Summary of the invention
Problem to be solved by this invention provides a kind of compositions for the treatment of osteoporosis, and its prescription is simplified, and is safe and effective, quality controllable.
Another technical problem to be solved by this invention provides a kind of preparation of compositions method, is made into modern preparation, the convenient use.
In order to solve the problems of the technologies described above, the present invention proposes following technical proposals:
A kind of compositions for the treatment of osteoporosis is characterized in that described compositions made by the raw material of following parts by weight: Herba Epimedii 5-10 part, Fructus Psoraleae 5-10 part, Endoconcha Sepiae 1-3 part, Radix Astragali 10-30 part, Rhizoma Dioscoreae 15-30 part, Radix Salviae Miltiorrhizae 5-15 part.
Prescription is preferably: 9 parts of Herba Epimedii, 9 parts of Fructus Psoraleaes, 2 parts of Endoconcha Sepiaes, 15 parts of the Radixs Astragali, 20 parts of Rhizoma Dioscoreaes, 10 parts of Radix Salviae Miltiorrhizaes.
Herba Epimedii is the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., arrow leaf Herba Epimedii Epimediumsagittatum (Sieb.et Zucc.) Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanense T.S.Ying or Herba Epimedii Epimedium koreanum Nakai.
Fructus Psoraleae is the dry mature fruit of legumes psoraleae Psoralea corylifolia L..
Endoconcha Sepiae is the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune Sepiella maindroni de Rochebrune or golden cuttlefish Sepiaesculenta Hoyle.
The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongho-licus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..
Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..
Herba Epimedii, Fructus Psoraleae, Endoconcha Sepiae invigorating the kidney and strengthening the bones in the side, the Radix Astragali, Rhizoma Dioscoreae air making-up and spleen enlivening, the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, all medicines share, and play the merit of invigorating the kidney and strengthening the bones, air making-up and spleen enlivening, blood circulation promoting and blood stasis dispelling altogether, can effectively prevent and treat osteoporosis.
The technique effect of traditional Chinese medicine composition for treating osteoporosis of the present invention can embody by following test.
Test example, the present composition are to the osteoporotic influence of castrated rats
1.1, test material
Medicine and reagent: the present composition, press the self-control of embodiment 13 methods; Synestrin tablets (1mg/ sheet), cod-liver oil (contains VD
35000 units/ml), calcium gluconate; Human serum estradiol (E2) radioimmunoassay determination box (Beijing nation decides Tyke Bioisystech Co., Ltd).
Animal: Healthy female Wistar rats, at 12 monthly ages, body weight is 250-320g, the Jiangsu Prov. Research Inst. Traditional Chinese Medical Experimental Animal Center provides.
Instrument: dual intensity X line bone densitometry instrument, DEXA (U.S.); The WD-1 type Material Testing Machine, Changchun experiment equipment factory; 724 spectrophotometers, the optical instrument factory, Shanghai.
1.2 test method
Method of emasculation: get healthy rat, anesthesia is extractd after the bilateral ovaries the 5th day by only carrying out vaginal smear examination, every day 1 time, continuous 5 days, gets ovariectomy and does not have fully emotionally that variation person's (castration group) is used for experiment.False castration treated animal operation is except that not extracing the ovary, and is surplus all with the castration group.
Female rats is got 10 castration groups that rehearse, and the passed examination animal is used for experiment after the remaining castration.Castrated rats is divided at random 10 every group.False castration group, castration group, all give normal saline, positive controls is irritated stomach and is given diethylstilbestrol 0.02mg/kg, cod-liver oil 450U/kg, calcium gluconate 0.5g/kg, high, medium and low dosage group is irritated stomach respectively and is given present composition 2.6g crude drug/kg, 5.2g crude drug/kg, 10.4g crude drug/kg, operation back beginning in the 9th day gastric infusion, every day 1 time, continuous three months, after the last administration, rat fasting 12h weighs.Behind the anesthetized animal, abdominal aortic blood is surveyed serum estradiol concentration, gets rat right side femur and measures bone density (BMD), gets the rats with left femur and measures bone biomechanical index (fracture load by bending, rigidity).Test data adopts t check carrying out statistical analysis between group.
