its drug effect, the inventor has abandoned the mode of existing traditional decoction, then has used the mode of extracting that its effective ingredient is extracted and makes up, and has finally obtained its drug extract, and its step is as follows:
(1) get Herba Cistanches, Radix Ophiopogonis, Radix Polygalae, Fructus Schisandrae Chinensis, Fructus Corni by prescription, with 8 times of amount alcohol reflux of 70% 3 times, each 2h merges 3 times alcohol extract, filtration, and decompression filtrate recycling ethanol gets the alcohol extraction concentrated solution, and is standby;
(2) Rhizoma Zingiberis Recens, Herba Menthae, the Rhizoma Acori Graminei steam distillation with recipe quantity adds 10 times of water gagings, extracts 6h, gets volatile oil, and be standby;
(3) will give birth to Radix Rehmanniae Preparata, Poria, Radix Morindae Officinalis, Herba Dendrobii, Cortex Cinnamomi, Radix Dipsaci, Radix Achyranthis Bidentatae, Herba Lycopodii, the Radix Astragali, Rhizoma Zingiberis Recens, Fructus Jujubae and extract the water that adds 16 times of weight of above-mentioned substance total amount after medicinal residues merge with alcohol extraction medicinal residues, volatile oil, reflux, extract, 3 times, each 1h, get water and carry medicinal liquid, merge the filtering filtrate of water extract 3 times;
(4) with the filtrate of above-mentioned gained and alcohol extract in the step (1) and the mixing of the volatile oil in the step (2), get its aqueous solution, concentrate after centrifugal, can obtain the water extraction concentrated solution, the former powder of Sanguis Draxonis that adds recipe quantity afterwards just can obtain the target extracting solution.
The contained ursolic acid of Fructus Corni, Herba Cistanches contains verbascoside, and Radix Ophiopogonis contains saponin and flavone Hesperidin, and Radix Polygalae contains saponin, and Fructus Schisandrae Chinensis contains schisandrin and schisandrin B etc., and pure dissolubility is better to add medicine to, and therefore uses alcohol reflux.Rhizoma Zingiberis Recens, Herba Menthae, Rhizoma Acori Graminei contain volatile oil, adopt steam distillation to extract.The pharmaceutically active ingredient water solublity is better in Radix Rehmanniae Preparata, Radix Morindae Officinalis, Herba Dendrobii, Radix Polygalae, the Fructus Jujubae etc., and decocting can propose main effective ingredient, and reaches the curative effect that this side has, and the method that therefore adopts decocting to boil is extracted; After making above-mentioned various extracts, can dissolve each other each other, always various purification liquid can be mixed and the final concentrated solution that obtains, add the former powder of Sanguis Draxonis afterwards and kept its original drug effect, obtain best drug extract.The inventor is through long-felt and experiment, obtained above-mentioned method of purification, the difference purification mode that particularly adopts at different pharmaceutical has wherein improved the degree of utilizing of effective ingredient in the medicine greatly, can its drug effect of maximized raising, thereby in the drug effect that has fundamentally improved whole medicine.
Extract the effective ingredient of medicine in this way, both strengthened its drug effect, made things convenient for patient's use again, medicine provided by the present invention in sum, the employing manufacture method is simple, traditional Chinese herbal medicine with low cost is as the host of medicine, according to nourishing kidney-yin, kidney-replenishing, by the guiding theory of arthralgia due to stagnation of blood, the main employing given birth to Radix Rehmanniae Preparata, Radix Morindae Officinalis, Fructus Corni, Herba Cistanches, Radix Ophiopogonis, Radix Polygalae, Chinese crude drugs such as Fructus Schisandrae Chinensis adopt water to carry the extract concentrated solution that is prepared and finally obtains this medicine with the method for alcohol extraction, the medicine that this processing method obtains, make things convenient for carrying and taking of patient, to apoplexy, spinal cord injury all has therapeutical effect, can satisfy clinical treatment, the needs of assisting patients functional rehabilitation, have the striking features and the advantage of the traditional Chinese medical science, market application foreground is wide.
