CN101455717A - Traditional Chinese medicine composition for treating osteoporosis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating osteoporosis and preparation method thereof Download PDFInfo
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- CN101455717A CN101455717A CNA2008102032942A CN200810203294A CN101455717A CN 101455717 A CN101455717 A CN 101455717A CN A2008102032942 A CNA2008102032942 A CN A2008102032942A CN 200810203294 A CN200810203294 A CN 200810203294A CN 101455717 A CN101455717 A CN 101455717A
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Abstract
The invention relates to a Chinese traditional medicine composition having kidney-nourishing and essence-benefiting, muscles and bones-strengthening, Qi-invigorating and blood-activating functions and treating osteoporosis and a preparation method thereof. The composition is made from the following raw materials in terms of parts by weight: 1-5 parts of barrenwort, 1-5 parts of rhizoma drynariae, 1-5 parts of fructus cnidii, 1-3 parts of radix astragali and 1-3 parts of roots of red-rooted salvia. The preparation method comprises the following steps: (1) adding the barrenwort, rhizoma drynariae and fructus cnidii into ethanol, heating under reflux, filtering, depressurizing the filtrate, recycling solvent, thus obtaining liquid medicine A for later use; (2) decocting the radix astragali and roots of red-rooted salvia with water, filtering, thus obtaining liquid medicine B; (3) combining the liquid medicine A and the liquid medicine B, condensating, adding in auxiliary materials, making into medicament forms pharmaceutically acceptable. The composition has clear curative effect and no side effect, and is prepared into conveniently used modern preparations by the preparation method of the invention.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, osteoporotic Chinese medicine composition of especially a kind of treatment and preparation method thereof.
Background technology
Osteoporosis is a kind of common metabolic osteopathy that threatens healthy elder, shows as the components unchanged of bone, and bone content reduces, and bone micro-structure changes, and fracture risk increases.
The traditional Chinese medical science thinks that osteoporosis belongs to lumbago, asthenia, atrophic debility of bones category.
Primary disease is a kind of multi-pathogenesis disease, and its basic pathology mechanism is that defective appears in bone resorption and osteoplastic coupling connection in the bone metabolism process.In the existing known body circulation in multiple hormone, the bone metabolism some local modulation factors, physical training, physical factor and trophic factor etc. all may influence the process that bone metabolism and bone are built again.But in numerous links, how which kind of factors contribute interacts between each factor actually, remains further to be disclosed.
Along with social senilization's process, osteoporosis has become a kind of commonly encountered diseases, and WHO classifies them one of as three big senile disease.Although research worker has been carried out a large amount of explorations to osteoporotic pathomechanism and Therapeutic Method, clinical efficacy is still not good enough at present.Research is efficient, safe drugs are the major subjects of control primary disease.
Summary of the invention
Problem to be solved by this invention provides the osteoporotic Chinese medicine composition of a kind of treatment, makes its kidney invigorating and essence nourishing, strong muscles and bones, benefiting QI for activating blood circulation.
Another technical problem to be solved by this invention provides a kind of preparation method of Chinese medicine composition, is made into modern preparation, the convenient use.
In order to solve the problems of the technologies described above, the present invention proposes following technical proposals:
The osteoporotic Chinese medicine composition of a kind of treatment is made by the raw material of following weight portion: Herba Epimedii 1-5 part, Rhizoma Drynariae 1-5 part, Fructus Cnidii 1-5 part, Radix Astragali 1-3 part, Radix Salviae Miltiorrhizae 1-3 part.
Above-mentioned raw materials is preferred: Herba Epimedii 2-4 part, Rhizoma Drynariae 1-3 part, Fructus Cnidii 1-3 part, Radix Astragali 1-2 part, Radix Salviae Miltiorrhizae 1-2 part; Further preferred: 3 parts of Herba Epimedii, 2 parts of Rhizoma Drynariae, 2 parts of Fructus Cnidiis, 1 part of the Radix Astragali, 1 part of Radix Salviae Miltiorrhizae.
