CN105126016A - Composition for dispelling effects of alcohol and protecting liver and preparation method of composition - Google Patents
Composition for dispelling effects of alcohol and protecting liver and preparation method of composition Download PDFInfo
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- CN105126016A CN105126016A CN201510524845.5A CN201510524845A CN105126016A CN 105126016 A CN105126016 A CN 105126016A CN 201510524845 A CN201510524845 A CN 201510524845A CN 105126016 A CN105126016 A CN 105126016A
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Abstract
An embodiment of the invention belongs to the technical field of healthcare products and discloses a composition for dispelling effects of alcohol and protecting the liver and a preparation method of the composition. The composition for dispelling the effects of alcohol and protecting the liver is prepared from, by weight, 50-150 parts of rhizoma curcumae longae, 50-150 parts of fructus phyllanthi, 50-150 parts of medicine terminalia fruits and 50-150 parts of olives, wherein the rhizoma curcumae longae has an anti-inflammatory function, a liver protection function and a cholagogue effect; the fructus phyllanthi and the medicine terminalia fruits have liver protection effects and are capable of realizing reduction of liver injuries and realizing an anti-liver fibrosis function; polyphenols in the olives have functions of blood purifying, liver soothing, stomach harmonizing and qi regulating and are capable of effectively alleviating symptoms such as headache, dizziness, stomachache, nausea, poor mental state and the like caused by alcohol consumption. Choleresis increasing and gallbladder contract promoting functions of the rhizoma curcumae longae and lipid metabolism promotion and gastrointestinal peristalsis promotion functions of the olives promote liver protection functions of the fructus phyllanthi and the medicine terminalia fruits, and remarkable healthcare effects of dispelling the effects of alcohol and protecting the liver are achieved owing to synergistic interaction of the four ingredients. The preparation method of the composition is suitable for industrial popularization and application.
Description
Technical field
The present invention relates to health product technology field, particularly relate to a kind of relieving alcoholism and protecting the liver composition and method of making the same.
Background technology
As the liver of the important removing toxic substances organ of human body, there is Hepatic artery and hepatic vein double blood supply.Chemical liver injury, be the hepatic injury caused by chemical Hepatoxic substance, these chemical substances comprise ethanol, the chemical toxicant in environment and some drugs.But in recent years, along with the development of Chinese national economy, the change of life style and dietary structure, alcoholic liver injury has become the main hepatic injury reason being only second to viral hepatitis, and presents the trend risen gradually.Alcoholic liver injury is the toxic hepatic disease because excessive drinking causes, in heavy drinker, more than 80% has fatty liver, 10% ~ 35% develops into alcoholic hepatitis, and 10% ~ 20% will develop into liver cirrhosis, is the public social hygiene problem received much concern in current worldwide.Therefore, research and development have relieve the effect of alcohol, detoxify, protect the liver, the product of liver-protecting function is nursing and liver-protective main development direction.
Along with people are to the attention of food and drug safety, domestic engendering utilizes medicinal herb components to play the effect of relieving the effect of alcohol, and there are some Antialcoholic teas, fruit vinegar or Other Drinks, as Chinese Patent Application No. 200710026344.X discloses a kind of Antialcoholic tea, its component primarily of following weight portion is made: Folium Camelliae sinensis 200 ~ 300 parts, Folium Kaki 35 ~ 45 parts, 5 ~ 10 parts, Rhizoma Curcumae Longae, Ganoderma 5 ~ 10 parts, Radix Salviae Miltiorrhizae 5 ~ 10 parts, anti-Flos Chrysanthemi 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, 10 ~ 20 parts, Radix Glycyrrhizae, Mel 5 ~ 10 parts, this product is to relieving alcoholic intoxication, be still drank after a night and there is certain effect, its weak point is that formula is complicated, cost is high.
Summary of the invention
Embodiments provide a kind of relieving alcoholism and protecting the liver composition and method of making the same, complicated to solve existing relieving alcoholism and protecting the liver formula for a product, the technical problem that cost is high.
In order to solve the problem, the embodiment of the invention discloses a kind of relieving alcoholism and protecting the liver compositions, the raw material primarily of following weight portion is made: 50 ~ 150 parts, Rhizoma Curcumae Longae, Fructus Phyllanthi 50 ~ 150 parts, Fructus Chebulae 50 ~ 150 parts, Fructus Canarii albi 50 ~ 150 parts.
Optionally, above-mentioned relieving alcoholism and protecting the liver compositions is made primarily of the raw material of following weight portion: Rhizoma Curcumae Longae extract 50 ~ 150 parts, Fructus Phyllanthi Rhizoma Curcumae Longae extract 50 ~ 150 parts, Fructus Chebulae's Rhizoma Curcumae Longae extract 50 ~ 150 parts, Fructus Canarii albi Rhizoma Curcumae Longae extract 50 ~ 150 parts.
Optionally, the dosage form of above-mentioned relieving alcoholism and protecting the liver compositions is granule.Also can be medical science and the acceptable any dosage form of health product technology field.
Optionally, when above-mentioned relieving alcoholism and protecting the liver compositions is prepared into granule, the adjuvant of following weight portion is also comprised: 50 ~ 150 parts, dextrin, stevioside 3 ~ 6 parts.
