CN101755800A - Bactericide composition containing iprovalicarb - Google Patents
Bactericide composition containing iprovalicarb Download PDFInfo
- Publication number
- CN101755800A CN101755800A CN200910223997A CN200910223997A CN101755800A CN 101755800 A CN101755800 A CN 101755800A CN 200910223997 A CN200910223997 A CN 200910223997A CN 200910223997 A CN200910223997 A CN 200910223997A CN 101755800 A CN101755800 A CN 101755800A
- Authority
- CN
- China
- Prior art keywords
- iprovalicarb
- methyl
- cyanogen
- weight ratio
- thiophanate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000000203 mixture Substances 0.000 title claims abstract description 55
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 43
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- 239000005842 Thiophanate-methyl Substances 0.000 claims abstract description 21
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical group COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 claims abstract description 21
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- 239000004480 active ingredient Substances 0.000 claims abstract description 8
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Abstract
The invention relates to a synergistic bactericide composition, in particular to a synergistic bactericide composition which comprises iprovalicarb and any one of bactericidal active ingredients selected from the group consisting of thiophanate methyl, dimethomorph, cymoxanil, thiram, mancozeb, chlorothalonil, metiram and cyazofamid.
Description
Technical field
The present invention relates to a kind of Synergistic bactericidal composition, particularly relate to a kind of Synergistic bactericidal composition that comprises iprovalicarb and be selected from arbitrary fungicide active ingredient of thiophanate-methyl, dimethomorph, white urea cyanogen, tmtd, mancozeb, tpn, Carbatene and cyanogen frost azoles.
Background technology
Iprovalicarb (iprovalicarb); chemical name is [2-methyl isophthalic acid-(4-tolyl) ethylamino formoxyl]-propyl group]-carbamic acid isopropyl ester; be carbamate derivates, have unique brand-new biomimetic features and make its mechanism of action be different from the bactericide that other prevent and treat Oomycete.Its mechanism of action is act on fungal cell wall and protein synthetic, can suppress infecting and sprouting of spore, can suppress mycelial growth simultaneously, causes its distortion, death, is mainly used in control cucumber, downy mildew of garpe.
Thiophanate-methyl (thiophanate-methyl), chemical name are 1,2-pair-(3-methoxycarbonyl group-α-ghiourea group) benzene, belong to benzimidazole, and be a kind of broad spectrum activity systemic fungicide, can prevent and treat the various crop disease, have interior suction, prevention and therapeutic action.It is converted into carbendazim in plant corpus, the formation of spindle influences cell division in the mitosis of interference bacterium.
Dimethomorph (dimethomorph), chemical name is (E, Z)-4-[3-(4-chlorphenyl)-3-(4-chlorphenyl)-3-(3,4-Dimethoxyphenyl-acryloyl) morpholine belongs to the morpholine series bactericidal agent, is known systemic fungicide, its effect characteristics are to destroy the formation of cell envelope, all there is effect in each stage to oomycetes history of life, and is particularly responsive in the formation stage of sporangiophore and egg spore, and Peronospora and Phytophthora fungi are had preventive effect preferably.
Frost urea cyanogen (cymoxanil); chemical name is 2-cyano group-N-[(ethylamino-) carbonyl]-2-(methoxyl group imido grpup) acetamide; it is a kind of high-efficiency low-toxicity bactericide; belong to the substituted urea class bactericide; have contact and local systemic action, can suppress spore germination, use with to prolong the lasting period with protective fungicide; be widely used in brassicaceous vegetable such as cucumber, grape, tomato, lichee, huge dish and tobacco etc. and go up the Peronosporales fungi, belong to as epidemic disease frost genus, Peronospora, single shaft frost.
Tmtd (thiram); tetramethyl thiuram disulfide; belong to organosulfureous fungicide; it is a kind of bactericide of tool protective effect; its has a broad antifungal spectrum is mainly used in and handles seed and soil, the seedling blight of control cereal class smut and various crop; also can be used for spraying, prevent and treat some fruit trees, vegetable disease.
Mancozeb (mancozeb); the complex salt of two two thiocarbamoyl manganese of ethylene and zinc; belong to organic sulfur class protective fungicide; fungicidal spectrum is wider; it mainly is the oxidation that suppresses pyruvic acid in the thalline; effective to multiple diseases such as the anthracnose on fruit tree, the vegetables, early blight, simultaneously its normal and systemic fungicide is mixed, and is used for the generation of delaying drug resistance.
