CN108578445A - Cortex Ilicis Rotundae extract and its preparation and the application for treating hepatitis - Google Patents
Cortex Ilicis Rotundae extract and its preparation and the application for treating hepatitis Download PDFInfo
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- CN108578445A CN108578445A CN201810248025.1A CN201810248025A CN108578445A CN 108578445 A CN108578445 A CN 108578445A CN 201810248025 A CN201810248025 A CN 201810248025A CN 108578445 A CN108578445 A CN 108578445A
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- cortex ilicis
- ilicis rotundae
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- rotundae extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The present invention proposes the application of a kind of Cortex Ilicis Rotundae extract and preparation method thereof and treatment hepatitis, and a kind of preparation method of Cortex Ilicis Rotundae extract includes the following steps：(1) it takes iron holly bark to crush, is sieved, Ethyl acetate Butyl acetate solution is added, refluxing extraction filters, and vacuum rotary steam removes solvent, obtains syrup.(2) syrup obtained by step (1) is added into ethyl alcohol, is mixed with polyamide, dried, loading first washes, then uses ethanol elution, and collection yellow colour band subtracts and solvent is evaporated off, obtains yellow powder to get Cortex Ilicis Rotundae extract.By melanterite, rainbow conk, Cortex Ilicis Rotundae extract, Radix Salviae Miltiorrhizae, prepared rehmannia root, tassel flower combination, it is prepared into the Chinese medicine composition for the treatment of hepatitis, Cortex Ilicis Rotundae extract of the present invention and its traditional Chinese medicine composition for treating hepatitis of preparation it is with obvious effects, there is wide medical application foreground.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, and in particular to Cortex Ilicis Rotundae extract and its preparation more particularly to this carry
Take object in the application for the treatment of hepatitis.
Background technology
Liver is known as the title in " maximum chemical plant in human body ", but liver be also easy to the damage by hepatotropic poison and
Cause inflammation.Hepatitis is the general designation of liver inflammation, is typically referred to by a variety of pathogenic factors such as virus, bacterium, parasite, chemistry poison
Object, drug, alcohol, role of autoimmune factors etc. make liver cell be destroyed, and the function of liver is damaged, and cause one system of body
The exception of row malaise symptoms and liver function index.Clinical symptoms are often shown as：Sclera or xanthochromia, fever, hepatic region are hidden
Bitterly, hepatomegaly is touched a tender spot, and anorexia, abdominal distension detests greasy food, and nausea, vomiting, easily tired, spider angioma and liver occur in some patientss
Palm etc..Hepatitis has the characteristics that incidence is high, infectiousness is strong, seriously affects work, the living and studying of patient.
Chinese medicine iron holly bark is the dry bark of holly plant ilexrotunda, is distributed widely in each province in southern China, main product
Civil to be usually used in clearing heat and detoxicating, swelling and pain relieving in Guangxi, Guangdong Province, cure cold fever, acute, chronic hepatitis, acute gastroenteritis, stomach
And duodenal ulcer, rheumatic arthritis, therefore, iron holly bark are the medicinal materials for having extensive use, also there is the title of " rescuing disease must answer ".
Scientific investigations showed that having significant effect in terms for the treatment of acute, chronic hepatitis.
Invention content
In order to solve the above technical problems, a kind of Cortex Ilicis Rotundae extract of present invention offer and preparation method thereof, and provide
A kind of Chinese medicine composition including the extract is used to treat the application of hepatitis, and the traditional Chinese medicine composition for treating effect is good, can be apparent
Mitigate patient anorexia, abdominal distension, detest greasy food, Nausea and vomiting, easily tired etc. clinical symptoms, can make patient skin xanthochromia,
The signs such as fever, dull pain in liver, hepatomegaly, tenderness disappear.