Each raw material abbreviated functional description:
Rhizoma Curcumae Longae, belongs to raw zingiberaceous plant.In Japan's family, river epoch, Rhizoma Curcumae Longae is greatly prevailing as medical herbs, and ancient Aisan is regarded as a kind of catholicon, as jewellery.Modern medicine study shows, Rhizoma Curcumae Longae except relieving the effect of alcohol, anti-be still drank after a night except, its pharmacological action is extensive; there is antiinflammatory, resisting pathogenic microbes, antioxidation, blood fat reducing, hepatic cholagogic; effect such as protection cardiovascular and cerebrovascular vessel etc., wherein protect the liver, hepatoprotective effect is widely used again, clinical effectiveness is remarkable.The curcumin contained in Rhizoma Curcumae Longae has suppression hepatitis, repairs the hepatocyte of damage, improves the effects such as liver parenchyma damage.Curcumin in Rhizoma Curcumae Longae extract, volatile oil, turmerone and zingiberene, Borneolum Syntheticum and sesquiterpenoid etc., have choleretic effect, can increase generation and the secretion of bile, and can promote gallbladder contraction, wherein the strongest with the effect of curcumin again.
Fructus Phyllanthi Euphorbiaceae phyllanthus emblica platymiscium, the extract of its dry mature fruit, is rich in the composition such as tannin and phenolic acid compound, flavone compound, alkaloids, terpene, sterol and glycoside, vitamin, aminoacid and trace element.Fructus Phyllanthi extract has preventive effect to the acute liver damage caused by acetaminophen, thioacetamide; to the acute liver damage caused by D ~ galactosamine, there is significant protective effect; to carbon tetrachloride cause chronic hepatic injury there is protection hepatocyte; reduce hepatic injury, effect of anti hepatic fibrosis.Fructus Phyllanthi extract obviously can reduce serum glutamic pyruvic transminase, cholesterol and liposome, thus reaches liver protective effect.
Fructus Chebulae is one of conventional Chinese medicine, is Combretum Racemosum plant.The dry mature fruit of Fructus Chebulae TerminaliachebulaRetz or Terminalia chebula Retz. var. tomentella Kurt. TchebulmRetzvartomentellaKurt, be produced in India and Sri Lanka, Yunnan Province of China also has production.Fructus Chebulae extract main constituent is chebulinic acid (chebulinicacid), Chebulagic acid (chebulagicacid), 1,3,6 ~ trigalloylglucose, there are three note classes, polyhydric phenols acids, aliphatic compound and aminoacid, mineral matter and other components.Find that Fructus Chebulae has the effects such as antibacterial, heart tonifying, antioxidation and spasmolytic to Fructus Chebulae's pharmacological research, having relieving diarrhea with astringents astringes the lung, effect of pathogenic fire reducing sore-throat relieving.Research find Fructus Chebulae to carbon tetrachloride cause chronic hepatic injury there is protection hepatocyte, reduce hepatic injury, effect of anti hepatic fibrosis.Serum pharmacological proves, Fructus Chebulae's hepatoprotective effect is relevant with raising lipoid peroxidization resistant.
Fructus Canarii albi is Burseraceae Canarium aiphyllium, is grown in the shaw of low altitude area or on hillside and coastal haugh area.Containing rich in protein, fat, vitamin C, carbohydrate, dietary fiber, carotene, retinol, vitamin B1, vitamin B2 and some volatile oil and flavone compound etc. in olive fruits.Meanwhile, modern study also finds, contain the antibacterial and anti-oxidation function factor---olive polyphenol in a large number in olive fruit, leaf, polyphenols is most important functional component in Fructus Canarii albi, and the bitterness of Fructus Canarii albi and many pharmacological actions all follow polyphenols relevant.Fructus Canarii albi has very high medical, edible and is worth, and can purify the blood soothing liver-QI, regulating the stomach to normalize QI, can effectively alleviate cause because drinking headache, dizziness, stomachache, the symptom such as nauseating, listless." Fructus Canarii albi relieves the effect of alcohol " is all described in detail in allusion doctor's nationality " agriculture book ", " supplement Bencao Beiyao " and " Japan hanako materia medica ", modern study confirms that Fructus Canarii albi and compound preparation thereof have significant sober-up function, significantly can reduce Serum ALT, AST and liver homogenate ALT level, improve hepatic tissue pathology state, promote that hepatocyte injury recovers.The SOD that Fructus Canrii Albi extract can significantly improve liver injury model is active, accelerates the removing of free radical, reduces the generation of LPO, thus stabilized cell membrane structure, alleviate the detrimental effect to hepatic tissue cell; Significantly can reduce serum and liver homogenate Tch, TG level, Liver Lipid Metabolism disorder can be corrected, thus alleviate the change of hepatocyte fat; Can accelerate gastric emptying, promote enterokinesia, the excretion of accelerating alcohol, reduce ethanol and absorb at gastrointestinal; Protection liver cell mitochondria, recovers its morphosis and function, maintains the vigorous albumen generative capacity of cell and nucleic acid metabolism ability, thus promotes cellular metabolism, strengthen cell function.In a word, Fructus Canrii Albi extract have good anti-intoxication, relieve the effect of alcohol, liver protection effect.
In order to solve the problem, the embodiment of the invention also discloses the preparation method that a kind of relieving alcoholism and protecting the liver compositions is prepared into granule, comprising following operating procedure:
1) extract Rhizoma Curcumae Longae and prepare Rhizoma Curcumae Longae extract; Extract Fructus Phyllanthi and prepare Fructus Phyllanthi extract; Extract Fructus Chebulae and prepare Fructus Chebulae extract; Extract Fructus Canarii albi and prepare Fructus Canrii Albi extract;
2) by Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract, dextrin mixing, obtained mixture;
3) stevioside being dissolved in mass concentration is in the ethanol of 75 ~ 95%, with step 2) obtained mixture mix and obtains soft material, soft material is crossed 14 ~ 20 mesh sieves and obtain wet granular, wet granular 60 ~ 70 DEG C of dryings are obtained dry granule, dry granule is crossed 14 ~ 20 mesh sieve granulate, obtain described relieving alcoholism and protecting the liver compositions.