Tpn (chlorothalonil), daconil M (2,4; 5,6-tetrachloro-1,3-benzene dicarbonitrile); belong to organochlorine class protective fungicide, can with the combined with protein of cysteine in the glyceraldehyde 3-phosphate dehydro-genase among the fungal cell, destroy the metabolism of cell and loss of life power.It mainly acts on is the prevention fungal infection, inhales conduction in not having, but at plant surface good adhesivity is arranged, and is not subject to rain drop erosion, and the long drug effect phase is arranged.
Carbatene (metriam) is a kind of good protective fungicide; can stop the sprouting of germ spore; suppress the elongation of germ germ tube; make germ can't infect plant tissue; the fungus-caused various diseases of Oomycete there is good preventive effect, belongs to low-toxin farm chemicals, wide, the difficult resistance that produces of bactericidal range; control efficiency obviously is better than other same series bactericidal agents, is the substitute products of present other protective fungicides.
Cyanogen frost azoles (cyazofamid), chemical name is 4-chloro-2-cyano group-N, N-dimethyl-5-p-methylphenyl imidazoles-1-sulfonamide, be the sulphaguanidine azoles fungicide, the Oomycete fungi had strong bactericidal activity, each vegetative stage to phytophthora history of life comprises sporangial formation, sporangial sprouting, the formation of egg spore, the release of zoospore, zoospore move and the growth of mycelia etc. all has very high inhibition effect.Compare with other medicament, cyanogen frost azoles has high protection activity to potato late blight, cucumber downy mildew.
The inventor studies have shown that by a series of, iprovalicarb is mixed with the arbitrary fungicide active ingredient that is selected from thiophanate-methyl, dimethomorph, white urea cyanogen, tmtd, mancozeb, tpn, Carbatene and cyanogen frost azoles the target bacterium is had extremely strong synergistic effect, improve bactericidal activity greatly, thereby finished the present invention.
Summary of the invention
The object of the present invention is to provide a kind of mixed ratio reasonable, control efficiency is good, the Synergistic bactericidal composition that drug cost is low.
Another object of the present invention is to provide by formulations such as the formulated missible oil of this bactericidal composition, microemulsion, aqueous emulsion, suspending agent, wetting powder, water dispersible granules, granules.
Another object of the present invention is to provide the purposes that bactericidal composition is used to prevent and treat the downy mildew that causes by the Oomycete disease fungus, eqpidemic disease, late blight.
Technical scheme of the present invention is as described below:
A kind of bactericidal composition, the arbitrary fungicide active ingredient that it is characterized in that containing the iprovalicarb of synergy effective dose and be selected from the white azoles of thiophanate-methyl, dimethomorph, white urea cyanogen, tmtd, mancozeb, tpn, Carbatene and cyanogen.
Wherein, iprovalicarb can change in very wide scope with the weight ratio of the arbitrary fungicide active ingredient that is selected from thiophanate-methyl, dimethomorph, white urea cyanogen, tmtd, mancozeb, tpn, Carbatene and cyanogen frost azoles, be preferably 40: 1～1: 40, more preferably 10: 1～1: 15.
And, the weight ratio of iprovalicarb and thiophanate-methyl more preferably 1: 8～1: 12; The weight ratio of iprovalicarb and dimethomorph more preferably 1: 1～1: 8; The weight ratio of iprovalicarb and white urea cyanogen or cyanogen frost azoles more preferably 3: 1～1: 3; The weight ratio of iprovalicarb and tmtd, mancozeb, tpn or Carbatene more preferably 1: 5-1: 15.
Active component is 0.5% to 95% of a gross weight in the composition of the present invention.
Except the fungicidal activity composition, also can comprise functional aid in the bactericidal composition of the present invention.That is to say that the present composition can add other components such as functional aid, be mixed with the preparation of missible oil, aqueous emulsion, microemulsion, suspending agent, wetting powder, water dispersible granules or other formulations.
In these preparations, except that active component, all contain surfactant, and also can contain thinners such as organic solvent or cosolvent, carrier (filler) or water, add other functional aids such as antifreeze, thickener, stabilizing agent, defoamer, disintegrant in case of necessity according to different dosage form.Surfactant can be emulsifier, dispersant, wetting agent or bleeding agent.Surfactant can be nonionic with ionic, also can be two or more compound uses.
Described emulsifier comprises alkylphenol-polyethenoxy (polyoxypropylene) ether, benzylphenol APEO, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether, polyoxyethylene carboxylate, phenethyl phenol polyethenoxy polyethenoxy ether, castor oil ethylene oxide adduct, alkylphenol polyoxyethylene formaldehyde condensation products, and the phosphate of these compounds, alkyl benzene sulphonate (calcium salt or sodium salt) or directly use commercially available emulsifier monomer and composite product.Concrete example is as farming breast 500
#Series, 600
#Series, 1600
#Series, NP is serial, OP is serial, AEO is serial, 700
#, 400
#Serial and composite kind 2201,0203B, 2021B, 4103 etc., these all are emulsifier productions well known in the art, market is on sale.