The present invention provides a kind of preparation method of Cortex Ilicis Rotundae extract, includes the following steps：
(1) it takes iron holly bark to crush, is sieved, according to mass ratio 1:10-1:30 are added ethyl acetate acetic acid butyl acetate solution, in
Refluxing extraction 2 times at a temperature of 82-90 DEG C, each 60-180min, filtering, vacuum rotary steam remove solvent, obtain syrup；
(2) syrup obtained by step (1) is added into 60% appropriate amount of ethanol, by medicinal material crude drug amount：Polyamide weight=2:1
~4:1 is sufficiently mixed, and sets 80 DEG C of drying, spare, the polyamide wet method dress post of non-dosing, according to the polyamide for mixing medicine in baking oven：
Polyamide=l of medicine is not mixed:1~1:3 loadings, are first washed, and abandon water lotion, then with 30%~50% ethanol elution, are collected yellow
Color colour band, vacuum rotary steam remove solvent, obtain yellow powder to get Cortex Ilicis Rotundae extract.
As further improvement of the invention, a kind of preparation method of Cortex Ilicis Rotundae extract includes the following steps：
(1) it takes iron holly bark to crush, is sieved, according to mass ratio 1:20 are added ethyl acetate acetic acid butyl acetate solution, in 85 DEG C of temperature
The lower refluxing extraction 2 times, each 120min of degree, filtering, vacuum rotary steam remove solvent, obtain syrup；
(2) syrup obtained by step (1) is added into 60% appropriate amount of ethanol, by medicinal material crude drug amount：Polyamide weight=3:1
It is sufficiently mixed, sets 80 DEG C of drying, spare, the polyamide wet method dress post of non-dosing, according to the polyamide for mixing medicine in baking oven：Medicine is not mixed
Polyamide=l:2 loadings, are first washed, and abandon water lotion, then with 40% ethanol elution, collect yellow colour band, vacuum rotary steam removes
Solvent is removed, obtains yellow powder to get Cortex Ilicis Rotundae extract.
As further improvement of the invention, sieving was No. 1 or No. 2 sieve.
It is improved as of the invention further, ethyl acetate acetic acid butyl acetate solution is ethyl acetate by volume：Acetic acid fourth
Ester=1:1~1:3 are formulated.
As further improvement of the invention, polyamide removes the organic residues such as toluene by pretreatment.
The present invention further protects the Cortex Ilicis Rotundae extract obtained by above method preparation method.
As further improvement of the invention, which is used to prepare the drug for the treatment of hepatitis.
The present invention further protects a kind of Chinese medicine composition for treating hepatitis, composition to be prepared by the raw material of following parts by weight
It forms：10-15 parts of melanterite, 10-15 parts of rainbow conk, 10-15 parts of Cortex Ilicis Rotundae extract, 5-10 parts of Radix Salviae Miltiorrhizae, 5-10 parts of prepared rehmannia root, a bit
It is 2-5 parts red.
Improved as of the invention further, treat the Chinese medicine composition of hepatitis prepared by the raw material of following parts by weight and
At：15 parts of melanterite, 15 parts of rainbow conk, 12 parts of Cortex Ilicis Rotundae extract, 10 parts of Radix Salviae Miltiorrhizae, 7 parts of prepared rehmannia root, 3 parts of tassel flower.
The present invention has the advantages that：
1, the present invention obtains activity extract with simple method from iron holly bark medicine, and resource, reduction is made full use of to be produced into
This；
2, other Chinese medicine materials of the invention are easy to get, and simple for process, easy to operate, product quality is easy to control, can in high volume throw
Enter production；
3, iron holly bark can effectively treat hepatitis, improve a series of malaise symptoms caused by dysfunction of liver, and addition is several
The Chinese medicine composition that other Chinese medicines are prepared, can obviously treat hepatitis, and effect is much better than Cortex Ilicis Rotundae extract, and its poison
Relatively low, the Small side effects of property.
