CN101804156B - Preparation process and antifatigue effect of compound rhodiola root extract - Google Patents
Preparation process and antifatigue effect of compound rhodiola root extract Download PDFInfo
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- CN101804156B CN101804156B CN2010101630062A CN201010163006A CN101804156B CN 101804156 B CN101804156 B CN 101804156B CN 2010101630062 A CN2010101630062 A CN 2010101630062A CN 201010163006 A CN201010163006 A CN 201010163006A CN 101804156 B CN101804156 B CN 101804156B
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Abstract
The invention relates to a preparation process and an antifatigue effect of a compound rhodiola root extractive, belonging to the technical field of medical product research and development. The preparation process comprises the following steps of: adding raw powder of 20-30 grams of rhodiola roots, 20-30 grams of sealwort, 10-20 grams of shizandra berry, 10-20 grams of herba epimedii and 3-5 grams of Chinese dates to 8-10 time water to soak for 4-6 hours; then extracting by heating at 10 DEG C; then carrying out ultraphonic processing for 1-1.5 hours at the temperature of 30 DEG C and the power of 80 W; then filtering by a gauze; then respectively repeating the steps for filter residues by respectively using 6 time and 4 time water once; merging three-time filter liquor; drying in vacuum; and adding 0.5-1 grams of panaxatriol saponin to obtain the compound rhodiola root extractive. The product has the main effect of antifatigue and is adapted to industrialized production.
Description
Technical field
Medical product research and development technical field under the present invention.The present invention relates to the preparation technology and the antifatigue effect of compound rhodiola root extractive.It is resisting fatigue that product of the present invention mainly acts on, and is fit to suitability for industrialized production.
Background technology
This prescription is made up of Radix Rhodiolae 20g-30g, Rhizoma Polygonati 20g-30g, Fructus Schisandrae Chinensis 10g-20g, Herba Epimedii 10g-20g, Fructus Jujubae 3g-5g and protopanaxatriol ginsenoside 0.5g-1g, has the effect of resisting fatigue.
This prescription drugs is a monarch drug with the dry root and rhizome of Radix Rhodiolae Rhodiola crenulata (Hook f.et ThoMs.) H.Ohba, and property is flat, sweet in the mouth, hardship, and heat-clearing and toxic substances removing is regulated the flow of vital energy, and the kidney invigorating, nourishes heart, calms the nerves, the effectiveness that have regulating menstruation and activating blood, makes eye bright.Dry rhizome with Yunnan Rhizoma Polygonati Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygona-tum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua is a monarch drug, and property is flat, sweet in the mouth, has nourishing kidney profit spleen, the effect of invigorating the spleen and replenishing QI; Be used for deficiency of YIN chronic cough, the xeropulmonary cough, insufficiency of the spleen weak, the lack of appetite xerostomia; Quench one's thirst deficiency of the kidney soreness of the waist and knees, impotence and seminal emission; The tinnitus order is dark, early whitening of beard and hair, the thin effectiveness of the empty win of body.The two can strengthening bone and muscle, beneficial marrow, can mend vital essence again, controls weakness of the spleen and stomach, and fatigue and lack of strength, Radix Rhodiolae and Rhizoma Polygonati are monarch drug altogether.Ministerial drug is the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill., and warm in nature, sour in the mouth, sweet has supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, an effect of calming the nerves, and the principal drug assistance astringing QI promotes the production of body fluid, controlling nocturnal emission with astringent drugs is supported marrow.Dry aerial parts with Herba Epimedii Epimedium brevicornum Maxim., arrow leaf Herba Epimedii Epimedium agittatum (Sieb.et Zucc.) Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanense T.S.Ying or Herba Epimedii Epimedium koreanum Nakai are adjuvant drug, slightly warm in nature, little suffering of distinguishing the flavor of; Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; The blood stasis dispelling of collateral dredging arteries and veins stagnates, and disappears too fat to move and the pain that relieves the pain, and it is capable to join monarch drug blood prosperous without obstacle; More help to treat weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite; Deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat disease such as quench one's thirst.Dry mature fruit with jujube Fructus Jujubae Ziziphus jujuba Mill.var.inermis (Bunge) Rehd. is a messenger drug, and warm in nature, sweet in the mouth has invigorating the spleen and replenishing QI, and the effect of nourishing blood to tranquillize the mind is used for insufficiency of the spleen lack of appetite, weak loose stool.More with protopanaxatriol ginsenoside, strongly invigorating primordial QI is answered arteries and veins and is taken off invigorating the spleen to benefit the lung admittedly.All medicines share to have and promote the production of body fluid, and QI invigorating is calmed the nerves, and controls weak body and prostration, the cold extremities faint pulse, and insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, the effect of prolonged illness weakness with emaciation.