Described dispersant; wetting agent; bleeding agent comprises lignosulfonates (sodium salt or calcium salt); Negel; condensation compound of methyl naphthalene sulfonic acid and formaldehyde sulphate; naphthalene sulfonic acid-formaldehyde condensation product; methanonaphthalene sodium sulfonate dibutyl naphthalene sulfonic acid-formaldehyde condensation product; N-methyl fatty acyl group sodium taurocholate; alkylphenol polyoxyethylene formaldehyde condensation products sulphate; polymerization of carboxylic acid sodium; the alkylphenol polyoxyethylene phosphate; the withered powder of tea; saponin; lignosulfite; aliphatic alcohol sulfate; dodecyl sodium sulfate; alkylbenzenesulfonate; penetrant t; bleeding agent OT; fatty acid amide-N methyl taurine sodium salt; sodium sulfate of polyethenoxy ether of fatty alcohol; draw back powder; JFC; can use separately, also can compoundly use.Above-mentioned surfactant all is materials well known in the art, can obtain by various commercial channel.
Described solvent, cosolvent comprise toluene, dimethylbenzene, chlorobenzene, solvent naphtha, alpha-methyl-naphthalene, turpentine oil, carrene, chloroform, methyl alcohol, ethanol, isopropyl alcohol, butanols, isoamyl alcohol, cyclohexanone, isophorone, acetophenone, ethyl acetate, butyl acetate, N.N-dimethyl formamide, dimethyl sulfoxide (DMSO), methyl cellosolve, ethyl cellosolve etc.
Described antifreeze comprises ethylene glycol, glycerine, propane diols, urea, glycerine, ether diglycol, polyethylene glycol, isopropyl alcohol etc.
Described carrier, filler comprise white carbon, precipitated calcium carbonate, potter's clay, attapulgite, kaolin, diatomite, bentonite, sepiolite, zeolite, quartz sand, talcum powder, can use separately, also can two kinds or above mixing use.
Described disintegrant has sodium alginate, sodium carboxymethyl starch, sulfuric acid amine, bentonite, urea, calcium chloride.
Described defoamer has bubble enemy, silicone, C
8-10Fatty alcohol, C
10-20Saturated fat acids (as capric acid, stearic acid etc.) and amide-type.
Described binding agent comprises starch, dextrin, gum Arabic, soybean protein, gelatine, sodium sulphate, gypsum, polyvinyl alcohol, polyethylene glycol, rosin, paraffin, CMC, sodium silicate.Can use separately, also can two or morely use with.
Can contain toner in the preparation, inorganic pigment iron oxide for example, titanium oxide or Prussian blue; Organic dyestuff is as A Lizhalin, azo dyes, metal phthalocyanine or kiton colors.In water-base preparation, for preventing moldy metamorphism, need to add a certain amount of preservative, described preservative has Sodium Benzoate, polyformaldehyde, sorbitol, formalin, citric acid, to the yl benzoic acid methyl esters, face phenyl phenol sodium, 1,2-benzisothiazole-3-ketone (code name BIT) etc.
The product that the present invention describes can be the finished product preparation form to be provided, and promptly each material mixes in the composition, but the composition of composition also can provide directly mixing in bucket (jar) before using with independent preparation.Concentrate of the present invention mixes the concentration that obtains required active substance usually with water.
Composition of the present invention can be used for various plants, as Chinese cabbage, wild cabbage, cauliflower, wax gourd, cucumber, tomato, lichee, grape, wheat, rape, potato, tobacco and flowers etc.The place of using of the product that composition of the present invention and carrier are made is farmland, orchard or warehouse etc.
Composition of the present invention also can with other compound with weeding, desinsection or bactericidal property particularly the protective fungicide agent composition use, also can use with nematocide, protective agent, growth regulator, nutrient for plants or soil conditioner mixture.Composition of the present invention can be used by common method, as cast, injection, spraying.Amount of application of the present invention is with weather condition or crop state variation, and time of application can be before or after crop be susceptible.The duration of protective effect is usually relevant with the content of individualized compound in the composition, also relevant with extraneous factor, weather for example, but by using suitable formulation can slow down climatic influences.
The remarkable advantage of composition of the present invention: the one, composition shows extremely strong synergistic effect in certain ratio range, the bactericidal effect of mixed composition is significantly improved than its single agent, thereby reduced using dosage, when reducing peasant's drug cost, reduced influence degree.The 2nd, interracial structure differs bigger, and the resistance that the application of said composition can delay single agent takes place and development.
