CN101869665B - Chinese medicinal composition for treating necrospermia, asthenospermia oligospermia, or aspermatism - Google Patents

Chinese medicinal composition for treating necrospermia, asthenospermia oligospermia, or aspermatism Download PDF

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CN101869665B
CN101869665B CN2010102073193A CN201010207319A CN101869665B CN 101869665 B CN101869665 B CN 101869665B CN 2010102073193 A CN2010102073193 A CN 2010102073193A CN 201010207319 A CN201010207319 A CN 201010207319A CN 101869665 B CN101869665 B CN 101869665B
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张鸿翔
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Abstract

The invention belongs to the technical field of traditional Chinese medicines, in particular discloses a Chinese medicinal composition for treating necrospermia, asthenospermia oligospermia, or aspermatism, which comprises the following raw material medicaments in part by weight: 10 to 20 parts of epimedium brevicornum, 10 to 20 parts of medicinal indianmulberry root, 10 to 20 parts of desertliving cistanche, 10 to 20 parts of south dodder seed, 10 to 20 parts of siberian solomonseal rhizome, 10 to 20 parts of Chinese angelica, 7 to 13 parts of common curculigo rhizome, 8 to 16 parts of Chinese thorowax root, 8 to 16 parts of large-headed atractylodes rhizome, 14 to 26 parts of astragalus, 14 to 26 parts of radix rehmanniae praeparata, 14 to 26 parts of dioscorea root, 3 to 8 parts of liquorice root, 5 to 13 parts of glossy privet fruit, 10 to 20 parts of plantain seed, 10 to 20 parts of palmleaf raspberry fruit, 20 to 40 parts of root of red-rooted salvia, 8 to 16 parts of eucommia bark, 7 to 13 parts of baicalin, 3 to 8 parts of salivia chinensis, 6 to 13 parts of Indian buead and 6 to 14 parts of oriental waterplantain rhizome. The Chinese medicinal composition has the effects of warming and invigorating kidney yang with tonifying qi and invigorating blood circulation and supplementing essence and replenishing marrow, and has the advantages of simple preparation, convenientadministration, good curative effect and no toxic or side effect.