The specific embodiment
Embodiment 1
A kind of medicine for the treatment of nervous system disease such as cerebrovascular accident, spinal cord injury and senile dementia, it is characterized in that: the each component of this medicine is according to the weight portion meter, and its proportioning is: give birth to each 25g of Radix Rehmanniae Preparata, Radix Morindae Officinalis 12g, Fructus Corni 12g, Herba Dendrobii 12g, Herba Cistanches 9g, Fructus Schisandrae Chinensis 9g, Cortex Cinnamomi 18g, Poria 12g, Radix Ophiopogonis 12g, Radix Polygalae 9g, Rhizoma Acori Graminei 12g, Herba Menthae 9g, Radix Dipsaci 12g, Radix Achyranthis Bidentatae 15g, Herba Lycopodii 15g, Sanguis Draxonis 12g, Radix Astragali 30g, Rhizoma Zingiberis Recens 6g, Fructus Jujubae 2g.
When preparing this drug extract, its step is as follows:
(1) get Herba Cistanches, Radix Ophiopogonis, Radix Polygalae, Fructus Schisandrae Chinensis, Fructus Corni by prescription, with 8 times of amount alcohol reflux of 70% 3 times, each 2h merges 3 times alcohol extract, filtration, and decompression filtrate recycling ethanol gets the alcohol extraction concentrated solution, and is standby;
(2) Rhizoma Zingiberis Recens, Herba Menthae, the Rhizoma Acori Graminei steam distillation with recipe quantity adds 10 times of water gagings, extracts 6h, gets volatile oil, and be standby;
(3) will give birth to Radix Rehmanniae Preparata, Poria, Radix Morindae Officinalis, Herba Dendrobii, Cortex Cinnamomi, Radix Dipsaci, Radix Achyranthis Bidentatae, Herba Lycopodii, the Radix Astragali, Rhizoma Zingiberis Recens, Fructus Jujubae and extract the water that adds 16 times of weight of above-mentioned substance total amount after medicinal residues merge with alcohol extraction medicinal residues, volatile oil, reflux, extract, 3 times, each 1h, get water and carry medicinal liquid, merge the filtering filtrate of water extract 3 times;
(4) with the filtrate of above-mentioned gained and alcohol extract in the step (1) and the mixing of the volatile oil in the step (2), get its aqueous solution, concentrate after centrifugal, can obtain the water extraction concentrated solution, the former powder of Sanguis Draxonis that adds recipe quantity afterwards just can obtain the target extracting solution.
Embodiment 2
A kind of medicine for the treatment of nervous system disease such as cerebrovascular accident, spinal cord injury and senile dementia, it is characterized in that: the each component of this medicine is according to the weight portion meter, and its proportioning is: give birth to each 50g of Radix Rehmanniae Preparata, Radix Morindae Officinalis 24g, Fructus Corni 24g, Herba Dendrobii 24g, Herba Cistanches 18g, Fructus Schisandrae Chinensis 18g, Cortex Cinnamomi 36g, Poria 24g, Radix Ophiopogonis 24g, Radix Polygalae 18g, Rhizoma Acori Graminei 24g, Herba Menthae 18g, Radix Dipsaci 24g, Radix Achyranthis Bidentatae 30g, Herba Lycopodii 30g, Sanguis Draxonis 24g, Radix Astragali 60g, Rhizoma Zingiberis Recens 12g, Fructus Jujubae 4g.
