CN101757322A - Vegetable drug compound preparation for treating urarthritis as well as preparation and application thereof - Google Patents
Vegetable drug compound preparation for treating urarthritis as well as preparation and application thereof Download PDFInfo
- Publication number
- CN101757322A CN101757322A CN 201010109604 CN201010109604A CN101757322A CN 101757322 A CN101757322 A CN 101757322A CN 201010109604 CN201010109604 CN 201010109604 CN 201010109604 A CN201010109604 A CN 201010109604A CN 101757322 A CN101757322 A CN 101757322A
- Authority
- CN
- China
- Prior art keywords
- radix
- drug compound
- compound preparation
- preparation
- plant drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a vegetable drug compound preparation for treating urarthritis, which comprises the following components of radix angelicae pubescentis, large-leaved gentian, cassia twig, Korthalsella japonica, divaricate saposhnikovia root, processed radix aconiti lateralis, the root of bidentate achyranthes, fructus psoraleae, notopterygium root, poria cocos, angelica sinensis, ligusticum wallichii, rubefacient, the dried rhizome of rehmannia, the rhizome of oriental water plantain, the root of red-rooted salvia, astragalus mongholicus and liquorice. A preparation method of the vegetable drug compound preparation comprises the following steps of: according to the formula, adding 4-12 times of water, decocting for 1-3 h and filtering out medicine juice; adding 4-12 times of water, decocting for 0.5-2 h, filtering out medicine juice, merging the decocting solution in the two steps, standing, leaching supernatant, condensing the supernatant to have the proportion of 1.08-1.35, drying and adding medicine auxiliary materials to prepare the vegetable drug compound preparation. The vegetable drug compound preparation has the efficiencies of warming yang, easing pain, clearing heat, cooling blood, promoting blood circulation and stopping pain, can reduce blood uric acid, eliminate arthritis disease caused by uric acid crystal, prevent recrudescence and treat both principal and secondary aspect of disease. In addition, the vegetable drug compound preparation has the advantages of stable quality, convenient taking, high curative effect, no toxic and side effect and the like.
Description
Technical field
The invention belongs to plant drug compound preparation and preparation thereof and application, particularly relate to a kind of plant drug compound preparation and preparation and application for the treatment of gouty arthritis.
Background technology
Gout is the systemic disease that a kind of purine metabolism obstacle causes.Because uric acid increases in serum and the body fluid, causes the urate crystal calmness in various mesenchymal tissues, when joint involvement, then is called gouty arthritis.Drug therapy gouts such as how pure with other purine doctor trained in Western medicine is, colchicine, glucocorticoid, but this class chemistry medicine of life-time service can cause side effect such as hepatic injury, gastrointestinal reaction and neurotoxicity.
The gouty disease, the past is in the less appearance of China, in recent years, and along with growth in the living standard, the change of dietary structure, the primary disease case has tangible increase trend, and gouty arthritis is a rheumatic arthritis by mistaken diagnosis sometimes.According to the clinical manifestation of primary disease, belong to the traditional Chinese medical science " arthromyodynia " category.The patient mostly is obesity, has a liking for food tobacco and wine person.The male is more than the women, and is more common in the old people.Main pathogenesis is that the damp and hot inclined to one side victory of the plain body of patient is experienced cold-damp or damp and hot heresy in addition, and interior foreign minister holds under the arm, and damp and hot more Sheng is stranded in skin, accumulates and hinders between the meridians joint, and meridians are obstructed and cause red and swollen heat pain.Chinese medicine is widely used preventing and treating the effect that gouty arthritis has its uniqueness.
Chinese patent publication number CN1144676A disclosed " gout miraculous cure wine and preparation technology thereof ", this invention is made medicated wine for Chinese medicine through the Chinese liquor dipping, though certain curative effect is arranged, reaching not to heart disease, hypertension, anemia of pregnant woman, alcoholic patient is not suitable for.Publication number CN1070070C disclosed " a kind of Chinese medicine for the treatment of goat ", this invention is by insect medicine and medical herbs compatibility, through with the broken direct pill of former medicated powder or incapsulate, better curative effect is arranged, but former medicine un-extracted, directly beat powder, cause many, the former medicines of medicament impurity to carry that assorted bacterium difficulty is gone out, using dosage is big, also be difficult to guarantee the quality of medicament.