1.3 result of the test
1.3.1 the present composition is to the influence of castrated rats femur density
Table 1 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Present composition low dose group |
??2.6g |
??0.248±0.006* |
Dosage group in the present composition |
??5.2g |
??0.251±0.007** |
Present composition high dose group |
??10.4g |
??0.257±0.005** |
Compare * P<0.05 with the castration group; * P<0.01, following table are together.
Result of the test shows, false castration group rat femur density is apparently higher than the castration group, and has highly significant meaning (p<0.01), shows the modeling success.Compare positive controls, each dosage group rat femur density of the present composition obviously raise (p<0.05,0.01) with the castration group.The above results shows, the present composition castrated rats bone density that can significantly raise.
1.3.2 the present composition is to the influence of castrated rats femur biomechanics
Table 2 present composition is to the influence of castrated rats femur biomechanics
Group |
Dosage (/Kg) |
Fracture load by bending (N) |
Rigidity (N/mm) |
The castration group |
??- |
??8.82±0.31 |
??12.26±2.46 |
False castration group |
??- |
??10.25±0.44** |
??18.27±2.66** |
Positive controls |
??(0.02mg+450U+0.5g) |
??9.67±0.39** |
??16.25±2.54** |
Low dose group |
??2.6g |
??9.23±0.40* |
??15.13±2.78* |
Middle dosage group |
??5.2g |
??9.45±0.42** |
??15.79±2.85** |
High dose group |
??10.4g |
??9.70±0.38** |
??16.40±3.02** |
Result of the test shows, false castration group rat femur fracture load by bending, rigidity is apparently higher than the castration group, and all has highly significant meaning (p<0.01), shows the modeling success.Compare with the castration group, positive controls, each dosage group rat femur fracture load by bending of the present composition, rigidity is obviously rising (p<0.05,0.01) all.
1.3.3 the present composition is to the influence of castrated rats serum E2 concentration
Table 3 present composition is to the influence of castrated rats serum E2 concentration
Group |
Dosage (/Kg) |
Serum E2 concentration (pg/ml) |
The castration group |
??- |
??40.1±15.5 |
False castration group |
??- |
??70.9±10.2** |
Positive controls |
??(0.02mg+450U+0.5g) |
??65.8±13.4** |
Present composition low dose group |
??2.6g |
??54.9±12.9* |
Dosage group in the present composition |
??5.2g |
??59.2±10.6** |
Present composition high dose group |
??10.4g |
??64.1±11.1** |
Result of the test shows, false castration group rat blood serum estradiol (E2) concentration is apparently higher than the castration group, and has highly significant meaning (p<0.01), shows the modeling success.Compare with the castration group, positive controls, each dosage group rat blood serum estradiol (E2) concentration of the present composition obviously raise, and have highly significant meaning (p<0.05,0.01).
In sum, the present composition can significantly strengthen the bone density of castrated rats, improves its bone biomechanical index, its serum estradiol (E2) concentration that raises, and above-mentioned effect is the pharmacological basis of its treatment osteoporosis.
The preparation method of the present composition is: gets Endoconcha Sepiae, is ground into fine powder, and standby; Get Herba Epimedii, add 80% alcohol heating reflux 2 times of 8 times of its weight amount volume, each 1.5 hours, merge medicinal liquid, filter, decompression recycling ethanol also concentrates, and concentrated solution is standby; Get Fructus Psoraleae, the Radix Astragali, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae 4 flavor medical materials, add 10 times of amounts of its gross weight volume decocting and boil 2 times, each 2 hours, merge decoction liquor, filter, add above-mentioned backflow concentrated solution, be concentrated into the thick paste shape, add the Endoconcha Sepiae fine powder, add adjuvant, make the acceptable preparation of pharmacy.
The dosage form of the present composition adopts peroral dosage form, is selected from a kind of in granule, sheet, capsule, drop pill, the soft capsule.
When Chinese medicine composition of the present invention is used for the treatment of osteoporosis, different according to the state of an illness and occupation mode, daily crude drug amount is 10-100g.
Technical scheme of the present invention hereinafter will do further statement, but the scope of protection of present invention is not limited to following embodiment in order better to illustrate to its specific embodiment.
The specific embodiment
Embodiment 1
Prescription: Herba Epimedii 717g, Fructus Psoraleae 1434g, Endoconcha Sepiae 430g, Radix Astragali 4301g, Rhizoma Dioscoreae 4301g, Radix Salviae Miltiorrhizae 2151g (being equivalent to 5: 10: 3: 30: 30: 15).