Pharmacological testing shows that Radix Rhodiolae has resisting fatigue, anti-hypoxia, radioprotective, heat-resisting motion, the effect of " adaptogen " appearance; Rhizoma Polygonati has anti-aging effects, blood fat reducing, blood sugar lowering, immunoregulation effect; Fructus Schisandrae Chinensis has antioxidation, hypoxia-bearing capability, antifatigue effect, immunoregulation effect and anti-aging effects; Herba Epimedii has effect of the osteoporosis of control and strengthening body effect; Fructus Jujubae has strengthening by means of tonics, strengthening the body resistance, resisting fatigue, delaying senility function; Protopanaxatriol ginsenoside has antifatigue effect.
Summary of the invention
1. the present invention relates to the preparation technology and the antifatigue effect of compound rhodiola root extractive, it is characterized in that the preparation technology of compound rhodiola root extractive comprises following process:
Step (one): after Radix Rhodiolae 20g-30g, Rhizoma Polygonati 20g-30g, Fructus Schisandrae Chinensis 10g-20g, Herba Epimedii 10g-20g, Fructus Jujubae 3g-5g coarse powder added the water logging bubble 4h-6h that 8-10 doubly measures; 100 ℃ of heating extraction; Ultrasonic again 1h-1.5h, temperature is 30 ℃, power is 80W; Use filtered through gauze then, obtain filtrating;
Step (two): the filtering residue in the step () is repeated above step respectively once with 6 times of amounts and 4 times of water gagings respectively again, merge filtrating three times, vacuum drying adds protopanaxatriol ginsenoside 0.5-1g, gets compound rhodiola root extractive;
Step (three): the compound rhodiola root extractive in the step (two) is carried out anti-fatigue test, and compound rhodiola root extractive has antifatigue effect.
2. the raw material Radix Rhodiolae according to preparation compound rhodiola root extractive of the present invention is the dry root and rhizome of Crassulaceae plant Radix Rhodiolae Rhodiola crenulata (Hook f.et ThoMs.) H.Ohba; Rhizoma Polygonati is the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.; Fructus Schisandrae Chinensis is the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill.; Herba Epimedii is the dry aerial parts of Berberidaceae plant Herba Epimedii Epimediumbrevicornum Maxim., arrow leaf Herba Epimedii Epimedium agittatum (Sieb.et Zucc.) Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanense T.S.Ying or Herba Epimedii Epimedium koreanum Nakai, and Fructus Jujubae is dry mature fruit and the protopanaxatriol ginsenoside of Rhamnaceae jujube Fructus Jujubae Ziziphus jujuba Mill.var.inermis (Bunge) Rehd..
According to the present invention, " % " among the present invention is percentage by weight.
The specific embodiment
Preparation technology and the antifatigue effect that relates to compound rhodiola root extractive of the present invention comprises following examples, and following embodiment can further specify the present invention, but does not limit the present invention in any way.
Embodiment 1:
Step (one): after Radix Rhodiolae 20g, Rhizoma Polygonati 20g, Fructus Schisandrae Chinensis 10g, Herba Epimedii 10g, Fructus Jujubae 3g coarse powder being added the water logging bubble 4h of 8 times of amounts, 100 ℃ of heating extraction, ultrasonic again 1h, temperature is 30 ℃, power is 80W, uses filtered through gauze then, obtains filtrating;
Step (two): the filtering residue in the step () is repeated above step respectively once with 6 times of amounts and 4 times of water gagings respectively again, merge filtrating three times, vacuum drying adds protopanaxatriol ginsenoside 0.5g, gets compound rhodiola root extractive;
Step (three): the compound rhodiola root extractive in the step (two) is carried out anti-fatigue test, and compound rhodiola root extractive has antifatigue effect.
Embodiment 2:
Step (one): after Radix Rhodiolae 30g, Rhizoma Polygonati 30g, Fructus Schisandrae Chinensis 20g, Herba Epimedii 20g, Fructus Jujubae 5g coarse powder being added the water logging bubble 6h of 10 times of amounts, 100 ℃ of heating extraction, ultrasonic again 1.5h, temperature is 30 ℃, power is 80W, uses filtered through gauze then, obtains filtrating;
Step (two): the filtering residue in the step () is repeated above step respectively once with 6 times of amounts and 4 times of water gagings respectively again, merge filtrating three times, vacuum drying adds protopanaxatriol ginsenoside 1g, gets compound rhodiola root extractive;
Step (three): the compound rhodiola root extractive in the step (two) is carried out anti-fatigue test, and compound rhodiola root extractive has antifatigue effect.