Embodiment:
The present invention is elaborated with following specific embodiment, so that advantage of the present invention is more obvious, but the present invention is limited to these examples absolutely not.Percentage all is weight percentage in the prescription of all preparations, and the processing of biologically-active moiety is effective content.
One, formulation Example:
1, the preparation of missible oil
By the prescription requirement, add solvent, former medicine, emulsifier respectively, mix, use the hot bath heating for dissolving in case of necessity, promptly obtain transparence missible oil.As embodiment 1～3 prescription.
Embodiment 1 (55% missible oil)
Iprovalicarb 5%, thiophanate-methyl 50%, farming breast 500
#7.5%, agricultural newborn 600-2
#4.5%, methyl alcohol 8%, dimethylbenzene complements to 100%.
Embodiment 2 (12.5% missible oil)
Iprovalicarb 5%, white urea cyanogen 7.5%, farming breast 507
#10%, agricultural newborn OX-653 3%, methyl alcohol 10%, dimethylbenzene complements to 100%.
Embodiment 3 (12.5% missible oil)
Iprovalicarb 5%, cyanogen frost azoles 7.5%, farming breast 500
#10%, agricultural newborn OX-635 5%, methyl alcohol 10%, dimethylbenzene complements to 100%.
2, the preparation of wetting powder
By the prescription requirement, former medicine, various auxiliary agent and filler etc. are fully mixed, after ultrafine crusher is pulverized, promptly obtain converted products.As embodiment 4～10 prescriptions.
Embodiment 4 (55% wetting powder)
Iprovalicarb 5%, thiophanate-methyl 50%, lauryl sodium sulfate 1.5%, carboxymethyl cellulose 1%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%.
Embodiment 5 (15% wetting powder)
Iprovalicarb 3%, dimethomorph 12%, lauryl sodium sulfate 1.5%, carboxymethyl cellulose 1%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%.
Embodiment 6 (10% wetting powder)
Iprovalicarb 4%, white urea cyanogen 6%, neopelex 1%, white carbon 10%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%.
Embodiment 7 (55% wetting powder)
Iprovalicarb 5%, tmtd 50%, neopelex 1%, white carbon 10%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%.
Embodiment 8 (65% wetting powder)
Iprovalicarb 5%, mancozeb 60%, alkyl amide taurate 2%, Fluhyzon formaldehyde condensation 5%, alkylphenol-polyethenoxy phosphate 5%, precipitated calcium carbonate complements to 100%.
Embodiment 9 (55% wetting powder)
Iprovalicarb 5%, tpn 50%, neopelex 1%, white carbon 10%, naphtholsulfonic acid formaldehyde condensation products sodium salt 10%, precipitated calcium carbonate complements to 100%.
Embodiment 10 (60% wetting powder)
Iprovalicarb 5%, Carbatene 55%, neopelex 1%, white carbon 10%, naphtholsulfonic acid formaldehyde condensation products sodium salt 10%, precipitated calcium carbonate complements to 100%.
3, the preparation of aqueous emulsion
Former medicine, solvent, emulsifier added with co-emulsifier be in the same place, make dissolving be even oil phase.Water, antifreeze etc. is mixed, becomes the homogeneous water.Under high-speed stirred, water is joined oil phase or oil phase is joined water, form the aqueous emulsion of favorable dispersibility.As embodiment 10～13 prescriptions.
Embodiment 11 (15% aqueous emulsion)
Iprovalicarb 3%, dimethomorph 12%, polyvinyl alcohol 0.8%, in triphenylethylene phenol+oxirane, phosphorylation, the triethanolamine and 8.5%, alkyl-diethylene glycol ether-sodium sulfonate 2.5%, farming breast 2,201 13%, dimethyl formamide 8%, ethylene glycol 5%, water complements to 100%.
Embodiment 12 (30% aqueous emulsion)
Iprovalicarb 3%, thiophanate-methyl 27%, polyvinyl alcohol 0.9%, alkylaryl polyoxyethylene propylene ether 8.5%, farming breast 220115%, dimethyl formamide 12%, ethylene glycol 5%, water complements to 100%.
Embodiment 13 (35% aqueous emulsion)
Iprovalicarb 3%, Carbatene 32%, polyvinyl alcohol 1.5%, alkylaryl polyoxyethylene propylene ether 10%, farming breast 2,201 15%, dimethyl formamide 15%, ethylene glycol 5%, water complements to 100%.
4, the preparation of water-dispersible granules
Former medicine and powder carrier, wetting spreader and binding agent etc. are mixed pulverizing, after adding water again and mediating, add in the comminutor that the certain specification screen cloth is housed and carry out granulation.And then drying, screening (pressing the screen cloth scope) promptly gets granular product.As embodiment 14～15 prescriptions.