Optionally, the process extracting Rhizoma Curcumae Longae is: comprise following operating procedure:
A: after Rhizoma Curcumae Longae being pulverized 10 ~ 20 mesh sieves, add mass concentration be 50 ~ 80% alcohol heating reflux extract 2 ~ 3 times, merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 8 ~ 10 times of Rhizoma Curcumae Longae weight, and Extracting temperature is 50 ~ 70 DEG C, and each extraction time is 0.5 ~ 2h;
B: extracting solution steps A obtained is 60 ~ 70 DEG C in temperature, and vacuum is under the condition of 0.07 ~ 0.08MPa, and being concentrated into relative density is 1.10 ~ 1.20, obtains concentrated solution;
C: be 170 ~ 180 DEG C in inlet temperature by concentrated solution obtained in step B, leaving air temp is carry out spraying dry under 70 ~ 80 DEG C of conditions, obtains Rhizoma Curcumae Longae extract.
Optionally, the process extracting Fructus Phyllanthi is: comprise following operating procedure:
A: after Fructus Phyllanthi being pulverized 10 ~ 20 mesh sieves, adds the ethanol that mass concentration is 50 ~ 80%, heating extraction 2 ~ 3 times, and merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 8 ~ 10 times of weight, and Extracting temperature is 50 ~ 70 DEG C, and each extraction time is 0.5 ~ 2h.
B: the extracting solution obtained by step a is 60 ~ 70 DEG C in temperature, and vacuum is under the condition of 0.07 ~ 0.08MPa, and being concentrated into relative density is 1.10 ~ 1.20, obtains concentrated solution;
C: the concentrated solution obtained by step b is 170 ~ 180 DEG C in inlet temperature, and leaving air temp is carry out spraying dry under 70 ~ 80 DEG C of conditions, obtains Fructus Phyllanthi extract.
Optionally, the process extracting Fructus Chebulae is: comprise following operating procedure:
I: after Fructus Chebulae being pulverized 10 ~ 20 mesh sieves, add mass concentration be 50 ~ 80% alcohol heating reflux extract 2 ~ 3 times, merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 8 ~ 10 times of Fructus Chebulae's weight, and Extracting temperature is 50 ~ 70 DEG C, and each extraction time is 0.5 ~ 2h;
II: extracting solution step I obtained is 60 ~ 70 DEG C in temperature, and vacuum is under the condition of 0.07 ~ 0.08MPa, and being concentrated into relative density is 1.10 ~ 1.20, obtains concentrated solution;
III: be 170 ~ 180 DEG C by the concentrated solution obtained in step II in inlet temperature, leaving air temp is carry out spraying dry under 70 ~ 80 DEG C of conditions, obtains Fructus Chebulae extract.
Optionally, the process extracting Fructus Canarii albi is: comprise following operating procedure:
I: after Fructus Canarii albi being pulverized 10 ~ 20 mesh sieves, add mass concentration be 50 ~ 80% alcohol heating reflux extract 2 ~ 3 times, merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 8 ~ 10 times of Fructus Canarii albi weight, and Extracting temperature is 50 ~ 70 DEG C, and each extraction time is 0.5 ~ 2h;
II: extracting solution step I obtained is 60 ~ 70 DEG C in temperature, and vacuum is under the condition of 0.07 ~ 0.08MPa, and being concentrated into relative density is 1.10 ~ 1.20, obtains concentrated solution;
III: be 170 ~ 180 DEG C in inlet temperature by the concentrated solution obtained in step II, leaving air temp is carry out spraying dry under 70 ~ 80 DEG C of conditions, obtains Fructus Canrii Albi extract.
Optionally, step 2) in Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract, dextrin mixing concrete grammar be: first Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract and dextrin are crossed 60 ~ 100 mesh sieves, for subsequent use; Then by Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract and the dextrin after sieving, mix homogeneously, obtained mixture.
Optionally, step 3) in the soft material obtained wet granular that sieves be that 12 ~ 20 mesh sieves obtain wet granular.
Alternatively, step 3) in the baking temperature of wet grain drying be 60 ~ 70 DEG C.
Alternatively, step 3) in the granulate that sieves be 12 ~ 20 mesh sieve granulate.
Optionally, also comprising step 4) obtained relieving alcoholism and protecting the liver compositions is wrapped inside dress, outer package, can puts in storage after the assay was approved.
Optionally, the concrete grammar of described inner packing is: adopt aluminum-plastic composite membrane to pack, every bag of 3g.Outer package carries out outer package for adopting corrugated case.The described inspection item required according to company standard that verify as are tested.
