CN101757100B - Basil seed chewable tablets - Google Patents
Basil seed chewable tablets Download PDFInfo
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- CN101757100B CN101757100B CN200910230083.2A CN200910230083A CN101757100B CN 101757100 B CN101757100 B CN 101757100B CN 200910230083 A CN200910230083 A CN 200910230083A CN 101757100 B CN101757100 B CN 101757100B
- Authority
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- China
- Prior art keywords
- ocimi pilosi
- chewable tablets
- basil seed
- water
- fine powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 22
- 235000010676 Ocimum basilicum Nutrition 0.000 title claims abstract description 16
- 240000007926 Ocimum gratissimum Species 0.000 title 1
- 241001529734 Ocimum Species 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000000284 extract Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000008187 granular material Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 11
- 239000003480 eluent Substances 0.000 claims description 10
- 238000010828 elution Methods 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000003463 adsorbent Substances 0.000 claims description 5
- 238000004440 column chromatography Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000000945 filler Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000011084 recovery Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 239000000314 lubricant Substances 0.000 claims description 4
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- 229960004998 acesulfame potassium Drugs 0.000 claims description 3
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 3
- 239000000619 acesulfame-K Substances 0.000 claims description 3
- 235000009508 confectionery Nutrition 0.000 claims description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 3
- 235000019359 magnesium stearate Nutrition 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 102000011759 adducin Human genes 0.000 claims description 2
- 108010076723 adducin Proteins 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000000746 purification Methods 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 239000000654 additive Substances 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 229940068682 chewable tablet Drugs 0.000 description 7
- 239000002671 adjuvant Substances 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003754 machining Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- 240000000786 Margyricarpus pinnatus Species 0.000 description 1
- 235000010838 Margyricarpus pinnatus Nutrition 0.000 description 1
- 235000011205 Ocimum Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000010437 gem Substances 0.000 description 1
- 229910001751 gemstone Inorganic materials 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of medicament, and discloses chewable tablets taking basil seed as main raw materials. Various auxiliary materials and flavouring agents are added to improve medicament taste while ensuring efficacy; and moreover, the additives are edible and harmless to human body. The adopted special basil seed purification method and conventional processing and tablet-making process ensure low production cost and high yield, and can be widely applied in the medicament field. The obtained basil seed chewable tablets have the advantages of good taste, convenient administration, quick absorption and response, and high bioavailability, and good application prospects.
Description
Technical field:
The present invention relates to a kind of chewable tablet taking Fructus Ocimi Pilosi as primary raw material and preparation method thereof, belong to medical technical field.
Background technology:
Fructus Ocimi Pilosi is Labiatae, Ocimum, and annual armaticity suffruticose herbaceous plant, originates in India, has another name called FRUCTUS OCIMI or Lan Xiangzi, and commercial popular name claims pollen, little Folium Perillae, pearl fruit, jewel fruit.All come from tight drought area short of rain with Caulis et Folium Hyptidis suaveolentis (SHANFEN circle), approximately 30 times of physical characteristics from volume expansion after the water suction of seed nature evolution evolution tool, store moisture content, increase the germination probability of seed.Its size, as Semen Sesami, is soaked in the rapid imbibition of meeting in boiled water, after absorption human body, can promote intestinal peristalsis promoting, contributes to digestion.Because Herba Ocimi (Herba Ocimi Pilosi) kind expands under one's belt, therefore eliminate hunger sensation, also can reach the object of controlling excessive diet.
Record according to Compendium of Material Medica: Fructus Ocimi Pilosi has improving eyesight, protects kidney, the function of diuresis, elimination constipation and body-building health, and has obvious cosmetic slimming effect.It is rich in various mineral, VB
1, VB
2, carotene, abundant machine acid, saccharide and vitamin B group etc.
But existing Fructus Ocimi Pilosi has all adopted the form of direct administration, wherein effective medicinal components utilization rate is low, cannot reach the medicinal object of expection, and due to the taste of medicine self, make user very inconvenient in use, also be not easy to swallowing of patient, in order to develop the medicine resource of Fructus Ocimi Pilosi, be badly in need of a kind of mode that it effectively can be utilized.
Summary of the invention:
For the upper weak point existing of existing Fructus Ocimi Pilosi exploitation, the invention provides a kind of basil seed chewable tablets and adopt the mode of tabletting to prepare chewable tablet, main is that raw material is made chewable tablet with Fructus Ocimi Pilosi extract, be aided with various adjuvants and correctives, in ensureing drug effect, improve the mouthfeel of medicine, and various additives are edible, harmless.The special Fructus Ocimi Pilosi method of purification and the conventional machining film-making technique that adopt, make production cost low, productive rate is high, can be widely used in field of medicaments, it is good that gained basil seed chewable tablets has mouthfeel, taking convenience, absorb rapidly, the advantage rapid-action, bioavailability is high, has good application prospect.