Herba Epimedii in the side, Rhizoma Drynariae, Fructus Cnidii the kidney invigorating and essence nourishing, strong muscles and bones; Radix Astragali QI invigorating bone strengthening, the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling.All medicines share, and play the merit of the kidney invigorating and essence nourishing, strong muscles and bones, benefiting QI for activating blood circulation altogether, are used for osteoporosis.
The osteoporotic technique effect of traditional Chinese medicine composition for treating of the present invention can embody by following test.
Test example 1 present composition is to the osteoporotic influence of castrated rats
1.1, test material
Medicine and reagent: the present composition, press the self-control of embodiment 5 methods; Synestrin tablets (1mg/ sheet), cod-liver oil (contains VD
35000 units/ml), calcium gluconate; Human serum estradiol (E2) radioimmunoassay determination box (Beijing nation decides Tyke Bioisystech Co., Ltd).
Animal: Healthy female Wistar rats, at 12 monthly ages, body weight is 250-320g, the Jiangsu Prov. Research Inst. Traditional Chinese Medical Experimental Animal Center provides.
Instrument: dual intensity X line bone densitometry instrument, DEXA (U.S.); WD-1 section bar material testing machine, Changchun experiment equipment factory; 724 spectrophotometers, the optical instrument factory, Shanghai.
1.2 test method
Method of emasculation: get healthy rat, anesthesia is extractd after the bilateral ovaries the 5th day by only carrying out vaginal smear examination, every day 1 time, continuous 5 days, gets ovariectomy and does not have fully emotionally that variation person's (castration group) is used for experiment.False castration treated animal operation is except that not extracing the ovary, and is surplus all with the castration group.
Female rats is got 12 castration groups that rehearse, and the passed examination animal is used for experiment after the remaining castration.Castrated rats is divided into 5 groups at random, 12 every group.False castration group, castration group, all give normal saline, positive controls is irritated stomach and is given diethylstilbestrol 0.02mg/kg, cod-liver oil 450U/kg, multi-calcium tablet 0.5g/kg, high, medium and low dosage group is irritated stomach respectively and is given present composition 12g crude drug/kg, 6g crude drug/kg, 3g crude drug/kg, beginning in the 9th day administration of operation back, every day 1 time, continuous three months, after the last administration, rat fasting 12h weighs.Behind the anesthetized animal, abdominal aortic blood is surveyed serum estradiol concentration, gets rat right side femur and measures bone density (BMD) and femur weight, gets the rats with left femur and measures bone biomechanical index (fracture load by bending, rigidity).Test data adopts t check carrying out statistical analysis between group.
1.3 result of the test
1.3.1 the present composition is to the influence of castrated rats femur density
Table 1 present composition is to the influence of castrated rats femur density (n=12, X ± SD)
Compare with the castration group,
*P＜0.05;
*P＜0.01.
Result of the test shows, false castration group rat femur density is apparently higher than the castration group, and has highly significant meaning (p＜0.01), shows the modeling success.Compare with the castration group, positive controls, present composition height, middle dosage group rat femur density obviously raise, and have highly significant meaning (p＜0.01), present composition low dose group rat femur density obviously raises, and has significance meaning (p＜0.05).The above results shows, the present composition castrated rats bone density that can significantly raise.
1.3.2 the present composition is to the influence of castrated rats femur biomechanics
Table 2 present composition is to the influence of castrated rats femur biomechanics
| Group | Dosage (/Kg) | Fracture load by bending (N) | Rigidity (N/mm) |
| The castration group | — | 8.97±0.95 | 13.25±3.22 |
| False castration group | — | 10.28±0.81 ** | 16.21±3.17 ** |
| Positive controls | (0.02mg+450U+0.5g) | 10.54±0.64 ** | 17.18±2.96 ** |
| Low dose group | 3g | 10.25±0.79 ** | 16.23±2.84 ** |
| Middle dosage group | 6g | 10.53±0.11 ** | 16.64±3.09 ** |
| High dose group | 12g | 10.67±0.92 ** | 17.54±3.46 ** |
Compare with the castration group,
*P＜0.05;
*P＜0.01.
