CN101766670A - Rhodiola rosea polyphenol microcapsule and preparation method - Google Patents
Rhodiola rosea polyphenol microcapsule and preparation method Download PDFInfo
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Abstract
The invention discloses a Rhodiola rosea polyphenol microcapsule and a preparation method. The method comprises: taking extractive of the Rhodiola rosea polyphenol as core materials; taking the uniform mixture of beta-cyclodextrin, glutin, sodium alga acid, modified starch and the like as wall materials; dissolving the core materials with ethanol; dissolving the wall materials with water; mixing the core materials and the wall materials and stirring uniformly; and dispersing the mixture uniformly with a high-speed disperser to obtain the Rhodiola rosea polyphenol microcapsule by spraying and drying. The preparation method of the Rhodiola rosea polyphenol microcapsule of the invention improves the stability of the Rhodiola rosea polyphenol, avoids the damage of the outside environmental factors such as oxygen gas, humidity level, heat, light, some metal materials and the like to the Rhodiola rosea polyphenol, prolongs the storage period and the stability of the Rhodiola rosea polyphenol during the processing course, and simultaneously can also lighten the biter taste of the Rhodiola rosea polyphenol.
Description
Technical field
The present invention relates to method that active components of plants makes microcapsule and uses thereof and belong to biological chemical field.Relate in particular the polyphenols microcapsule that extracts in a kind of Radix Rhodiolae rhizome and preparation method.
Background technology
Radix Rhodiolae is Crassulaceae (Crassulaceae) rhodiola (Rhodiola L.) perennial herb.Rhodiola has 90 kinds approximately, and China has kind more than 70 approximately, is distributed in southwest, northwest, North, Northeast China area.Wherein Tibet distributes at most, and about 34 kinds, about 27 kinds of Sichuan, about 26 kinds of Yunnan, also there is distribution in Gansu, Xinjiang, Qinghai, Shaanxi, Heilungkiang, Jilin, the Inner Mongol, Shanxi, Hebei and Beijing.
Radix Rhodiolae contains polyphenols such as Quercetin, kaempferol ， Yi Quercetin, catechol, epicatechol, gallic acid and their derivant etc.Knekt P etc. discovers that polyphenol compound can suppress hematoblastic gathering and adhesion and can the induction of vascular diastole thereby can prevent apoplexy, antithrombotic and atherosclerosis.Researchs such as Matsumoto think that polyphenol has blood pressure regulation, and the effect of blood fat reducing can angiocardiopathy preventing, treatment coronary heart disease.Have a plurality of activity hydroxies in the polyphenolic substance molecule and can stop free chain reaction in the cell, remove superoxide ion, very strong non-oxidizability is arranged, thereby the biomacromolecule damage that free radical brings out is had protective effect, prevent cell senescence.Aviram.M finds that polyphenols can suppress tumor and take place in mammalian cell, and Seema JAVEDN.K. utilizes the mouse skin model to find that polyphenol has preventive effect to tumor.
Phenolic hydroxyl group activity contained in the polyphenol molecule is very strong, very easily is subjected to various environmental condition image height temperature, humidity, and reaction such as oxidation, polymerization, condensation takes place and loses antioxidation and other biological activity in influences such as illumination.If thereby generation oxidation meeting reduces its result of use greatly during the preservation of polyphenol substance, transportation and the processing.
Microcapsule technology is meant to be utilized natural or synthesized polymer material, and with dispersed solids, liquid, or even gaseous matter wraps up, and forms the technology of the fine particle with semi permeability or sealing cyst membrane.These fine particles are called as microcapsule.Can make encapsulated material avoid the influence of environment behind the micro encapsulation, and can improve its physical property, improve stability; Shielding taste and abnormal smells from the patient.
The present invention improves the stability of Radix Rhodiolae polyphenol by microcapsule technology, prevents that it from preservation term with add the oxidation in man-hour, improve its bitter taste, widening the range of application of Radix Rhodiolae polyphenol.
Summary of the invention
The present invention is in order to solve the stability of Radix Rhodiolae polyphenol, prevents that promptly it is in preservation term with add the oxidation in man-hour, improve its bitter taste and propose a kind of Radix Rhodiolae polyphenol microcapsule and preparation method thereof.
Technical solution of the present invention
A kind of Radix Rhodiolae polyphenol microcapsule comprises core, wall material, and the quality proportioning of core and wall material is: 0.1～0.4: 1.
