CN106310038A - Medicine for combining traditional Chinese medicine and western medicine to treat spine and spinal cord injury, and preparation method thereof - Google Patents

Medicine for combining traditional Chinese medicine and western medicine to treat spine and spinal cord injury, and preparation method thereof Download PDF

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CN106310038A
CN106310038A CN201610701636.8A CN201610701636A CN106310038A CN 106310038 A CN106310038 A CN 106310038A CN 201610701636 A CN201610701636 A CN 201610701636A CN 106310038 A CN106310038 A CN 106310038A
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herba
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刘洪英
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

The invention discloses a medicine for combining traditional Chinese medicine and western medicine to treat spine and spinal cord injury, and a preparation method thereof, belonging to the technical field of medicines. The medicine is prepared from the following raw materials: elaeagnus pungens, pittosporum illicioides makino, oblongleaf kadsura stem and root, nothopanax delavayi(Franch.)harms, Cyperus iria, multiflora rose roots, ginseng, longleaf bastardtoadflax herb, lumbricus, sassafras tzumu, berchermia lineata, rhizoma dioscoreae colletii, folium eucalypti, digitateleaf eria herbs, indigoplant fruit, elk's horns, vitamin B1, pentazocine, dexamethasone and indomethacin. The medicine combines traditional Chinese medicine and western medicine, ingredients are mutually interacted, according to functions of liver, spleen, kidney and lung of patients, the medicine can nourish liver and kidney, strengthen governor meridians, generate new marrows, strengthen muscle strength, lead nerves, tonify qi and blood, activate blood and remove blood stasis, reduce phlegm and clear away heat, strengthen spleen and tonify lung, nourish blood and liver, reinforce the kidney to replenish essence, prevent the local microvessel spasm and ischemia of spine and spinal cords, reduce the permeability of blood vessels, prevent rupture of venules, avoid the occurrence of hemorrhagic necrotic hepatitis, and promote the rapid restoration of normal neurological functions.

Description

A kind of therapy of combining Chinese and Western medicine spinal column, the medicine of spinal cord injury and preparation method
Art
The present invention relates to pharmaceutical technology field, particularly relate to a kind of therapy of combining Chinese and Western medicine spinal column, the medicine of spinal cord injury And preparation method.
Background technology
Can occur in batch when spinal column, spinal cord injury often betide industrial and mineral, vehicle accident, wartime and natural disaster.Traumatic condition is tight Repeating miscellaneous, multiple injury, combined injury are more, and complication is many, poor prognosis when merging Spinal Cord Injury, even cause the most maimed or jeopardize life Life.
Spinal column, the clinical manifestation of spinal cord injury be:
1. spinal fracture
Have severe trauma history, as under placement in height, weight hit head and neck or shoulder back, cave in accident, vehicle accident etc., patient Experiencing local pain, cervical region moving obstacle, lower back muscle spasm, it is impossible to stand up and stand up, fracture local can be laid one's hand on and after limitation Prominent deformity.Owing to vegetative nerve is stimulated by retroperitoneal hematoma, enterokinesia is slowed down, and the symptom such as abdominal distention, stomachache often occurs.
2. merge spinal cord and nerve root injury
(1) sensory disturbance.The pain sensation, thermo aesthesia, sense of touch and proprioceptive sensation below lesion level weaken or disappear.
(2) dyskinesia.The spinal shock phase, show as collapsing from physical exhaustion below spinal cord injury sections, areflexia.After shock stage If spinal cord transection wound then occurs that upper motor neuron is paralysed, hypermyotonia, there is patellar clonus and ankle battle array in tendon hyperreflexia Contraction and pathologic reflex.
(3) sphincter dysfunction.The spinal shock phase shows as urine retention, is that detrusor of bladder paralysis forms no-station pole canopy Caused by bladder, after shock stage, if spinal cord injury is more than sacrum marrow plane, can form automatic reflection bladder, residual urine is less than 100ml, but can not arbitrarily urinate.
(4) incomplete spinal cord injury.1. anterior spinal cord injury: show as autonomic movement and the pain sensation of below lesion level Disappear.2. spinal cord central damage: common when Cervical cord injuries, performance upper extremity exercise lose, but lower extremity motor function exist or Upper extremity exercise afunction substantially ratio severe lower extremity, the tendon reflex of lesion level disappears and tendon reflex below lesion level is high Enter.3. the half side injury syndrome of spinal cord: the offside pain athalposis below performance lesion level, the motor function of homonymy, position Feel, movement sensation and 2 distinguish that feel is lost.4. spinal cord rear portion damage: the deep sensory below performance lesion level, deep pressure sensation, topognosis Lose, and the pain sense of heat and motor function are the most normal.
Spinal column, the functional rehabilitation of spinal cord injury depend primarily on spinal column, degrees of spinal cord injury, but release early to spinal column, The compressing of spinal cord is to ensure that the matter of utmost importance that spinal column, spinal function recover.Operative treatment is comprehensive to spinal column, Patients of Spinal The pith of rehabilitation, recovers the normal axis of spinal column, recovers vertebral canal diameter, releases sclerite or dislocation directly or indirectly Compressing to spinal cord and nerve roots, stablizes spinal column, and beneficially patient quickly gets well, but postoperative remains a need for medicine assisted care, Though Western medicine instant effect, side effect is big, and dependency is strong, although Chinese medicine does not has dependency, side effect, but it is the slowest to take effect.Therefore, In conjunction with tcm therapy and western medicine therapy, work out a kind of determined curative effect and take effect and fast medicine is of great value.