In order to improve the quality of product further, place operating environment to the pollution of product, optionally, in above-mentioned preparation method, the production operation of each step is all carried out according to GMP, wherein except for the outer packaging and testing sequence outside other steps all carry out in 300,000 grades of clean areas
The present invention has following beneficial effect:
Relieving alcoholism and protecting the liver compositions of the present invention, mainly with Rhizoma Curcumae Longae, Fructus Phyllanthi, Fructus Chebulae and Fructus Canarii albi for raw material is prepared from.Wherein Rhizoma Curcumae Longae has the effect of antiinflammatory, hepatic cholagogic, can suppress hepatitis, repairs the hepatocyte of damage, improves liver parenchyma damage; Fructus Phyllanthi can reduce serum SGPT, cholesterol and liposome, thus reaches liver protective effect, reduces hepatic injury, anti-hepatic fibrosis; Fructus Chebulae has the effect improving anti peroxidation of lipid, thus protection hepatocyte; Polyphenols in Fructus Canarii albi has the soothing liver-QI that purifies the blood, the effect of regulating the stomach to normalize QI, can effectively alleviate cause because drinking headache, dizziness, stomachache, the symptom such as nauseating, listless.Rhizoma Curcumae Longae, Fructus Phyllanthi, Fructus Chebulae and Fructus Canarii albi are in the amount ranges limited, Rhizoma Curcumae Longae increases bile secretion and promotes the effect of gallbladder contraction, and Fructus Canarii albi promotes the effect of lipid metabolism and gastrointestinal peristalsis, promote Fructus Phyllanthi and Fructus Chebulae's liver protection function, four Synergistics, have the health-care effect of significant relieving alcoholism and protecting the liver.
The preparation method of relieving alcoholism and protecting the liver compositions of the present invention, easy and simple to handle, be easy to realize, be suitable for industrial application.
Detailed description of the invention
Hereinafter will describe the present invention in detail in conjunction with the embodiments.It should be noted that, when not conflicting, the embodiment in the present invention and the feature in embodiment can combine mutually.
In following embodiment mass concentration be 95% ethanol meet the regulation of GB10343 ~ 2002 " edible ethanol "; In following embodiment, relieving alcoholism and protecting the liver compositions is all prepared into granule, but it is to be understood that said composition also can be medical science and other acceptable dosage forms of health product technology field, the change of dosage form does not affect the health-care effect of compositions.
Embodiment 1
Present embodiments provide a kind of relieving alcoholism and protecting the liver compositions, be made up of the raw material of following weight fraction: 50 parts, Rhizoma Curcumae Longae, Fructus Phyllanthi 100 parts, Fructus Chebulae 100 parts, Fructus Canarii albi 50 parts, 150 parts, dextrin, stevioside 6 parts.
The preparation method of the present embodiment relieving alcoholism and protecting the liver compositions, concrete operation step is as follows:
1) extract Rhizoma Curcumae Longae and prepare Rhizoma Curcumae Longae extract:
A: after Rhizoma Curcumae Longae being pulverized 10 mesh sieves, add the alcohol heating reflux extraction twice that mass concentration is 75%, merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 8 times of Rhizoma Curcumae Longae weight, and Extracting temperature is 50 DEG C, and extraction time is 2h;
B: extracting solution steps A obtained is 60 DEG C in temperature, and vacuum is under the condition of 0.07MPa, and being concentrated into relative density is 1.20, obtains concentrated solution;
C: be 170 DEG C in inlet temperature by concentrated solution obtained in step B, leaving air temp is carry out spraying dry under 70 DEG C of conditions, obtains Rhizoma Curcumae Longae extract.
2) extract Fructus Phyllanthi and prepare Fructus Phyllanthi extract:
A: after Fructus Phyllanthi being pulverized 10 mesh sieves, add the ethanol that mass concentration is 50%, heating extraction twice, merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 8 times of weight, and Extracting temperature is 50 DEG C, and extraction time is 2h.
B: the extracting solution obtained by step a is 60 DEG C in temperature, and vacuum is under the condition of 0.07MPa, and being concentrated into relative density is 1.20, obtains concentrated solution;
C: the concentrated solution obtained by step b is 170 DEG C in inlet temperature, and leaving air temp is carry out spraying dry under 70 DEG C of conditions, obtains Fructus Phyllanthi extract;
3) extract Fructus Chebulae and prepare Fructus Chebulae extract:
I: after Fructus Chebulae being pulverized 10 mesh sieves, add mass concentration be 75% alcohol heating reflux extract 3 times, merge three filtrates, obtain extracting solution; Wherein each Extraction solvent consumption is 8 times of Fructus Chebulae's weight, and Extracting temperature is 50 DEG C, and extraction time is 1h;
II: extracting solution step I obtained is 70 DEG C in temperature, and vacuum is under the condition of 0.08MPa, and being concentrated into relative density is 1.10, obtains concentrated solution;
III: be 180 DEG C by the concentrated solution obtained in step II in inlet temperature, leaving air temp is carry out spraying dry under 80 DEG C of conditions, obtains Fructus Chebulae extract;
4) extract Fructus Canarii albi and prepare Fructus Canrii Albi extract:
I: after Fructus Canarii albi being pulverized 10 mesh sieves, add the alcohol heating reflux extraction twice that mass concentration is 60%, merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 10 times of Fructus Canarii albi weight, and Extracting temperature is 50 DEG C, and extraction time is 1h;
II: extracting solution step I obtained is 60 DEG C in temperature, and vacuum is under the condition of 0.08MPa, and being concentrated into relative density is 1.20, obtains concentrated solution;
III: be 170 DEG C in inlet temperature by the concentrated solution obtained in step II, leaving air temp is carry out spraying dry under 80 DEG C of conditions, obtains Fructus Canrii Albi extract;
5) Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract and dextrin are crossed 80 mesh sieves, for subsequent use; Then by Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract and the dextrin after sieving, mix homogeneously, obtained mixture;
6) stevioside being dissolved in mass concentration is in the ethanol of 95%, with step 5) obtained mixture mix and obtains soft material; Soft material is crossed 14 mesh sieves and obtain wet granular; By wet granular dry obtained dry granule under 60 DEG C of conditions; Dry granule is crossed 12 mesh sieve granulate, obtained relieving alcoholism and protecting the liver composition grain;
7) by step 6) obtained relieving alcoholism and protecting the liver composition grain inner packing aluminum-plastic composite membrane packs, every bag of 3g; Then by the product external packaging after inner packing, then test according to the inspection item that company standard requires, product, through putting preservation in storage after the assay was approved, namely completes.
