CN101745093A - Medicine for quickly treating infantile chronic diarrhea - Google Patents
Medicine for quickly treating infantile chronic diarrhea Download PDFInfo
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- CN101745093A CN101745093A CN201010114429A CN201010114429A CN101745093A CN 101745093 A CN101745093 A CN 101745093A CN 201010114429 A CN201010114429 A CN 201010114429A CN 201010114429 A CN201010114429 A CN 201010114429A CN 101745093 A CN101745093 A CN 101745093A
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Abstract
The invention discloses a medicine for quickly treating infantile chronic diarrhea, which is prepared by decocting and extracting a certain weight ratio of gizzard pepsin, Chinese yam, euryale seed, hawthorn, cassia, dark plum, white hyacinth bean, amomun fruit and dried ginger which are used as raw materials. The medicine of the invention can be prepared into any one of common oral formulations, has the functions of strengthening the spleen, tonifying qi, promoting digestion, relieving diarrhea and the like, has reliable effect on treating the infantile chronic diarrhea and the like, and has quick curative effect and no toxic side effect.
Description
Technical field
The present invention relates to a kind of medicine of quick treatment infantile chronic diarrhea, particularly relate to a kind of with botanical herbs and all be that the Chinese medicine of medicine-food two-purpose is the medicine of the treatment infantile chronic diarrhea made of raw material.
Background technology
Infantile diarrhea is one of modal disease of China's department of pediatrics, and chronic diarrhea is the most difficult type of treatment in the infantile diarrhea disease.Due to illness journey is more than two months, and complication is more, cures difficulty, has a strong impact on its normal development.In the last few years, owing to diet collocation unreasonable, the many reasons such as snacks too much, hypokinesia of the head of a family to the child, digestive functional disturbance person was increasing, had become the disease that influences child's health.More used medicine usually based on Western medicine, belongs to symptomatic treatment, and certain side effect is arranged at present, should not take for a long time, and preparation of the present invention can be taken for a long time, prolongs Time of Administration for the slow person that takes effect and can improve cure rate.
In the medicine of treatment infantile chronic diarrhea, although some herbal species are arranged, some Chinese patent medicine has some side effect, should not take for a long time.In the Western medicine of many treatment infantile chronic diarrheaes, toxic and side effects is in various degree arranged all.
Confirm that through clinical observation this invention medicine has the good curing effect equally to the diarrhoea of initiations such as rotavirus, antibacterial.
This medicine also can be treated adult's chronic diarrhea, has good effect equally.
Inventing that a kind of to have curative effect reliable and do not have toxic and side effects, combined treatment of infantile chronic diarrhea that the medicine that improves immunologic function is arranged, is inventor's purpose.Make a general survey of Chinese medicine and western medicine market, use all is that such medicine of medicine-food two-purpose medicament composing prescription still belongs to blank.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of infantile chronic diarrhea.With traditional determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is criterion, spleen invigorating is held concurrently with QI invigorating, the stomach function regulating assistant is with antidiarrheal, monarch is clearly demarcated, and it is apt to fill a prescription, and dialectically combines with differential diagnosis of diseases, Chinese and Western medicine is closed ginseng, used medicine all proves that it is aid digestion, ends the produce effects and the reliability of chronic diarrhea through the relevant pharmacological evaluation of modern medicine, and every herbal medicine all points out and do not have toxic and side effects, is the good medicine of a kind of combined treatment of infantile dyspepsia and chronic diarrhea.
The present invention realizes with following technical scheme.A kind of medicine for the treatment of infantile chronic diarrhea is characterized in that it is to make with conventional preparation method with the raw material of following weight parts: Endothelium Corneum Gigeriae Galli 6-30 part, Rhizoma Dioscoreae 10-30 part, Semen Euryales 6-24 part, Fructus Crataegi 10-30 part, Cortex Cinnamomi 10-20 part, Fructus Mume 6-30 part, Semen Lablab Album 10-30 part, Fructus Amomi 6-20 part, Rhizoma Zingiberis 10-30 part.
Above-mentioned raw materials medicine and consumption prescription are the inventors just to be drawn with how tame medical institutions associating clinical trials through nearly 30 years, all had significant curative effect in above-mentioned amount ranges.