Summary of the invention
The invention provides a kind of therapy of combining Chinese and Western medicine spinal column, the medicine of spinal cord injury and preparation method, the present invention is Combination of Chinese and Western medicine medicine, composition interacts, in conjunction with liver,spleen,kidney, the organ function of lung of patient, starts with from entirety, tonifying liver Kidney, strong governor vessel, tissue regeneration promoting marrow, key muscular strength, logical nerve, benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling, reducing phlegm and fever, strengthening spleen and tonifying lung, nourishing blood to suppress the hyperactive liver, Kidney tonifying, essence replenishing, it is possible to prevent spinal column, spinal cord local blood capillary spasm, ischemia, reduce the permeability of blood vessel, prevent venule from breaking Split, it is to avoid the generation of hemorrhagic necrosis, promote that the fast quick-recovery of function of nervous system is normal；Drug administration of the present invention is convenient, absorbs effect The best, evident in efficacy, without bad and toxic and side effects, additionally it is possible to supplement the nutrients in time, strengthen the resistance of patient, low cost, warp Clinical verification, short treating period, cure rate are high, treating both the principal and secondary aspects of a disease.
For achieving the above object, technical scheme is implemented as follows:
A kind of therapy of combining Chinese and Western medicine spinal column, the medicine of spinal cord injury, described medicine is made up of Chinese medicine and western medicine composition, system Become described Chinese medicine ingredients raw material composition and parts by weight be: Fructus Elaeagni 60～90 parts, beggar 57～87 parts, Caulis Seu Radix Kadsurae Oblongifoliae 55～ 85 parts, Herba seu Radix Nothopanacis delavayi 51～81 parts, Herba Cyperi Iriae 50～80 parts, Radix rosae multiflorae 45～75 parts, Radix Ginseng 42～72 parts, Herba Thesii Longifolii 40～70 Part, Pheretima 36～66 parts, Radix sassafratis 35～65 parts, Radix berchemiae lineatae 33～63 parts, Rhizoma Smilacis 31～61 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 30～60 parts, Herba Eriae Panneae 26～56 parts, Fructus polygoni tinctorii 25～55 parts, Cornu Elaphuri pantotrichum 20～50 parts；Make described western medicine composition raw material composition and parts by weight be: dimension Raw element B17～16 parts, pentazocine 0.5～2.0 parts, dexamethasone 0.5～1.8 parts, indomethacin 0.3～1.7 parts.
Described medicine is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Fructus Elaeagni 83 parts, beggar 80 parts, Caulis Seu Radix Kadsurae Oblongifoliae 78 parts, Herba seu Radix Nothopanacis delavayi 74 parts, Herba Cyperi Iriae 73 parts, Radix rosae multiflorae 68 parts, Radix Ginseng 66 parts, nine Herba mesonae chinensis 64 parts, Pheretima 62 parts, Radix sassafratis 58 parts, Radix berchemiae lineatae 56 parts, Rhizoma Smilacis 54 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 53 parts, Herba Eriae Panneae 49 parts, Fructus polygoni tinctorii 48 parts, Cornu Elaphuri pantotrichum 43 parts；Make described western medicine composition raw material composition and parts by weight be: vitamin B113 parts, pentazocine 1.6 parts, ground Sai meter Song 1.4 parts, indomethacin 1.3 parts.
Described medicine is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Fructus Elaeagni 76 parts, beggar 73 parts, Caulis Seu Radix Kadsurae Oblongifoliae 71 parts, Herba seu Radix Nothopanacis delavayi 69 parts, Herba Cyperi Iriae 66 parts, Radix rosae multiflorae 61 parts, Radix Ginseng 59 parts, nine Herba mesonae chinensis 56 parts, Pheretima 55 parts, Radix sassafratis 51 parts, Radix berchemiae lineatae 49 parts, Rhizoma Smilacis 45 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 46 parts, Herba Eriae Panneae 42 parts, Fructus polygoni tinctorii 41 parts, Cornu Elaphuri pantotrichum 36 parts；Make described western medicine composition raw material composition and parts by weight be: vitamin B111 parts, pentazocine 1.3 parts, ground Sai meter Song 1.0 parts, indomethacin 0.8 part.
Described medicine is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Fructus Elaeagni 68 parts, beggar 64 parts, Caulis Seu Radix Kadsurae Oblongifoliae 63 parts, Herba seu Radix Nothopanacis delavayi 62 parts, Herba Cyperi Iriae 58 parts, Radix rosae multiflorae 53 parts, Radix Ginseng 50 parts, nine Herba mesonae chinensis 49 parts, Pheretima 44 parts, Radix sassafratis 46 parts, Radix berchemiae lineatae 42 parts, Rhizoma Smilacis 39 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 37 parts, Herba Eriae Panneae 34 parts, Fructus polygoni tinctorii 33 parts, Cornu Elaphuri pantotrichum 28 parts；Make described western medicine composition raw material composition and parts by weight be: vitamin B19 parts, pentazocine 0.7 part, ground Sai meter Song 0.6 part, indomethacin 0.4 part.