Embodiment 2
Present embodiments provide a kind of relieving alcoholism and protecting the liver compositions, be made up of the raw material of following weight fraction: 150 parts, Rhizoma Curcumae Longae, Fructus Phyllanthi 150 parts, Fructus Chebulae 50 parts, Fructus Canarii albi 100 parts, 50 parts, dextrin, stevioside 3 parts.
The preparation method of the present embodiment relieving alcoholism and protecting the liver compositions, concrete operation step is as follows:
1) extract Rhizoma Curcumae Longae and prepare Rhizoma Curcumae Longae extract:
A: after Rhizoma Curcumae Longae being pulverized 12 mesh sieves, add mass concentration be 50% alcohol heating reflux extract 3 times, merging filtrate, obtain extracting solution; Wherein each Extraction solvent consumption is 10 times of Rhizoma Curcumae Longae weight, and Extracting temperature is 60 DEG C, and extraction time is 1h;
B: extracting solution steps A obtained is 70 DEG C in temperature, and vacuum is under the condition of 0.08MPa, and being concentrated into relative density is 1.10, obtains concentrated solution;
C: be 180 DEG C in inlet temperature by concentrated solution obtained in step B, leaving air temp is carry out spraying dry under 80 DEG C of conditions, obtains Rhizoma Curcumae Longae extract.
2) extract Fructus Phyllanthi and prepare Fructus Phyllanthi extract:
A: after Fructus Phyllanthi being pulverized 12 mesh sieves, add the ethanol that mass concentration is 80%, heating extraction twice, merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 10 times of weight, and Extracting temperature is 60 DEG C, and extraction time is 0.5h.
B: the extracting solution obtained by step a is 80 DEG C in temperature, and vacuum is under the condition of 0.08MPa, and being concentrated into relative density is 1.10, obtains concentrated solution;
C: the concentrated solution obtained by step b is 180 DEG C in inlet temperature, and leaving air temp is carry out spraying dry under 80 DEG C of conditions, obtains Fructus Phyllanthi extract;
3) extract Fructus Chebulae and prepare Fructus Chebulae extract:
I: after Fructus Chebulae being pulverized 14 mesh sieves, add mass concentration be 80% alcohol heating reflux extract 3 times, merging filtrate, obtain extracting solution; Wherein each Extraction solvent consumption is 8 times of Fructus Chebulae's weight, and Extracting temperature is 60 DEG C, and extraction time is 0.5h;
II: extracting solution step I obtained is 60 DEG C in temperature, and vacuum is under the condition of 0.07MPa, and being concentrated into relative density is 1.20, obtains concentrated solution;
III: be 170 DEG C by the concentrated solution obtained in step II in inlet temperature, leaving air temp is carry out spraying dry under 70 DEG C of conditions, obtains Fructus Chebulae extract;
4) extract Fructus Canarii albi and prepare Fructus Canrii Albi extract:
I: after Fructus Canarii albi being pulverized 12 mesh sieves, add the alcohol heating reflux extraction twice that mass concentration is 70%, merging filtrate, obtains extracting solution; Wherein extract 10 times that acetone consumption is Fructus Canarii albi weight, Extracting temperature is 60 DEG C, and extraction time is 1h at every turn;
II: extracting solution step I obtained is 70 DEG C in temperature, and vacuum is under the condition of 0.07MPa, and being concentrated into relative density is 1.10, obtains concentrated solution;
III: be 180 DEG C in inlet temperature by the concentrated solution obtained in step II, leaving air temp is carry out spraying dry under 70 DEG C of conditions, obtains Fructus Canrii Albi extract;
5) Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract and dextrin are crossed 100 mesh sieves, for subsequent use; Then by Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract and the dextrin after sieving, mix homogeneously, obtained mixture;
6) stevioside being dissolved in mass concentration is in the ethanol of 80%, with step 5) obtained mixture mix and obtains soft material; Soft material is crossed 14 mesh sieves and obtain wet granular; By wet granular dry obtained dry granule under 70 DEG C of conditions; Dry granule is crossed 14 mesh sieve granulate; Obtained relieving alcoholism and protecting the liver composition grain;
7) by step 6) obtained relieving alcoholism and protecting the liver composition grain inner packing aluminum-plastic composite membrane packs, every bag of 3g; Then adopt corrugated case to carry out outer package the product after inner packing, then test according to the inspection item that company standard requires, product, through putting preservation in storage after the assay was approved, namely completes.
Embodiment 3
Present embodiments provide a kind of relieving alcoholism and protecting the liver compositions, be made up of the raw material of following weight fraction: 100 parts, Rhizoma Curcumae Longae, Fructus Phyllanthi 50 parts, Fructus Chebulae 150 parts, Fructus Canarii albi 150 parts, 100 parts, dextrin, stevioside 4 parts.