Description

A kind of treat dead, weak, less or the Chinese medicine composition of azoospermia
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of treat dead, weak, less or the Chinese medicine composition of azoospermia.
Background technology
Show according to reported literature: China's sterility and infertility incidence rate is about 1.6%~10%; Account for 25%~33% by bridegroom's or husband's side factor causer; Wife's side factor causer accounts for 35%~45%, and men and women's factor causer accounts for 20%~22%, and agnogenio person accounts for 8%~15%.Male infertility is a kind of common frdquently encountered disease, is meant because that male factor causes is sterile, does not generally take any contraceptives more than 2 years living together after marriage and the wife's side is conceived, is called infertility.Along with the quickening of modern society's rhythm, environmental pollution is on the rise, the increase of male's pressure, and the quantity quality of sperm constantly descends, and male infertility is in rising trend.According to WHO report, male sterility accounts for 40%~50% of whole sterility and infertility now.Current clinical medicine research also shows: the male infertility that causes because of the matter or the amount problem of mankind spermatozoon in recent years also is rise trend, such as sperm survival rate low (necrospermia), motility of sperm weak (azoospermia), sperm quantity few (oligospermia) or even there is not sperm (azoospermia).This shows that the matter of sperm or amount as generation are unusual, the physical and mental health that not only seriously endangers the patient, and usually also can therefore cause breaking of marriage and family, cause unstable factor to society.Just because of this, in science and technology fast-developing day by day today, the medical matters scientist treats dead, weak, less or azoospermia by fair means or foul at the various medicines of development; In the hope of further treating its male infertility that causes; Have at present multiple treatment dead, weak, less or the Western medicine of azoospermia be used for clinically, like Western medicine clomiphene, injection chorionic gonadotrophin, tamoxifen, but these courses of pharmaceuticals are long; Administrated method inconvenience, price is high and curative effect is lower, cure rate is lower, adaptability is relatively poor.Though there also have part Chinese medicine to be used for to be clinical, as a whole, effect is unsatisfactory, remains to be looked forward to the appearance of new medicine.
Summary of the invention
The object of the present invention is to provide a kind of eutherapeutic treatment dead, weak, less or the Chinese medicine composition of azoospermia.
For realizing above-mentioned purpose, the present invention has taked following technical scheme:
A kind ofly treat deadly, weak, less or the Chinese medicine composition of azoospermia, form by each crude drug of following parts by weight: 10~20 parts of Herba Epimedii, 10~20 parts of Radix Morindae Officinaliss, 10~20 parts of Herba Cistanches, 10~20 parts of Semen Cuscutae, 10~20 parts of Rhizoma Polygonatis, 10~20 parts of Radix Angelicae Sinensis, 7~13 parts of Rhizoma Curculiginises, 8~16 parts of Radix Bupleuri, 8~16 parts of the Rhizoma Atractylodis Macrocephalaes, 14~26 parts of the Radixs Astragali, 14~26 parts of Radix Rehmanniae Preparata, 14~26 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 3~8 parts in Radix Glycyrrhizae, 5~13 parts of Fructus Ligustri Lucidi, 10~20 parts of Semen Plantaginiss, 10~20 parts of Fructus Rubies, 20~40 parts of Radix Salviae Miltiorrhizaes, 8~16 parts of the Cortexs Eucommiae, 7~13 parts of Radix Scutellariaes, 3~8 parts of Cortex Moutans, 6~13 parts in Poria, 6~14 parts of Rhizoma Alismatis.
Optimum formula of the present invention is (weight portion): 15 parts of Herba Epimedii, 15 parts of Radix Morindae Officinaliss, 15 parts of Herba Cistanches, 15 parts of Semen Cuscutae, 15 parts of Rhizoma Polygonatis, 15 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Curculiginises, 12 parts of Radix Bupleuri, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of the Radixs Astragali, 20 parts of Radix Rehmanniae Preparata, 20 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 5 parts in Radix Glycyrrhizae, 8 parts of Fructus Ligustri Lucidi, 15 parts of Semen Plantaginiss, 15 parts of Fructus Rubies, 30 parts of Radix Salviae Miltiorrhizaes, 12 parts of the Cortexs Eucommiae, 10 parts of Radix Scutellariaes, 5 parts of Cortex Moutans, 10 parts in Poria, 10 parts of Rhizoma Alismatis.
Pharmacology of the present invention: Herba Epimedii: the another name Herba Epimedii, hot, sweet, warm, return liver, kidney channel, kidney-replenishing, bone and muscle strengthening, wind-damp dispelling are used for impotence and seminal emission, the muscles and bones flaccidity is soft; Radix Morindae Officinalis: hot, sweet, tepor, return kidney channel, reinforcing the kidney and supporting YANG, expelling wind and removing dampness; Herba Cistanches: sweet, salty, warm, return kidney, large intestine channel, the kidney invigorating and essence nourishing, loosening bowel to relieve constipation; Semen Cuscutae: property is flat, and sweet in the mouth, suffering are returned liver, kidney channel; Can YANG invigorating; Again can yin nourishing, be the dirty key medicine of flat invigorating the liver and kidney board three, have the effect of tonifying the kidney to consolidate the essence, liver-benefiting eye-brightening, invigorating the spleen to arrest diarrhea; Cure mainly deficiency of the kidney lumbago, sexual impotence, seminal emission, frequent micturition, diseases such as leukorrhagia or bleary-eyed and insufficiency