A kind of therapy of combining Chinese and Western medicine spinal column, the preparation method of medicine of spinal cord injury, comprise the following steps that:
(1) Fructus Elaeagni, Herba Eriae Panneae, Fructus polygoni tinctorii and Cornu Elaphuri pantotrichum are put in container, add the steaming of relative mixture quality 6～8 times amount Distilled water is soaked 2～3 days, adds the ethanol that mass concentration is 45%～55% of 3～4 times amount, is heated to reflux 4 hours, filters, Obtain extracting solution；The medicinal residues obtained after filtering add the distilled water of relative medicinal residues quality 4～6 times amount, are heated to reflux 2 hours； Filter, obtain extracting solution；Merge twice extracting solution, filter, obtain filtrate, cool to 25 DEG C～30 DEG C, reclaim ethanol, be concentrated into Water content is the extractum of 30%-40%, standby；
(2) beggar, Herba Cyperi Iriae and Herba Thesii Longifolii are cleaned, juice of squeezing out in being placed in juice extractor, cold preservation 4 hours, filter, remove Decontamination and precipitate, carry out desolventing technology through activated carbon adsorption, is concentrated into the extractum that water content is 30%-40%, standby；
(3) Caulis Seu Radix Kadsurae Oblongifoliae and Radix Ginseng are done the wash totally, be placed in the boiling water of relative mixture quality 10 times amount immersion 3～7 points Clock, pulls out, then immerses immersion 9～12 minutes in the cold water of relative mixture quality 10 times amount, takes out, with pin along Caulis Seu Radix Kadsurae Oblongifoliae and people Parallel and the vertical direction of ginseng pricks aperture, is dipped in the syrup of relative mixture quality 5 times amount 24 hours, takes out, wash away floating sugar, Dry, grind into powder in being placed in mortar, obtained the fine powder of 160 mesh, standby；
(4) by Herba seu Radix Nothopanacis delavayi, Radix rosae multiflorae, Radix sassafratis, Radix berchemiae lineatae, Rhizoma Smilacis and Folium eucalypti globueli (Eucalyptus globulus Labill.) decontamination, shine to half-dried, then regain heap Putting, cover with burlap, stewing removing burlap also shines to parching completely, smashs to pieces two days later, screens out ash bits, grinds into powder in being placed in mortar, Arrived the fine powder of 140 mesh, standby；
(5) being washed by Pheretima, mash, add three/white sugar of an amount and the water of 1/2nd amounts, stirring is all Even, stand 48 hours, filter, obtain filtrate, at 60 DEG C, be concentrated into the extractum that water content is 30%-40%, standby；
(6) it is ground into fine powder in vitamin B1, pentazocine, dexamethasone and indomethacin being placed in mortar, obtains 200 ～220 fine powders of mesh, standby；
(7) by step (1), step (2), the extractum of step (5) gained, step (3), step (4), the fine powder of (6) gained Mix homogeneously, lyophilization, Co60 radiation sterilization, it is pressed into tablet, every weight is 30mg, packaging, is in described treatment Doctor trained in Western medicine combined treatment spinal column, the medicine of spinal cord injury.
The drug effect of Chinese medicine used by the present invention is as follows:
Fructus Elaeagni: expelling wind and removing dampness, clots absorbing stops blooding.For infectious hepatitis, infantile malnutrition, rheumatic arthritis, spit blood and spit blood, Have blood in stool metrorrhagia, leucorrhea, traumatic injury, bronchitis, enteritis and dysentery, inappetence." conventional Chinese herbal folk proved recipe a collection of selected materials " carries: " astringing to arrest diarrhea, relieving cough and asthma, control dyspepsia, and hernia is breathed with cough, metrorrhagia, osteomyelitis, hemorrhoid, lumbar strain.”
Beggar: detoxification and promoting urination, promoting blood circulation and detumescence.For venom, arthralgia, general edema with yellowish tinge of the skin swells, carbuncle furuncle, and traumatic injury is hindered Folding, skin eczema." conventional Chinese herbal folk proved recipe a collection of selected materials " carries: " eliminating inflammation and expelling toxin, detumescent of invigorating blood circulation control venom, eczema bone Folding, arthritis, furuncle carbuncle, osteomyelitis, cellulitis.”
Caulis Seu Radix Kadsurae Oblongifoliae: wind-damp dispelling, and the intestines and stomach, promoting the circulation of QI to relieve pain.For catching a cold, rheumatic arthralgia, diarrhea and vomiting, traumatic injury." literary composition Mountain Chinese herbal medicine " carry: " promoting the circulation of QI to relieve pain, expelling wind and removing dampness, control gastroenteritis, flu, traumatic injury, rheumatalgia, fracture.”
Herba seu Radix Nothopanacis delavayi: heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation.For acute pharyngitis, acute conjunctivitis, dyspepsia, lumbago, skelalgia of rheumatism, Fracture, traumatic injury." Yunnan Chinese herbal medicine " carries: " heat-clearing and toxic substances removing, relaxing muscles and tendons of regulating the flow of vital energy.”
Herba Cyperi Iriae: expelling wind and removing dampness, promoting blood flow to regulate menstruation.For rheumatism bones and muscles pain, paralysis, menoxenia, amenorrhea is educated through, traumatic injury Damage." classifying herbal " carries: " dispelling the wind and dampness pathogens bones and muscles pain, the right paralysis of left paralysis.”