Method for making: get Endoconcha Sepiae, be ground into fine powder, standby; Get Herba Epimedii, add 80% alcohol heating reflux 2 times of 8 times of its weight amount volume, each 1.5 hours, merge medicinal liquid, filter, decompression recycling ethanol also concentrates, and concentrated solution is standby; Get Fructus Psoraleae, the Radix Astragali, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae 4 flavor medical materials, add 10 times of amounts of its gross weight volume decocting and boil 2 times, each 2 hours, merge decoction liquor, filter, add above-mentioned backflow concentrated solution, be concentrated into the thick paste shape, add the Endoconcha Sepiae fine powder, add starch, sodium carboxymethyl cellulose is an amount of, the system granule, the encapsulating capsule is made 1000.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 6.4g crude drug/kg, and result of the test sees the following form:
Table 4 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 1 |
??6.4g |
??0.249±0.006* |
Result of the test shows, compares can obviously the raise femur density (p<0.05) of rat of present embodiment compositions group with the castration group.
Embodiment 2
Prescription: Herba Epimedii 1630g, Fructus Psoraleae 815g, Endoconcha Sepiae 163g, Radix Astragali 1630g, Rhizoma Dioscoreae 2446g, Radix Salviae Miltiorrhizae 815g (being equivalent to 10: 5: 1: 10: 15: 5)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 3.6g crude drug/kg, and result of the test sees the following form:
Table 5 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 2 |
??3.6g |
??0.248±0.005* |
Result of the test shows, compares can obviously the raise femur density (p<0.05) of rat of present embodiment compositions group with the castration group.
Embodiment 3
Prescription: Herba Epimedii 1344g, Fructus Psoraleae 672g, Endoconcha Sepiae 403g, Radix Astragali 4032g, Rhizoma Dioscoreae 4032g, Radix Salviae Miltiorrhizae 2016g (being equivalent to 10: 5: 3: 30: 30: 15)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 6.0g crude drug/kg, and result of the test sees the following form:
Table 6 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 3 |
??6.0g |
??0.248±0.005* |
Result of the test shows, compares can obviously the raise femur density (p<0.05) of rat of present embodiment compositions group with the castration group.
Embodiment 4
Prescription: Herba Epimedii 815g, Fructus Psoraleae 1630g, Endoconcha Sepiae 163g, Radix Astragali 1630g, Rhizoma Dioscoreae 2446g, Radix Salviae Miltiorrhizae 815g (being equivalent to 5: 10: 1: 10: 15: 5)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 3.6g crude drug/kg, and result of the test sees the following form:
Table 7 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 4 |
??3.6g |
??0.247±0.004* |
Result of the test shows, compares can obviously the raise femur density (p<0.05) of rat of present embodiment compositions group with the castration group.
Embodiment 5
Prescription: Herba Epimedii 1389g, Fructus Psoraleae 1389g, Endoconcha Sepiae 139g, Radix Astragali 4167g, Rhizoma Dioscoreae 4167g, Radix Salviae Miltiorrhizae 2083g (being equivalent to 10: 10: 1: 30: 30: 15)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 6.4g crude drug/kg, and result of the test sees the following form:
Table 8 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 5 |
??6.4g |
??0.252±0.009** |
Result of the test shows, compares can obviously the raise femur density (p<0.01) of rat of present embodiment compositions group with the castration group.
Embodiment 6
Prescription: Herba Epimedii 872g, Fructus Psoraleae 872g, Endoconcha Sepiae 523g, Radix Astragali 1744g, Rhizoma Dioscoreae 2616g, Radix Salviae Miltiorrhizae 872g (being equivalent to 5: 5: 3: 10: 15: 5)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2.
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 3.6g crude drug/kg, and result of the test sees the following form:
Table 9 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 6 |
??3.6g |
??0.249±0.008* |
Result of the test shows, compares can obviously the raise femur density (p<0.05) of rat of present embodiment compositions group with the castration group.