of the spleen diarrhoea; Rhizoma Polygonati: sweet, flat, return spleen, lung, kidney channel, nourishing YIN and moistening the lung, invigorating the spleen and replenishing QI; Radix Angelicae Sinensis: sweet, hot, temperature is returned liver, the heart, spleen channel, blood-activating and qi-promoting; Rhizoma Curculiginis: hot, temperature, poisonous, go into kidney, Liver Channel, the kidney warming sun, strengthening bone and muscle; Radix Bupleuri: bitter, be slightly cold, return liver, gallbladder meridian, reconciling superficies and interior, soothing the liver, yang invigorating; The Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm, return spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis; The Radix Astragali: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, benefit is defended consolidating superficial resistance, sun is given birth in QI invigorating; Radix Rehmanniae Preparata, sweet in the mouth, warm in nature is returned liver, kidney channel, and moist, the beneficial essence of enriching blood is filled out marrow; RHIIZOMA DIOSCOREAE frOm Henan of China: sweet, flat, return spleen, lung, kidney channel, spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission; Radix Glycyrrhizae: sweet, flat, GUIXIN, spleen, lung, stomach warp, invigorating the spleen and replenishing QI; Fructus Ligustri Lucidi: sweet, bitter, cool, return liver, kidney channel, nourishing the liver and kidney; Semen Plantaginis: sweet, be slightly cold, return liver, kidney, lung, small intestine meridian, clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, the latus rectum of invigorating blood circulation; Fructus Rubi: sweet, sour, warm, return liver, kidney channel, controlling nocturnal emission with astringent drugs reducing urination, kidney tonifying nourishing the liver; Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel have promoting blood circulation to restore menstrual flow, an effect of the relieving restlessness that clears away heart-fire; The Cortex Eucommiae: sweet, warm, return liver, kidney channel, invigorating the liver and kidney, bone and muscle strengthening; Radix Scutellariae: cold, bitter, return lung, gallbladder, spleen, large intestine, small intestine meridian, heat clearing and damp drying, eliminating fire and detoxication; Cortex Moutan: cold in nature, bitter in the mouth, suffering, go into the heart, liver, kidney channel, clearing away heat and cooling blood, blood circulation promoting competent silt; Poria: sweet, light, flat, GUIXIN, spleen, kidney channel, promoting diuresis to eliminate damp pathogen, spleen invigorating is calmed the nerves; Rhizoma Alismatis: sweet, light, cold, return kidney, urinary bladder channel, promoting diuresis to eliminate damp pathogen, expel the heat-evil.More than all mutual compatibilities of medicine, play altogether warming and recuperating the kidney-YANG, assistant with benefiting QI for activating blood circulation, increase the effect of lean marrow.
Method for preparing: with each crude drug of the present invention by conventional method packing capsulae vacuus behind the porphyrize powder altogether, every capsules 0.5g.
Method for using: early respectively obey 5 after ante cibum, the supper every day, took continuously 2~3 months.
The scope of application: medicine of the present invention is applicable to the male infertility that treatment causes because of necrospermia, azoospermia, oligospermatism or azoospermia.
The advantage of medicine of the present invention: warming and recuperating the kidney-YANG, assistant with benefiting QI for activating blood circulation, increase the lean marrow, preparation is simple, taking convenience, good effect has no side effect.
The specific embodiment
Below in conjunction with specific embodiment technical scheme of the present invention is done into a ground and introduce in detail, but protection scope of the present invention is not limited thereto:
Embodiment 1
Treat deadly, weak, less or the Chinese medicine composition of azoospermia, form by each crude drug of following weight: Herba Epimedii 15g, Radix Morindae Officinalis 15g, Herba Cistanches 15g, Semen Cuscutae 15g, Rhizoma Polygonati 15g, Radix Angelicae Sinensis 15g, Rhizoma Curculiginis 10g, Radix Bupleuri 12g, Rhizoma Atractylodis Macrocephalae 12g, Radix Astragali 20g, Radix Rehmanniae Preparata 20g, RHIIZOMA DIOSCOREAE frOm Henan of China 20g, Radix Glycyrrhizae 5g, Fructus Ligustri Lucidi 8g, Semen Plantaginis 15g, Fructus Rubi 15g, Radix Salviae Miltiorrhizae 30g, Cortex Eucommiae 12g, Radix Scutellariae 10g, Cortex Moutan 5g, Poria 10g, Rhizoma Alismatis 10g.With above-mentioned each crude drug by conventional method packing capsulae vacuus behind the porphyrize powder altogether, every capsules 0.5g.
Embodiment 2
In the present embodiment, the weight of each crude drug is: Herba Epimedii 10g, Radix Morindae Officinalis 10g, Herba Cistanches 10g, Semen Cuscutae 10g, Rhizoma Polygonati 10g, Radix Angelicae Sinensis 10g, Rhizoma Curculiginis 7g, Radix Bupleuri 8g, Rhizoma Atractylodis Macrocephalae 8g, Radix Astragali 14g, Radix Rehmanniae Preparata 14g, RHIIZOMA DIOSCOREAE frOm Henan of China 14g, Radix Glycyrrhizae 3g, Fructus Ligustri Lucidi 5g, Semen Plantaginis 10g, Fructus Rubi 10g, Radix Salviae Miltiorrhizae 20g, Cortex Eucommiae 8g, Radix Scutellariae 7g, Cortex Moutan 3g, Poria 6g, Rhizoma Alismatis 6g.With above-mentioned each crude drug by conventional method packing capsulae vacuus behind the porphyrize powder altogether, every capsules 0.5g.
Embodiment 3