Medicament selection Endothelium Corneum Gigeriae Galli of the present invention, Rhizoma Dioscoreae, Semen Euryales, Fructus Crataegi, Cortex Cinnamomi, Fructus Mume, Semen Lablab Album, Fructus Amomi, Rhizoma Zingiberis carry out compatibility, and each efficacy of drugs produces synergism, thereby reach the curative effect of invigorating the spleen and regulating the stomach, warming middle-JIAO to stop diarrhea.Endothelium Corneum Gigeriae Galli promotes gastric secretion in the side, facilitating digestion, and gastric peristalsis is strengthened; The Rhizoma Dioscoreae invigorating the spleen and benefiting QI, aid digestion, end chronic diarrhea; Semen Euryales spleen invigorating astringing intestine to stop diarrhea, eliminating dampness to stop diarrhea has original effect for chronic diarrhea; The Fructus Crataegi invigorating the spleen and benefiting QI, aid digestion, end chronic diarrhea; The spleen invigorating of Cortex Cinnamomi stomach warming has functions such as antiulcer, inhibition chronic diarrhea; The Fructus Mume astringing intestine to stop diarrhea of astringing the lung, anti-bacteria and anti-virus, treatment infantile chronic diarrhea effect is remarkable; The Semen Lablab Album invigorating the spleen and benefiting QI, eliminating dampness to stop diarrhea, anti-bacteria and anti-virus, enhance immunity etc.; Fructus Amomi is warming spleen and stopping diarrha, regulating QI to relieve pain, and facilitating digestion, and the rising motilin etc.; The spleen invigorating of Rhizoma Zingiberis stomach warming, antidiarrheal is unsting.
The pharmacological action of said medicine all has relevant pharmacological research, animal experiment and the effective conclusion of our clinical observation.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to make dosage form for oral administration.Medicine of the present invention can be ground into crude drug in powder and be mixed into powder, electuary, granule, oral liquid.Can get active ingredient with being condensed into decocting liquid behind each crude drug decocting, refabrication becomes various oral agents, but these do not limit protection scope of the present invention.
The present invention preferably adopts following capsule formulation and granule.
The preparation method of described medicine, carry out as follows:
(1) take by weighing raw material in proportion, standby;
(2) Endothelium Corneum Gigeriae Galli, Rhizoma Dioscoreae, Semen Euryales, Fructus Crataegi, Cortex Cinnamomi, Fructus Mume, Semen Lablab Album, Fructus Amomi, the Rhizoma Zingiberis 9 flavor medicines with described weight ratio decoct with water 5 times, merge decocting liquid then 5 times;
(3) step (2) gained decocting liquid is condensed into extractum;
(4) extractum is dried dry extract;
(5) pulverize the dry extract powdering;
(6) after 110 ℃ keep 10 minutes down, reduce to 105 ℃ and kept 5 minutes, and then be cooled to 100 ℃, kept 5 minutes, be cooled to room temperature;
(7) incapsulate.
Each amount of water of described step (2) was not advisable to have powder, decocted 30 minutes at every turn.
Described step (5) gained medicated powder and tablet adjuvant commonly used is mixed, make granule.
Medicine of the present invention shows that through clinical use result following advantage is arranged:
1, to select the natural edible-plant medicine for use be raw material in the present invention, and each component meets Medicine Act regulation and tcm prescription principle, gives prominence to the basic characteristic that Chinese medical discrimination combines with the doctor trained in Western medicine differential diagnosis of diseases, etiological treatment combines with symptomatic treatment.
2, medicine of the present invention need not decoct, good mouthfeel, and taking convenience, all nontoxic before and after each herbal medicine prescription, normal dose is taken and is not found any side effect.
3, medicine of the present invention not only has excellent curative to infantile chronic diarrhea, and good facilitating digestion and functions of prevention and health care are also arranged, and the scope of application is extensive.
4, all selected but safety is higher in the kind of Ministry of Public Health regulation medicine-food two-purpose for medicine of the present invention, and treatment infantile dyspepsia and chronic chronic diarrhea can be taken for a long time, have reliable health-care effect.
5, medicine of the present invention has the good property taken into account, and to symptoms such as child's infantile dyspepsia, inappetence, tired anorexia, has certain therapeutical effect of taking into account.
6, medicine treating both the principal and secondary aspects of a disease of the present invention takes effect rapidly the cure rate height.
The specific embodiment
Add up the effect that further specifies medicine of the present invention below in conjunction with embodiment and clinical practice.
Embodiment 1: the capsule preparation
Endothelium Corneum Gigeriae Galli 12kg, Rhizoma Dioscoreae 24kg, Semen Euryales 15kg, Fructus Crataegi 24kg, Cortex Cinnamomi 10kg, Fructus Mume 24kg, Semen Lablab Album 24kg, Fructus Amomi 12kg, Rhizoma Zingiberis 18kg add the common decoction of water 5 times, add water at every turn and are not advisable to have powder, decoct 30 minutes at every turn, merge 5 times decocting liquid; Decocting liquid by conventional alcohol extraction, is condensed into extractum; Extractum is put into drying baker oven dry back pulverizing be fine powder, and carry out conventional high-temperature sterilization; Fine powder is incapsulated every medicated powder 0.45g.