Summary of the invention
Technical problem to be solved by this invention provides a kind of plant drug compound preparation and preparation and application for the treatment of gouty arthritis, and this plant drug compound preparation has warming YANG a surname numbness, clearing away heat and cooling blood, the effect of promoting blood circulation and stopping pain; Can reduce blood uric acid, eliminate the arthritis pathological changes that uric acid crystal causes, and prevention of recurrence, treating both the principal and secondary aspects of a disease; And advantages such as this medicine has steady quality, taking convenience, curative effect is high and have no side effect.
A kind of plant drug compound preparation for the treatment of gouty arthritis of the present invention, its plant amedica compositions comprises the raw material of following weight portion:
Radix Angelicae Pubescentis 5-15, Radix Gentianae Macrophyllae 5-15, Ramulus Cinnamomi 3-8, parasitic 3-8, Radix Saposhnikoviae 3-8
Cortex Eucommiae 5-12, Radix Aconiti Lateralis Preparata 3-8, Radix Achyranthis Bidentatae 3-8, Fructus Psoraleae 3-8, Rhizoma Et Radix Notopterygii 3-8,
Poria 3-8, Radix Angelicae Sinensis 5-15, Rhizoma Chuanxiong 3-8, Radix Polygoni Ciliinerve 3-8, Radix Rehmanniae 3-8,
Rhizoma Alismatis 3-8, Radix Salviae Miltiorrhizae 5-12, Radix Astragali 5-15 Radix Glycyrrhizae 3-8.
Described plant amedica compositions comprises the raw material of following weight portion:
Radix Angelicae Pubescentis 8-10, Radix Gentianae Macrophyllae 8-10, Ramulus Cinnamomi 3-6, parasitic 3-6, Radix Saposhnikoviae 3-6
Cortex Eucommiae 6-10, Radix Aconiti Lateralis Preparata 3-6, Radix Achyranthis Bidentatae 3-6, Fructus Psoraleae 3-6, Rhizoma Et Radix Notopterygii 3-6,
Poria 3-6, Radix Angelicae Sinensis 8-10, Rhizoma Chuanxiong 3-6, Radix Polygoni Ciliinerve 3-6, Radix Rehmanniae 3-6,
Rhizoma Alismatis 3-6, Radix Salviae Miltiorrhizae 8-10, Radix Astragali 8-10 Radix Glycyrrhizae 3-6.
In the plant drug compound preparation of described treatment gouty arthritis, preferred plant amedica compositions comprises the raw material of following weight portion:
Radix Angelicae Pubescentis 9, Radix Gentianae Macrophyllae 9, Ramulus Cinnamomi 4.5, parasitism 6, Radix Saposhnikoviae 6
The Cortex Eucommiae 9, Radix Aconiti Lateralis Preparata 4.5, Radix Achyranthis Bidentatae 6, Fructus Psoraleae 6, Rhizoma Et Radix Notopterygii 6,
Poria 6, Radix Angelicae Sinensis 9, Rhizoma Chuanxiong 6, Radix Polygoni Ciliinerve 6, the Radix Rehmanniae 6,
Rhizoma Alismatis 6, Radix Salviae Miltiorrhizae 9, the Radix Astragali 9 Radix Glycyrrhizaes 3.
A kind of preparation for the treatment of the plant drug compound preparation of gouty arthritis of the present invention comprises:
According to above-mentioned prescription, add 4-12 times of water gaging, decocted 1-3 hour, leach medicine juice; Add 4-12 times of water gaging again, decocted 0.5-2 hour, leach medicine juice, merge the secondary decocting liquid, leave standstill, the leaching supernatant, vacuum concentration is to proportion 1.08-1.35, and drying adds pharmaceutic adjuvant, makes plant drug compound preparation.
The application of plant drug compound preparation of the present invention in the relevant medicines of disease such as gouty arthritis due to preparation prevention or treatment blood uric acid increase.