Radix rosae multiflorae: clearing away heat-damp and promoting diuresis, expelling wind and activating blood circulation, removing toxic substances.Quench one's thirst for lung abscess, dysentery, arthritis, paralysis, tell, be defeated in battle, just Blood, frequent urination and enuresis, menoxenia, traumatic injury, furuncle scabies." detailed outline " carries: " except wind heat is damp and hot, urine reducing, only quench one's thirst.”
Radix Ginseng: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen food Few, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb, heart failure, cardiogenic shock. " cure mainly secret will " carries: " invigorating primordial QI, antidiarrheal, born fluid.”
Herba Thesii Longifolii: dispel the wind, heat clearing away, spasmolytic.For heatstroke of catching a cold, infantile pneumonia, infantile convulsion of coughing." Yunnan Chinese herbal medicine " carries: " spasmolytic of bringing down a fever, antiinflammatory parasite killing, control infantile pneumonia, hepatitis of coughing, infantile convulsion, thrombocytopenic purpura, malnutrition due to parasitic infestation, schistosomicide Sick.”
Pheretima: heat clearing away is calmed the frightened, dredging collateral is relievingd asthma, diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, Hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Radix sassafratis: dispel the wind by wet, promoting blood circulation to remove blood stasis.For rheumatic arthritis, rheumatoid arthritis, lumbar muscle strain, chronic waist Skelalgia, hemiplegia, traumatic injury, bruise, knife injury is hemorrhage." register planted by Guangxi medicine " carries: " control gastropathy rheumatism, hemiplegia, Edema, arthritis.”
Radix berchemiae lineatae: removing stasis to stop bleeding, antitussive pain relieving.For hemoptysis of pulmonary tuberculosis, taste-blindness rate is hemorrhage, schizophrenia Disease, traumatic injury, rheumatic ostalgia, furuncle furuncle and phyma, deradenoncus, painful and swollen testis." south of the Five Ridges gather medicinal herbs record " carries: " antidote against snake bite, reason Malignant boil, reason traumatic injury wound, bone pain relieving can be refuted, control hernia.”
Rhizoma Smilacis: expelling wind and removing dampness, regulating menstruation diuresis.For rheumatic arthritis, urinary system infection, oedema due to nephritis, chronic stomach Inflammation, menoxenia." choosing of Yunnan Chinese herbal medicine " carries: " expelling wind and removing dampness, stranguria treating and diuresis inducing, eliminating inflammation and expelling toxin, treating rheumatic arthritis, urinary system System infects, chronic gastritis, menoxenia, furuncle.”
Folium eucalypti globueli (Eucalyptus globulus Labill.): dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, high dyspnea of heat type coughs, pertussis, abdominal distention, burn and scald, traumatic hemorrhage." Sichuan Chinese medicinal herbal " carry: " control arthralgia and make the net for catching birds or fish bag of surgical site infections.”
Herba Eriae Panneae: promoting blood circulation to remove blood stasis, heat-clearing and toxic substances removing.For traumatic injury, fracture, ulcerative carbuncle furuncle and phyma, burn." mountain of papers Chinese herbal medicine " Carry: " removing toxic substances spasmolytic.”
Fructus polygoni tinctorii: heat clearing away, removing heat from blood, removing toxic substances.For epidemic febrile disease high heat, telling nosebleed and send out speckle, laryngopharynx swelling and pain, furuncle and phyma, innominate toxic swelling, infantile malnutrition is lost Skin ulcer, honeybee insect sting." property of medicine opinion " carries: " fills out bone marrow, bright knowledge, profit the five internal organs, adjusts six internal organs, profit joint, control stagnation of QI in meridians, make people Strong, sleep less, benefit mental and physical efforts.”
Cornu Elaphuri pantotrichum: kidney-replenishing, benefiting essence-blood, bone and muscle strengthening, strong waist knee joint.Winning thin for asthenia, asthenia of essence and blood, sexual impotence is infertile, waist knee joint Aching and limp, bones and muscles pain." detailed outline " carries: " control deficiency of YIN strain, all disorders of blood, muscles and bones soreness of waist and knee joint, nourishing YIN for benefiting the kidney.”
The present invention compared with prior art, has the advantages that
1, the present invention is combination of Chinese and Western medicine medicine, and composition interacts, in conjunction with liver,spleen,kidney, the internal organs merit of lung of patient Can, start with from entirety, invigorating the liver and kidney, strong governor vessel, tissue regeneration promoting marrow, key muscular strength, logical nerve, benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling, reducing phlegm and fever, Strengthening spleen and tonifying lung, nourishing blood to suppress the hyperactive liver, kidney tonifying, essence replenishing, it is possible to prevent spinal column, spinal cord local blood capillary spasm, ischemia, reduce blood vessel Permeability, prevent venule from rupturing, it is to avoid the generation of hemorrhagic necrosis, promotes that the fast quick-recovery of function of nervous system is normal.
2, drug administration of the present invention is convenient, and good absorbing effect is evident in efficacy, without bad and toxic and side effects, additionally it is possible in time Supplementing the nutrients, strengthen the resistance of patient, low cost, according to clinical verification, short treating period, cure rate are high, treating both the principal and secondary aspects of a disease.
