CN101780058B - Quick liquid absorption soluble contraceptive membranes - Google Patents
Quick liquid absorption soluble contraceptive membranes Download PDFInfo
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- CN101780058B CN101780058B CN2009102153509A CN200910215350A CN101780058B CN 101780058 B CN101780058 B CN 101780058B CN 2009102153509 A CN2009102153509 A CN 2009102153509A CN 200910215350 A CN200910215350 A CN 200910215350A CN 101780058 B CN101780058 B CN 101780058B
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- contraceptive
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- liquid absorption
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- vegetable oil
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Abstract
The invention relates to quick-liquid absorption soluble contraceptive membranes, which comprises the following raw materials in part by weight: nonoxinol-9 0.045-0.9, high-water absorptivity resin 0.5-5, polyvinyl alcohol 5-13, vegetable oil 0.5-1 and water 65-95. The external contraceptive membranes manufactured by using the raw materials of the invention are quick-liquid absorption soluble contraceptive membranes. Each quick-liquid absorption soluble contraceptive membrane can absorb about 50 milliliters of liquid, absorb all seminal fluid generated in each sexual intercourse within 5 minutes and kill all sperms in the seminal fluid within 1 minute. The external quick-liquid absorption soluble contraceptive membrane products manufactured by the invention has a quick liquid absorbing performance, improves contraceptive effect, reduces stimulation of vagina mucosas and improve use comfort. The external quick-liquid absorption soluble contraceptive membrane products manufactured by the invention can absorb residual fluid, secretions and pathogenic microorganisms such as bacteria and viruses in the secretions in vaginas, have a killing function and can slowly release medicaments and prolong medicament effect duration.
Description
Technical field
The present invention relates to the external contraceptive medical instrument, specifically a kind of quick-liquid absorption soluble contraceptive membranes.
Existing external contraceptive membrane have fill in behind the vagina local irritation strong with defective such as sexual intercourse immediately, for overcoming these defectives, I in first to file " a kind of high imbibition dissoluble drug release external contraceptive membrane " patent of invention, application number 2009101322355.The filmogen compositions of this invention application includes Nonoxynol-9, super absorbent resin, polyvinyl alcohol, polypropylene glycol and vegetable oil.
Utilize the made external contraceptive membrane of above-mentioned prescription, in use still have weak point.Because polypropylene glycol has certain zest to mucosa, if overcome this shortcoming, use amount that will corresponding increase vegetable oil, or add some other raw material.And the increase of variety of raw material can make the cost price of external contraceptive membrane product increase; The consumption of vegetable oil increases, and the shelf-life of external contraceptive membrane product is shortened, and the water absorption minimizing and the absorption speed of product are slowed down, and this has had influence on the high liquid-absorbing ability of made external contraceptive membrane product.
Summary of the invention
The object of the invention just provides a kind of quick-liquid absorption soluble contraceptive membranes of less expensive, to reduce cost of material, the water absorption of invention product is strengthened, and absorption speed is accelerated, and extends the shelf life.
The present invention is achieved in that quick-liquid absorption soluble contraceptive membranes, and it comprises the raw material of following weight portion:
Nonoxynol-9 0.045～0.9, super absorbent resin 0.5～5,
Polyvinyl alcohol 5～13, vegetable oil 0.5～1,
Water 65～95.
The present invention is modulated into aqueous solution with the polyvinyl alcohol water earlier, and then adds raw material components such as vegetable oil, super absorbent resin and Nonoxynol-9, according to the film-forming process operation, can make a kind of quick-liquid absorption soluble contraceptive membranes.
The present invention compares with my patent application formerly; Its main feature is a water modulation polyvinyl alcohol; Saved the use of polypropylene glycol raw material thus; The external contraceptive membrane of having avoided containing the polypropylene glycol raw material components makes that in use to the stimulation that mucosa produced the use of external contraceptive membrane is more comfortable.Because the zest of made external contraceptive membrane product is eliminated; Therefore; The consumption of vegetable oil component just can correspondingly reduce to 1/8 of original use amount in the raw material, and the minimizing of vegetable oil use amount, just makes the oxidation deterioration time lengthening of vegetable oil; Make the shelf-life of product prolong half a year, reached 24 months time limit.
Cost with the made contraceptive membrane product of filmogen of the present invention can reduce more than 2/3 than the contraceptive membrane product cost of formerly declaring patent; And; The liquid absorption of product increases, and rate of liquid aspiration improves, and has guaranteed the high liquid-absorbing ability of made external contraceptive membrane product and the abundant realization of contraceptive effect.
The used vegetable oil of the present invention can be a kind of in medical soybean oil, Semen Maydis oil, Fructus Zanthoxyli oil or the Oleum menthae, also can be wherein any two kinds combination.The preferred medical soybean oil of the present invention.
Institute of the present invention water can be distilled water, pure water or deionized water.
Using the made external contraceptive membrane of filmogen of the present invention, is a kind of quick-liquid absorption soluble contraceptive membranes.The about 50ml of every fluid-absorbing of this contraceptive membrane can absorb all seminal fluid (normal person arranges smart amount at every turn and is 2-6ml) of once discharging in the sexual intercourse process, and in 1 minute, kill whole sperms wherein in 5 minutes.Because have more by force, absorbent fast, so can improve contraceptive effect, and reduced stimulation to vaginal mucosa, improved the comfortableness of using.The made external contraceptive membrane product of the present invention can absorb pathogenic microorganism such as antibacterial in intravaginal debris secretions and the secretions, virus, and has kill activity.Also can slowly discharge medicine, prolong EDD.The present invention promptly has antibacterial action if add antibacterial.Also can add Mentholum etc. and have the flavouring agent of bactericidal action.The present invention also can be made into external contraceptive medical instruments such as unguentum, suppository, gel and vaginal septum except that system external contraceptive membrane product.