Embodiment 14 (15% water-dispersible granules)
Iprovalicarb 6%, white urea cyanogen 9%, methyl naphthalene sulfonate formaldehyde condensate 12%, epoxidized polyether 5%, soluble starch 15%, gypsum complements to 100%.
Embodiment 15 (60% water-dispersible granules)
Iprovalicarb 5%, Carbatene 55%, methanonaphthalene sodium sulfonate 5%, epoxidized polyether 5%, sodium sulphate, gypsum complements to 100%.
5, the preparation of suspending agent
By the prescription requirement, be medium with water, former medicine, dispersant, suspending agent and antifreezing agent etc. are added in the sand milling still, carry out porphyrize, make suspending agent.As embodiment 16～18 prescriptions.
Embodiment 16 (55% suspending agent)
Iprovalicarb 5%, thiophanate-methyl 50%, methyl naphthalene sulfonate formaldehyde condensate 5.5%, white carbon 0.2%, aluminium-magnesium silicate 0.18%, ethylene glycol 4%, silicone a little, water complements to 100%.
Embodiment 17 (20% suspending agent)
Iprovalicarb 4%, dimethomorph 16%, calcium lignosulfonate 5%, white carbon 0.3%, ethylene glycol 4%, silicone a little, water complements to 100%.
Embodiment 18 (10% suspending agent)
Iprovalicarb 4%, cyanogen frost azoles 6%, methyl naphthalene sulfonic acid naphthaldehyde condensation compound 2.5%, bentonite 1.0%, farming breast 1,601 3%, glycerine 4%, silicone a little, water complements to 100%.
6, the preparation of microemulsion
Former medicine, solvent, emulsifier added with co-emulsifier be in the same place, make dissolving be even oil phase.Water, antifreeze etc. is mixed, becomes the homogeneous water.Under high-speed stirred, water is joined oil phase or oil phase is joined water, form the microemulsion of favorable dispersibility.As embodiment 19～21 prescriptions.
Embodiment 19 (30% microemulsion)
Iprovalicarb 3%, thiophanate-methyl 27%, propyl alcohol 7%, phenethyl phenol polyethenoxy ether 10%, carrene 10%, glycerine 5%, water complements to 100%.
Embodiment 20 (10% microemulsion)
Iprovalicarb 4%, white urea cyanogen 6%, dimethylbenzene 12%, phenyl xenol polyvinylether 15%, ring ethanol 8%, ethylene glycol 8%, water complements to 100%.
Embodiment 21 (30% microemulsion)
Iprovalicarb 3%, tmtd 27%, ethanol 6%, sodium alkyl benzene sulfonate 8%, the third hexanone 8%, propane diols 6%, water complements to 100%.
Two, biological Examples:
The joint toxicity measuring of test example 1 iprovalicarb and thiophanate-methyl
For the examination bacterium
Capsicum epidemic disease (Phytophthora capsici Leonian)
For the examination capsicum variety
" rich green pepper No. ", capsicum is potted plant to be cultured to two open and flat phases of few leaf in the greenhouse.
The experimental concentration design
The combination medicament experimental concentration is five concentration of 40,20,10,5,2.5 μ g/ml, the iprovalicarb concentration of treatment is 32,16,8,4,2 μ g/ml, the thiophanate-methyl concentration of treatment is 80,40,20,10,5 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Select second true leaf of the potted plant capsicum of growth neat and consistent, cutting the back puts to culture dish at petiole place humidification cotton balls, by the processing of on the crop sprayer, spraying of top set concentration, treat that the blade soup dries the back in second day inoculation capsicum epidemic disease germ, places then in the crop cultivation case and cultivates.
Condition of culture
Cultivation temperature: 28 ℃ of daytimes, 23 ℃ of nights.Incubation time: 6 days.
Investigation and method of counting
In incubator, preserve moisture and cultivate 6 days " Invest, Then Investigate " control efficiency,, calculate control efficiency with disease index, and obtain virulence regression equation and EC by the grade scale classification record of medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals field trial criterion "
50,, calculate interactional ratio behind two single agent compositions (be that SR＜0.5 is antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) according to Wadley bactericide mixture synergy evaluation assessment.
Result of the test sees the following form 1.
The joint toxicity measuring result of table 1 iprovalicarb and thiophanate-methyl
Result of the test shows; Iprovalicarb and thiophanate-methyl weight ratio are 1: 10 o'clock, and its interaction ratio is respectively 1.97, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of test example 2 iprovalicarbs and dimethomorph
For the examination bacterium
Downy mildew of garpe (Plasmopara viticola)
For the examination grape variety
" huge cutting edge of a knife or a sword ", grape is potted plant to be cultured to two open and flat phases of few leaf in the greenhouse.