Description of the drawings
Fig. 1 is the preparation technology flow chart of Cortex Ilicis Rotundae extract.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical solution in the embodiment of the present invention carries out clear, complete description,
Obviously, the embodiment described is the embodiment of the part of representative of the present invention, rather than whole embodiments, this field are general
Other all embodiments that logical technical staff is obtained without making creative work belong to the protection of the present invention
Range.
The preparation of 1 Cortex Ilicis Rotundae extract of embodiment
It follows the steps below：
(1) it takes iron holly bark to crush, is sieved, according to mass ratio 1:10 are added ethyl acetate acetic acid butyl acetate solution, in 82 DEG C of temperature
The lower refluxing extraction 2 times, each 60min of degree, filtering, vacuum rotary steam remove solvent, obtain syrup；
(2) syrup obtained by step (1) is added into 60% appropriate amount of ethanol, by medicinal material crude drug amount：Polyamide weight=2:1
It is sufficiently mixed, sets 80 DEG C of drying, spare, the polyamide wet method dress post of non-dosing, according to the polyamide for mixing medicine in baking oven：Medicine is not mixed
Polyamide=l:1 loading, is first washed, and abandons water lotion, then with 30% ethanol elution, collects yellow colour band, vacuum rotary steam removes
Solvent is removed, obtains yellow powder to get Cortex Ilicis Rotundae extract, yield 72%.
The preparation of 2 Cortex Ilicis Rotundae extract of embodiment
It follows the steps below：
(1) it takes iron holly bark to crush, is sieved, according to mass ratio 1:20 are added ethyl acetate acetic acid butyl acetate solution, in 85 DEG C of temperature
The lower refluxing extraction 2 times, each 120min of degree, filtering, vacuum rotary steam remove solvent, obtain syrup；
(2) syrup obtained by step (1) is added into 60% appropriate amount of ethanol, by medicinal material crude drug amount：Polyamide weight=3:1
It is sufficiently mixed, sets 80 DEG C of drying, spare, the polyamide wet method dress post of non-dosing, according to the polyamide for mixing medicine in baking oven：Medicine is not mixed
Polyamide=l:2 loadings, are first washed, and abandon water lotion, then with 40% ethanol elution, collect yellow colour band, vacuum rotary steam removes
Solvent is removed, obtains yellow powder to get Cortex Ilicis Rotundae extract, yield 95%.
The preparation of 3 Cortex Ilicis Rotundae extract of embodiment
(1) it takes iron holly bark to crush, is sieved, according to mass ratio 1:30 are added ethyl acetate acetic acid butyl acetate solution, in 90 DEG C of temperature
The lower refluxing extraction 2 times, each 180min of degree, filtering, vacuum rotary steam remove solvent, obtain syrup；
(2) syrup obtained by step (1) is added into 60% appropriate amount of ethanol, by medicinal material crude drug amount：Polyamide weight=4:1
It is sufficiently mixed, sets 80 DEG C of drying, spare, the polyamide wet method dress post of non-dosing, according to the polyamide for mixing medicine in baking oven：Medicine is not mixed
Polyamide=1:3 loadings, are first washed, and abandon water lotion, then with 50% ethanol elution, collect yellow colour band, vacuum rotary steam removes
Solvent is removed, obtains yellow powder to get Cortex Ilicis Rotundae extract, yield 84%.
Prepared by embodiment 4 is added the medicinal powder that Cortex Ilicis Rotundae extract is used to treat hepatitis
Raw material forms：15 parts of melanterite, 15 parts of rainbow conk, 15 parts of Cortex Ilicis Rotundae extract, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of prepared rehmannia root, a bit
Red 4 parts.
Preparation process：
(1) it takes melanterite, rainbow conk, Radix Salviae Miltiorrhizae, prepared rehmannia root, tassel flower to be mixed after crushing, 10 times of volume of water is added, impregnate 30min,
120min is decocted, is filtered under diminished pressure, filtrate is spare；
(2) 5 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 60min, is filtered under diminished pressure, filtrate is spare；
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate to relative density 0.9-
1.3 to get Chinese medicine composition water extract；
(4) it is added in Chinese medicine composition water extract after yellow powder Cortex Ilicis Rotundae extract being diluted 5 times with ethanol solution,
And be spray-dried, obtain solid medicinal powder.