Described core is the Radix Rhodiolae polyphenol;
Described wall material is one of following mixture:
The mixture that soybean protein isolate, beta-schardinger dextrin-and Fructus Hordei Germinatus are stuck with paste, and wherein soybean protein isolate is the hydrolyzed soy protein isolate of degree of hydrolysis 30～33%;
The mixture of gelatin, beta-schardinger dextrin-, arabic gum, sodium alginate and maltodextrin;
The mixture of beta-schardinger dextrin-, modified starch and gelatin.
The wall material is soybean protein isolate, beta-schardinger dextrin-and maltodextrin mixture, and preferably the quality proportioning of each composition is a soybean protein isolate: beta-schardinger dextrin-: maltodextrin is 1: 2: 2;
The wall material is the mixture of gelatin, beta-schardinger dextrin-, arabic gum, sodium alginate, and preferably the quality proportioning of each composition is a gelatin: beta-schardinger dextrin-: arabic gum: sodium alginate is 1: 2: 2: 0.1;
The wall material is the mixture of maltodextrin, beta-schardinger dextrin-, modified starch and gelatin, and preferably the quality proportioning of each composition is a maltodextrin: beta-schardinger dextrin-: modified starch: gelatin is 1: 1: 2.5: 0.5;
Its mesospore material is the mixture that soybean protein isolate, beta-schardinger dextrin-and Fructus Hordei Germinatus are stuck with paste, and will add emulsifying agent soybean lecithin or glyceryl monostearate in the wall material; The addition of emulsifying agent is 0.2～0.4% of a wall material.
A kind of Radix Rhodiolae polyphenol microcapsule, its preparation technology's schematic flow sheet is seen Fig. 1.
A kind of preparation method of Radix Rhodiolae polyphenol microcapsule comprises the following steps:
(1), the preparation of Radix Rhodiolae polyphenol extract
Be about to the Radix Rhodiolae raw material through alcohol reflux by the plant polyphenol method for extraction and purification, liquid-solid separation, waste, liquid concentrating under reduced pressure, purification by macroporous resin, the further dry Radix Rhodiolae extract that gets behind the eluent concentrating under reduced pressure;
Above-mentioned Radix Rhodiolae raw material is graceful Radix Rhodiolae (R.coccinea), Radix Rhodiolae (R.crenulataH), Rhodiola kirilowii (Regel) Maxim. (R.kirilowii Maxim), Folium Trapae Radix Rhodiolae (R.hennyi), long whip Radix Rhodiolae (R.gelida Schrenk), Rhodiola tibetica (Hook. f. et Thoms.) S. H. Fu (R.tibetica S), Changbai Mountain Radix Rhodiolae (R.angustaNakai), happiness horse horse Radix Rhodiolae (R.himalensis); Bar leaf Radix Rhodiolae (R.linearifolia) Radix Rhodiolae (R.rosea), post premium Herba hylotelephii erythrosticti (R.menovii), light green Radix Rhodiolae (R.purpureoviridis) or four split Radix Rhodiolae (R.quadrifida Fisch);
(2), the preparation of Radix Rhodiolae polyphenol microcapsule
1., the preparation of Radix Rhodiolae polyphenol solution
Take by weighing the Radix Rhodiolae polyphenol extract of gained in the step (1), add 95% ethanol and fully dissolve, promptly get Radix Rhodiolae polyphenol solution;
Wherein alcoholic acid addition is the Radix Rhodiolae polyphenol extract by mass volume ratio: 95% ethanol is 1g: 3～5ml;
2., the preparation of wall material mixed liquor
Take by weighing a certain amount of wall material and be dissolved in 40 ℃ of water, be stirred to full and uniformly, promptly get wall material mixed liquor, its mesospore material and the blended mass volume ratio of water are by the wall material: water is 1g: 5～7ml;
3., the preparation of Radix Rhodiolae polyphenol microcapsule solution
The Radix Rhodiolae polyphenol solution that step is obtained in 1. slowly adds in the wall material mixed liquor that step obtains in 2., mix in the rearmounted high speed dispersion device 40 ℃, 10000～12000r/min disperses 8min, promptly disperse 2min, intermittently 3min repeats 4 times, put in the agitator after the taking-up, 40 ℃ of temperature, 2000r/min gets Radix Rhodiolae polyphenol microcapsule solution behind the stirring 30min;
4., the preparation of Radix Rhodiolae polyphenol microcapsule
With step 3. the Radix Rhodiolae polyphenol microcapsule solution of gained 180～190 ℃ of inlet temperature, spray drying under 80～90 ℃ of conditions of leaving air temp, get final product Radix Rhodiolae polyphenol microcapsule of the present invention.