Described plant drug compound preparation is to be applied to the patient who needs this treatment by oral way;
Described plant drug compound preparation is made solid preparation such as tablet, granule or capsule, makes liquid preparation such as water or oiliness suspending agent etc. or other liquid preparation such as syrup, mixture or oral liquid;
The consumption of described plant drug compound preparation is according to the type and the order of severity adjustment of route of administration, patient's age, body weight, the disease of being treated, its, dosage was tablet or capsule, the oral liquid of 60ml or the granule of 30g of the syrup of 60ml or mixture, 6-8 grain every day, can use by one or many;
The specification of described granule is the 10g/ bag; The specification of capsule is the 0.5g/ grain;
Described plant drug compound preparation is made slow releasing tablet or coated tablet.
The medicament sources of Chinese medicine pharmaceutical composition of the present invention:
Rhizoma Alismatis is the dry tuber of Alismataceae plant Rhizoma Alismatis Alisma orientalis (Sam.) Juzep.;
The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fish.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fish.) Bge.;
Radix Angelicae Pubescentis is the dry root of the heavy peristome Radix Angelicae Sinensis of samphire Angelica pubescens Maxim.f.biserrata Shan et Yuan;
Ramulus Cinnamomi is the dry twig of canella Cortex Cinnamomi Cinnamomum Presl;
The processed goods of the daughter root of the plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx. of Radix Aconiti Lateralis Preparata Liang section;
Radix Saposhnikoviae is the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk.;
Rhizoma Et Radix Notopterygii is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii Notopterygium incisum Ting ex H.T.Chang or Radix et Rhizoma Notopterygii Notop-terygium forbesii Boiss.;
Radix Paeoniae Rubra is the dry root of cohosh Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch;
Fructus Psoraleae is the dry mature fruit of legumes psoraleae Psoralea corylifolia L.;
The Cortex Eucommiae is Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv.Dry bark;
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..
Radix Gentianae Macrophyllae is the dry root of gentianaceae plant Radix Gentianae Macrophyllae Gentiana macrophylla Pall..
Parasitism be Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) danser. dry stem and branch with leaf,
Radix Achyranthis Bidentatae is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Bl..
Poria is the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Schw.) Wolf..
When the dry root that is classified as umbelliferae angelica Angelica sinensis (Oliv.) Diels.
Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..
The Radix Rehmanniae is the dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..
Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch..
Ramulus Cinnamomi in this product side, the hot temperature of Radix Aconiti Lateralis Preparata are got its exploitation flesh natural fibre line of meat, dredging the meridian, activating YANG and prormoting functioning of QI and relieve the pain pain, the arteries and veins of invigorating blood circulation; Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae are to strengthen the power of expelling wind and dampness; Radix Astragali tonifying Qi and lifting yang has the function of human body immunity improving power; Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami are invigorated blood circulation with the pain that relieves the pain; Radix Paeoniae Rubra, Rhizoma Alismatis, Radix Rehmanniae clearing away heat and cooling blood, and control pyretic arthralgia pain; Other adds Herba Taxilli, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Fructus Psoraleae invigorating the liver and kidney, logically scurries the product of invigorating blood circulation, with the removing blood stasis reducing swelling and alleviating pain, the sweet Heibei provincial opera of Radix Glycyrrhizae and.
Beneficial effect
Plant amedica preparation of the present invention is to goat, and particularly outbreak has unique curative effect to gouty arthritis, and this product has warming YANG a surname numbness, clearing away heat and cooling blood, the effect of promoting blood circulation and stopping pain; Can make uric acid quicken to drain, reduce purine substance savings in the body, thereby reduce blood uric acid, eliminate the arthritis pathological changes that uric acid crystal causes, and prevention of recurrence, treating both the principal and secondary aspects of a disease; And advantages such as this medicine has steady quality, taking convenience, curative effect is high and have no side effect.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Embodiment 1
Get Radix Angelicae Pubescentis 450g, Radix Gentianae Macrophyllae 450g, Ramulus Cinnamomi 225g, parasitic 300g, Radix Saposhnikoviae 300g,
Cortex Eucommiae 450g, Radix Aconiti Lateralis Preparata 225g, Radix Achyranthis Bidentatae 300g, Fructus Psoraleae 300g, Rhizoma Et Radix Notopterygii 300g,
Poria 300g, Radix Angelicae Sinensis 450g, Rhizoma Chuanxiong 300g, Radix Polygoni Ciliinerve 300g, Radix Rehmanniae 300g,
Rhizoma Alismatis 300g, Radix Salviae Miltiorrhizae 450g, Radix Astragali 450g, Radix Glycyrrhizae 150g.
