CN101433199A - Bactericidal composition - Google Patents
Bactericidal composition Download PDFInfo
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- CN101433199A CN101433199A CNA2007101773844A CN200710177384A CN101433199A CN 101433199 A CN101433199 A CN 101433199A CN A2007101773844 A CNA2007101773844 A CN A2007101773844A CN 200710177384 A CN200710177384 A CN 200710177384A CN 101433199 A CN101433199 A CN 101433199A
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- enestroburin
- tpn
- bactericidal composition
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Abstract
The invention discloses a bactericidal composition. The weight portion ratio of enostrobilurin to chlorothalonil based on active constituents in the composition is between 1 to 15 and 15 to 1. The composition can be prepared into preparation formulations such as missible oil, suspending agents, (aqueous) emulsion, wettable powder, (water dispersible) granules and so on. The composition contains at least two carriers, wherein at least one carrier is a surfactant. Application occasions of the product prepared by the composition and the carriers are farmlands, orchards or warehouses and so on, and the product is used for controlling various plant diseases of grain, vegetable, fruit trees, lawns, tropical crops and so on, such as watermelon anthracnose, cucumber downy mildew, wheat powdery mildew, tomato early blight, potato late blight and so on.
Description
Technical field
The invention belongs to the disinfectant use in agriculture field, relate to a kind of bactericidal composition that contains Enestroburin and tpn particularly.
Background technology
Enestroburin all has the better prevention effect by Shenyang Chemical Engineering Inst's exploitation and production to the plurality of plant diseases on the crops such as cereal, fruit tree, vegetables.Its fungicidal spectrum is wide, active high, has prevention and therapeutic action and with environmental organism good compatibility is arranged.To good control efficiency being arranged by fungus-caused plurality of plant diseases such as mastigomycetes, zygomycete, sac fungis.This compound is open in CN1191670A.Enestroburin is the mitochondrial respiratory inhibitor, and it is very single to suppress mitochondrial electronics transfer function site, and germ produces adaptive variation to medicament easily, the preventive effect of medicament is reduced even invalid, and this type of medicament is existing drug-fast relevant report in Europe.
Summary of the invention
For fear of the resistance of using the agent of Enestroburin list to bring take place, degradation problem under the drug effect, inventor of the present invention is devoted to develop a kind of new dual-active component bactericidal composition that contains Enestroburin, to realize purpose of the present invention.
The technical scheme that the present invention proposes is as follows:
A kind of bactericidal composition, active component is Enestroburin and tpn, the ratio of weight and number in the composition between Enestroburin and the tpn is 1:15 to 15:1; Comparatively optimized technical scheme is, the ratio of two active components is 1: 5 to 5: 1.
Enestroburin belongs to methoxy acrylic bactericide, novel structure, mode of action uniqueness.The chemical name of Enestroburin is: 3-methoxyl group-2-[2-((((1-methyl-3-(4-chlorphenyl)-2-acrylic fork) amino) oxygen)-methyl) phenyl] methyl acrylate, and structural formula is as follows:
Tpn is a kind of fragrant same clan wide-spectrum bactericide, and the fungal disease of various crop is had prevention effect.The chemical name of tpn is: tetrachloro-1, and 3-benzene dicarbonitrile (chlorothalonil), structural formula is as follows:
Tpn can be had an effect with the glyceraldehyde 3-phosphate dehydro-genase among the fungal cell, and with the combined with protein that contains cysteine in this enzyme body, the vigor of destructive enzyme is damaged and loss of life power fungal cell's metabolism.The main effect of tpn is to prevent that plant is subjected to the infringement of fungi.Tpn has good tackness at plant surface, is not subject to rainwater etc. and washes away, and therefore has the long lasting period.Under conventional amount used, the general lasting period is about 7～10 days.Can prevent and treat black spot of cabbage, downy mildew, Kidney bean rust, gray mold and anthracnose, celery leaf spot, horse bell blind late blight, early blight and gray mold, early blight of tomato, late blight, leaf mold, spot blight, plant diseases such as pimento anthracnose, early blight show very high bactericidal activity in actual use.