Beneficial effect of the present invention
A kind of Radix Rhodiolae polyphenol microcapsule of the present invention has improved the stability of Radix Rhodiolae polyphenol, promptly prevent of the harmful effects such as destruction of external environment factor effectively to core, for example oxygen, humidity, heat, light and some metallicses etc. prevent the destruction of Radix Rhodiolae polyphenol stability, with improve rhodiola plant polyphenol bitter taste, prolong the stability in the Radix Rhodiolae polyphenol preservation term and the course of processing, widen the range of application of rhodiola rosea polyphenol material.Radix Rhodiolae polyphenol microencapsulated product of the present invention can be used for cosmetics, health product.
Description of drawings
The preparation method process flow diagram of Fig. 1, Radix Rhodiolae polyphenol microcapsule
The specific embodiment
Below by embodiment the present invention is further set forth, but do not limit the present invention.
Embodiment 1
Get the dry Radix Rhodiolae rhizome of 60 orders powder 100g, the ethanol that adds 10 times concentration 70% fully stirs, 50 ℃ of water-bath reflux, extract, 2h, the centrifugal 15min of 4000rpm, collect supernatant, under 40 ℃, be concentrated into 1/20 of original volume, get the polyphenol crude extract through rotary evaporator.
With resultant Radix Rhodiolae polyphenol crude extract D
101The macroporous resin adsorption chromatography carries out purification.Earlier with 2BV (column volume) distilled water eluting, the ethanol water elution of 3BV50% again, eluent flow rate is 2BV/h, collects the eluent that contains polyphenol, at 38 ℃ of rotary evaporator evaporate to dryness ethanol, 35 ℃ of vacuum dryings get the Radix Rhodiolae polyphenol extract with it.
Take by weighing Radix Rhodiolae polyphenol extract 3g and join 10mL95% ethanol and fully dissolve, polyphenol solution (core), standby.Take by weighing the 6g soybean protein isolate, 12g beta-schardinger dextrin-, 12g maltodextrin and 0.06g soybean lecithin are dissolved in and are stirred to the full and uniform wall material mixed liquor that makes in 40 ℃ of water of 155mL.
Polyphenol solution (core) is slowly added in the wall material mixed liquor, mix rearmounted high speed dispersion device, at 40 ℃, under the 12000r/min, disperse 8min, promptly disperse 2min, intermittently 3min repeats 4 times, put in the agitator after the taking-up, 2000r/min, gets Radix Rhodiolae polyphenol microcapsule solution behind the stirring 30min by 40 ℃.
With Radix Rhodiolae polyphenol microcapsule solution spray drying under 90 ℃ of conditions of 190 ℃ of leaving air temps of inlet temperature of gained, get final product Radix Rhodiolae polyphenol microencapsulated product.
Embodiment 2
Get the dry Radix Rhodiolae rhizome of 80 orders powder 100g, the ethanol that adds 20 times concentration 60% fully stirs, 50 ℃ of water-bath reflux, extract, 2h, the centrifugal 15min of 4000rpm, collect supernatant, under 40 ℃, be concentrated into 1/30 of original volume, get the polyphenol crude extract through rotary evaporator.
With resultant Radix Rhodiolae polyphenol crude extract D
101The macroporous resin adsorption chromatography carries out separation and purification.Earlier with 2BV (column volume) distilled water eluting, the ethanol water elution of 3BV50% again, eluent flow rate is 2BV/h, collects to contain the polyphenol eluent, at 38 ℃ of rotary evaporator evaporate to dryness ethanol, 35 ℃ of vacuum dryings get the Radix Rhodiolae polyphenol extract with it.
Take by weighing Radix Rhodiolae polyphenol extract 4g and join 20mL95% ethanol and fully dissolve, polyphenol solution (core) is standby.
Take by weighing the 7g gelatin and add stirring and dissolving 30min in 60 ℃ of water of 140ml, add the 14g beta-schardinger dextrin-again, the 7g arabic gum, the 0.7g sodium alginate mixes 30min.Be cooled to room temperature.Make wall material mixed liquor.
Polyphenol solution (core) is slowly added in the wall material mixed liquor, mix rearmounted high speed dispersion device, at 40 ℃, under the 12000r/min, disperse 8min, promptly disperse 2min, intermittently 3min repeats 4 times, put in the agitator after the taking-up, 3000r/min, gets Radix Rhodiolae polyphenol microcapsule solution by 40 ℃ behind the 30min.
With Radix Rhodiolae polyphenol microcapsule solution spray drying under 85 ℃ of conditions of 185 ℃ of leaving air temps of inlet temperature of gained, get final product Radix Rhodiolae polyphenol microencapsulated product.
