CN101755793A - Fungicidal composition containing triflumizole and thiophanate-methyl - Google Patents
Fungicidal composition containing triflumizole and thiophanate-methyl Download PDFInfo
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- CN101755793A CN101755793A CN200910218526A CN200910218526A CN101755793A CN 101755793 A CN101755793 A CN 101755793A CN 200910218526 A CN200910218526 A CN 200910218526A CN 200910218526 A CN200910218526 A CN 200910218526A CN 101755793 A CN101755793 A CN 101755793A
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- thiophanate
- methyl
- bacterium azoles
- fluorine
- fluorine bacterium
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Abstract
The invention discloses a fungicidal composition, the active components of which contain triflumizole and thiophanate-methyl, wherein the weight ratio of the triflumizole and the thiophanate-methyl is 1:20 to 80:1. Additives and excipients can be added in the active components to produce wettable powder, water dispersible granule and suspending agent which are mainly used to control the powdery mildew, scab and alternaria leaf spot of crops.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains fluorine bacterium azoles and thiophanate-methyl and be used to prevent and treat powdery mildew, scab, spot defoliation.
Technical background
Fluorine bacterium azoles (triflumizole), structural formula are (E)-4-chloro-α, α, α-three fluoro-N-(1-imidazoles-1-base-α-third oxygen ethylidene) neighbour-toluidines thiophanate-methyl, molecular formula: C
15H
15N
3F
3ClO.
Fluorine bacterium azoles is by the imidazoles bactericide of Japanese Cao Da company exploitation, is sterol demethylation inhibitor, has the systemic fungicide of protection, treatment and output effect.Be applicable to wheat class, various vegetables, fruit tree and other crops, to crop safety.
Thiophanate-methyl (carbendazim) belongs to benzimidazole germicide, and chemical name is 1, and 2-pair-(3-carbethoxyl group-α-ghiourea group) benzene, molecular formula: C
12H
14N
4O
4S
2
Thiophanate-methyl is a kind of broad spectrum activity systemic fungicide, can prevent and treat the various crop disease, has interior suction, prevention and therapeutic action.It is converted into carbendazim in plant corpus, the formation of spindle influences cell division in the mitosis of interference bacterium, is used to prevent and treat crop powdery mildew, anthracnose, scab etc.
No matter be fluorine bacterium azoles or thiophanate-methyl, still other efficient germicides singlely use on a kind of disease repeatedly, and through after the regular hour, drug effect just obviously goes down, even nearly unavailable, and this phenomenon is be exactly germ has produced pesticide resistance.Drug-fast generation forces the peasant to have to increase dosage and medication number of times, has formed a kind of pernicious upgrading phenomenon so again just.After germ is subjected to the doses action of agricultural chemicals, the death that has, wherein insensitive individuality is just survived, and raise up seed, such offspring's pesticide resistance is just stronger, for preventing and treating the disease that develops immunity to drugs on the agricultural, a kind of method is to release the new component that new and existing kind do not have cross resistance, but new component development cost height, construction cycle is long, and the speed that develops immunity to drugs less than disease forever, additive method such as crop allocation adjustment etc. are difficult to play obvious effects in actual mechanical process.Adopting the agriculture chemical compounding of two kinds of different sterilization mechanisms is good methods, owing to obviously improved preventive effect, and reduced dosage, and different classes of active ingredient application point is also different, thereby has delayed the generation of disease drug resistance greatly.
Draw according to the test of pesticide effectiveness repeatedly, prescription screening report, fluorine bacterium azoles and thiophanate-methyl be composite to have good synergistic effects, has obviously improved control efficiency, is the important means of integrated control powdery mildew, scab, spot defoliation.
Do not see the report of the bactericidal composition that relevant fluorine bacterium azoles and thiophanate-methyl are composite up to now as yet.
Summary of the invention
Purpose of the present invention proposes a kind of have synergistic effect, use cost is low, preventive effect is good fluorine-containing bacterium azoles and the bactericidal composition of thiophanate-methyl.
The present invention is achieved through the following technical solutions:
The bactericidal composition of a kind of fluorine-containing bacterium azoles and thiophanate-methyl, wherein fluorine bacterium azoles and thiophanate-methyl percentage by weight are 1～20: 80～1.