Prepared by embodiment 5 is added the medicinal powder that Cortex Ilicis Rotundae extract is used to treat hepatitis
Raw material forms：15 parts of melanterite, 15 parts of rainbow conk, 12 parts of Cortex Ilicis Rotundae extract, 10 parts of Radix Salviae Miltiorrhizae, 7 parts of prepared rehmannia root, tassel flower
3 parts.
Preparation process：
(1) it takes melanterite, rainbow conk, Radix Salviae Miltiorrhizae, prepared rehmannia root, tassel flower to be mixed after crushing, 10 times of volume of water is added, impregnate 30min,
120min is decocted, is filtered under diminished pressure, filtrate is spare；
(2) 5 times of volume of water are added in the dregs of a decoction obtained by step (1), decocts 60min, is filtered under diminished pressure, filtrate is spare；
(3) filtrate obtained by step (1) and step (2) is merged, crosses 400 mesh sieve, concentration filtrate to relative density 1.0-
1.3 to get Chinese medicine composition water extract；
(4) it is added in Chinese medicine composition water extract after yellow powder Cortex Ilicis Rotundae extract being diluted 5 times with ethanol solution,
And be spray-dried, obtain solid medicinal powder.
1 rat of test example is tested
1, group is tested.Male SPF grades of SD rat 80,160~200g of weight.
The foundation of NASH rat models：Take rat 80, adaptable fed 1W.It is randomly divided into blank group, control group group, rescues
It must answer extract-treated groups (1 group) and Chinese medicine composition processing group (2 groups), every group 20.Blank group is fed with normal diet,
Excess-three group is fed with high lipid food.The ends 12W, every group is put to death 2 rats at random, is verified into mould situation.
2, experimental method.Iron holly bark processing group animal gives the Cortex Ilicis Rotundae extract of the preparation of 10mg/mL embodiments 2 daily
Aqueous solution gavage, dosage 0.75mL/l00g；Chinese medicine composition processing group animal gives the preparation of 10mg/mL embodiments 5 daily
The aqueous solution gavage of the Chinese medicine composition containing Cortex Ilicis Rotundae extract, dosage 0.75mL/l00g；Blank group and control group with
The distilled water gavage of 0.75mL/100g.
3, Indexs measure.In the ends 24W, it is deprived of food but not water, after next day claims weight, with 10% chloraldurate solution 0.3mL/
100g intraperitoneal injections anesthesia, fixed rat, opens abdominal cavity, is taken a blood sample from inferior caval vein with vacuum blood collection tube, rapid to dissociate and take
Go out liver, after rushing bloodstain to the greatest extent with pre- cold saline, the wet quality of liver is weighed, to calculate liver index (liver index=liver quality, body
Quality × 100%).
(1) detection of blood biochemistry index：It is detected using Vitros5.1FS automatic biochemistry analyzers.
(2) detection of hepatic tissue oxidative stress index：A small amount of fresh liver tissue is taken, the PBS buffer solution of 20 times of volumes is added
It is fully ground in ice bath, centrifuges, take supernatant, BCA method row protein quantifications.It is operated by ROS test kit specifications, measures various kinds
As a result this ROS contents are indicated with fluorescence intensity/mg protein；A small amount of fresh liver tissue is taken, the PBS that 10 times of volumes are added is slow
It is fully homogenized in fliud flushing ice bath, centrifuges, take supernatant, after protein quantification, by Cu/Zn/Mn-SOD activity detection kits (W ST-8
Method) specification operation, is detected each sample SOD activity, is as a result indicated with U/mg protein.
Experimental result is shown in Tables 1 and 2s.