Embodiment 3
Get the dry Radix Rhodiolae rhizome of 40 orders powder 100g, the ethanol that adds 25 times concentration 50% fully stirs, 50 ℃ of water-bath reflux, extract, 2h, the centrifugal 15min of 4000rpm, collect supernatant, under 40 ℃, be concentrated into 1/40 of original volume, get the polyphenol crude extract through rotary evaporator.
With resultant Radix Rhodiolae polyphenol crude extract D
101The macroporous resin adsorption chromatography carries out purification.Earlier with 2BV (column volume) distilled water eluting, the ethanol water elution of 3BV60% again, eluent flow rate is 2BV/h, collects to contain the polyphenol eluent, at 38 ℃ of rotary evaporator evaporate to dryness ethanol, 35 ℃ of vacuum dryings get the Radix Rhodiolae polyphenol extract with it.
Take by weighing 8g Radix Rhodiolae polyphenol extract adding 30mL95% ethanol and fully dissolve, get polyphenol solution (core), standby.
Take by weighing the 10g modified starch and be dissolved in 40 ℃ of water of 70mL, stir, it is later on standby to place 16h.
Take by weighing the 2g gelatin and add stirring and dissolving 30min in 60 ℃ of water of 40ml, add the 4g beta-schardinger dextrin-again, the 4g maltodextrin, standby again modified starch solution mixes, and is stirred to the full and uniform wall material mixed liquor that makes.
Polyphenol solution (core) is slowly added in the wall material mixed liquor, mix rearmounted high speed dispersion device, at 40 ℃, under the 12000r/min, disperse 8min, promptly disperse 2min, intermittently 3min repeats 4 times, put in the agitator after the taking-up, 3000r/min, gets Radix Rhodiolae polyphenol microcapsule solution by 40 ℃ behind the 30min.
With Radix Rhodiolae polyphenol microcapsule solution spray drying under 80 ℃ of conditions of 180 ℃ of leaving air temps of inlet temperature of gained, get final product Radix Rhodiolae polyphenol microencapsulated product.
Embodiment 4
Get the dry Radix Rhodiolae rhizome of 20 orders powder 100g, the ethanol that adds 10 times concentration 70% fully stirs, 50 ℃ of water-bath reflux, extract, 2h, the centrifugal 15min of 4000rpm, collect supernatant, under 40 ℃, be concentrated into 1/20 of original volume, get the polyphenol crude extract through rotary evaporator.
With resultant Radix Rhodiolae polyphenol crude extract D
101The macroporous resin adsorption chromatography carries out purification.Earlier with 2BV (column volume) distilled water eluting, the ethanol water elution of 3BV50% again, eluent flow rate is 2BV/h, collects the eluent that contains polyphenol, at 38 ℃ of rotary evaporator evaporate to dryness ethanol, 35 ℃ of vacuum dryings get the Radix Rhodiolae polyphenol extract with it.
Take by weighing Radix Rhodiolae polyphenol extract 3g and join 10mL95% ethanol and fully dissolve, polyphenol solution (core), standby.Take by weighing the 6g soybean protein isolate, 12g beta-schardinger dextrin-, 12g maltodextrin and 0.012g soybean lecithin are dissolved in and are stirred to the full and uniform wall material mixed liquor that makes in 40 ℃ of water of 155mL.Polyphenol solution (core) is slowly added in the wall material mixed liquor, mix rearmounted high speed dispersion device, at 40 ℃, under the 10000r/min, disperse 8min, promptly disperse 2min, intermittently 3min repeats 4 times, put in the agitator after the taking-up, 3000r/min, gets Radix Rhodiolae polyphenol microcapsule solution behind the stirring 30min by 40 ℃.
With Radix Rhodiolae polyphenol microcapsule solution spray drying under 80 ℃ of conditions of 180 ℃ of leaving air temps of inlet temperature of gained, get final product Radix Rhodiolae polyphenol microencapsulated product.
Above said content only is the basic explanation of the present invention under conceiving, and according to any equivalent transformation that technical scheme of the present invention is done, all should belong to protection scope of the present invention.
Claims (5)
1. a Radix Rhodiolae polyphenol microcapsule comprises core, wall material, it is characterized in that:
Described core is the Radix Rhodiolae polyphenol;
Described wall material is one of following mixture:
The mixture that soybean protein isolate, beta-schardinger dextrin-and Fructus Hordei Germinatus are stuck with paste;
The mixture of gelatin, beta-schardinger dextrin-, arabic gum and sodium alginate;
The mixture of maltodextrin, beta-schardinger dextrin-, modified starch and gelatin;
Wherein said soybean protein isolate is the hydrolyzed soy protein isolate of degree of hydrolysis 30～33%;
Its mesospore material is the mixture that soybean protein isolate, beta-schardinger dextrin-and Fructus Hordei Germinatus are stuck with paste, and will add emulsifying agent soybean lecithin or glyceryl monostearate in the wall material; The addition of emulsifying agent is 0.2～0.4% of a wall material amount;
The quality proportioning of core and wall material is: 0.1～0.4: 1.