Embodiment 7
Prescription: Herba Epimedii 1282g, Fructus Psoraleae 1282g, Endoconcha Sepiae 385g, Radix Astragali 1282g, Rhizoma Dioscoreae 3846g, Radix Salviae Miltiorrhizae 1923g (being equivalent to 10: 10: 3: 10: 30: 15)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 4.8g crude drug/kg, and result of the test sees the following form:
Table 10 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 7 |
??4.8g |
??0.251±0.010* |
Result of the test shows, compares can obviously the raise femur density (p<0.05) of rat of present embodiment compositions group with the castration group.
Embodiment 8
Prescription: Herba Epimedii 820g, Fructus Psoraleae 820g, Endoconcha Sepiae 164g, Radix Astragali 4918g, Rhizoma Dioscoreae 2459g, Radix Salviae Miltiorrhizae 820g (being equivalent to 5: 5: 1: 30: 15: 5)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 4.8g crude drug/kg, and result of the test sees the following form:
Table 11 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 8 |
??4.8g |
??0.249±0.006* |
Result of the test shows, compares can obviously the raise femur density (p<0.05) of rat of present embodiment compositions group with the castration group.
Embodiment 9
Prescription: Herba Epimedii 1305g, Fructus Psoraleae 1305g, Endoconcha Sepiae 392g, Radix Astragali 3916g, Rhizoma Dioscoreae 1958g, Radix Salviae Miltiorrhizae 1958g (being equivalent to 10: 10: 3: 30: 15: 15)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 5.2g crude drug/kg, and result of the test sees the following form:
Table 12 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 9 |
??5.2g |
??0.251±0.007** |
Result of the test shows, compares can obviously the raise femur density (p<0.01) of rat of present embodiment compositions group with the castration group.
Embodiment 10
Prescription: Herba Epimedii 818g, Fructus Psoraleae 818g, Endoconcha Sepiae 164g, Radix Astragali 1637g, Rhizoma Dioscoreae 4911g, Radix Salviae Miltiorrhizae 818g (being equivalent to 5: 5: 1: 10: 30: 5)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 4.4g crude drug/kg, and result of the test sees the following form:
Table 13 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 10 |
??4.4g |
??0.253±0.009** |
Result of the test shows, compares can obviously the raise femur density (p<0.01) of rat of present embodiment compositions group with the castration group.
Embodiment 11
Prescription: Herba Epimedii 1326g, Fructus Psoraleae 1326g, Endoconcha Sepiae 398g, Radix Astragali 3977g, Rhizoma Dioscoreae 3977g, Radix Salviae Miltiorrhizae 663g (being equivalent to 10: 10: 3: 30: 30: 5)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 5.6g crude drug/kg, and result of the test sees the following form:
Table 14 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 11 |
??5.6g |
??0.248±0.006* |
Result of the test shows, compares can obviously the raise femur density (p<0.05) of rat of present embodiment compositions group with the castration group.
Embodiment 12
Prescription: Herba Epimedii 899g, Fructus Psoraleae 899g, Endoconcha Sepiae 180g, Radix Astragali 1797g, Rhizoma Dioscoreae 2696g, Radix Salviae Miltiorrhizae 2696g (being equivalent to 5: 5: 1: 10: 15: 15)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2
Pharmacological testing: with reference to the test example, present embodiment compositions dosage is 4.4g crude drug/kg, and result of the test sees the following form:
Table 15 present composition is to the influence of castrated rats femur density
Group |
Dosage (/Kg) |
Femur BMD (g/cm
2)
|
The castration group |
??- |
??0.241±0.007 |
False castration group |
??- |
??0.278±0.005** |
Positive controls |
??(0.02mg+450U+0.5g) |
??0.255±0.005** |
Embodiment 12 |
??4.4g |
??0.247±0.005** |
Result of the test shows, compares can obviously the raise femur density (p<0.05) of rat of present embodiment compositions group with the castration group.
Embodiment 13
Prescription: Herba Epimedii 1500g, Fructus Psoraleae 1500g, Endoconcha Sepiae 333g, Radix Astragali 2500g, Rhizoma Dioscoreae 3333g, Radix Salviae Miltiorrhizae 1667g (being equivalent to 9: 9: 2: 15: 20: 10)
Method for making: with embodiment 1.
Usage: every day 3 times, each 2.