1 each group rat liver index of table and Biochemical Indices In Serum compare
The comparison of 2 each group hepatic tissue oxidative stress index of table
By the above experimental result it is found that by each group NASH rats liver index and Biochemical Indices In Serum variation comparison (table 1),
Control rats liver index and Biochemical Indices In Serum are significantly increased compared with blank group, and Cortex Ilicis Rotundae extract processing group is then bright compared with model group
It is aobvious to decline, and the fall bigger of Chinese medicine composition processing group, display Cortex Ilicis Rotundae extract can obviously improve NASH rats'livers
Function and lipid-metabolism, and the Chinese medicine composition containing Cortex Ilicis Rotundae extract is to the improvement result of Liver Function and lipid-metabolism
It is more obvious, it is much better than Cortex Ilicis Rotundae extract.
By the comparison (table 2) of hepatic tissue oxidative stress index, control group group hepatic tissue ROS contents are significantly higher than blank
Group, Cortex Ilicis Rotundae extract processing group is reduced compared with control group, and Chinese medicine composition processing group also has compared with Cortex Ilicis Rotundae extract processing group
It is substantially reduced.In addition, control group group hepatic tissue SOD activity is substantially less than blank group, Cortex Ilicis Rotundae extract processing group is compared with control group
It increases, and Chinese medicine composition processing group is then increased significantly compared with Cortex Ilicis Rotundae extract processing group.
Those skilled in the art is not under conditions of departing from the spirit and scope of the present invention of claims determination, also
Various modifications can be carried out to the above content.Therefore the scope of the present invention is not limited in above explanation, but by
The range of claims determines.
Claims (9)
1. a kind of preparation method of Cortex Ilicis Rotundae extract, which is characterized in that include the following steps：
(1) it takes iron holly bark to crush, is sieved, according to mass ratio 1:10-1:30 are added ethyl acetate acetic acid butyl acetate solution, in 82-90
Refluxing extraction 2 times at a temperature of DEG C, each 60-180min, filtering, vacuum rotary steam remove solvent, obtain syrup；
(2) syrup obtained by step (1) is added into 60% appropriate amount of ethanol, by medicinal material crude drug amount：Polyamide weight=2:1~4:
1 is sufficiently mixed, and sets 80 DEG C of drying, spare, the polyamide wet method dress post of non-dosing, according to the polyamide for mixing medicine in baking oven：It does not mix
Polyamide=l of medicine:1~1:3 loadings, are first washed, and abandon water lotion, then with 30%~50% ethanol elution, collect yellow color
Band, vacuum rotary steam remove solvent, obtain yellow powder to get Cortex Ilicis Rotundae extract.
2. preparation method according to claim 1, which is characterized in that the step includes：
(1) it takes iron holly bark to crush, is sieved, according to mass ratio 1:20 are added ethyl acetate acetic acid butyl acetate solution, at a temperature of 85 DEG C
Refluxing extraction 2 times, each 120min, filtering, vacuum rotary steam remove solvent, obtain syrup；
(2) syrup obtained by step (1) is added into 60% appropriate amount of ethanol, by medicinal material crude drug amount：Polyamide weight=3:1 fully
80 DEG C of drying, spare, the polyamide wet method dress post of non-dosing, according to the polyamide for mixing medicine in baking oven are set in mixing：The poly- of medicine is not mixed
Amide=l:2 loadings, are first washed, and abandon water lotion, then with 40% ethanol elution, collect yellow colour band, vacuum rotary steam removes molten
Agent obtains yellow powder to get Cortex Ilicis Rotundae extract.
3. preparation method according to claim 1 or claim 2, which is characterized in that the sieving was No. 1 or No. 2 sieve.
4. preparation method according to claim 1 or claim 2, which is characterized in that the ethyl acetate acetic acid butyl acetate solution is by body
Product compares ethyl acetate：Butyl acetate=1:1~1:3 are formulated.