More than 19 flavors, decoct with water secondary, add for the first time 10 times of amounts of water, decocted 2 hours, and added 8 times of amounts of water for the second time, decocted 1.5 hours, filter, filtrate merges, and gets the clear paste that supernatant concentration becomes relative density 1.30-1.35 (90 ℃), add an amount of dextrin, 60 ℃ of drying under reduced pressure are pulverized, cross 40 mesh sieves, drying, it is an amount of to admix lubricant, incapsulate, make 1000, promptly.
Embodiment 2
Get Radix Angelicae Pubescentis 600g, Radix Gentianae Macrophyllae 600g, Ramulus Cinnamomi 200g, parasitic 200g, Radix Saposhnikoviae 200g,
Cortex Eucommiae 500g, Radix Aconiti Lateralis Preparata 200g, Radix Achyranthis Bidentatae 200g, Fructus Psoraleae 200g, Rhizoma Et Radix Notopterygii 200g,
Poria 200g, Radix Angelicae Sinensis 600g, Rhizoma Chuanxiong 200g, Radix Polygoni Ciliinerve 200g, Radix Rehmanniae 200g,
Rhizoma Alismatis 200g, Radix Salviae Miltiorrhizae 500g, Radix Astragali 600g, Radix Glycyrrhizae 200g.
More than 20 flavors, decoct with water secondary, add for the first time 10 times of amounts of water, decocted 2 hours, and added 8 times of amounts of water for the second time, decocted 1.5 hours, filter, filtrate merges, and gets the extractum that supernatant concentration becomes relative density 1.10-1.15 (90 ℃), add an amount of dextrin, spray drying is crossed 40 mesh sieves, drying, it is an amount of to admix magnesium stearate lubricant, incapsulates, make 1000, promptly.
Embodiment 3
Get Radix Angelicae Pubescentis 400g, Radix Gentianae Macrophyllae 400g, Ramulus Cinnamomi 275g, parasitic 275g, Radix Saposhnikoviae 275g,
Cortex Eucommiae 300g, Radix Aconiti Lateralis Preparata 275g, Radix Achyranthis Bidentatae 275g, Fructus Psoraleae 275g, Rhizoma Et Radix Notopterygii 275g,
Poria 275g, Radix Angelicae Sinensis 400g, Rhizoma Chuanxiong 275g, Radix Polygoni Ciliinerve 275g, Radix Rehmanniae 275g,
Rhizoma Alismatis 275g, Radix Salviae Miltiorrhizae 300g, Radix Astragali 400g, Radix Glycyrrhizae 275g.
More than 20 flavors, decoct with water secondary, for the first time add 8 times of amounts of water, decocted 2 hours, add 6 times of amounts of water the second time, decocted 1.5 hours, and filtered, filtrate merges, and is concentrated into proportion 1.08-1.18 (90 ℃), spray drying, add an amount of medicinal dextrin, granulate every 0.5g of compressed tablets, film coating.
Embodiment 4
The capsule quality standard
[character] this product is a capsule, and content is brown granular or powder.