The preparation method of the present embodiment relieving alcoholism and protecting the liver compositions, concrete operation step is as follows:
1) extract Rhizoma Curcumae Longae and prepare Rhizoma Curcumae Longae extract:
A: after Rhizoma Curcumae Longae being pulverized 20 mesh sieves, add mass concentration be 80% alcohol heating reflux extract 3 times, merge three filtrates, obtain extracting solution; Wherein extract 8 times that ethanol consumption is Rhizoma Curcumae Longae weight, Extracting temperature is 70 DEG C, and extraction time is 0.5h at every turn;
B: extracting solution steps A obtained is 65 DEG C in temperature, and vacuum is under the condition of 0.075MPa, and being concentrated into relative density is 1.15, obtains concentrated solution;
C: be 175 DEG C in inlet temperature by concentrated solution obtained in step B, leaving air temp is carry out spraying dry under 75 DEG C of conditions, obtains Rhizoma Curcumae Longae extract.
2) extract Fructus Phyllanthi and prepare Fructus Phyllanthi extract:
A: after Fructus Phyllanthi being pulverized 20 mesh sieves, adds the ethanol that mass concentration is 60%, heating extraction twice, merges twice filtrate, obtain extracting solution; Wherein extract 10 times that ethanol consumption is weight, Extracting temperature is 70 DEG C, and extraction time is 1h at every turn.
B: the extracting solution obtained by step a is 65 DEG C in temperature, and vacuum is under the condition of 0.075MPa, and being concentrated into relative density is 1.15, obtains concentrated solution;
C: the concentrated solution obtained by step b is 175 DEG C in inlet temperature, and leaving air temp is carry out spraying dry under 75 DEG C of conditions, obtains Fructus Phyllanthi extract;
3) extract Fructus Chebulae and prepare Fructus Chebulae extract:
I: after Fructus Chebulae being pulverized 20 mesh sieves, add mass concentration be 50% alcohol heating reflux extract 2 times, merge three filtrates, obtain extracting solution; Wherein extract 10 times that ethanol consumption is Fructus Chebulae's weight, Extracting temperature is 70 DEG C, and extraction time is 2h at every turn;
II: extracting solution step I obtained is 65 DEG C in temperature, and vacuum is under the condition of 0.075MPa, and being concentrated into relative density is 1.15, obtains concentrated solution;
III: be 175 DEG C by the concentrated solution obtained in step II in inlet temperature, leaving air temp is carry out spraying dry under 75 DEG C of conditions, obtains Fructus Chebulae extract;
4) extract Fructus Canarii albi and prepare Fructus Canrii Albi extract:
I: after Fructus Canarii albi being pulverized 20 mesh sieves, add mass concentration be 80% alcohol heating reflux extract 3 times, merging filtrate, obtain extracting solution; Wherein each Extraction solvent consumption is 8 times of Fructus Canarii albi weight, and Extracting temperature is 70 DEG C, and extraction time is 2h;
II: extracting solution step I obtained is 65 DEG C in temperature, and vacuum is under the condition of 0.075MPa, and being concentrated into relative density is 1.15, obtains concentrated solution;
III: be 175 DEG C in inlet temperature by the concentrated solution obtained in step II, leaving air temp is carry out spraying dry under 75 DEG C of conditions, obtains Fructus Canrii Albi extract;
5) Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract and dextrin are crossed 60 mesh sieves, for subsequent use; Then by Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract and the dextrin after sieving, mix homogeneously, obtained mixture;
6) stevioside being dissolved in mass concentration is in the ethanol of 75%, with step 5) obtained mixture mix and obtains soft material; Soft material is crossed 20 mesh sieves and obtain wet granular; By wet granular dry obtained dry granule under 65 DEG C of conditions; Dry granule is crossed 20 mesh sieve granulate; Obtained relieving alcoholism and protecting the liver composition grain;
7) by step 6) obtained relieving alcoholism and protecting the liver composition grain inner packing aluminum-plastic composite membrane packs, every bag of 3g; Then adopt corrugated case to carry out outer package the product after inner packing, then test according to the inspection item that company standard requires, product, through putting preservation in storage after the assay was approved, namely completes.
Test example 1 performance animal is tested
One, material
1, sample: relieving alcoholism and protecting the liver composition grain prepared by the embodiment of the present invention 1;
2, laboratory animal: select female KM kind mice, body weight 20.7 ~ 23.2 grams, 50;
3, dosage choice and tested material give mode: establish three dosage groups, be respectively 0.25,0.5,1.0g/kgBW (being equivalent to 5,10,20 times of human body recommended amounts), with distilled water diluting to desired concn, gavage amount 20ml/kgBW, establishes blank group and alcoholic liver injury model control group simultaneously.
4, key instrument and reagent: 723A type spectrophotometer, freezing microtome, electronic balance, centrifuge, soudan III+IV mixed liquor, triglyceride determination test kit, malonaldehyde, reduced glutathion measure test kit.
Two, experimental technique:
1, each dosage group gavage gives tested material, and blank group and model control group are given and distilled water, continuous 30 days, once a day.30th day each dosage group and model control group gavage give 50% ethanol (12ml/kgBW) and cause acute hepatic injury model, fasting puts to death animal in 16 hours, get mouse liver lobus sinister 10% formaldehyde to fix, permanent cold cryo-etching (thick 6 μm), soudan III and IV dyed blended, do histopathologic examination; Separately get the liver homogenate that liver normal saline makes 10%, detect malonaldehyde (MDA in hepatic tissue, TBA colorimetry), the content of reduced glutathion (GSH, DTNB colorimetry), triglyceride (TG, GPO peroxidase method);
2, ethylism mouse liver Histopathologic changes and standards of grading: comprehensively observe (any visual field must not be omitted) often opening pathological section, observe fat drop at the distribution of liver, scope and area, and quantize according to fatty change degree, by " ~ (0 point) ,+(1 point), ++ (2 points), +++ (3 points), ++++(4 points) " quantize integration.