Detailed description of the invention
The present invention is further elaborated by compound recipe specific embodiment below.
Embodiment 1
The raw material of ingredient of the present invention forms and weight is: Fructus Elaeagni 89 parts, beggar 86 parts, and Caulis Seu Radix Kadsurae Oblongifoliae 84 parts is good Prosperous tea 80 parts, Herba Cyperi Iriae 79 parts, Radix rosae multiflorae 74 parts, Radix Ginseng 71 parts, Herba Thesii Longifolii 69 parts, Pheretima 65 parts, Radix sassafratis 64 parts, Radix berchemiae lineatae 62 Part, Rhizoma Smilacis 60 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 59 parts, Herba Eriae Panneae 55 parts, Fructus polygoni tinctorii 54 parts, Cornu Elaphuri pantotrichum 49 parts, vitamin B115 parts, pentazocine 1.9 parts, Dexamethasone 1.7 parts, indomethacin 1.6 parts.
The processing step of process for preparing medicine of the present invention is:
(1) Fructus Elaeagni, Herba Eriae Panneae, Fructus polygoni tinctorii and Cornu Elaphuri pantotrichum are put in container, add the steaming of relative mixture quality 6～8 times amount Distilled water is soaked 2～3 days, adds the ethanol that mass concentration is 45%～55% of 3～4 times amount, is heated to reflux 4 hours, filters, Obtain extracting solution；The medicinal residues obtained after filtering add the distilled water of relative medicinal residues quality 4～6 times amount, are heated to reflux 2 hours； Filter, obtain extracting solution；Merge twice extracting solution, filter, obtain filtrate, cool to 25 DEG C～30 DEG C, reclaim ethanol, be concentrated into Water content is the extractum of 30%-40%, standby；
(2) beggar, Herba Cyperi Iriae and Herba Thesii Longifolii are cleaned, juice of squeezing out in being placed in juice extractor, cold preservation 4 hours, filter, remove Decontamination and precipitate, carry out desolventing technology through activated carbon adsorption, is concentrated into the extractum that water content is 30%-40%, standby；
(3) Caulis Seu Radix Kadsurae Oblongifoliae and Radix Ginseng are done the wash totally, be placed in the boiling water of relative mixture quality 10 times amount immersion 3～7 points Clock, pulls out, then immerses immersion 9～12 minutes in the cold water of relative mixture quality 10 times amount, takes out, with pin along Caulis Seu Radix Kadsurae Oblongifoliae and people Parallel and the vertical direction of ginseng pricks aperture, is dipped in the syrup of relative mixture quality 5 times amount 24 hours, takes out, wash away floating sugar, Dry, grind into powder in being placed in mortar, obtained the fine powder of 160 mesh, standby；
(4) by Herba seu Radix Nothopanacis delavayi, Radix rosae multiflorae, Radix sassafratis, Radix berchemiae lineatae, Rhizoma Smilacis and Folium eucalypti globueli (Eucalyptus globulus Labill.) decontamination, shine to half-dried, then regain heap Putting, cover with burlap, stewing removing burlap also shines to parching completely, smashs to pieces two days later, screens out ash bits, grinds into powder in being placed in mortar, Arrived the fine powder of 140 mesh, standby；
(5) being washed by Pheretima, mash, add three/white sugar of an amount and the water of 1/2nd amounts, stirring is all Even, stand 48 hours, filter, obtain filtrate, at 60 DEG C, be concentrated into the extractum that water content is 30%-40%, standby；
(6) it is ground into fine powder in vitamin B1, pentazocine, dexamethasone and indomethacin being placed in mortar, obtains 200 ～220 fine powders of mesh, standby；
(7) by step (1), step (2), the extractum of step (5) gained, step (3), step (4), the fine powder of (6) gained Mix homogeneously, lyophilization, Co60 radiation sterilization, it is pressed into tablet, every weight is 30mg, packaging, is in described treatment Doctor trained in Western medicine combined treatment spinal column, the medicine of spinal cord injury.
Usage and dosage: oral, each 1,1 30mg, three times a day, the morning, noon and afternoon the most once, 10 days are a course for the treatment of, logical Normal 2～3 courses for the treatment of of recovery from illness, pertinacious disease needs 4～5 recoveries from illness course for the treatment of.
Embodiment 2
The raw material of ingredient of the present invention forms and weight is: Fructus Elaeagni 83 parts, beggar 80 parts, and Caulis Seu Radix Kadsurae Oblongifoliae 78 parts is good Prosperous tea 74 parts, Herba Cyperi Iriae 73 parts, Radix rosae multiflorae 68 parts, Radix Ginseng 66 parts, Herba Thesii Longifolii 64 parts, Pheretima 62 parts, Radix sassafratis 58 parts, Radix berchemiae lineatae 56 Part, Rhizoma Smilacis 54 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 53 parts, Herba Eriae Panneae 49 parts, Fructus polygoni tinctorii 48 parts, Cornu Elaphuri pantotrichum 43 parts, vitamin B113 parts, pentazocine 1.6 parts, Dexamethasone 1.4 parts, indomethacin 1.3 parts.