The bactericidal composition of described fluorine-containing bacterium azoles and thiophanate-methyl, wherein the percentage by weight of fluorine bacterium azoles and thiophanate-methyl is 1～15: 70～10.
The bactericidal composition of described fluorine-containing bacterium azoles and thiophanate-methyl, wherein the percentage by weight of fluorine bacterium azoles and thiophanate-methyl is 5～10: 60～20.
The bactericidal composition of described fluorine-containing bacterium azoles and thiophanate-methyl can be made into wetting powder, water dispersible granules, suspending agent.
The bactericidal composition effective active component content of described fluorine-containing bacterium azoles and thiophanate-methyl is 2～80%.
When making wetting powder, composition comprises following constituent content: fluorine bacterium azoles 1～20%, thiophanate-methyl 1～80%, dispersant 3～15%, wetting agent 2～12%, filler 10～83%.
Fluorine bacterium azoles, thiophanate-methyl, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into fluorine bacterium azoles thiophanate-methyl wetting powder product.
When making water dispersible granules, composition comprises following constituent content: fluorine bacterium azoles 1～20%, thiophanate-methyl 1～80%, dispersant 3～12%, wetting agent 2～8%, disintegrant 0～8%, filler 8～83%.
Fluorine bacterium azoles, thiophanate-methyl, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes fluorine bacterium azoles thiophanate-methyl water dispersible granules product.
Comprise following constituent content when composition is made suspending agent: fluorine bacterium azoles 1～10%, thiophanate-methyl 1～50%, dispersant 3～12%, wetting agent 2～10%, defoamer 0.1～0.5%, thickener 0～2%, antifreeze 0～8%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add fluorine bacterium azoles, thiophanate-methyl, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes fluorine bacterium azoles thiophanate-methyl suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, fatty acid glyceride polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, aluminium-magnesium silicate, polyvinyl alcohol, the polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in powdery mildew, scab, the spot defoliation of control vegetables and fruit tree.
Beneficial effect of the present invention: (1) present composition effective active composition fluorine bacterium azoles and thiophanate-methyl belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict; (2) present composition within the specific limits the antagonism disease have good synergistic effect, preventive effect is higher than single agent, dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.By Toxicity Determination, the synergy ratio after clear and definite two kinds of medicaments are composite by a certain percentage on this basis, carries out field trial more earlier.
Implementation of an application example one the implementation of Formulation Example
Embodiment 1 80% fluorine bacterium azoles thiophanate-methyl wetting powder
Fluorine bacterium azoles 20%, thiophanate-methyl 60%, alkyl benzene sulfonate calcium salt 2%, alkylphenol-polyethenoxy are phonetic 2%, lauryl sodium sulfate 2%, moistening bleeding agent F 2%, white carbon 12%, mixture carries out comminution by gas stream, makes 80% fluorine bacterium azoles thiophanate-methyl wetting powder.
Embodiment 2 60% fluorine bacterium azoles thiophanate-methyl wetting powders
Fluorine bacterium azoles 10%, thiophanate-methyl 50%, polycarboxylate 4%, spaonin powder 4%, white carbon 10%, kaolin 22%, mixture carries out comminution by gas stream, makes 60% fluorine bacterium azoles thiophanate-methyl wetting powder.
Embodiment 3 34% fluorine bacterium azoles thiophanate-methyl wetting powders
Fluorine bacterium azoles 4%, thiophanate-methyl 30%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, Nekal BX 4%, white carbon 15%, bentonite 42%, mixture carries out comminution by gas stream, makes 34% fluorine bacterium azoles thiophanate-methyl wetting powder.
Embodiment 4 75% fluorine bacterium azoles thiophanate-methyl water dispersible granules
Fluorine bacterium azoles 10%, thiophanate-methyl 65%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, starch 13%, the mixed 75% fluorine bacterium azoles thiophanate-methyl water dispersible granules that gets.
Embodiment 5 68% fluorine bacterium azoles thiophanate-methyl water dispersible granules
Fluorine bacterium azoles 8%, thiophanate-methyl 60%, the phonetic formaldehyde condensation products sulphate 7% of alkylphenol-polyethenoxy, wetting and penetrating agent F 4%, urea 3%, starch 18%, the mixed 68% fluorine bacterium azoles thiophanate-methyl water dispersible granules that gets.