Result of the test shows, false castration group rat femur fracture load by bending, rigidity is apparently higher than the castration group, and all has highly significant meaning (p＜0.01), shows the modeling success.Compare with the castration group, positive controls, the high, medium and low dosage group of present composition rat femur fracture load by bending, rigidity are all obviously high, and all have highly significant meaning (p＜0.01).The above results shows, the present composition castrated rats bone density that can significantly raise.
1.3.3 the present composition is to the influence of castrated rats serum E2 concentration
Table 3 present composition is to the influence of castrated rats serum E2 concentration (n=12, X ± SD)
Compare with the castration group,
*P＜0.05;
*P＜0.01.
Result of the test shows, false castration group rat blood serum estradiol (E2) concentration is apparently higher than the castration group, and has highly significant meaning (p＜0.01), shows the modeling success.Compare with the castration group, positive controls, present composition height, middle dosage group rat blood serum estradiol (E2) concentration obviously raise, and have highly significant meaning (p＜0.01).The above results shows, present composition castrated rats serum estradiol (E2) concentration that can significantly raise.
Above-mentioned result of the test shows that the present composition causes osteoporotic rat to have the good curing effect to castration.
The preparation method of Chinese medicine composition of the present invention is as follows:
(1) Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii 3 flavor medical materials add alcohol heating reflux, filter, and filtrate decompression reclaims solvent, gets medicinal liquid A, and is standby;
The alcohol heating reflux technological parameter is: the percent by volume that adds Herba Epimedii, Rhizoma Drynariae, 8 times of amounts of Fructus Cnidii 3 flavor medical material gross weights is 70% ethanol, reflux 2 times, and each 1.5 hours, merge medicinal liquid, filter.
(2) Radix Astragali, Radix Salviae Miltiorrhizae 2 flavor medical materials decoct with water, and filter, and get medical liquid B;
The decocting process parameter is: add the Radix Astragali, the water of 8 times of amounts of Radix Salviae Miltiorrhizae 2 flavor medical material gross weights decocts 2 times, and each 2 hours, merge medicinal liquid, filter.
(3) merge medicinal liquid A, B, concentrate, add adjuvant, make pharmaceutically acceptable dosage form.
The dosage form of this compositions can adopt a kind of in capsule, sheet, soft capsule, drop pill, the granule.
When Chinese medicine composition of the present invention is used for the treatment of osteoporosis, different according to the state of an illness and occupation mode, daily crude drug amount is 1-100g.
Technical scheme of the present invention hereinafter will do further statement, but the scope of protection of present invention is not limited to following embodiment in order better to illustrate to its specific embodiment.
The specific embodiment
Embodiment 1
Prescription: Herba Epimedii 1200g, Rhizoma Drynariae 1200g, Fructus Cnidii 1200g, Radix Astragali 1200g, Radix Salviae Miltiorrhizae 1200g
Method for making: take by weighing Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii, mixing, the percents by volume that add 8 times of amounts of 3 flavor medical material gross weights are 70% ethanol, reflux 2 times, each 1.5 hours, merge medicinal liquid, filter, get medicinal liquid A, standby; Take by weighing the Radix Astragali, Radix Salviae Miltiorrhizae, the water of 8 times of amounts of adding 2 flavor medical material gross weights decocts each 2 hours 2 times, merge medicinal liquid, filter, get medical liquid B, merge medicinal liquid A, B, be condensed into thick extractum, add starch, sodium carboxymethyl cellulose is an amount of, the system granule, the encapsulating capsule is made 1000.
Pharmacological testing: the present embodiment compositions is to the influence to castrated rats femur density
Only give 6g crude drug/kg dosage for reagent, all the other methods are with test example 1, and result of the test is as follows:
Table 4 embodiment 1 compositions is to the influence of castrated rats femur density (n=12, X ± SD)
Compare with the castration group,
*P＜0.05;
*P＜0.01.