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 3
The raw material of ingredient of the present invention forms and weight is: Fructus Elaeagni 76 parts, beggar 73 parts, and Caulis Seu Radix Kadsurae Oblongifoliae 71 parts is good Prosperous tea 69 parts, Herba Cyperi Iriae 66 parts, Radix rosae multiflorae 61 parts, Radix Ginseng 59 parts, Herba Thesii Longifolii 56 parts, Pheretima 55 parts, Radix sassafratis 51 parts, Radix berchemiae lineatae 49 Part, Rhizoma Smilacis 45 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 46 parts, Herba Eriae Panneae 42 parts, Fructus polygoni tinctorii 41 parts, Cornu Elaphuri pantotrichum 36 parts, vitamin B111 parts, pentazocine 1.3 parts, Dexamethasone 1.0 parts, indomethacin 0.8 part.
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 4
The raw material of ingredient of the present invention forms and weight is: Fructus Elaeagni 68 parts, beggar 64 parts, and Caulis Seu Radix Kadsurae Oblongifoliae 63 parts is good Prosperous tea 62 parts, Herba Cyperi Iriae 58 parts, Radix rosae multiflorae 53 parts, Radix Ginseng 50 parts, Herba Thesii Longifolii 49 parts, Pheretima 44 parts, Radix sassafratis 46 parts, Radix berchemiae lineatae 42 Part, Rhizoma Smilacis 39 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 37 parts, Herba Eriae Panneae 34 parts, Fructus polygoni tinctorii 33 parts, Cornu Elaphuri pantotrichum 28 parts, vitamin B19 parts, pentazocine 0.7 part, Dexamethasone 0.6 part, indomethacin 0.4 part.
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Toxicity test:
One, acute toxicity test:
1, test procedure: randomly selecting healthy mice 48, male and female half and half, body weight 18～28g, mice is randomly divided into two Group, i.e. experimental group and matched group, equal fasting 12 hours before experiment, respectively by the perfusion amount that gavage volume is 5ml/kg to experimental group Carrying out perfusion with matched group, experimental group is selected in 1 water being dissolved in 10ml of medicine of the present invention, and matched group chooses the physiology of equivalent Saline, experimental group and matched group homogeneous sky perfusion 3 times, perfusion interval time is 8 hours, Continuous Observation 15 days after perfusion, and root Toxic reaction degree and death toll according to evaluation methodology record mice.
2, evaluation methodology:
3, there is not death in result: acute toxicity test mice perfusion postabdomen has no irritant reaction, breathes normal, body Body is healthy, body weight does not declines, and after dissecting it accordingly, tissue or internal organs have no obvious abnormal change.
Two, long term toxicity test
1, test procedure: randomly selecting healthy rat 52, male and female half and half, body weight 220～240g, rat is randomly divided into two Group, i.e. experimental group and matched group, after testing front all fasting 12 hours, respectively by the perfusion amount that gavage volume is 5ml/kg to experiment Group and matched group carry out perfusion, and experimental group is selected in 1 water being dissolved in 40ml of medicine of the present invention, and matched group chooses the life of equivalent Reason saline, experimental group and matched group equal perfusion every day in the 1st～30 day 3 times, perfusion interval time is 8 hours, within later every 6 hours, passs Increase 1.3 multiple doses, perfusion 100 days, according to the evaluation methodology record rat in acute toxicity test toxic reaction degree and Death toll.
2, there is not death in result: the rat abdomen of long term toxicity test has no irritant reaction, breathes normal, to size Just, body weight, organ weights, hepatic and renal function, blood fat etc. all have no significant effect.Clinical data:
1, case selection:
Selecting spinal column, Patients of Spinal 228 example clinical observation that my institute or outer court make a definite diagnosis, patient is randomly divided into two groups, Treatment group 114 example, wherein male 57 example, women 57 example, age 8～64 years old, 50 years old mean age, the course of disease 3 months～1 year, flat Equal 6 months.Matched group 114 example, wherein male 58 example, women 56 example, age 7～62 years old, 51 years old mean age, the course of disease 2 months ～1 year, average 5 months.The course of disease of two groups of cases, degrees of symptoms are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient takes medicine of the present invention, oral, each 1,1 30mg, three times a day, the morning, noon and afternoon the most once, 10 It is a course for the treatment of, usual 2～3 courses for the treatment of of recovery from illness, and pertinacious disease needs 4～5 recoveries from illness course for the treatment of.
Matched group use citicoline, quiet, intravenous or intramuscular injection, 100～500mg/ time, 1～2 times/day, can be according to year Age, symptom suitably increase and decrease.
3, efficacy determination:
(1) cure: the transference cures such as sensory disturbance, the dyskinesia, muscle spasm, fracture deformity；Activity freely, health extensive Rehabilitation health.
(2) effective: above-mentioned symptom has been alleviated.
(3) invalid: above-mentioned symptom is unchanged.
4, result:
Result above shows, treatment group cure rate and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Guo's ××, man, 8 years old, student.Patient causes spinal fracture, injured spinal cords, cervical region moving obstacle, waist because of traffic accident Muscle of back spasm, it is impossible to stand up and stand up, motor neuron is paralysed.Postoperative take 3 courses for the treatment of of medicine of the present invention after, above disease Shape disappears, and freely, physical recovery is healthy, follows up a case by regular visits to not recur so far in activity.