3, experimental data statistics: adopt SPSS statistical software to carry out data analysis.Each dosage group compares employing variance analysis with model control group, adds up with the comparative approach between two of mean between multiple experimental group and a matched group; Suitable variable transitions is carried out to the data of heterogeneity of variance, after meeting variance and requiring together, adds up by the data after conversion.Model control group compares with blank matched group and adopts t to check;
4, result judges: liver MDA, reduced form GSH and TG tri-Testing index results are positive; or liver MDA, wantonly two indexs are positive and histopathologic examination's result is positive in reduced form GSH and TG tri-indexs, can judge that given the test agent has assistant protection function to chemical liver injury.
Three, experimental result
1, sample is on the impact of the weight of animals: result is as shown in table 1 below:
Table 1 sample is on the impact of the weight of animals
From table 1, there are no significant (P > 0.05) for model control group and each dosage treated animal body weight and blank group comparing difference.
2, sample is on the impact of MDA, GSH, TG in animal liver tissue, and result is as shown in following table 2,3:
Table 2 sample is on the impact of malonaldehyde in animal liver tissue (MDA)
| Dosage group (g/kg BW) | Number of animals (only) | MDA content (μm ol/g liver) | P value (blank) | P value (model) |
| 0.00 (blank) | 10 | 0.20±0.02 | – | – |
| 0.00 (model) | 10 | 0.52±0.08## | 0.000 | – |
| Low | 10 | 0.47±0.10 | – | 0.377 |
| In | 10 | 0.42±0.07* | – | 0.020 |
| High | 10 | 0.42±0.07* | – | 0.023 |
Note: ##P < 0.01, compares with blank group; * P < 0.05, compares with model control group
Table 3 sample is on the impact of triglyceride in animal liver tissue (TG)
| Dosage group (g/kg BW) | Number of animals (only) | TG content (μm ol/g liver) | P value (blank) | P value (model) |
| 0.00 (blank) | 10 | 14.75±5.55 | – | – |
| 0.00 (model) | 10 | 94.40±54.04## | 0.001 | – |
| Low | 10 | 77.55±53.68 | – | 0.978 |
| In | 10 | 34.57±17.97* | – | 0.037 |
| High | 10 | 42.75±10.72 | – | 0.075 |
Note: ##P < 0.01, compares with blank group; * P < 0.05, compares with model control group
By MDA, TG of table 2,3 visible model control group all higher than blank group, the GSH of model control group is lower than blank group, and difference all has significance (P < 0.01); In sample, the TG of dosage group and the MDA of middle and high dosage group is lower than model control group, and difference all has significance (P < 0.05).
3, sample impact that hepatic tissue pathology is checked: result is as shown in table 4 below:
The impact that table 4 sample checks hepatic tissue pathology
Note: ##P < 0.01, compares with blank group; * P < 0.01, compares with model control group
From table 4, the degree that model control group liver fat changes is higher than blank group, and difference has significance (P < 0.01); The degree that in sample, the liver fat of dosage group changes is lighter than model control group, and difference has significance (P < 0.01).
3, assay:
The continuous gavage of mice gave low middle high dose sample after 30 days, caused acute hepatic injury model with ethanol.In sample, the TG of dosage group and the MDA of middle high dose group is lower than model control group, and the degree that the liver fat of middle dosage group changes is lighter than model control group, and difference all has significance (P < 0.05).Therefore, the relieving alcoholism and protecting the liver compositions that prepared by the embodiment of the present invention 1 has assistant protection function to the hepatic injury that ethanol causes.
The functional trial result of relieving alcoholism and protecting the liver compositions prepared by the embodiment of the present invention 2 ~ 3 is with embodiment 1.
It should be noted that, for aforesaid embodiment of the method, in order to simple description, therefore it is all expressed as a series of combination of actions, but those skilled in the art should know, the present invention is not by the restriction of described sequence of movement, because according to the present invention, some step can adopt other orders or carry out simultaneously.Secondly, those skilled in the art also should know, the embodiment described in description all belongs to preferred embodiment, and involved action might not be essential to the invention.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (10)
1. a relieving alcoholism and protecting the liver compositions, is characterized in that, the raw material primarily of following weight portion is made: 50 ~ 150 parts, Rhizoma Curcumae Longae, Fructus Phyllanthi 50 ~ 150 parts, Fructus Chebulae 50 ~ 150 parts, Fructus Canarii albi 50 ~ 150 parts.
2. relieving alcoholism and protecting the liver compositions according to claim 1, it is characterized in that, the raw material primarily of following weight portion is made: Rhizoma Curcumae Longae extract 50 ~ 150 parts, Fructus Phyllanthi extract 50 ~ 150 parts, Fructus Chebulae extract 50 ~ 150 parts, Fructus Canrii Albi extract 50 ~ 150 parts.
3. relieving alcoholism and protecting the liver compositions according to claim 1 and 2, is characterized in that, the dosage form of said composition is granule.