The experimental concentration design
The experimental concentration of combination medicament and the agent of iprovalicarb list is five concentration of 24,12,6,3,1.5 μ g/ml, and the dimethomorph concentration of treatment is 40,20,10,5,2.5 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Select second true leaf of the grape pot of growth neat and consistent, cutting the back puts to culture dish at petiole place humidification cotton balls, by the processing of on the crop sprayer, spraying of top set concentration, treat that the blade soup dries the back in second day inoculation downy mildew of garpe germ, places then in the crop cultivation case and cultivates.
Condition of culture
Cultivation temperature: 28 ℃ of daytimes, 23 ℃ of nights.Incubation time: 6 days.
Investigation and method of counting
In incubator, preserve moisture and cultivate 6 days " Invest, Then Investigate " control efficiency,, calculate control efficiency with disease index, and obtain virulence regression equation and EC by the grade scale classification record of medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals field trial criterion "
50,, calculate interactional ratio behind two single agent compositions (be that SR＜0.5 is antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) according to Wadley bactericide mixture synergy evaluation assessment.
Result of the test sees the following form 2.
The joint toxicity measuring result of table 2 iprovalicarb and dimethomorph
Result of the test shows: iprovalicarb and dimethomorph weight ratio are 1: 4 o'clock, and its interaction ratio is respectively 2.11, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of test example 3 iprovalicarbs and white urea cyanogen
For the examination bacterium
Tomato late blight (Phytophthora infestans)
For the examination tomato variety
" Fu Dan ", tomato is potted plant to be cultured to two open and flat phases of few leaf in the greenhouse.
The experimental concentration design
The experimental concentration of combination medicament and the agent of iprovalicarb list is five concentration of 20,10,5,2.5,1.25 μ g/ml, and white urea cyanogen concentration of treatment is 40,20,10,5,2.5 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Select second true leaf of the potted plant tomato of growth neat and consistent, cutting the back puts to culture dish at petiole place humidification cotton balls, by the processing of on the crop sprayer, spraying of top set concentration, treat that the blade soup dries the back in second day inoculating tomato late blight germ, places then in the crop cultivation case and cultivates.
Condition of culture
Cultivation temperature: 28 ℃ of daytimes, 23 ℃ of nights.Incubation time: 6 days.
Investigation and method of counting
In incubator, preserve moisture and cultivate 6 days " Invest, Then Investigate " control efficiency,, calculate control efficiency with disease index, and obtain virulence regression equation and EC by the grade scale classification record of medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals field trial criterion "
50,, calculate interactional ratio behind two single agent compositions (be that SR＜0.5 is antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) according to Wadley bactericide mixture synergy evaluation assessment.
Result of the test sees the following form 3.
The joint toxicity measuring result of table 3 iprovalicarb and white urea cyanogen
Result of the test shows: fluazinam and white urea cyanogen weight ratio are 2: 3 o'clock, and its interaction ratio is respectively 1.87, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of test example 4 iprovalicarbs and tmtd
For the examination bacterium
Cucumber downy mildew (Psenudoperonos pora.Cubensis)
For the examination cucumber variety
" the close thorn in Shandong ", cucumber is potted plant to be cultured to two open and flat phases of few leaf in the greenhouse.
The experimental concentration design
The experimental concentration of combination medicament is five concentration of 160,80,40,20,10 μ g/ml, the iprovalicarb concentration of treatment is 32,16,8,4,2 μ g/ml, the tmtd concentration of treatment is 800,400,200,100,50 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Select second true leaf of the potted plant cucumber of growth neat and consistent, cutting the back puts to culture dish at petiole place humidification cotton balls, by the processing of on the crop sprayer, spraying of top set concentration, treat that the blade soup dries the back in second day inoculation cucumber downy mildew germ, places then in the crop cultivation case and cultivates.
Condition of culture
Cultivation temperature: 28 ℃ of daytimes, 23 ℃ of nights.Incubation time: 6 days.
Investigation and method of counting
In incubator, preserve moisture and cultivate 6 days " Invest, Then Investigate " control efficiency,, calculate control efficiency with disease index, and obtain virulence regression equation and EC by the grade scale classification record of medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals field trial criterion "
50,, calculate interactional ratio behind two single agent compositions (be that SR＜0.5 is antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) according to Wadley bactericide mixture synergy evaluation assessment.
Result of the test sees the following form 4.