When preparing this drug extract, its step is as follows:
(1) get Herba Cistanches, Radix Ophiopogonis, Radix Polygalae, Fructus Schisandrae Chinensis, Fructus Corni by prescription, with 8 times of amount alcohol reflux of 70% 3 times, each 2h merges 3 times alcohol extract, filtration, and decompression filtrate recycling ethanol gets the alcohol extraction concentrated solution, and is standby;
(2) Rhizoma Zingiberis Recens, Herba Menthae, the Rhizoma Acori Graminei steam distillation with recipe quantity adds 10 times of water gagings, extracts 6h, gets volatile oil, and be standby;
(3) will give birth to Radix Rehmanniae Preparata, Poria, Radix Morindae Officinalis, Herba Dendrobii, Cortex Cinnamomi, Radix Dipsaci, Radix Achyranthis Bidentatae, Herba Lycopodii, the Radix Astragali, Rhizoma Zingiberis Recens, Fructus Jujubae and extract the water that adds 16 times of weight of above-mentioned substance total amount after medicinal residues merge with alcohol extraction medicinal residues, volatile oil, reflux, extract, 3 times, each 1h, get water and carry medicinal liquid, merge the filtering filtrate of water extract 3 times;
(4) with the filtrate of above-mentioned gained and alcohol extract in the step (1) and the mixing of the volatile oil in the step (2), get its aqueous solution, concentrate after centrifugal, can obtain the water extraction concentrated solution, the former powder of Sanguis Draxonis that adds recipe quantity afterwards just can obtain the target extracting solution.
Experimental example 1
Seedling, man, 70 years old, in on February 26th, 2005 with left upper extremity motion can not, the left lower extremity motion is ineffective, two just control the capable rehabilitation of being admitted to hospital in bad 8 years, the blood pressure 170/100mmHg that is admitted to hospital, heart rate 68 times/minute, loll and take back, left side babinski sign (+) is diagnosed as: 1. cerebral infarction sequela.2. hypertension.3.2 type diabetes.
Dialectical: refreshing clear, greasy fur, singultus, xerostomia but do not think drink, the left limb activity is ineffective, and it is clear that speech is owed, and pulse condition is heavy, thin.
With embodiment 1 prepared drug extract, according to each 9g, 2 times mode administration every day cooperates speech, hemiplegic limb comprehensive rehabilitation training, and medication is blood pressure 150/100mmHg after 2 days, deep-slow pulse; Medication after 15 days language more preceding clear, medication after 60 days left side lower limb walking ability increase, can walk about 2000m voluntarily, but stair activity, medication is the more preceding improvement of left side upper limb activity after 75 days, two just control is good.
Experimental example 2
Jiang, the man, 45 years old, on April 13rd, 2005 was admitted to hospital.The patient before half a year no bright reason occur suddenly, shiver with cold, the paralysis of two weakness of the lower extremitiess, incontinence of urination and defecation, neurologic check: two relaxing property of lower limb paralysiss, analgesis, hypopselaphesia, depth areflexia, plantar reflex disappears, the defecation retention.Check through waist MR, be diagnosed as acute myelitis.Through using treatments such as hormone, vitamin B complex, antibiotic, catheter open drainage, stable disease.There are two relaxing property of lower limb paralysiss, sensory disturbance, two just to control bad when being admitted to hospital.
Tcm diagnosis is a hemiplegia after apoplexy, April 20 began to throw embodiment 1 prepared drug extract, according to each 9g, 2 times mode administration every day, simultaneously various vitamin continue to use, and cooperate recovery function training and bladder function Control Training, and April 30, the lower limb pain sensation was partly recovered, muscular hypertonia, tendon reflex occurs.The stool may command.May 27, right lower extremity slightly can be movable, and May 28, two lower limb all slightly can be movable, and bitterly, sense of touch has recovery, both sides Ba Binsijishi occurs and levy.Urine can be controlled voluntarily.June 23, the energy walker was walked down.
Claims (3)
1. medicine for the treatment of nervous system disease such as cerebrovascular accident, spinal cord injury and senile dementia, it is characterized in that: the each component of this medicine is according to the weight portion meter, and its proportioning is: give birth to each 25 parts of Radix Rehmanniae Preparata, 12 parts of Radix Morindae Officinaliss, 12 parts of Fructus Corni, 12 parts of Herba Dendrobiis, 9 parts of Herba Cistanches, 9 parts of Fructus Schisandrae Chinensis, 18 parts of Cortex Cinnamomi, 12 parts in Poria, 12 parts of Radix Ophiopogonis, 9 parts of Radix Polygalaes, 12 parts of Rhizoma Acori Gramineis, 9 parts of Herba Menthaes, 12 parts of Radix Dipsaci, 15 parts of Radix Achyranthis Bidentataes, 15 parts of Herba Lycopodiis, 12 parts of Sanguis Draxonis, 30 parts of the Radixs Astragali, 6 parts in Rhizoma Zingiberis Recens, 2 parts in Fructus Jujubae.