Embodiment 6 40% fluorine bacterium azoles thiophanate-methyl water dispersible granules
Fluorine bacterium azoles 5%, thiophanate-methyl 35%, polyoxyethylene carboxylate 5%, soapberry powder 4%, succinic acid 2%, ammonium sulfate 2%, starch 47%, the mixed 40% fluorine bacterium azoles thiophanate-methyl water dispersible granules that gets.
Embodiment 7 50% fluorine bacterium azoles thiophanate-methyl suspending agents
Fluorine bacterium azoles 6%, thiophanate-methyl 44%, polycarboxylate 2%, aliphatic amine polyoxyethylene are phonetic 4%, DBSA 4%, silicone oil 0.1%, polyvinyl alcohol 0.2%, and deionized water adds to 100%, mixed 50% fluorine bacterium azoles thiophanate-methyl suspending agent.
Embodiment 8 25% fluorine bacterium azoles thiophanate-methyl suspending agents
Fluorine bacterium azoles 3%, thiophanate-methyl 22%, fatty acid glyceride polyoxyethylene are phonetic 5%, Nekal BX 4%, silicone compound 0.1%, aluminium-magnesium silicate 0.5%, ethylene glycol 2%, deionized water add to 100%, mixed 25% fluorine bacterium azoles thiophanate-methyl suspending agent.
Embodiment 9 10% fluorine bacterium azoles thiophanate-methyl suspending agents
Fluorine bacterium azoles 1%, thiophanate-methyl 9%, aliphatic amine polyoxyethylene are phonetic 4%, silkworm excrement 4%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mixed 10% fluorine bacterium azoles thiophanate-methyl suspending agent.
Implementation of an application example difluoro bacterium azoles and thiophanate-methyl are mixed to the wheat powdery mildew Toxicity Determination
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
Test medicine is provided with 5 dose concentrations respectively to be handled, if there is not the medicine contrast, each concentration is handled and is repeated 4 times, carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", in culturing room, evenly shake off to receive on the cultured wheat seedling with the fresh spore of white powder germ on the wheat seedling of inoculation in advance and fully morbidity.Treat wheat powdery mildew germ their early stage, handle with the medicine liquid spray of above-mentioned concentration.Every processing repeats 4 times, 2 glasss of every repetitions, 4 every glass, put into 20 ℃, 16L:8D cultivates in the illumination box of 60% relative moisture, the incidence of routine observation inoculation blade and newborn blade, after treating that control treatment was fully fallen ill about 8-10 days, begin to put down in writing an incidence of handling, and calculate disease index and protection effect thereof.Concentration-preventive effect is converted into corresponding logarithm-probit value, obtains virulence regression equation, calculate EC
50Value.
Computing formula is as follows:
Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.
Wherein: a, b are respectively fluorine bacterium azoles and thiophanate-methyl shared ratio in combination
A is a fluorine bacterium azoles;
B is a thiophanate-methyl;
Result of the test is as shown in the table:
Table 1 fluorine bacterium azoles, thiophanate-methyl and composite to the wheat powdery mildew toxicity test
As shown in Table 1, fluorine bacterium azoles and thiophanate-methyl are composite to the wheat powdery mildew toxicity test, fluorine bacterium azoles virulence is higher than the thiophanate-methyl virulence, its proportioning is that 1: 1,1: 4,1: 7,1: 10,1: 13 o'clock synergy ratio is respectively 1.53,1.94,2.23,1.81,1.51, all show as synergistic effect, so fluorine bacterium azoles and thiophanate-methyl ratio had synergistic effect between 1: 13 the time at 1: 1, synergy ratio maximum can be used as best proportioning when fluorine bacterium azoles and thiophanate-methyl ratio are 1: 7.
Implementation of an application example trifluoro bacterium azoles, thiophanate-methyl and the composite powdery mildew of cucumber field efficacy of preventing and treating thereof
This experimental establishment is in the Pucheng County, Shaanxi Province, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, observes disease index behind the last medicine after 7 days, 14 days and calculates preventive effect.Result of the test is as follows:
Table 2 fluorine bacterium azoles, thiophanate-methyl and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | The preparation consumption | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine |
| Embodiment 1 | 28 gram/mus | ??90.44 | ??94.03 |
| Embodiment 6 | 65 gram/mus | ??91.36 | ??95.28 |
| Embodiment 8 | 110 gram/mus | ??92.72 | ??95.62 |
| 30% triflumizole wettable powder | 18 gram/mus | ??80.29 | ??82.74 |
| 50% thiophanate-methyl wetting powder | 70 gram/mus | ??64.13 | ??70.25 |
Result of the test shows, can effectively prevent and treat the generation of powdery mildew of cucumber after fluorine bacterium azoles and thiophanate-methyl are composite, and preventive effect is better than contrasting single agent, and dosage is little, the test scope of medication in to crop safety.