Basil seed chewable tablets of the present invention is made up of Fructus Ocimi Pilosi, and its raw material components is as follows, and each amounts of components is weight portion:
Fructus Ocimi Pilosi fine powder 50-160 part
Filler 750-950 part
Correctives 1-5 part
Water 5-20 part
Lubricant 1-5 part
Wherein selected Fructus Ocimi Pilosi fine powder extracts as follows:
Get Fructus Ocimi Pilosi coarse powder, add 95% ethanol of 8-10 times of weight, 70-90 DEG C of water-bath reflux, extract, three times, each 2-3h, merges three times filtrate, and concentrating under reduced pressure recovery solvent, is concentrated into 5-8% volume, obtains extract; Add a small amount of water and make extract suspendible, through AB-8 macroporous adsorbent resin column chromatography, with water elution, eluent discards; With 95% (w) ethanol elution, collect eluent again, concentrating under reduced pressure reclaims solvent, is concentrated into 1-3% volume, obtains extractum; Gained extractum, in vacuum 55-60 DEG C of dry 20-24 hour, is obtained to drying solid, be ground into powder, obtain Fructus Ocimi Pilosi fine powder.
Adopt this purifying technique the impurity in Fructus Ocimi Pilosi coarse powder can be extracted, and the efficiency of extracting is high, can further improve the active drug composition in residue Fructus Ocimi Pilosi fine powder, and the solvent adopting can not affect the drug effect of Fructus Ocimi Pilosi, ensure its application pharmaceutically.
The adjuvant adopting mainly comprises: filler used is selected from one or more mixture of microcrystalline Cellulose or sucrose or mannitol or dextrin; Correctives used is selected from acesulfame potassium or A Siba is sweet or protein sugar in one or more mixture; With lubricator be selected from one or more mixture in micropowder silica gel or magnesium stearate or Pulvis Talci
Select above-mentioned various adjuvants, can effectively improve the mouthfeel of gained chewable tablet, prevent due to Fructus Ocimi Pilosi self taste cause patient be difficult to take, various adjuvants is mixed simultaneously, can be for follow-up manufacturing procedure provides better preparation, make the chewable tablet of final gained have better basis on being shaped.
The method of preparing this chewable tablet is as follows: the Fructus Ocimi Pilosi coarse powder of getting formula ratio; filler; correctives; spraying adds water; mix homogeneously, sends into granule mechanism granule, at 30～80 DEG C, granule is dried; in dried particles, add lubricant, after mixing, send into tablet machine and make in flakes basil seed chewable tablets.
Adopt this preparation technology can make the chewable tablet that meets pharmaceutical standards, and be all conventional preparation method and equipment due to what adopt, can adopt existing equipment directly to produce, save production cost, facilitate large-area promotion and application simultaneously, ensured its application pharmaceutically.
It is good that gained basil seed chewable tablets of the present invention has mouthfeel, and taking convenience absorbs rapidly, and rapid-action, the advantage that bioavailability is high, has good application prospect; The special Fructus Ocimi Pilosi method of purification and the conventional machining film-making technique that adopt, make production cost low, and productive rate is high, can be widely used in field of medicaments,
Detailed description of the invention:
Understand technical scheme of the present invention for better, below describe in further detail by specific embodiment.
Embodiment 1:
Get Fructus Ocimi Pilosi coarse powder 2kg, add 18kg95% ethanol, 80 DEG C of water-bath reflux, extract, three times, each 2.5h, merges three times filtrate, and concentrating under reduced pressure recovery solvent, is concentrated into 7% volume, obtains extract; Add a small amount of water and make extract suspendible, through AB-8 macroporous adsorbent resin column chromatography, with water elution, eluent discards; With 95% (w) ethanol, collect eluent again, concentrating under reduced pressure reclaims solvent, is concentrated into 2% volume, obtains extractum; Gained extractum is dried to 24 hours in 60 DEG C, vacuum, obtains drying solid, be ground into powder, obtain Fructus Ocimi Pilosi fine powder.
Get the above-mentioned Fructus Ocimi Pilosi fine powder of 100g, 800g microcrystalline Cellulose, 4g acesulfame potassium; spraying adds 15g water, and mix homogeneously is sent into granule mechanism granule; at 60 DEG C, granule is dried, in dried particles, adds 3g micropowder silica gel, mix and send into tablet machine and make in flakes basil seed chewable tablets.
Embodiment 2:
Get Fructus Ocimi Pilosi coarse powder 2kg, add 18kg 95% ethanol, 80 DEG C of water-bath reflux, extract, three times, each 2.5h, merges three times filtrate, and concentrating under reduced pressure recovery solvent, is concentrated into 7% volume, obtains extract; Add a small amount of water and make extract suspendible, through AB-8 macroporous adsorbent resin column chromatography, with water elution, eluent discards; Wash so that 95% (w) ethanol is de-, collect eluent, concentrating under reduced pressure reclaims solvent, is concentrated into 2% volume, obtains extractum; Gained extractum is dried to 24 hours in 60 DEG C, vacuum, obtains drying solid, be ground into powder, obtain Fructus Ocimi Pilosi fine powder.