Because Enestroburin possesses different structure types and different mechanism of action with tpn two class medicaments, the two composite can generation and develop delaying the pathogen pesticide resistance to a greater extent.Have now found that the use that is mixed of Enestroburin and tpn has very obvious synergistic effect, have significance to improve, and can enlarge fungicidal spectrum, delay the drug-fast generation of pathogen the control efficiency of corps diseases.
The amount of application of compound also depended on the ratio of a kind of compound and another kind of compound and the degree of synergistic effect when the content of active component depended on independent the use in the present composition.As required, the total weight percentage of active component can be between 0.5% to 95% in the composition; Comparatively preferred, the total weight percentage of active component is 5% to 80%.
Composition of the present invention has three advantages: the one, and composition shows fabulous synergistic effect in certain ratio range, mixed composition has obviously improved bactericidal effect than its single agent, thereby reduced using dosage, when reducing peasant's drug cost, reduced influence degree.The 2nd, enlarged fungicidal spectrum, the medicament characteristic also obtains extremely strong mutual supplement with each other's advantages, and a kind of medicament can be prevented and treated the various crop disease simultaneously, and a kind of means of prevention extremely easily and effectively is provided.The powdery mildew of various plants such as cereal, vegetables, fruit, lawn and tropical crop, gray mold, anthracnose, downy mildew, early blight, late blight, leaf spot etc. all there is good control efficiency.The 3rd, the application of said composition, the resistance that can delay single agent takes place and development, and interracial structure differs bigger, does not have cross resistance.
Composition of the present invention can be mixed with missible oil, suspending agent, (water) emulsion, wetting powder, (aqueous dispersion) granula etc., and these preparations can be prepared by method in common.At least comprise two kinds of carriers in the composition of the present invention, carrier can be solid or liquid, and any carrier that is generally used for preparing microbicide compositions all can use.At least a carrier is a surfactant in the composition of the present invention, for example can be emulsifier, dispersant or wetting agent etc.Surfactant is commercially available, and its selection is that those skilled in the art are known, for example, and lauryl sodium sulfate, Teepol, neopelex, polyoxyethylene fatty acid fat, polyoxyethylene aliphatic alcohol ether or polyoxyethylene fatty amine etc.
The product that the present invention describes both can the finished product preparation form provide, be that each material mixes in the composition.Simultaneously, the composition of composition also separately the form of preparation directly mixing in bucket (jar) before using is provided.Concentrate of the present invention mixes the concentration that obtains required active substance usually with water.
The place of using of the product that the present composition and carrier are made is farmland, orchard or warehouse etc.Composition of the present invention can be used for preventing and treating the disease of various plants: cereal such as wheat, paddy rice, vegetables such as cucumber, capsicum, pimento, eggplant, Chinese cabbage, potato, fruit such as watermelon, tomato, banana, apple, pears, strawberry, grape, and peanut, flowers, traditional Chinese medicine, lawn etc.Therefore comprised that also said composition is used for the purposes of controlling plant diseases as bactericide in the technical scheme of the present invention.
Composition of the present invention can be used by common method, as cast, injection, spraying, dusting, scatter or be fuming.Its amount of application changes to some extent with weather condition or crop state, and the period of using can be before or after crop be susceptible.The duration of protective effect is usually relevant with the content of individualized compound in the composition, also relevant with extraneous factor, weather for example, but by using suitable formulation can slow down climatic influences.
Embodiment
The present invention is elaborated with following instantiation, so that advantage of the present invention is more obvious, but the present invention is limited to these examples absolutely not.Percentage all is weight percentage in the prescription of all preparations, and the treatment dosage of biologically-active moiety is active constituent content.
Formulation examples
1, the preparation of missible oil
By the prescription requirement, add solvent, former medicine, emulsifier respectively, mix, use the hot bath heating for dissolving in case of necessity, promptly obtain transparence missible oil.
Example 1 10% missible oil
Enestroburin 8%, tpn 2%, farming breast 500
#7.5%, agricultural newborn 600-2
#4.5%, methyl alcohol 8%, dimethylbenzene complements to 100%.