[discriminating] gets this product content 3g, adds methanol 25ml, reflux 1 hour, filter, filtrate evaporate to dryness, residue add water 20ml makes dissolving, extract 2 times with water saturated n-butyl alcohol jolting, each 20ml merges n-butyl alcohol liquid, earlier with ammonia solution washing 2 times, each 15ml, the saturated water washing of reuse n-butyl alcohol 2 times, each 15ml, n-butyl alcohol liquid evaporate to dryness, residue add methanol 0.5ml makes dissolving, as need testing solution.Other gets the astragaloside reference substance, adds methanol and makes the solution that every 1ml contains 1mg, in contrast product solution.According to thin layer chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, placing stratified lower floor solution below 10 ℃ with chloroform-methanol-water (65: 35: 10) is developing solvent, launch, take out, dry.Spray is with 10% ethanol solution of sulfuric acid (v/v), and 105 ℃ to be heated to the speckle colour developing clear.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
[inspection] moisture: get content, the photograph aquametry (" Chinese pharmacopoeia version in 2005, an appendix IX H) measure, must not cross 9.0%.
Content uniformity: get this product, check (" Chinese pharmacopoeia version in 2005, an appendix IL), should be up to specification. in accordance with the law
Disintegration: photograph inspection technique disintegration (" Chinese pharmacopoeia version in 2005, an appendix IL) check, should be up to specification.
Microbial limit: the photograph microbial limit test (" Chinese pharmacopoeia version in 2005, an appendix XIII C) check, should be up to specification.
Other: should meet every regulation relevant under the capsule item (" Chinese pharmacopoeia version in 2005, an appendix IL).
[function with cure mainly] this product has warming YANG a surname numbness, clearing away heat and cooling blood, the effect of promoting blood circulation and stopping pain; The treatment gouty arthritis can reduce blood uric acid, improves symptom.
[untoward reaction] takes this product no side effects.
[points for attention]
1. the careful usefulness of allergic constitution needs to instruct through the doctor.
2. period in a medicine, the high purine food of diet, as bean product, seafood, foods such as medicated beer; Reach careful food raw meat, peppery, raw and cold food.
[usage and consumption] is oral, each 3-4 grain, every day secondary.
[specification] every dress 0.5g.
Shady and cool place is put in [storage] sealing.
[effect duration] 2 years.
Embodiment 5
Embodiment 1 capsule stability research
According to Chinese Pharmacopoeia one one of version " medicine stability test guideline " and " specification requirement of new Chinese medicine steady quality Journal of Sex Research " in 2005, embodiment one capsule is carried out stability test under the room temperature condition of 6 months accelerated test and 6 months.
One, 6 months accelerated stability tests of sample
1, the time: 2007.5-2007.11
2, accelerated test method:
With the pack sample the same,, placed 6 months in the constant temperature and humidity incubator of relative humidity 75% ± 5% 40 ℃ ± 2 ℃ of temperature with listing.
Two, checking item
Check by the requirement of gout curing capsule quality standard draft, carry out limit test of microbe simultaneously.Concrete investigation project is character, discriminating, inspection (content uniformity, disintegration, moisture), limit test of microbe.
Three, examination method and result
By embodiment one capsule quality standard draft requirement, the results are shown in subordinate list 1.
Four, conclusion and useful life
According to accelerated stability test, no significant change before and after every test item is basicly stable in experiment periods.
Table 1 accelerated stability test
Embodiment 6
Clinical data
48 routine patients, male's 35 examples wherein, women's 13 examples; Age was at 41～75 years old; The course of disease 1 month to 5 years.Refer to (toe) joint and refer to (toe) sole of the foot arthralgia person 29 examples; Invade simultaneously and ankle, knee joint person's 9 examples, gout calculus person 6 examples are arranged; Merge gout kidney person 2 examples.
All do blood uric acid inspection and liver function test before and after all case treatments.The blood uric acid meansigma methods is that (normal value is 150～430umol/L) to 523.20umol/L, and liver function is all normal before the 48 routine patient treatments.
Diagnostic criteria is examined condition with reference to 9 plans of the diagnostic criteria of American Rheumatism Association in 1977, need have wherein more than 4.Its 9 conditions are: 1. acute arthritis is shown effect more than 1 time, and reaches a climax at one day; 2. acute inflammation is confined to indivedual joints bitterly; 3. whole joint is kermesinus; 4. the first toe sole of the foot arthralgia; 5. one-sided toe sole of the foot joint acute inflammation; The tophus that 6. suspicious confirmation is arranged; 7. hyperuricemia; 8. asymmetry arthroncus; 9. outbreak can stop voluntarily.Therapeutic Method: oral embodiment one capsule, 4/once, and a twice-daily, 15 days is a course of treatment.