Implementation of an application example tetrafluoro bacterium azoles, thiophanate-methyl and the composite pear scab field trial of preventing and treating thereof
This experimental establishment is closed the town at the county town, Pucheng, test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and in the their early stage dispenser, dispenser in per 10 days once is total to dispenser 3 times, checks disease index and calculates preventive effect in 7 days, 20 days behind the last medicine.Result of the test is as follows:
Table 3 fluorine bacterium azoles, thiophanate-methyl and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine |
| Embodiment 2 | 2000 times | ??90.72 | ??96.74 |
| Embodiment 4 | 3000 times | ??95.42 | ??98.27 |
| Embodiment 9 | 400 times | ??93.08 | ??97.22 |
| 30% triflumizole wettable powder | 3000 times | ??80.77 | ??88.85 |
| 70% thiophanate-methyl wetting powder | 500 times | ??63.67 | ??70.45 |
Result of the test shows that the composite back of fluorine bacterium azoles and thiophanate-methyl has obvious synergistic effect to the control of pear scab, and preventive effect obviously is better than contrasting single agent, has quick-acting and long-acting advantage, crop safety in this experimental drug scope.
Implementation of an application example five fluorine bacterium azoles, thiophanate-methyl and the test of composite control alternaria leaf spot of apple thereof
This experimental establishment is at Shaanxi Province's Luochuan County, test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., begins dispenser in the alternaria leaf spot of apple their early stage, and dispenser in per seven days once, dispenser is 5 times altogether, checks disease index and calculates preventive effect in 7 days, 30 days behind the last medicine.Result of the test is as follows:
Table 4 fluorine bacterium azoles, thiophanate-methyl and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| Embodiment 3 | 1200 times | ??93.44 | ??93.00 |
| Embodiment 5 | 2500 times | ??95.29 | ??94.28 |
| Embodiment 7 | 2000 times | ??95.95 | ??96.72 |
| 30% triflumizole wettable powder | 2500 times | ??83.55 | ??88.74 |
| 70% thiophanate-methyl wetting powder | 400 times | ??70.13 | ??73.06 |
Result of the test shows that the composite back of fluorine bacterium azoles and thiophanate-methyl has obvious synergistic effect to the control of alternaria leaf spot of apple, and preventive effect all is better than contrasting single agent, has quick-acting and long-acting advantage, crop safety in this experimental drug scope.
Claims (6)
1. the bactericidal composition of a fluorine-containing bacterium azoles, its effective active composition contains fluorine bacterium azoles and thiophanate-methyl, and wherein the percentage by weight of fluorine bacterium azoles and thiophanate-methyl is 1～20: 80～1.
2. the bactericidal composition of fluorine-containing bacterium azoles according to claim 1 and thiophanate-methyl is characterized in that: the percentage by weight of fluorine bacterium azoles and thiophanate-methyl is 1～15: 70～10.
3. the bactericidal composition of fluorine-containing bacterium azoles according to claim 2 and thiophanate-methyl is characterized in that: the percentage by weight of fluorine bacterium azoles and thiophanate-methyl is 5～10: 60～20.
4. the bactericidal composition according to described fluorine-containing bacterium azoles of claim 1 to 3 and thiophanate-methyl can be made into wetting powder, water dispersible granules, suspending agent.
5. the bactericidal composition effective active component content of fluorine-containing bacterium azoles according to claim 4 and thiophanate-methyl is 2～80%.
6. the bactericidal composition according to described fluorine-containing bacterium azoles of claim 1 to 5 and thiophanate-methyl is mainly used in control crop powdery mildew, scab, spot defoliation.
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|---|---|---|---|
| CN200910218526A CN101755793A (en) | 2009-10-26 | 2009-10-26 | Fungicidal composition containing triflumizole and thiophanate-methyl |
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Application publication date: 20100630 |