The joint toxicity measuring result of table 4 iprovalicarb and tmtd
Result of the test shows: iprovalicarb and tmtd weight ratio are 1: 10 o'clock, and its interaction ratio is respectively 1.93, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of test example 5 iprovalicarbs and mancozeb
For the examination bacterium
Downy mildew of garpe (Plasmopara viticola)
For the examination grape variety
" huge peak ", grape is potted plant to be cultured to two open and flat phases of few leaf in the greenhouse.
The experimental concentration design
The experimental concentration of combination medicament is five concentration of 120,60,30,15,7.5 μ g/ml, the iprovalicarb concentration of treatment is 24,12,6,3,1.5 μ g/ml, the mancozeb concentration of treatment is 1000,500,250,125,62.5 μ g/ml, other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Select second true leaf of the grape pot of growth neat and consistent, cutting the back puts to culture dish at petiole place humidification cotton balls, by the processing of on the crop sprayer, spraying of top set concentration, treat that the blade soup dries the back in second day inoculation downy mildew of garpe germ, places then in the crop cultivation case and cultivates.
Condition of culture
Cultivation temperature: 28 ℃ of daytimes, 23 ℃ of nights.Incubation time: 6 days.
Investigation and method of counting
In incubator, preserve moisture and cultivate 6 days " Invest, Then Investigate " control efficiency,, calculate control efficiency with disease index, and obtain virulence regression equation and EC by the grade scale classification record of medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals field trial criterion "
50,, calculate interactional ratio behind two single agent compositions (be that SR＜0.5 is antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) according to Wadley bactericide mixture synergy evaluation assessment.
Result of the test sees the following form 5.
The joint toxicity measuring result of table 5 iprovalicarb and mancozeb
Result of the test shows; Iprovalicarb and mancozeb weight ratio are 1: 12 o'clock, and its interaction ratio is respectively 2.11, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of test example 6 iprovalicarbs and tpn
For the examination bacterium
Cucumber downy mildew (Psenudoperonos pora.Cubensis)
For the examination cucumber variety
" the close thorn in Shandong ", cucumber is potted plant to be cultured to two open and flat phases of few leaf in the greenhouse.
The experimental concentration design
The experimental concentration of combination medicament is five concentration of 160,80,40,20,10 μ g/ml, the iprovalicarb concentration of treatment is 32,16,8,4,2 μ g/ml, the tpn concentration of treatment is 1200,600,300,150,75 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Select second true leaf of the potted plant cucumber of growth neat and consistent, cutting the back puts to culture dish at petiole place humidification cotton balls, by the processing of on the crop sprayer, spraying of top set concentration, treat that the blade soup dries the back in second day inoculation cucumber downy mildew germ, places then in the crop cultivation case and cultivates.
Condition of culture
Cultivation temperature: 28 ℃ of daytimes, 23 ℃ of nights.Incubation time: 6 days.
Investigation and method of counting
In incubator, preserve moisture and cultivate 6 days " Invest, Then Investigate " control efficiency,, calculate control efficiency with disease index, and obtain virulence regression equation and EC by the grade scale classification record of medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals field trial criterion "
50,, calculate interactional ratio behind two single agent compositions (be that SR＜0.5 is antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) according to Wadley bactericide mixture synergy evaluation assessment.
Result of the test sees the following form 6.
The joint toxicity measuring result of table 6 iprovalicarb and tpn
Result of the test shows: iprovalicarb and tpn weight ratio are 1: 10 o'clock, and its interaction ratio is respectively 1.98, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of test example 7 iprovalicarbs and Carbatene
For the examination bacterium
Cucumber downy mildew (Psenudoperonos pora.Cubensis)
For the examination cucumber variety
" the close thorn in Shandong ", cucumber is potted plant to be cultured to two open and flat phases of few leaf in the greenhouse.
The experimental concentration design
The experimental concentration of combination medicament is five concentration of 160,80,40,20,10 μ g/ml, the iprovalicarb concentration of treatment is 32,16,8,4,2 μ g/ml, the Carbatene concentration of treatment is 1000,500,250,125,62.5 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Select second true leaf of the potted plant cucumber of growth neat and consistent, cutting the back puts to culture dish at petiole place humidification cotton balls, by the processing of on the crop sprayer, spraying of top set concentration, treat that the blade soup dries the back in second day inoculation cucumber downy mildew germ, places then in the crop cultivation case and cultivates.
Condition of culture
Cultivation temperature: 28 ℃ of daytimes, 23 ℃ of nights.Incubation time: 6 days.
Investigation and method of counting
In incubator, preserve moisture and cultivate 6 days " Invest, Then Investigate " control efficiency,, calculate control efficiency with disease index, and obtain virulence regression equation and EC by the grade scale classification record of medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals field trial criterion "
50,, calculate interactional ratio behind two single agent compositions (be that SR＜0.5 is antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) according to Wadley bactericide mixture synergy evaluation assessment.