Criterion of therapeutical effect
The recovery from illness: clinical symptoms all disappears, joint motion freely, blood uric acid is reduced to normally;
Produce effects: clinical symptoms takes a turn for the better, and joint motion is flexible, and the more preceding reduction of blood uric acid is more than 10%;
Invalid: remission is not obvious, blood uric acid and the preceding no significant change of treatment.
Therapeutic outcome
Add up by above-mentioned criterion of therapeutical effect: 38 routine patients are through a course of therapy, and 27 examples of fully recovering account for 56.25%; Produce effects 19 examples account for 39.58%; Invalid 2 examples account for 4.17%.It is 95.83% that rate is always arranged.
Blood uric acid decline result is relatively before and after the treatment: the treatment back blood uric acid 125.20 ± 11.20umol/L that on average descends, wherein reduce to normal person's 27 examples, 10% above person's 19 examples that descend, no significant change person's 2 examples.Blood uric acid decline is learned by statistics and is handled P＜0.05 before and after the treatment.Liver function test is all normal before and after the treatment.
Arthralgia improves relatively: after a course of therapy, and arthralgia 27 examples that disappear, 19 examples that take a turn for the better, invalid 2 examples.
Claims (10)
1. plant drug compound preparation for the treatment of gouty arthritis, its plant amedica compositions comprises the raw material of following weight portion:
Radix Angelicae Pubescentis 5-15, Radix Gentianae Macrophyllae 5-15, Ramulus Cinnamomi 3-8, parasitic 3-8, Radix Saposhnikoviae 3-8
Cortex Eucommiae 5-12, Radix Aconiti Lateralis Preparata 3-8, Radix Achyranthis Bidentatae 3-8, Fructus Psoraleae 3-8, Rhizoma Et Radix Notopterygii 3-8,
Poria 3-8, Radix Angelicae Sinensis 5-15, Rhizoma Chuanxiong 3-8, Radix Polygoni Ciliinerve 3-8, Radix Rehmanniae 3-8,
Rhizoma Alismatis 3-8, Radix Salviae Miltiorrhizae 5-12, Radix Astragali 5-15 Radix Glycyrrhizae 3-8.
2. a kind of plant drug compound preparation for the treatment of gouty arthritis according to claim 1 is characterized in that: in the plant drug compound preparation of described treatment gouty arthritis, described plant amedica compositions comprises the raw material of following weight portion:
Radix Angelicae Pubescentis 8-10, Radix Gentianae Macrophyllae 8-10, Ramulus Cinnamomi 3-6, parasitic 3-6, Radix Saposhnikoviae 3-6
Cortex Eucommiae 6-10, Radix Aconiti Lateralis Preparata 3-6, Radix Achyranthis Bidentatae 3-6, Fructus Psoraleae 3-6, Rhizoma Et Radix Notopterygii 3-6,
Poria 3-6, Radix Angelicae Sinensis 8-10, Rhizoma Chuanxiong 3-6, Radix Polygoni Ciliinerve 3-6, Radix Rehmanniae 3-6,
Rhizoma Alismatis 3-6, Radix Salviae Miltiorrhizae 8-10, Radix Astragali 8-10 Radix Glycyrrhizae 3-6.
3. a kind of plant drug compound preparation for the treatment of gouty arthritis according to claim 1 is characterized in that: in the plant drug compound preparation of described treatment gouty arthritis, described plant amedica compositions comprises the raw material of following weight portion:
Radix Angelicae Pubescentis 9, Radix Gentianae Macrophyllae 9, Ramulus Cinnamomi 4.5, parasitism 6, Radix Saposhnikoviae 6
The Cortex Eucommiae 9, Radix Aconiti Lateralis Preparata 4.5, Radix Achyranthis Bidentatae 6, Fructus Psoraleae 6, Rhizoma Et Radix Notopterygii 6,
Poria 6, Radix Angelicae Sinensis 9, Rhizoma Chuanxiong 6, Radix Polygoni Ciliinerve 6, the Radix Rehmanniae 6,
Rhizoma Alismatis 6, Radix Salviae Miltiorrhizae 9, the Radix Astragali 9 Radix Glycyrrhizaes 3.