2, Yuan's ××, female, 15 years old, student.Patient causes spinal column, spinal cord injury, whole body multiple fracture because of flood damage, includes About muscular function obstacle, injury of sacral nerve roots, urinary incontinence.Postoperative after people recommends to take 1 course for the treatment of of medicine of the present invention, health is gradually Rehabilitation, above symptom takes a turn for the better, continues to take 2 courses for the treatment of, and health is fully recovered, and follows up a case by regular visits to not recur so far.
3, yellow ××, female, 23 years old, intern.Patient at work accidentally from high falling, spinal column, bone marrow damage, bitterly Feel, thermo aesthesia, sense of touch weaken, it is impossible to the most movable, simultaneously with stomachache, the symptom of abdominal distention.Take 2 courses for the treatment of of medicine of the present invention After, symptom takes a turn for the better, and continues to take 1 course for the treatment of, transference cure, and activity freely, is not recurred.
4, old ××, man, 36 years old, sales manager.Patient spine, bone marrow injury, injury region local congestion and swelling pain, muscle convulsion Contraction, compression of spinal cord, myelatrophy, once applied 20% mannitol to carry out dehydration therapy, and failed to fully recover.Take medicine of the present invention 3 After the course for the treatment of, transference cure, not recurrence.
5, ×× slowly, man, 45 years old, builder.Patient is clashed into by falling object from high altitude at work, causes spinal fracture, ridge Marrow is impaired, performs the operation and it is recovered the normal axis of spinal column, recover vertebral canal diameter, release the sclerite compressing to spinal cord and nerve roots.Art After take medicine of the present invention and treat, after taking 1 course for the treatment of, pick body, continue to take 1 course for the treatment of, physical recovery is healthy, Follow up a case by regular visits to not recur so far.
6, Soviet Union's ××, female, 59 years old, retired worker.Patient spine damages, and because failing to treat in time, oppresses spinal cord, makes spinal cord Damage, damage zone has an intense pain after a few days, it is impossible to do any activity.Postoperative take 2 courses for the treatment of of medicine of the present invention after, symptom is obvious Alleviating, then take 1 course for the treatment of, physical recovery is normal, and activity freely, follows up a case by regular visits to not recur so far.

Claims (5)

1. a therapy of combining Chinese and Western medicine spinal column, the medicine of spinal cord injury, it is characterised in that: described medicine is become with Western medicine by Chinese medicine Be grouped into, make described Chinese medicine ingredients raw material composition and parts by weight be: Fructus Elaeagni 60～90 parts, beggar 57～87 parts, Caulis Seu Radix Kadsurae Oblongifoliae 55～85 parts, Herba seu Radix Nothopanacis delavayi 51～81 parts, Herba Cyperi Iriae 50～80 parts, Radix rosae multiflorae 45～75 parts, Radix Ginseng 42～72 parts, nine is celestial Grass 40～70 parts, Pheretima 36～66 parts, Radix sassafratis 35～65 parts, Radix berchemiae lineatae 33～63 parts, Rhizoma Smilacis 31～61 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 30～60 Part, Herba Eriae Panneae 26～56 parts, Fructus polygoni tinctorii 25～55 parts, Cornu Elaphuri pantotrichum 20～50 parts；Make raw material composition and the weight portion of described western medicine composition Number is: vitamin B17～16 parts, pentazocine 0.5～2.0 parts, dexamethasone 0.5～1.8 parts, indomethacin 0.3～1.7 Part.
A kind of therapy of combining Chinese and Western medicine spinal column the most according to claim 1, the medicine of spinal cord injury, it is characterised in that: institute State medicine to be made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Fructus Elaeagni 83 parts, Beggar 80 parts, Caulis Seu Radix Kadsurae Oblongifoliae 78 parts, Herba seu Radix Nothopanacis delavayi 74 parts, Herba Cyperi Iriae 73 parts, Radix rosae multiflorae 68 parts, Radix Ginseng 66 parts, Herba Thesii Longifolii 64 parts, ground Dragon 62 parts, Radix sassafratis 58 parts, Radix berchemiae lineatae 56 parts, Rhizoma Smilacis 54 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 53 parts, Herba Eriae Panneae 49 parts, Fructus polygoni tinctorii 48 parts, Cornu Elaphuri pantotrichum 43 parts；System The raw material becoming described western medicine composition forms and parts by weight are: vitamin B113 parts, pentazocine 1.6 parts, dexamethasone 1.4 Part, indomethacin 1.3 parts.
A kind of therapy of combining Chinese and Western medicine spinal column the most according to claim 1, the medicine of spinal cord injury, it is characterised in that: institute State medicine to be made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Fructus Elaeagni 76 parts, Beggar 73 parts, Caulis Seu Radix Kadsurae Oblongifoliae 71 parts, Herba seu Radix Nothopanacis delavayi 69 parts, Herba Cyperi Iriae 66 parts, Radix rosae multiflorae 61 parts, Radix Ginseng 59 parts, Herba Thesii Longifolii 56 parts, ground Dragon 55 parts, Radix sassafratis 51 parts, Radix berchemiae lineatae 49 parts, Rhizoma Smilacis 45 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 46 parts, Herba Eriae Panneae 42 parts, Fructus polygoni tinctorii 41 parts, Cornu Elaphuri pantotrichum 36 parts；System The raw material becoming described western medicine composition forms and parts by weight are: vitamin B111 parts, pentazocine 1.3 parts, dexamethasone 1.0 Part, indomethacin 0.8 part.