Get the above-mentioned Fructus Ocimi Pilosi fine powder of 100g, 800g sucrose, 4g A Siba is sweet; spraying adds 15g water, and mix homogeneously is sent into granule mechanism granule; at 60 DEG C, granule is dried, in dried particles, adds 3g magnesium stearate, mix and send into tablet machine and make in flakes basil seed chewable tablets.
Embodiment 3:
Get Fructus Ocimi Pilosi coarse powder 2kg, add 18kg 95% ethanol, 80 DEG C of water-bath reflux, extract, three times, each 2.5h, merges three times filtrate, and concentrating under reduced pressure recovery solvent, is concentrated into 7% volume, obtains extract; Add a small amount of water and make extract suspendible, through AB-8 macroporous adsorbent resin column chromatography, with water elution, eluent discards; With 95% (w) ethanol elution, collect eluent again, concentrating under reduced pressure reclaims solvent, is concentrated into 2% volume, obtains extractum; Gained extractum is dried to 24 hours in 60 DEG C, vacuum, obtains drying solid, be ground into powder, obtain Fructus Ocimi Pilosi fine powder.
Get the above-mentioned Fructus Ocimi Pilosi fine powder of 100g, 800g mannitol, 4g protein sugar; spraying adds 15g water, and mix homogeneously is sent into granule mechanism granule; at 60 DEG C, granule is dried, in dried particles, adds 3g Pulvis Talci, mix and send into tablet machine and make in flakes basil seed chewable tablets.
Claims (2)
1. a basil seed chewable tablets, is characterized in that: the active component adopting is Fructus Ocimi Pilosi fine powder, is aided with other pharmaceutic adjuvant, and its raw material components is as follows, and each amounts of components is weight portion:
Wherein selected Fructus Ocimi Pilosi fine powder extracts as follows:
Get Fructus Ocimi Pilosi coarse powder, add 95% ethanol of 8-10 times of weight, 70-90 DEG C of water-bath reflux, extract, three times, each 2-3h, merges three times filtrate, and concentrating under reduced pressure recovery solvent, is concentrated into 5-8% volume, obtains extract; Add a small amount of water and make extract suspendible, through AB-8 macroporous adsorbent resin column chromatography, with water elution, eluent discards; With percentage by weight 95% ethanol elution, collect eluent again, concentrating under reduced pressure reclaims solvent, is concentrated into 1-3% volume, obtains extractum; Gained extractum, in vacuum 55-60 DEG C of dry 20-24 hour, is obtained to drying solid, be ground into powder, obtain Fructus Ocimi Pilosi fine powder;
Wherein said filler is selected from one or more mixture of microcrystalline Cellulose or sucrose or mannitol or dextrin;
Described correctives is selected from acesulfame potassium or A Siba one or more the mixture in sweet;
Described lubricant is selected from one or more the mixture in micropowder silica gel or magnesium stearate or Pulvis Talci.
2. the method for preparation basil seed chewable tablets as claimed in claim 1; it is characterized in that: its preparation method is as follows: the Herba Ocimi (Herba Ocimi Pilosi) of getting formula ratio gives fine powder; filler; correctives, spraying adds water, mix homogeneously; send into granule mechanism granule; at 30～80 DEG C, granule is dried, in dried particles, adds lubricant, after mixing, send into tablet machine and make in flakes basil seed chewable tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910230083.2A CN101757100B (en) | 2009-11-13 | 2009-11-13 | Basil seed chewable tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910230083.2A CN101757100B (en) | 2009-11-13 | 2009-11-13 | Basil seed chewable tablets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101757100A CN101757100A (en) | 2010-06-30 |
| CN101757100B true CN101757100B (en) | 2014-12-10 |
Family
ID=42488582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910230083.2A Expired - Fee Related CN101757100B (en) | 2009-11-13 | 2009-11-13 | Basil seed chewable tablets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101757100B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104643090B (en) * | 2015-03-24 | 2016-11-30 | 吉林工商学院 | A kind of containing the Folium Perillae dregs of rice, Herba Ocimi (Herba Ocimi Pilosi) seed and the manufacture method of Abelmoschus esculentus slimming capsule |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444245A (en) * | 2007-11-26 | 2009-06-03 | 天津市金圭谷木糖醇有限公司 | Mulberry leaf chewing tablet with sugar-lowering function |
-
2009
- 2009-11-13 CN CN200910230083.2A patent/CN101757100B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444245A (en) * | 2007-11-26 | 2009-06-03 | 天津市金圭谷木糖醇有限公司 | Mulberry leaf chewing tablet with sugar-lowering function |
Non-Patent Citations (2)
| Title |
|---|
| 《咀嚼片的研究进展》;施昕磊等;《中国药业》;20081231;第17卷(第14期);17-18 * |
| 施昕磊等.《咀嚼片的研究进展》.《中国药业》.2008,第17卷(第14期),17-18. * |
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| Publication number | Publication date |
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| CN101757100A (en) | 2010-06-30 |
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