4. preparation for the treatment of the plant drug compound preparation of gouty arthritis comprises:
According to above-mentioned prescription, add 4-12 times of water gaging, decocted 1-3 hour, leach medicine juice; Add 4-12 times of water gaging again, decocted 0.5-2 hour, leach medicine juice, merge the secondary decocting liquid, leave standstill, the leaching supernatant, vacuum concentration is to proportion 1.08-1.35, and drying adds pharmaceutic adjuvant, makes plant drug compound preparation.
5. a plant drug compound preparation of the treating gouty arthritis application in the relevant medicines of disease such as gouty arthritis due to preparation prevention or treatment blood uric acid increase.
6. the application of plant drug compound preparation according to claim 5 is characterized in that: described plant drug compound preparation be by oral, snuffing is gone into, the mode of rectum or parenteral, local application is applied to the patient of this treatment of needs.
7. the application of plant drug compound preparation according to claim 6, it is characterized in that: described plant drug compound preparation is made solid preparation such as tablet, powder, granule or capsule, makes liquid preparation such as water or oiliness suspending agent or other liquid preparation such as syrup, mixture or oral liquid; When being used for parenteral, can be made into solution, water or the oiliness suspending agent of injection; During topical, be made into cream, ointment, patch, spray or subcutaneous implant.
8. according to the application of claim 6 or 7 described plant drug compound preparations, it is characterized in that: the consumption of described plant drug compound preparation is according to the type and the order of severity adjustment of route of administration, patient's age, body weight, the disease of being treated, its, dosage was tablet or capsule, the oral liquid of 60ml or the granule of 30g of the syrup of 60ml or mixture, 6-8 grain every day, can use by one or many.
9. the application of plant drug compound preparation according to claim 7 is characterized in that: the specification of described granule is the 10g/ bag; The specification of capsule is the 0.5g/ grain.
10. according to the application of claim 6 or 7 described plant drug compound preparations, it is characterized in that: described plant drug compound preparation is made slow releasing tablet or coated tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101096041A CN101757322B (en) | 2010-02-11 | 2010-02-11 | Vegetable drug compound preparation for treating urarthritis as well as preparation and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101096041A CN101757322B (en) | 2010-02-11 | 2010-02-11 | Vegetable drug compound preparation for treating urarthritis as well as preparation and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101757322A true CN101757322A (en) | 2010-06-30 |
| CN101757322B CN101757322B (en) | 2012-02-22 |
Family
ID=42488806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101096041A Expired - Fee Related CN101757322B (en) | 2010-02-11 | 2010-02-11 | Vegetable drug compound preparation for treating urarthritis as well as preparation and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101757322B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488768A (en) * | 2011-12-03 | 2012-06-13 | 王宝香 | Traditional Chinese medicine for treating gout |
| CN103479800A (en) * | 2013-09-22 | 2014-01-01 | 王贵胜 | Traditional Chinese medicine for treating sciatica |
| CN103479801A (en) * | 2013-09-22 | 2014-01-01 | 王贵胜 | Traditional Chinese medicine for treating lumbar disc herniation |
| CN104258051A (en) * | 2014-10-25 | 2015-01-07 | 陈红 | Traditional Chinese medicine composition for treating gouty arthritis, and preparation method thereof |
| CN105456844A (en) * | 2015-12-31 | 2016-04-06 | 刘宝龙 | Pharmaceutical composition for preventing and treating gout |
| CN107854633A (en) * | 2017-11-16 | 2018-03-30 | 闫位国 | Treat composition of gout and preparation method thereof |
| CN113679818A (en) * | 2021-10-13 | 2021-11-23 | 邱衍臣 | Composition for treating gout and rheumatoid osteoarthritis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229658A (en) * | 1998-03-24 | 1999-09-29 | 刘月江 | Compound sanbi medicinal liquor for treating gout |