Result of the test sees the following form 7.
The joint toxicity measuring result of table 7 iprovalicarb and Carbatene
Result of the test shows: iprovalicarb and Carbatene weight ratio are 1: 11 o'clock, and its interaction ratio is respectively 1.88, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of test example 8 iprovalicarbs and cyanogen frost azoles
For the examination bacterium
Downy mildew of garpe (Plasmopara viticola)
For the examination grape variety
" huge peak ", grape is potted plant to be cultured to two open and flat phases of few leaf in the greenhouse.
The experimental concentration design
The experimental concentration of combination medicament and the agent of iprovalicarb list is five concentration of 20,10,5,2.5,1.25 μ g/ml, and cyanogen frost azoles concentration of treatment is 40,20,10,5,2.5 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Select second true leaf of the grape pot of growth neat and consistent, cutting the back puts to culture dish at petiole place humidification cotton balls, by the processing of on the crop sprayer, spraying of top set concentration, treat that the blade soup dries the back in second day inoculation downy mildew of garpe germ, places then in the crop cultivation case and cultivates.
Condition of culture
Cultivation temperature: 28 ℃ of daytimes, 23 ℃ of nights.Incubation time: 6 days.
Investigation and method of counting
In incubator, preserve moisture and cultivate 6 days " Invest, Then Investigate " control efficiency,, calculate control efficiency with disease index, and obtain virulence regression equation and EC by the grade scale classification record of medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals field trial criterion "
50,, calculate interactional ratio behind two single agent compositions (be that SR＜0.5 is antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) according to Wadley bactericide mixture synergy evaluation assessment.
Result of the test sees the following form 8.
The joint toxicity measuring result of table 8 iprovalicarb and cyanogen frost azoles
Result of the test shows; Iprovalicarb and cyanogen frost azoles weight ratio are 2: 3 o'clock, and its interaction ratio is respectively 1.92, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
Though above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (6)
1. bactericidal composition is characterized in that containing the iprovalicarb and the arbitrary fungicide active ingredient that is selected from thiophanate-methyl, dimethomorph, white urea cyanogen, tmtd, mancozeb, tpn, Carbatene and cyanogen frost azoles of synergy effective dose.
2. according to the bactericidal composition of claim 1, it is characterized in that the iprovalicarb and the weight ratio of the arbitrary fungicide active ingredient that is selected from thiophanate-methyl, dimethomorph, white urea cyanogen, tmtd, mancozeb, tpn, Carbatene and cyanogen frost azoles be preferably 40: 1～1: 40.
3. according to the bactericidal composition of claim 1-2, it is characterized in that the iprovalicarb and the weight ratio of the arbitrary fungicide active ingredient that is selected from thiophanate-methyl, dimethomorph, white urea cyanogen, tmtd, mancozeb, tpn, Carbatene and cyanogen frost azoles be preferably 10: 1～1: 15.
4. according to the bactericidal composition of claim 1-3, the weight ratio that it is characterized in that iprovalicarb and thiophanate-methyl more preferably 1: 8-1: 12; The weight ratio of iprovalicarb and dimethomorph more preferably 1: 1-1: 8; The weight ratio of iprovalicarb and white urea cyanogen or cyanogen frost azoles more preferably 3: 1-1: 3; The weight ratio of iprovalicarb and tmtd, mancozeb, tpn or Carbatene more preferably 1: 5-1: 15.
5. missible oil, microemulsion, aqueous emulsion, suspending agent, wetting powder, water dispersible granules or the granule formulated according to the described bactericidal composition of arbitrary claim of claim 1-4.
6. be used to prevent and treat the purposes of the downy mildew, eqpidemic disease and the late blight that cause by the Oomycete disease fungus according to the described bactericidal composition of arbitrary claim of claim 1-4.
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| CN1228918A (en) * | 1998-12-16 | 1999-09-22 | 余永功 | Diethofencarb and chlorothalonil compound agent |
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| CN102845442A (en) * | 2012-10-15 | 2013-01-02 | 吴治国 | Bactericidal composition containing polyoxins and iprovalicarb |
| CN105265456A (en) * | 2014-07-02 | 2016-01-27 | 江苏龙灯化学有限公司 | Bactericidal composition |
| CN105265456B (en) * | 2014-07-02 | 2018-03-20 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
| CN104738061A (en) * | 2015-03-31 | 2015-07-01 | 陕西康禾立丰生物科技药业有限公司 | Iprovalicarb single dosage and pesticide composition |
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