2. Radix Rhodiolae polyphenol microcapsule as claimed in claim 1, it is characterized in that working as described wall material is soybean protein isolate, beta-schardinger dextrin-and maltodextrin mixture, the quality proportioning of each composition is a soybean protein isolate in its preferred soybean protein isolate, beta-schardinger dextrin-and the maltodextrin mixture: beta-schardinger dextrin-: maltodextrin is 1: 2: 2.
3. Radix Rhodiolae polyphenol microcapsule as claimed in claim 1, it is characterized in that working as described wall material the mixture that is gelatin, beta-schardinger dextrin-, arabic gum and sodium alginate, the quality proportioning of each composition is a gelatin in the mixture of its preferred gelatin, beta-schardinger dextrin-, arabic gum and sodium alginate: beta-schardinger dextrin-: arabic gum: sodium alginate is 1: 2: 2: 0.1.
4. Radix Rhodiolae polyphenol microcapsule as claimed in claim 1, it is characterized in that working as described wall material the mixture that is maltodextrin, beta-schardinger dextrin-, modified starch and gelatin, the quality proportioning of each composition is a maltodextrin in the mixture of its preferred maltodextrin, beta-schardinger dextrin-, modified starch and gelatin: beta-schardinger dextrin-: modified starch: gelatin is 1: 1: 2.5: 0.5.
5. the preparation method as claim 1,2,3 or 4 described Radix Rhodiolae polyphenol microcapsules is characterized in that comprising the following steps:
(1), the preparation of Radix Rhodiolae polyphenol extract
Be about to the Radix Rhodiolae raw material through alcohol reflux by the plant polyphenol method for extraction and purification, liquid-solid separation, waste, liquid concentrating under reduced pressure, purification by macroporous resin, the further dry Radix Rhodiolae extract that gets behind the eluent concentrating under reduced pressure;
Radix Rhodiolae raw material wherein is graceful Radix Rhodiolae (R.coccinea), Radix Rhodiolae (R.crenulata H), Rhodiola kirilowii (Regel) Maxim. (R.kirilowii Maxim), Folium Trapae Radix Rhodiolae (R.hennyi), long whip Radix Rhodiolae (R.gelida Schrenk), Rhodiola tibetica (Hook. f. et Thoms.) S. H. Fu (R.tibeticaS), Changbai Mountain Radix Rhodiolae (R.angusta Nakai), happiness horse horse Radix Rhodiolae (R.himalensis); Bar leaf Radix Rhodiolae (R.linearifolia) Radix Rhodiolae (R.rosea), post premium Herba hylotelephii erythrosticti (R.menovii), light green Radix Rhodiolae (R.purpureoviridis) or four split Radix Rhodiolae (R.quadrifida Fisch);
(2), the preparation of Radix Rhodiolae polyphenol microcapsule
1., the preparation of Radix Rhodiolae polyphenol solution
Take by weighing the Radix Rhodiolae polyphenol extract of gained in the step (1), add 95% ethanol and fully dissolve, promptly get Radix Rhodiolae polyphenol solution;
Wherein alcoholic acid addition is the Radix Rhodiolae polyphenol extract by mass volume ratio: 95% ethanol is 1g: 3～5ml;
2., the preparation of wall material mixed liquor
Take by weighing a certain amount of wall material and be dissolved in 40 ℃ of water, be stirred to full and uniformly, promptly get wall material mixed liquor, its mesospore material and the blended mass volume ratio of water are by the wall material: water is 1g: 5～7ml;
3., the preparation of Radix Rhodiolae polyphenol microcapsule solution
The Radix Rhodiolae polyphenol solution that step is obtained in 1. slowly adds in the wall material mixed liquor that step obtains in 2., mix in the rearmounted high speed dispersion device 40 ℃, 10000～12000r/min disperses 8min, promptly disperse 2min, intermittently 3min repeats 4 times, put in the agitator after the taking-up, 40 ℃ of temperature, 2000r/min gets Radix Rhodiolae polyphenol microcapsule solution behind the stirring 30min;
4., the preparation of Radix Rhodiolae polyphenol microcapsule
With step 3. the Radix Rhodiolae polyphenol microcapsule solution of gained 180～190 ℃ of inlet temperature, spray drying under 80～90 ℃ of conditions of leaving air temp, get final product Radix Rhodiolae polyphenol microcapsule of the present invention.
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