Result of the test shows, false castration group rat femur density is apparently higher than the castration group, and has highly significant meaning (p＜0.01), shows the modeling success.Compare with the castration group, positive controls, this compositions group rat femur density obviously raise, and have highly significant meaning (p＜0.01).The above results shows, the present composition castrated rats bone density that can significantly raise.
Embodiment 2
Prescription: Herba Epimedii 1428g, Rhizoma Drynariae 1428g, Fructus Cnidii 1428g, Radix Astragali 857g, Radix Salviae Miltiorrhizae 857g
Method for making: take by weighing Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii, mixing, the percents by volume that add 8 times of amounts of 3 flavor medical material gross weights are 70% ethanol, reflux 2 times, each 1.5 hours, merge medicinal liquid, filter, get medicinal liquid A, standby; Take by weighing the Radix Astragali, Radix Salviae Miltiorrhizae, the water of 8 times of amounts of adding 2 flavor medical material gross weights decocts each 2 hours 2 times, merge medicinal liquid, filter, get medical liquid B, merge medicinal liquid A, B, be condensed into thick extractum, add starch, sodium carboxymethyl cellulose is an amount of, the system granule, the encapsulating capsule is made 1000.
Pharmacological testing: the present embodiment compositions is to the influence to castrated rats femur density
Only give 6g crude drug/kg dosage for reagent, all the other methods are with test example 1, and result of the test is as follows:
Table 5 embodiment 2 compositionss are to the influence of castrated rats femur density (n=12, X ± SD)
Compare with the castration group,
*P＜0.05;
*P＜0.01.
Result of the test shows, false castration group rat femur density is apparently higher than the castration group, and has highly significant meaning (p＜0.01), shows the modeling success.Compare with the castration group, positive controls, this compositions group rat femur density obviously raise, and have highly significant meaning (p＜0.01).The above results shows, the present composition castrated rats bone density that can significantly raise.
Embodiment 3
Prescription: Herba Epimedii 2000g, Rhizoma Drynariae 1000g, Fructus Cnidii 1000g, Radix Astragali 10000g, Radix Salviae Miltiorrhizae 1000g
Method for making: take by weighing Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii, mixing, the percents by volume that add 8 times of amounts of 3 flavor medical material gross weights are 70% ethanol, reflux 2 times, each 1.5 hours, merge medicinal liquid, filter, get medicinal liquid A, standby; Take by weighing the Radix Astragali, Radix Salviae Miltiorrhizae, the water of 8 times of amounts of adding 2 flavor medical material gross weights decocts each 2 hours 2 times, merge medicinal liquid, filter, get medical liquid B, merge medicinal liquid A, B, be condensed into thick extractum, add starch, sodium carboxymethyl cellulose is an amount of, the system granule, the encapsulating capsule is made 1000.
Pharmacological testing: the present embodiment compositions is to the influence to castrated rats femur density
Only give 6g crude drug/kg dosage for reagent, all the other methods are with test example 1, and result of the test is as follows:
Table 6 embodiment 3 compositionss are to the influence of castrated rats femur density (n=12, X ± SD)
Compare with the castration group,
*P＜0.05;
*P＜0.01.
Result of the test shows, false castration group rat femur density is apparently higher than the castration group, and has highly significant meaning (p＜0.01), shows the modeling success.Compare with the castration group, positive controls, this compositions group rat femur density obviously raise, and have highly significant meaning (p＜0.01).The above results shows, the present composition castrated rats bone density that can significantly raise.
Embodiment 4
Prescription: Herba Epimedii 1714g, Rhizoma Drynariae 1286g, Fructus Cnidii 1286g, Radix Astragali 857g, Radix Salviae Miltiorrhizae 857g
Method for making: take by weighing Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii, mixing, the percents by volume that add 8 times of amounts of 3 flavor medical material gross weights are 70% ethanol, reflux 2 times, each 1.5 hours, merge medicinal liquid, filter, get medicinal liquid A, standby; Take by weighing the Radix Astragali, Radix Salviae Miltiorrhizae, the water of 8 times of amounts of adding 2 flavor medical material gross weights decocts each 2 hours 2 times, merge medicinal liquid, filter, get medical liquid B, merge medicinal liquid A, B, be condensed into thick extractum, add starch, sodium carboxymethyl cellulose is an amount of, the system granule, the encapsulating capsule is made 1000.