A kind of therapy of combining Chinese and Western medicine spinal column the most according to claim 1, the medicine of spinal cord injury, it is characterised in that: institute State medicine to be made up of Chinese medicine and western medicine composition, make raw material composition and the weight of described Chinese medicine ingredients
Amount number is: Fructus Elaeagni 68 parts, beggar 64 parts, Caulis Seu Radix Kadsurae Oblongifoliae 63 parts, Herba seu Radix Nothopanacis delavayi 62 parts, Herba Cyperi Iriae 58 parts, Radix rosae multiflorae 53 Part, Radix Ginseng 50 parts, Herba Thesii Longifolii 49 parts, Pheretima 44 parts, Radix sassafratis 46 parts, Radix berchemiae lineatae 42 parts, Rhizoma Smilacis 39 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) 37 parts, Herba Eriae Panneae 34 parts, Fructus polygoni tinctorii 33 parts, Cornu Elaphuri pantotrichum 28 parts；Make described western medicine composition raw material composition and parts by weight be: vitamin B19 parts, spray Ta Zuoxin 0.7 part, dexamethasone 0.6 part, indomethacin 0.4 part.
5. the preparation side of the medicine of a therapy of combining Chinese and Western medicine spinal column as described in any one of Claims 1 to 4, spinal cord injury Method, it is characterised in that: comprise the following steps that:
(1) Fructus Elaeagni, Herba Eriae Panneae, Fructus polygoni tinctorii and Cornu Elaphuri pantotrichum are put in container, add the distilled water of relative mixture quality 6～8 times amount Soak 2～3 days, add the ethanol that mass concentration is 45%～55% of 3～4 times amount, be heated to reflux 4 hours, filter, obtain extraction Liquid；The medicinal residues obtained after filtering add the distilled water of relative medicinal residues quality 4～6 times amount, are heated to reflux 2 hours；Filter, Extracting solution；Merge twice extracting solution, filter, obtain filtrate, cool to 25 DEG C～30 DEG C, reclaim ethanol, be concentrated into water content For the extractum of 30%-40%, standby；
(2) beggar, Herba Cyperi Iriae and Herba Thesii Longifolii are cleaned, juice of squeezing out in being placed in juice extractor, cold preservation 4 hours, filter, remove miscellaneous Matter and precipitate, carry out desolventing technology through activated carbon adsorption, is concentrated into the extractum that water content is 30%-40%, standby；
(3) Caulis Seu Radix Kadsurae Oblongifoliae and Radix Ginseng are done the wash totally, be placed in the boiling water of relative mixture quality 10 times amount immersion 3～7 minutes, drag for Go out, then immerse in the cold water of relative mixture quality 10 times amount and soak 9～12 minutes, take out, with pin along Caulis Seu Radix Kadsurae Oblongifoliae and Radix Ginseng Parallel and vertical direction pricks aperture, is dipped in the syrup of relative mixture quality 5 times amount 24 hours, takes out, wash away floating sugar, roasting Dry, grind into powder in being placed in mortar, obtained the fine powder of 160 mesh, standby；
(4) by Herba seu Radix Nothopanacis delavayi, Radix rosae multiflorae, Radix sassafratis, Radix berchemiae lineatae, Rhizoma Smilacis and Folium eucalypti globueli (Eucalyptus globulus Labill.) decontamination, shine to half-dried, then regain stacking, Covering with burlap, stewing removing burlap also shines to parching completely, smashs to pieces two days later, screens out ash bits, grinds into powder, obtain in being placed in mortar Cross the fine powder of 140 mesh, standby；
(5) Pheretima is washed, mash, add three/white sugar of an amount and the water of 1/2nd amounts, stir, quiet Putting 48 hours, filter, obtain filtrate, being concentrated into water content at 60 DEG C is 30%-40%'s
Extractum, standby；
(6) be ground into fine powder in vitamin B1, pentazocine, dexamethasone and indomethacin being placed in mortar, obtained 200～ The fine powder of 220 mesh, standby；
(7) by step (1), step (2), the extractum of step (5) gained, step (3), step (4), the fine powder mixing of (6) gained Uniformly, lyophilization, Co60 radiation sterilization, it is pressed into tablet, every weight is 30mg, packaging, is described treatment Chinese and western medicine Combined treatment spinal column, the medicine of spinal cord injury.
CN201610701636.8A 2016-08-22 2016-08-22 Medicine for combining traditional Chinese medicine and western medicine to treat spine and spinal cord injury, and preparation method thereof Pending CN106310038A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101810843A (en) * 2010-03-19 2010-08-25 冷军 Medicament for treating nerve system diseases such as cerebrovascular accident, spinal cord injury and senile dementia
CN102106893A (en) * 2009-12-23 2011-06-29 李泽兵 Traditional Chinese medicine preparation for relieving pain in myeleterosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102106893A (en) * 2009-12-23 2011-06-29 李泽兵 Traditional Chinese medicine preparation for relieving pain in myeleterosis
CN101810843A (en) * 2010-03-19 2010-08-25 冷军 Medicament for treating nerve system diseases such as cerebrovascular accident, spinal cord injury and senile dementia

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