| CN101642535A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Medicinal composition for treating gout |
-
2010
- 2010-02-11 CN CN2010101096041A patent/CN101757322B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229658A (en) * | 1998-03-24 | 1999-09-29 | 刘月江 | Compound sanbi medicinal liquor for treating gout |
| CN101642535A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Medicinal composition for treating gout |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488768A (en) * | 2011-12-03 | 2012-06-13 | 王宝香 | Traditional Chinese medicine for treating gout |
| CN103479800A (en) * | 2013-09-22 | 2014-01-01 | 王贵胜 | Traditional Chinese medicine for treating sciatica |
| CN103479801A (en) * | 2013-09-22 | 2014-01-01 | 王贵胜 | Traditional Chinese medicine for treating lumbar disc herniation |
| CN104258051A (en) * | 2014-10-25 | 2015-01-07 | 陈红 | Traditional Chinese medicine composition for treating gouty arthritis, and preparation method thereof |
| CN105456844A (en) * | 2015-12-31 | 2016-04-06 | 刘宝龙 | Pharmaceutical composition for preventing and treating gout |
| CN107854633A (en) * | 2017-11-16 | 2018-03-30 | 闫位国 | Treat composition of gout and preparation method thereof |
| CN113679818A (en) * | 2021-10-13 | 2021-11-23 | 邱衍臣 | Composition for treating gout and rheumatoid osteoarthritis and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101757322B (en) | 2012-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102068625B (en) | Traditional Chinese medicinal composition for reducing blood sugar and blood pressure and preparation method thereof | |
| CN101757322B (en) | Vegetable drug compound preparation for treating urarthritis as well as preparation and application thereof | |
| CN103120742B (en) | Traditional Chinese medicine capsule for treating fatty liver and alcoholic liver and preparation method thereof | |
| CN101347605B (en) | Chinese medicinal composition for treating gout and preparation method and application thereof | |
| CN103463425B (en) | A kind of treat blood-stasis internal-depression Chinese medicine extract and preparation and method for making | |
| CN103006989B (en) | Medical composition for treating diabetic nephropathy | |
| CN102526230B (en) | Traditional Chinese composition for curing liver disease and preparation method, quality detection method and application thereof | |
| CN104940596A (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof | |
| CN106215118A (en) | Antineoplastic health preparation and preparation method thereof | |
| CN101224283A (en) | Chinese traditional medicine compounds for treating diabetes and preparing method thereof | |
| CN105327121A (en) | Traditional Chinese medicine composition for treating female postmenopausal osteoporosis and preparing method thereof | |
| CN105194355A (en) | Traditional Chinese medicine preparation for treating primary hypertension | |
| CN101313989B (en) | Chinese medicinal composition for treating coronary disease, stenocardia | |
| CN104173681B (en) | Traditional Chinese herbal medicine composition for treating castration-resistant prostate cancer | |
| CN1814153A (en) | Medicine composition for preventing and treating breast cancer and preparing method | |
| CN103961602B (en) | The treatment Chinese medicine composition of chronic gastritis and tablet thereof and preparation method | |
| CN103690834B (en) | A kind of blood pressure lowering Chinese medicinal composition and preparation method thereof | |
| CN1065765C (en) | Chinese medicine for curing female endocrinopathy and its preparation | |
| CN114796417B (en) | Blood sugar reducing traditional Chinese medicine formula and preparation method thereof | |
| CN108210873B (en) | Traditional Chinese medicine composition for increasing estrogen and application thereof | |
| CN114588228B (en) | Composition for treating type 2 diabetes | |
| CN101987188A (en) | Biological Chinese patent drug for preventing and treating hyperlipoidemia | |
| CN106389965A (en) | Traditional Chinese medicine composition for treating diabetes and preparation method thereof | |
| CN101468124A (en) | Chinese medicinal composition for preventing and treating menoxenia and method for preparing the same | |
| CN106728640A (en) | It is a kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120222 Termination date: 20150211 |
|
| EXPY | Termination of patent right or utility model |