Pharmacological testing: the present embodiment compositions is to the influence to castrated rats femur density
Only give 6g crude drug/kg dosage for reagent, all the other methods are with test example 1, and result of the test is as follows:
Table 7 embodiment 4 compositionss are to the influence of castrated rats femur density (n=12, X ± SD)
Compare with the castration group,
*P＜0.05;
*P＜0.01.
Result of the test shows, false castration group rat femur density is apparently higher than the castration group, and has highly significant meaning (p＜0.01), shows the modeling success.Compare with the castration group, positive controls, this compositions group rat femur density obviously raise, and have highly significant meaning (p＜0.01).The above results shows, the present composition castrated rats bone density that can significantly raise.
Embodiment 5
Prescription: Herba Epimedii 2000g, Rhizoma Drynariae 1333g, Fructus Cnidii 1333g, Radix Astragali 667g, Radix Salviae Miltiorrhizae 667g
Method for making: take by weighing Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii, mixing, the percents by volume that add 8 times of amounts of 3 flavor medical material gross weights are 70% ethanol, reflux 2 times, each 1.5 hours, merge medicinal liquid, filter, get medicinal liquid A, standby; Take by weighing the Radix Astragali, Radix Salviae Miltiorrhizae, the water of 8 times of amounts of adding 2 flavor medical material gross weights decocts each 2 hours 2 times, merge medicinal liquid, filter, get medical liquid B, merge medicinal liquid A, B, be condensed into thick extractum, add starch, sodium carboxymethyl cellulose is an amount of, the system granule, the encapsulating capsule is made 1000.
Embodiment 6
Prescription: Herba Epimedii 2000g, Rhizoma Drynariae 1333g, Fructus Cnidii 1333g, Radix Astragali 667g, Radix Salviae Miltiorrhizae 667g
Method for making: take by weighing Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii, mixing, the percents by volume that add 8 times of amounts of 3 flavor medical material gross weights are 70% ethanol, reflux 2 times, each 1.5 hours, merge medicinal liquid, filter, get medicinal liquid A, standby; Take by weighing the Radix Astragali, Radix Salviae Miltiorrhizae, the water of 8 times of amounts of adding 2 flavor medical material gross weights decocts each 2 hours 2 times, merge medicinal liquid, filter, get medical liquid B, merge medicinal liquid A, B, be condensed into thick extractum, add starch, sodium carboxymethyl cellulose is an amount of, the system granule, tabletting is made 1000.
Embodiment 7
Prescription: Herba Epimedii 2000g, Rhizoma Drynariae 1333g, Fructus Cnidii 1333g, Radix Astragali 667g, Radix Salviae Miltiorrhizae 667g
Method for making: take by weighing Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii, mixing, the percents by volume that add 8 times of amounts of 3 flavor medical material gross weights are 70% ethanol, reflux 2 times, each 1.5 hours, merge medicinal liquid, filter, get medicinal liquid A, standby; Take by weighing the Radix Astragali, Radix Salviae Miltiorrhizae, the water of 8 times of amounts of adding 2 flavor medical material gross weights decocts 2 times, and each 2 hours, merge medicinal liquid, filter, get medical liquid B, merging medicinal liquid A, B are condensed into thick extractum, add starch, and the system granule is made 1000g.
Embodiment 8
Prescription: Herba Epimedii 2000g, Rhizoma Drynariae 1333g, Fructus Cnidii 1333g, Radix Astragali 667g, Radix Salviae Miltiorrhizae 667g
Method for making: take by weighing Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii, mixing, the percents by volume that add 8 times of amounts of 3 flavor medical material gross weights are 70% ethanol, reflux 2 times, each 1.5 hours, merge medicinal liquid, filter, get medicinal liquid A, standby; Take by weighing the Radix Astragali, Radix Salviae Miltiorrhizae, the water of 8 times of amounts of adding 2 flavor medical material gross weights decocts each 2 hours 2 times, merge medicinal liquid, filter, get medical liquid B, merge medicinal liquid A, B, concentrate, drying is crushed to 80 orders, adds soybean oil, paraffin is an amount of, mixing, and the compacting soft capsule becomes 1000.