5. preparation method according to claim 1 or claim 2, which is characterized in that the polyamide removes toluene etc. by pretreatment
Organic residue.
6. the Cortex Ilicis Rotundae extract that preparation method according to claim 1 or claim 2 obtains.
7. Cortex Ilicis Rotundae extract according to claim 6, which is characterized in that the Cortex Ilicis Rotundae extract is used to prepare treatment
The drug of hepatitis.
8. a kind of Chinese medicine composition for treating hepatitis, which is characterized in that composition is prepared by the raw material of following parts by weight：Soap
10-15 parts of alum, 10-15 parts of rainbow conk, 10-15 parts of Cortex Ilicis Rotundae extract, 5-10 parts of Radix Salviae Miltiorrhizae, 5-10 parts of prepared rehmannia root, tassel flower 2-5
Part.
9. composition according to claim 8, which is characterized in that composition is prepared by the raw material of following parts by weight：Soap
15 parts of alum, 15 parts of rainbow conk, 12 parts of Cortex Ilicis Rotundae extract, 10 parts of Radix Salviae Miltiorrhizae, 7 parts of prepared rehmannia root, 3 parts of tassel flower.
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| CN201810248025.1A CN108578445A (en) | 2018-03-23 | 2018-03-23 | Cortex Ilicis Rotundae extract and its preparation and the application for treating hepatitis |
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| CN201810248025.1A CN108578445A (en) | 2018-03-23 | 2018-03-23 | Cortex Ilicis Rotundae extract and its preparation and the application for treating hepatitis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114644677A (en) * | 2020-12-21 | 2022-06-21 | 广西大学 | Novel compound separated from ovate leaf holly bark and separation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1309372C (en) * | 2004-09-23 | 2007-04-11 | 内蒙古伊泰医药科技开发有限责任公司 | Preparation of granular powder for treating hepatitis and quality control method |
| CN102558253A (en) * | 2010-12-24 | 2012-07-11 | 苏州宝泽堂医药科技有限公司 | Method for extracting syringin from ovate leaf holly bark |
| CN102836388A (en) * | 2012-08-25 | 2012-12-26 | 李新欣 | Traditional Chinese medicine for chronic hepatitis treatment |
| CN103351419A (en) * | 2013-07-09 | 2013-10-16 | 陕西中药研究所 | Two-step simultaneous preparation method for pedunculoside and syringin |
-
2018
- 2018-03-23 CN CN201810248025.1A patent/CN108578445A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1309372C (en) * | 2004-09-23 | 2007-04-11 | 内蒙古伊泰医药科技开发有限责任公司 | Preparation of granular powder for treating hepatitis and quality control method |
| CN102558253A (en) * | 2010-12-24 | 2012-07-11 | 苏州宝泽堂医药科技有限公司 | Method for extracting syringin from ovate leaf holly bark |
| CN102836388A (en) * | 2012-08-25 | 2012-12-26 | 李新欣 | Traditional Chinese medicine for chronic hepatitis treatment |
| CN103351419A (en) * | 2013-07-09 | 2013-10-16 | 陕西中药研究所 | Two-step simultaneous preparation method for pedunculoside and syringin |
Non-Patent Citations (3)
| Title |
|---|
| 杨文娟等: "紫丁香苷对小鼠急性肝损伤的保护作用", 《天然产物研究与开发》 * |
| 陈壮等: "救必应对小鼠急性化学性肝损伤的保护作用 ", 《中国医药导报》 * |
| 陈娟等: "白藜芦醇对非酒精性脂肪性肝炎大鼠肝组织SIRT3表达的影响", 《实用肝脏病杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114644677A (en) * | 2020-12-21 | 2022-06-21 | 广西大学 | Novel compound separated from ovate leaf holly bark and separation method thereof |
| CN114644677B (en) * | 2020-12-21 | 2023-05-12 | 广西大学 | New compound separated from cortex Ilicis Rotundae and separation method thereof |
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Application publication date: 20180928 |