2. medicine according to claim 1, it is characterized in that: the medicine that is adopted is its extracting solution.
3. process the method for nervous system disease medicines such as cerebrovascular accident, spinal cord injury and senile dementia according to claim 1, its step is as follows:
(1) get Herba Cistanches, Radix Ophiopogonis, Radix Polygalae, Fructus Schisandrae Chinensis, Fructus Corni by prescription, with 8 times of amount alcohol reflux of 70% 3 times, each 2h merges 3 times alcohol extract, filtration, and decompression filtrate recycling ethanol gets the alcohol extraction concentrated solution, and is standby;
(2) Rhizoma Zingiberis Recens, Herba Menthae, the Rhizoma Acori Graminei steam distillation with recipe quantity adds 10 times of water gagings, extracts 6h, gets volatile oil, and be standby;
(3) will give birth to Radix Rehmanniae Preparata, Poria, Radix Morindae Officinalis, Herba Dendrobii, Cortex Cinnamomi, Radix Dipsaci, Radix Achyranthis Bidentatae, Herba Lycopodii, the Radix Astragali, Rhizoma Zingiberis Recens, Fructus Jujubae and extract the water that adds 16 times of weight of above-mentioned substance total amount after medicinal residues merge with alcohol extraction medicinal residues, volatile oil, reflux, extract, 3 times, each 1h, get water and carry medicinal liquid, merge the filtering filtrate of water extract 3 times;
(4) with the filtrate of above-mentioned gained and alcohol extract in the step (1) and the mixing of the volatile oil in the step (2), get its mixed aqueous solution, concentrate after centrifugal, can obtain the water extraction concentrated solution, the former powder of Sanguis Draxonis that adds recipe quantity afterwards just can obtain the target extracting solution.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101277530A CN101810843B (en) | 2010-03-19 | 2010-03-19 | Medicament for treating nerve system diseases such as cerebrovascular accident, spinal cord injury and senile dementia |
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| CN2010101277530A CN101810843B (en) | 2010-03-19 | 2010-03-19 | Medicament for treating nerve system diseases such as cerebrovascular accident, spinal cord injury and senile dementia |
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| CN101810843B CN101810843B (en) | 2011-12-14 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743494A (en) * | 2012-07-24 | 2012-10-24 | 中国人民解放军第三军医大学第一附属医院 | Application of rehmanniae potion to preparation of medicament for promoting spinal cord injury restoration |
| CN104524503A (en) * | 2014-12-20 | 2015-04-22 | 丁立 | Traditional Chinese medicine for treatment of stroke |
| CN106310038A (en) * | 2016-08-22 | 2017-01-11 | 刘洪英 | Medicine for combining traditional Chinese medicine and western medicine to treat spine and spinal cord injury, and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1310020A (en) * | 2001-02-27 | 2001-08-29 | 沈瑜 | Medicine for preventing and treating radiation damage of central nervous system |
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2010
- 2010-03-19 CN CN2010101277530A patent/CN101810843B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1310020A (en) * | 2001-02-27 | 2001-08-29 | 沈瑜 | Medicine for preventing and treating radiation damage of central nervous system |
Non-Patent Citations (1)
| Title |
|---|
| 《中医药信息》 20080131 关慧波 等 地黄饮子临床研究进展 43-46 1-3 第25卷, 第1期 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743494A (en) * | 2012-07-24 | 2012-10-24 | 中国人民解放军第三军医大学第一附属医院 | Application of rehmanniae potion to preparation of medicament for promoting spinal cord injury restoration |
| CN104524503A (en) * | 2014-12-20 | 2015-04-22 | 丁立 | Traditional Chinese medicine for treatment of stroke |
| CN106310038A (en) * | 2016-08-22 | 2017-01-11 | 刘洪英 | Medicine for combining traditional Chinese medicine and western medicine to treat spine and spinal cord injury, and preparation method thereof |
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| CN101810843B (en) | 2011-12-14 |
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