Example 2 24% missible oil
Enestroburin 4%, tpn 20%, farming breast 507
#10%, agricultural newborn 0201B 7%, dimethyl formamide 12%, dimethylbenzene complements to 100%.
2, the preparation of wetting powder
By the prescription requirement, former medicine, various auxiliary agent and filler etc. are fully mixed, after ultrafine crusher is pulverized, promptly obtain converted products.
Example 3 20% wetting powders
Enestroburin 10%, tpn 10%, lauryl sodium sulfate 1.5%, carboxymethyl cellulose 1%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%.
Example 4 72% wetting powders
Enestroburin 60%, tpn 12%, lauryl alcohol polyethylene glycol oxide base ether sulfonic acid sodium 1.5%, carboxymethyl cellulose 1.0%, white carbon black 7%, dibutyl naphthalene sulfonic acid-formaldehyde condensation product 8%, precipitated calcium carbonate complements to 100%.
3, the preparation of water dispersible granules
Former medicine and powder carrier, wetting spreader-sticker and binding agent etc. are mixed pulverizing, after adding water again and mediating, add in the comminutor that the certain specification screen cloth is housed and carry out granulation.And then drying, screening (pressing the screen cloth scope), promptly get granular product.
Example 5 50% water dispersible granules
Enestroburin 30%, tpn 20%, methyl naphthalene sulfonate formaldehyde condensate 12%, epoxidized polyether 5%, soluble starch 15%, gypsum complements to 100%.
4, the preparation of suspending agent
By the prescription requirement, be medium with water, former medicine, dispersant, suspending agent and antifreezing agent etc. are added in the sand milling still, carry out porphyrize, make suspending agent.
Example 6 40% suspending agents
Enestroburin 15%, tpn 25%, calcium lignosulfonate 5%, white carbon black 0.3%, ethylene glycol 4%, defoamer a little, water complements to 100%.
Example 7 7% suspending agents
Enestroburin 2%, tpn 5%, methanonaphthalene sodium sulfonate 3.5%, agricultural newborn 0201B3%, white carbon black 0.2%, xanthans 0.1%, ethylene glycol 4%, water complements to 100%.
The biologically active example
1. greenhouse pot culture biologically active
The potted plant determination method of seedling is adopted in test.Trial crops was cultured to for 2～3 leaf phases in the greenhouse.Carrying out foliar spray by design dosage on the crop sprayer handles.Inoculation in 24 hours is for the examination pathogen after the chemicals treatment.Postvaccinal test material is positioned over the cultivation of preserving moisture in the phytotron.Carry out result's investigation when the blank of not dispenser is fully fallen ill, disease classification, preventive effect computational methods are all with reference to State Standard of the People's Republic of China " pesticide field efficacy medicine test criterion ".Result of the test shows, the microbicide compositions of Enestroburin and tpn, and to having very excellent control efficiency for the examination target, the potted plant biologically active of mixture all has obvious synergistic effect apparently higher than the single agent of contrast, and result of the test sees example 8,9 for details.
Example 8 wheat powdery mildews (Blumeria graminis)
Example 9 gray molds of cucumber (Botrytis cinerea)
2. sub-district, field control efficiency
Test is carried out under the natural conditions of field, according to the routine requirement of agricultural production trial crops is carried out cultivation management.The reagent agent of field plot trial is all established 3 dosage, and other establishes the blank of not dispenser agent, 4 repetitions.Insecticide-applying way is a blade spraying, and spraying equipment is a knapsack hand sprayer.All small plot experiments are natural occurrence, carry out result's investigation when the blank of not dispenser is fully fallen ill, and the result sees example 7～12 for details.Disease classification, preventive effect computational methods are all carried out State Standard of the People's Republic of China's " pesticide field efficacy medicine test criterion ".
Example 10 watermelon anthraxes (Colletotrichum lagenarium)
Example 11 cucumber downy mildews (Pseudoperonosporacubensis)
Example 12 earlys blight of tomato (Alternariasolani)
Example 13 potato late blight (Phytophthora infestans)
Example 14 careless mould powdery mildews (Sphaerotheca macularis)
Example 15 cercospora brown spots of peanut (Cercospora arachidicola)
Claims (5)
1, a kind of bactericidal composition, active component is Enestroburin and tpn, the ratio of weight and number in the composition between Enestroburin and the tpn is 1:15 to 15:1.