4. relieving alcoholism and protecting the liver compositions according to claim 3, is characterized in that, also comprises the adjuvant of following weight portion: 50 ~ 150 parts, dextrin, stevioside 3 ~ 6 parts.
5. a preparation method for relieving alcoholism and protecting the liver compositions as claimed in claim 4, is characterized in that, comprises following operating procedure:
1) extract Rhizoma Curcumae Longae and prepare Rhizoma Curcumae Longae extract; Extract Fructus Phyllanthi and prepare Fructus Phyllanthi extract; Extract Fructus Chebulae and prepare Fructus Chebulae extract; Extract Fructus Canarii albi and prepare Fructus Canrii Albi extract;
2) by Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract, dextrin mixing, obtained mixture;
3) stevioside being dissolved in mass concentration is in the ethanol of 75 ~ 95%, with step 2) obtained mixture mix and obtains soft material; Sieve soft material obtained wet granular; Wet grain drying is obtained dry granule; By dry pellet through sieves granulate, obtain described relieving alcoholism and protecting the liver compositions.
6. the preparation method of relieving alcoholism and protecting the liver compositions according to claim 5, is characterized in that, the process extracting Rhizoma Curcumae Longae is: comprise following operating procedure:
A: after Rhizoma Curcumae Longae being pulverized 10 ~ 20 mesh sieves, add mass concentration be 50 ~ 80% alcohol heating reflux extract 2 ~ 3 times, merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 8 ~ 10 times of Rhizoma Curcumae Longae weight, and Extracting temperature is 50 ~ 70 DEG C, and each extraction time is 0.5 ~ 2h;
B: extracting solution steps A obtained is 60 ~ 70 DEG C in temperature, and vacuum is under the condition of 0.07 ~ 0.08MPa, and being concentrated into relative density is 1.10 ~ 1.20, obtains concentrated solution;
C: be 170 ~ 180 DEG C in inlet temperature by concentrated solution obtained in step B, leaving air temp is carry out spraying dry under 70 ~ 80 DEG C of conditions, obtains Rhizoma Curcumae Longae extract.
7. the preparation method of relieving alcoholism and protecting the liver compositions according to claim 5, is characterized in that, the process extracting Fructus Phyllanthi is: comprise following operating procedure:
A: after Fructus Phyllanthi being pulverized 10 ~ 20 mesh sieves, adds the ethanol that mass concentration is 50 ~ 80%, heating extraction 2 ~ 3 times, and merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 8 ~ 10 times of weight, and Extracting temperature is 50 ~ 70 DEG C, and each extraction time is 0.5 ~ 2h.
B: the extracting solution obtained by step a is 60 ~ 70 DEG C in temperature, and vacuum is under the condition of 0.07 ~ 0.08MPa, and being concentrated into relative density is 1.10 ~ 1.20, obtains concentrated solution;
C: the concentrated solution obtained by step b is 170 ~ 180 DEG C in inlet temperature, and leaving air temp is carry out spraying dry under 70 ~ 80 DEG C of conditions, obtains Fructus Phyllanthi extract.
8. the preparation method of relieving alcoholism and protecting the liver compositions according to claim 5, is characterized in that, the process extracting Fructus Chebulae is: comprise following operating procedure:
I: after Fructus Chebulae being pulverized 10 ~ 20 mesh sieves, add mass concentration be 50 ~ 80% alcohol heating reflux extract 2 ~ 3 times, merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 8 ~ 10 times of Fructus Chebulae's weight, and Extracting temperature is 50 ~ 70 DEG C, and each extraction time is 0.5 ~ 2h;
II: extracting solution step I obtained is 60 ~ 70 DEG C in temperature, and vacuum is under the condition of 0.07 ~ 0.08MPa, and being concentrated into relative density is 1.10 ~ 1.20, obtains concentrated solution;
III: be 170 ~ 180 DEG C by the concentrated solution obtained in step II in inlet temperature, leaving air temp is carry out spraying dry under 70 ~ 80 DEG C of conditions, obtains Fructus Chebulae extract.
9. the preparation method of relieving alcoholism and protecting the liver compositions according to claim 5, is characterized in that, the process extracting Fructus Canarii albi is: comprise following operating procedure:
I: after Fructus Canarii albi being pulverized 10 ~ 20 mesh sieves, add mass concentration be 50 ~ 80% alcohol heating reflux extract 2 ~ 3 times, merging filtrate, obtains extracting solution; Wherein each Extraction solvent consumption is 8 ~ 10 times of Fructus Canarii albi weight, and Extracting temperature is 50 ~ 70 DEG C, and extraction time is 0.5 ~ 2h;
II: extracting solution step I obtained is 60 ~ 70 DEG C in temperature, and vacuum is under the condition of 0.07 ~ 0.08MPa, and being concentrated into relative density is 1.10 ~ 1.20, obtains concentrated solution;
III: be 170 ~ 180 DEG C in inlet temperature by the concentrated solution obtained in step II, leaving air temp is carry out spraying dry under 70 ~ 80 DEG C of conditions, obtains Fructus Canrii Albi extract.
10. the preparation method of relieving alcoholism and protecting the liver compositions according to claim 5, it is characterized in that, step 2) in Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract, dextrin mixing concrete grammar be: first Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract and dextrin are crossed 60 ~ 100 mesh sieves, for subsequent use; Then by Rhizoma Curcumae Longae extract, Fructus Phyllanthi extract, Fructus Chebulae extract, Fructus Canrii Albi extract and the dextrin after sieving, mix homogeneously, obtained mixture.
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