Embodiment 14
Prescription: Herba Epimedii 1500g, Fructus Psoraleae 1500g, Endoconcha Sepiae 333g, Radix Astragali 2500g, Rhizoma Dioscoreae 3333g, Radix Salviae Miltiorrhizae 1667g (being equivalent to 9: 9: 2: 15: 20: 10)
Method for making: get Endoconcha Sepiae, be ground into fine powder, standby; Get Herba Epimedii, add 80% alcohol heating reflux 2 times of 8 times of its weight amount volume, each 1.5 hours, merge medicinal liquid, filter, decompression recycling ethanol also concentrates, and concentrated solution is standby; Get Fructus Psoraleae, the Radix Astragali, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae 4 flavor medical materials, add 10 times of amounts of its gross weight volume decocting and boil 2 times, each 2 hours, merge decoction liquor, filter, add above-mentioned backflow concentrated solution, be concentrated into the thick paste shape, add the Endoconcha Sepiae fine powder, add starch, sodium carboxymethyl cellulose is an amount of, the system granule, tabletting is made 1000.
Usage: every day 3 times, each 2.
Embodiment 15
Prescription: Herba Epimedii 1500g, Fructus Psoraleae 1500g, Endoconcha Sepiae 333g, Radix Astragali 2500g, Rhizoma Dioscoreae 3333g, Radix Salviae Miltiorrhizae 1667g (being equivalent to 9: 9: 2: 15: 20: 10)
Method for making: get Endoconcha Sepiae, be ground into fine powder, standby; Get Herba Epimedii, add 80% alcohol heating reflux 2 times of 8 times of its weight amount volume, each 1.5 hours, merge medicinal liquid, filter, decompression recycling ethanol also concentrates, and concentrated solution is standby; Get Fructus Psoraleae, the Radix Astragali, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae 4 flavor medical materials, add 10 times of amounts of its gross weight volume decocting and boil 2 times, each 2 hours, merge decoction liquor, filter, add above-mentioned backflow concentrated solution, be concentrated into the thick paste shape, add the Endoconcha Sepiae fine powder, add starch, the system granule is made 1000g.
Usage: every day 3 times, each 2g.
Embodiment 16
Prescription: Herba Epimedii 1500g, Fructus Psoraleae 1500g, Endoconcha Sepiae 333g, Radix Astragali 2500g, Rhizoma Dioscoreae 3333g, Radix Salviae Miltiorrhizae 1667g (being equivalent to 9: 9: 2: 15: 20: 10)
Method for making: get Endoconcha Sepiae, be ground into fine powder, standby; Get Herba Epimedii, add 80% alcohol heating reflux 2 times of 8 times of its weight amount volume, each 1.5 hours, merge medicinal liquid, filter, decompression recycling ethanol also concentrates, and concentrated solution is standby; Get Fructus Psoraleae, the Radix Astragali, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae 4 flavor medical materials, add 10 times of amounts of its gross weight volume decocting and boil 2 times, each 2 hours, merge decoction liquor, filter, add above-mentioned backflow concentrated solution, be concentrated into the thick paste shape, add the Endoconcha Sepiae fine powder, it is an amount of to add Polyethylene Glycol, and mixing drips the system drop pill and becomes 3000.
Usage: every day 3 times, each 6.
Embodiment 17
Prescription: Herba Epimedii 1500g, Fructus Psoraleae 1500g, Endoconcha Sepiae 333g, Radix Astragali 2500g, Rhizoma Dioscoreae 3333g, Radix Salviae Miltiorrhizae 1667g (being equivalent to 9: 9: 2: 15: 20: 10)
Method for making: get Endoconcha Sepiae, be ground into fine powder, standby; Get Herba Epimedii, add 80% alcohol heating reflux 2 times of 8 times of its weight amount volume, each 1.5 hours, merge medicinal liquid, filter, decompression recycling ethanol also concentrates, and concentrated solution is standby; Get Fructus Psoraleae, the Radix Astragali, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae 4 flavor medical materials, adding 10 times of amounts of its gross weight volume decocting boils 2 times, each 2 hours, merge decoction liquor, filter, add above-mentioned backflow concentrated solution, be concentrated into the thick paste shape, add the Endoconcha Sepiae fine powder, add soybean oil, paraffin is an amount of, mixing, the compacting soft capsule becomes 1000.
Usage: every day 3 times, each 2.