2, bactericidal composition according to claim 1 is characterized in that: the ratio of weight and number of Enestroburin and tpn is 1:5 to 5:1.
3, bactericidal composition according to claim 1 and 2 is characterized in that: the active component weight percentage in the composition is 0.5-95%.
4, bactericidal composition according to claim 3 is characterized in that: the active component weight percentage in the composition is 5-80%.
5, a kind of bactericidal composition according to claim 1 is used for the purposes of controlling plant diseases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101773844A CN101433199A (en) | 2007-11-15 | 2007-11-15 | Bactericidal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101773844A CN101433199A (en) | 2007-11-15 | 2007-11-15 | Bactericidal composition |
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| CN101433199A true CN101433199A (en) | 2009-05-20 |
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| CNA2007101773844A Pending CN101433199A (en) | 2007-11-15 | 2007-11-15 | Bactericidal composition |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953348A (en) * | 2010-10-13 | 2011-01-26 | 山东农业大学 | Thermal aerosol containing chlorothalonil and other components used for controlling plastic shed cucumber downy mildew |
| CN101999374A (en) * | 2010-10-13 | 2011-04-06 | 山东农业大学 | Hot fogging concentrate for controlling cucumber downy mildew in plastic greenhouses |
| CN102106355A (en) * | 2009-12-23 | 2011-06-29 | 中国中化股份有限公司 | Antifungal composition containing pyraoxystrobin |
| CN104170837A (en) * | 2009-12-23 | 2014-12-03 | 中国中化股份有限公司 | Antifungal composition containing pyraoxystrobin |
| CN106973898A (en) * | 2017-04-21 | 2017-07-25 | 广西南宁益土生物科技有限责任公司 | A kind of bactericidal composition |
| CN111315217A (en) * | 2017-10-31 | 2020-06-19 | 悉尼大学 | Novel polymer-coated chlorothalonil particles |
-
2007
- 2007-11-15 CN CNA2007101773844A patent/CN101433199A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106355A (en) * | 2009-12-23 | 2011-06-29 | 中国中化股份有限公司 | Antifungal composition containing pyraoxystrobin |
| CN102106355B (en) * | 2009-12-23 | 2013-02-27 | 中国中化股份有限公司 | Antifungal composition containing pyraoxystrobin |
| CN104170837A (en) * | 2009-12-23 | 2014-12-03 | 中国中化股份有限公司 | Antifungal composition containing pyraoxystrobin |
| CN104170837B (en) * | 2009-12-23 | 2016-06-29 | 沈阳中化农药化工研发有限公司 | A kind of Fungicidal composition containing pyraoxystrobin |
| CN101953348A (en) * | 2010-10-13 | 2011-01-26 | 山东农业大学 | Thermal aerosol containing chlorothalonil and other components used for controlling plastic shed cucumber downy mildew |
| CN101999374A (en) * | 2010-10-13 | 2011-04-06 | 山东农业大学 | Hot fogging concentrate for controlling cucumber downy mildew in plastic greenhouses |
| CN106973898A (en) * | 2017-04-21 | 2017-07-25 | 广西南宁益土生物科技有限责任公司 | A kind of bactericidal composition |
| CN111315217A (en) * | 2017-10-31 | 2020-06-19 | 悉尼大学 | Novel polymer-coated chlorothalonil particles |
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Effective date of registration: 20100613 Address after: 100031 Beijing, Xicheng District, the door of the revitalization of the main street, No. 28 Applicant after: Sinochem Corporation Co-applicant after: Shenyang Research Institute of Chemical Industry Address before: 100045 Beijing City 28 fuxingmennei Avenue Chemsunny World Trade Center F6-F12 Applicant before: Zhonghua Co., Ltd., China Co-applicant before: Shenyang Institute of Chemical Engineering |
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Open date: 20090520 |