In the present embodiment, the weight of each crude drug is: Herba Epimedii 20g, Radix Morindae Officinalis 20g, Herba Cistanches 20g, Semen Cuscutae 20g, Rhizoma Polygonati 20g, Radix Angelicae Sinensis 20g, Rhizoma Curculiginis 13g, Radix Bupleuri 16g, Rhizoma Atractylodis Macrocephalae 16g, Radix Astragali 26g, Radix Rehmanniae Preparata 26g, RHIIZOMA DIOSCOREAE frOm Henan of China 26g, Radix Glycyrrhizae 8g, Fructus Ligustri Lucidi 13g, Semen Plantaginis 20g, Fructus Rubi 20g, Radix Salviae Miltiorrhizae 40g, Cortex Eucommiae 16g, Radix Scutellariae 13g, Cortex Moutan 8g, Poria 13g, Rhizoma Alismatis 14g.With above-mentioned each crude drug by conventional method packing capsulae vacuus behind the porphyrize powder altogether, every capsules 0.5g.
The observation on Clinical Application of medicine of the present invention is reported as follows:
One, basic document (year January in January, 08 to 2010)
Accept patient's 198 examples altogether for medical treatment, 23~42 years old age (average 28.0 ± 2.0 years old); The course of disease 2~8 years (average 4.0 ± 1.5 years).Wherein, by the disease typing, necrospermia 75 examples, azoospermia 55 examples, oligospermatism 23 examples, azoospermia 45 examples.
Two, diagnostic criteria
" human seminal fluid and sperm--cervical mucus interaction laboratory inspection handbook is formulated according to WHO.The seminal fluid routine examination: adopt seminal fluid computer for analysis system to detect, all ascetic 3~7d before the patient, masturbation is got essence, semen volume 2~6ml, average 3.5ml.Look into seminal fluid continuously 3 times, get its meansigma methods,,, diagnose as follows according to the semen efamination result as observation index:
The disease typing Diagnostic criteria
Necrospermia Sperm survival rate<50%
Azoospermia Motility of sperm (a level+b level)<50% or a level<25%
Oligospermatism Sperm count<20 * 10 6/ml
Azoospermia Sperm count is 0
Three, criterion of therapeutical effect
Figure GSB00000539932600041
Figure GSB00000539932600051
Four, Therapeutic Method
With each crude drug of the present invention by conventional method packing capsulae vacuus behind the porphyrize powder altogether, every capsules 0.5g; Early respectively obey 5 after ante cibum, the supper every day, took continuously 2~3 months.
Five, statistical result
Figure GSB00000539932600052
Can find out from last table: curative effect of medication of the present invention is good, and total effective rate reaches 96.47%.
Below for utilizing the model case of medicine of the present invention:
Case 1
Mr. Wei, 29 years old, secondary school teachers, 3 years after marriage wives are unpregnancy always.Through local examination in hospital, bridegroom's or husband's side sperm survival rate has only 2%, spends units up to ten thousand in hospitalize; No actual effect here is afterwards gone to a doctor, and is diagnosed as necrospermia, and advises it to take the embodiment of the invention 3 medicines; Early respectively obey 5 after ante cibum, the supper every day, take 50 days after, sperm survival rate is 40%; Hold on again take 30 days after, the seminal fluid routine examination learns that survival rate reaches 70%, wife's pregnancy in inferior month.
Case 2
Mr. Liu, 30 years old, the peasant, marry 5 years surplus, live together and do not educate, sexual life is normal, health check-up: grow normally, nutrition is medium, and external genitalia is normal, two testis, epididymis, spermatic vein are no abnormal.Motility of sperm is found in the seminal fluid routine examination: a level: 15%, and the b level: 19%, the c level: 20%, d level: 46%.Be diagnosed as: azoospermia, and advise it to take the embodiment of the invention 1 medicine, early respectively obey 5 after ante cibum, the supper every day, take 40 days after; Motility of sperm: a level: 18%, the b level: 25%, the c level: 40%, d level: 17%; Hold on again take 50 days after, motility of sperm: a level: 28%, b level: 40%; The c level: 20%, the d level: 12%, wife's pregnancy in inferior month.
Case 3
Mr. Chen, 35 years old, the businessman; Married 10 years, wife is conceived always, and some that think originally that the contraceptive before the wife eats is excessive; But, be not influence to the result of examination in hospital, hope to prepare to make children so continue to have in arms; Always buy a lot of tonics to her, the family members also helps and has looked for the sub-folk prescription of a lot of lifes.But do not take effect all the time, have no alternative but, the man and wife goes to hospital to do coherence check in pairs; Learn it is the reason of oneself, and (treated 8 months continuously through local Chinese medicine before 2 years quantity 8,000,000~1,100 ten thousand/ml) to be diagnosed as oligospermatism; Effect is undesirable, before the end of the year 2008, goes to a doctor, and advises it to take the embodiment of the invention 2 medicines; Early respectively obey 5 after ante cibum, the supper every day, take 30 days after, sperm quantity is 1800~1,900 ten thousand/ml; After continuing again to take 20 days, sperm quantity is greater than 2,000 ten thousand/ml, wife's pregnancy in inferior month.
Case 4
Mr. Yuan, 25 years old, the peasant, 2 years after marriage, the man and wife lived together, and sexual life is normal, does not take contraceptives.Wife's side gynecologial examination is normal, and menstruation, ovulation are normal, and the reproductive immunology inspection is normal.Bridegroom's or husband's side seminal fluid routine examination is not found sperm 3 times.Be diagnosed as azoospermia, and advise it to take the embodiment of the invention 3 medicines, early respectively obey 5 after ante cibum, the supper every day; After taking 60 days, sperm quantity is 1500~1,700 ten thousand/ml, after continuing again to take 30 days; Sperm quantity is greater than 2,000 ten thousand/ml, wife's pregnancy in inferior month.