Method for preparing of the present invention is: accurately measure Nonoxynol-9, super absorbent resin, polyvinyl alcohol, vegetable oil.At first in polyvinyl alcohol, add entry and be prepared into aqueous solution, add Nonoxynol-9, vegetable oil and super absorbent resin again, treat abundant mix homogeneously after, inject in the mould, take out after the film forming; Also can coat the dull and stereotyped film forming that goes up, cut into the contraceptive membrane product of different shape after the film forming.The made external contraceptive membrane of the present invention is opaque milky to little yellow circular film, smooth in appearance, clean and tidy, and immaculate, no-sundries, its pH value are 6.5 ± 0.2.Catabolite: detect through HPLC, its catabolite is 0.
Made external contraceptive membrane product of the present invention and the external contraceptive membrane of formerly applying for a patent; Two kinds of products are respectively got 3 batches and are supplied test agent; In room temperature natural conditions held; And, investigate appearance character and Nonoxynol-9 content on schedule, and detect regularly respectively at 0,3,6,12,18 and time sampling in 24 months.Measure the result and see table 1.
Table 1: two kinds of product room temperatures are placed Nonoxynol-9 assay result relatively
The specific embodiment
Embodiment 1:
Measure Nonoxynol-9 0.9g, super absorbent resin 3g, polyvinyl alcohol 8g, medical soybean oil 1g and distilled water 90ml in proportion.
At first in polyvinyl alcohol, add distilled water and be prepared into aqueous solution, add Nonoxynol-9, medical soybean oil and super absorbent resin again, treat abundant mix homogeneously after, inject in the mould, take out after the film forming; Also can coat on the flat board, cut into the external contraceptive membrane of different shape after the film forming, every flake products contains Nonoxynol-9 50-100mg.
Embodiment 2:
Measure Nonoxynol-9 0.045g, super absorbent resin 0.5g, polyvinyl alcohol 5g, medical soybean oil 0.5g, Fructus Zanthoxyli oil 0.5g and deionized water 65ml in proportion.Its preparation technology is with embodiment 1, and every external contraceptive membrane contains Nonoxynol-9 5-50mg.
Embodiment 3:
Measure Nonoxynol-9 0.45g, super absorbent resin 5g, polyvinyl alcohol 13g, Oleum menthae 0.5g and pure water 95ml in proportion.Its preparation technology is with embodiment 1, and every contains Nonoxynol-9 5-50mg.
Each component of other embodiment and consumption thereof and embodiment 1,2,3 differences see the following form:
Unit: gram
Claims (2)
1. quick-liquid absorption soluble contraceptive membranes is characterized in that being processed by the raw material of following weight portion:
Nonoxynol-9 0.045～0.9, super absorbent resin 0.5～5,
Polyvinyl alcohol 5～13, vegetable oil 0.5～1, water 65～95;
Wherein, said vegetable oil is a kind of in medical soybean oil, Fructus Zanthoxyli oil, Semen Maydis oil and the Oleum menthae, or wherein any two kinds combination;
Accurately measure Nonoxynol-9, super absorbent resin, polyvinyl alcohol, vegetable oil; At first in polyvinyl alcohol, add entry and be prepared into aqueous solution, add Nonoxynol-9, vegetable oil and super absorbent resin again, treat abundant mix homogeneously after, inject in the mould, take out after the film forming; Also can coat the dull and stereotyped film forming that goes up, cut into the contraceptive membrane product of different shape after the film forming.
2. quick-liquid absorption soluble contraceptive membranes according to claim 1 is characterized in that said water is distilled water and/or deionized water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102153509A CN101780058B (en) | 2009-12-24 | 2009-12-24 | Quick liquid absorption soluble contraceptive membranes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102153509A CN101780058B (en) | 2009-12-24 | 2009-12-24 | Quick liquid absorption soluble contraceptive membranes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101780058A CN101780058A (en) | 2010-07-21 |
| CN101780058B true CN101780058B (en) | 2012-12-05 |
Family
ID=42520289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102153509A Expired - Fee Related CN101780058B (en) | 2009-12-24 | 2009-12-24 | Quick liquid absorption soluble contraceptive membranes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101780058B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100683B (en) * | 2011-01-27 | 2012-03-21 | 李荣秀 | Slow-soluble external contraceptive membrane |
| CN103385781B (en) * | 2013-07-25 | 2015-07-22 | 董翠艳 | Contraceptive |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2301204Y (en) * | 1998-04-24 | 1998-12-23 | 许秀峰 | Female sterilization film |
-
2009
- 2009-12-24 CN CN2009102153509A patent/CN101780058B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2301204Y (en) * | 1998-04-24 | 1998-12-23 | 许秀峰 | Female sterilization film |
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| Publication number | Publication date |
|---|---|
| CN101780058A (en) | 2010-07-21 |
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Address after: Shijiazhuang City, Hebei Province, West Bridge 050081 District three road Kaitai Jane 14-2-201 Patentee after: Li Rongxiu Address before: 050071 No. 480 Heping West Road, Hebei, Shijiazhuang Patentee before: Li Rongxiu |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121205 Termination date: 20211224 |