The anti-fatigue test of compound rhodiola root extractive:
45 of 1 test material Kunming mouses, available from Jilin University experimental animal center, credit number SCXK-(Ji) 2008-0009, male and female are not limit.
2 test methods and result take anti-fatigue test---mice swimming with a load attached to the body and pole-jump test.
(1) swimming with a load attached to the body experiment
Get 45 of mices, be divided into 3 groups at random, 15 every group; First group is that matched group (not administration), second group are compound rhodiola root extractive (dosage is the 8g/kg body weight, clinical every day of the dosage of behaving approximately 10 times), and gastric infusion is 10 days continuously; After 1 hour, mice is put into depth of water 30cm in the last administration, swim in the water that water temperature is 25 ℃ ± 0.5 ℃; The lead of Mus afterbody load 2g, the record mice begins can not emerge to submerged 10s from swimming, and can't accomplish the continuous swimming time of righting reflex when being placed on the plane; Carry out variance analysis, the result sees table 1.
Table 1 compound extract is to the influence of mice swimming with a load attached to the body time
(annotating: compare p＜0.01) with matched group
(2) pole-climbing experiment
Get 45 of mices, be divided into 3 groups at random, 15 every group; First group is that matched group (not administration), second group are compound rhodiola root extractive (dosage is the 8g/kg body weight, clinical every day of the dosage of behaving approximately 10 times), and gastric infusion is 10 days continuously; Be placed on each group mice on the perspex bar respectively in the last administration after 1 hour; Make muscle be in the static(al) tense situation, the record mice is because muscle fatigue and from the time that Glass rod falls, and the time that accumulative total is three times is the pole-climbing time of mice.Statistics matched group and 3 experimental grouies are tried the mice pole-climbing time, and record data also carry out variance analysis, and the result sees table 2.
Table 2 compound extract is to the influence of mice pole-climbing time
(annotating: compare p＜0.01) with matched group
Visible by table 1 and table 2, compound rhodiola root extractive has antifatigue effect.
Claims (2)
1. the preparation technology of a compound rhodiola root extractive is characterized in that the preparation technology of compound rhodiola root extractive comprises following process:
Step (one): after Radix Rhodiolae 20g-30g, Rhizoma Polygonati 20g-30g, Fructus Schisandrae Chinensis 10g-20g, Herba Epimedii 10g-20g, Fructus Jujubae 3g-5g coarse powder added the water logging bubble 4h-6h that 8-10 doubly measures; 100 ℃ of heating extraction; Ultrasonic again 1h-1.5h, temperature is 30 ℃, power is 80W; Use filtered through gauze then, obtain filtrating;
Step (two): the filtering residue in the step () is repeated above step respectively once with 6 times of amounts and 4 times of water gagings respectively again, merge filtrating three times, vacuum drying adds protopanaxatriol ginsenoside 0.5g-1g, gets compound rhodiola root extractive.
2. the purposes of a kind of compound rhodiola root extractive as claimed in claim 1 is characterized in that this extract is used to prepare the preparation with antifatigue effect.
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| CN2010101630062A CN101804156B (en) | 2010-04-02 | 2010-04-02 | Preparation process and antifatigue effect of compound rhodiola root extract |
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| CN103815471A (en) * | 2012-11-16 | 2014-05-28 | 郭天伊 | Rhodiola rosea anti-fatigue health drink and preparation method thereof |
| CN103169079A (en) * | 2013-03-04 | 2013-06-26 | 无锡市天赐康生物科技有限公司 | Health-care food with anti-fatigue and immunity-enhancing effects, and preparation method thereof |
| CN103436417B (en) * | 2013-09-03 | 2014-12-03 | 孟宗科 | Health wine and preparation method |
| CN104187952B (en) * | 2014-08-14 | 2017-01-18 | 吉林省中医药科学院 | Ginseng-sealwort composite sports health beverage |
| CN106721772A (en) * | 2016-11-15 | 2017-05-31 | 合肥工业大学 | A kind of Chinese medicine composition and its application with fatigue-relieving function |
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| CN1426787A (en) * | 2001-12-20 | 2003-07-02 | 肖永良 | Health care mixture for antifatigne and enhancing immunity |
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Granted publication date: 20120523 Termination date: 20130402 |