Embodiment 9
Prescription: Herba Epimedii 2000g, Rhizoma Drynariae 1333g, Fructus Cnidii 1333g, Radix Astragali 667g, Radix Salviae Miltiorrhizae 667g
Method for making: take by weighing Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii, mixing, the percents by volume that add 8 times of amounts of 3 flavor medical material gross weights are 70% ethanol, reflux 2 times, each 1.5 hours, merge medicinal liquid, filter, get medicinal liquid A, standby; Take by weighing the Radix Astragali, Radix Salviae Miltiorrhizae adds the water of 8 times of amounts of 2 flavor medical material gross weights, decocts 2 times, each 2 hours, merge medicinal liquid, filter, medical liquid B, merge medicinal liquid A, B, concentrate, drying is crushed to 80 orders, it is an amount of to add Polyethylene Glycol, mixing drips and makes a drop pill and become 1000.
Claims (7)
1, the osteoporotic Chinese medicine composition of a kind of treatment is characterized in that described compositions made by the raw material of following weight portion: Herba Epimedii 1-5 part, Rhizoma Drynariae 1-5 part, Fructus Cnidii 1-5 part, Radix Astragali 1-3 part, Radix Salviae Miltiorrhizae 1-3 part.
2, Chinese medicine composition according to claim 1 is characterized in that described compositions made by the raw material of following weight portion: Herba Epimedii 2-4 part, Rhizoma Drynariae 1-3 part, Fructus Cnidii 1-3 part, Radix Astragali 1-2 part, Radix Salviae Miltiorrhizae 1-2 part.
3, Chinese medicine composition according to claim 1 is characterized in that described compositions made by the raw material of following weight portion: 3 parts of Herba Epimedii, 2 parts of Rhizoma Drynariae, 2 parts of Fructus Cnidiis, 1 part of the Radix Astragali, 1 part of Radix Salviae Miltiorrhizae.
4, the preparation method of the described Chinese medicine composition of claim 1 is characterized in that described method comprises the following steps:
(1) Herba Epimedii, Rhizoma Drynariae, Fructus Cnidii 3 flavor medical materials add alcohol heating reflux, filter, and filtrate decompression reclaims solvent, gets medicinal liquid A, and is standby;
(2) Radix Astragali, Radix Salviae Miltiorrhizae 2 flavor medical materials decoct with water, and filter, and get medical liquid B;
(3) merge medicinal liquid A, B, concentrate, add adjuvant, make pharmaceutically acceptable dosage form.
5, preparation method according to claim 4, it is characterized in that described alcohol heating reflux technological parameter is: the percent by volume that adds Herba Epimedii, Rhizoma Drynariae, 8 times of amounts of Fructus Cnidii 3 flavor medical material gross weights is 70% ethanol, reflux 2 times, each 1.5 hours, merge medicinal liquid, filter.
6, preparation method according to claim 4 is characterized in that described decocting process parameter is: add the Radix Astragali, the water of 8 times of amounts of Radix Salviae Miltiorrhizae 2 flavor medical material gross weights decocts 2 times, and each 2 hours, merge medicinal liquid, filter.
7,, it is characterized in that described dosage form is selected from a kind of in capsule, sheet, soft capsule, drop pill, the granule according to each described preparation method of claim 4-6.
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| CN103083443A (en) * | 2012-03-05 | 2013-05-08 | 湖南中医药大学 | Chinese medicinal composition for treating arthritis and preparation method thereof |
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| CN103083443A (en) * | 2012-03-05 | 2013-05-08 | 湖南中医药大学 | Chinese medicinal composition for treating arthritis and preparation method thereof |
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