Claims (2)

1. a treatment is dead, weak, less or the Chinese medicine composition of azoospermia, it is characterized in that being made up of each crude drug of following parts by weight: 10~20 parts of Herba Epimedii, 10~20 parts of Radix Morindae Officinaliss, 10~20 parts of Herba Cistanches, 10~20 parts of Semen Cuscutae, 10~20 parts of Rhizoma Polygonatis, 10~20 parts of Radix Angelicae Sinensis, 7~13 parts of Rhizoma Curculiginises, 8~16 parts of Radix Bupleuri, 8~16 parts of the Rhizoma Atractylodis Macrocephalaes, 14~26 parts of the Radixs Astragali, 14~26 parts of Radix Rehmanniae Preparata, 14~26 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 3~8 parts in Radix Glycyrrhizae, 5~13 parts of Fructus Ligustri Lucidi, 10~20 parts of Semen Plantaginiss, 10~20 parts of Fructus Rubies, 20~40 parts of Radix Salviae Miltiorrhizaes, 8~16 parts of the Cortexs Eucommiae, 7~13 parts of Radix Scutellariaes, 3~8 parts of Cortex Moutans, 6~13 parts in Poria, 6~14 parts of Rhizoma Alismatis.
2. treatment as claimed in claim 1 is dead, weak, less or the Chinese medicine composition of azoospermia, it is characterized in that forming: 15 parts of Herba Epimedii, 15 parts of Radix Morindae Officinaliss, 15 parts of Herba Cistanches, 15 parts of Semen Cuscutae, 15 parts of Rhizoma Polygonatis, 15 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Curculiginises, 12 parts of Radix Bupleuri, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of the Radixs Astragali, 20 parts of Radix Rehmanniae Preparata, 20 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 5 parts in Radix Glycyrrhizae, 8 parts of Fructus Ligustri Lucidi, 15 parts of Semen Plantaginiss, 15 parts of Fructus Rubies, 30 parts of Radix Salviae Miltiorrhizaes, 12 parts of the Cortexs Eucommiae, 10 parts of Radix Scutellariaes, 5 parts of Cortex Moutans, 10 parts in Poria, 10 parts of Rhizoma Alismatis by each crude drug of following parts by weight.
CN2010102073193A 2010-06-23 2010-06-23 Chinese medicinal composition for treating necrospermia, asthenospermia oligospermia, or aspermatism Expired - Fee Related CN101869665B (en)

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CN102205031B (en) * 2011-05-10 2012-11-21 张棠 Traditional Chinese medicine for treating male sterility
CN102579705A (en) * 2012-01-19 2012-07-18 刘天岐 Curculigo orchioides impotence eliminating pill
CN102885981A (en) * 2012-10-26 2013-01-23 李为彬 Traditional Chinese medicine (TCM) pills for treating necrospermia and preparation method thereof
CN103550427B (en) * 2013-10-14 2015-09-02 刘铭成 The Chinese medicine composition that treatment man yang deficiency is sterile
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CN104274625B (en) * 2014-10-21 2017-12-29 上海市闸北区中医医院 A kind of application of Chinese medicine in the few sperm disease for the treatment of
CN110801485A (en) * 2018-08-06 2020-02-18 严育斌 Fleece-flower root essence-increasing capsule
CN110507746A (en) * 2019-09-18 2019-11-29 河南世豪医药科技有限公司 A kind of Chinese medicine and preparation method thereof for treating azoospermia

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