Embodiment 2: the granule preparation
Endothelium Corneum Gigeriae Galli 10kg, Rhizoma Dioscoreae 22kg, Semen Euryales 15kg, Fructus Crataegi 22kg, Cortex Cinnamomi 10kg, Fructus Mume 22kg, Semen Lablab Album 20kg, Fructus Amomi 10kg, Rhizoma Zingiberis 15kg, make medicated powder with embodiment 1 described method, be aided with tablet adjuvant commonly used again and make dissolved granule or tablet, every bag of 2g of dissolved granule.
Clinical drug of the present invention is observed
One, ordinary circumstance and test method
For confirming the clinical efficacy of medicine of the present invention, in in April, 2009-2009 year December, treat 130 examples from Pediatric Clinic chronic diarrhea infant, its diagnosis all meets Chinese diarrhoeal diseases diagnoses and treatment scheme standard (Fang Hesong, Wei Chengyu, Duan Shucheng, etc. Chinese diarrhoeal diseases diagnoses and treatment scheme. Chinese practical department of pediatrics magazine, 1998,3 (6): 381).Adopt double-blind method 130 routine infants to be divided into treatment group and matched group at random, every group 65 example.Wherein male 34 examples are organized in treatment, women 31 examples; 3.82 ± 2.15 years old mean age; Average diarrhoea number of times 5.69 ± 1.2 times/day; Average course of disease 73.92 days.Male 32 examples in the matched group, women 33 examples; Mean age 3.80 ± 1.95) year; Average diarrhoea number of times 5.32 ± 1.3 times/day; Average course of disease 75.81 days.Two groups of state of an illness and ordinary circumstance are learned processing by statistics, and difference no difference of science of statistics (P＞0.05) has comparability.The treatment group is all taken embodiment 1 medicinal granule, 2-4 every day in year 3 times, each 1 bag; Every day 3 times more than 5 years old, each 1.5 bags.Matched group adopts conventional doctor trained in Western medicine Primary Care, comprises adjusting dietary structure, correct dehydration and electrolyte disturbance, selects antibiotic or antifungal agent for use according to stool cultivation results and drug sensitive test, and gives mucosa protective agent, microbial ecological agent and the Supporting Therapy of suiting the medicine to the illness.Two groups of two weeks of treatment time were 1 course of treatment.
Two, clinical observation criterion of therapeutical effect: with reference to the standard of " Chinese diarrhoeal diseases diagnoses and treatment scheme ".Infant times of defecation character recovered normal after treatment expired for 1 course of treatment, and it is normal that digestive function and diet recover, and following up a case by regular visits to 6 months no recidivists is recovery from illness; The stool molding, number of times is reduced in average daily 2 times, and digestive function is improved as effectively; Even infant times of defecation shape does not have the obvious change person of increasing the weight of for invalid.
Three, two groups of observation of curative effect results: measurement data adopts the t check, and enumeration data adopts chi-square criterion.With P＜0.05 is that difference has statistical significance.Treatment group is as a result cured 43 examples, effective 18 examples, invalid 4 examples, cure rate 66.2%; Matched group is cured 19 examples, effective 41 examples, invalid 5 examples, cure rate 29.2%.Treatment group cure rate is better than matched group (P＜0.05).Of particular note, treatment is organized effective case and is continued the extended treatment time, and 16 examples reach criterion of cure.
Claims (7)
1. quick medicine of treatment infantile chronic diarrhea is characterized in that it is to be made by following raw medicaments in portion by weight:
Endothelium Corneum Gigeriae Galli 6-30 part Rhizoma Dioscoreae 10-30 part Semen Euryales 6-24 part
Fructus Crataegi 10-30 part, Cortex Cinnamomi 10-20 part Fructus Mume 6-30 part
Semen Lablab Album 10-30 part Fructus Amomi 6-20 part Rhizoma Zingiberis 10-30 part.
2. preparation method for preparing the described medicine of claim 1 is characterized in that it may further comprise the steps:
A) take by weighing each crude drug, standby;
B) decoct with water 5 times after Endothelium Corneum Gigeriae Galli, Rhizoma Dioscoreae, Semen Euryales, Fructus Crataegi, Cortex Cinnamomi, Fructus Mume, Semen Lablab Album, Fructus Amomi and the Rhizoma Zingiberis 9 flavor medicine water purification flushings with described weight proportion, add water at every turn and be not advisable, merge 5 times decoction liquor, filter to get filtrate 1 to have powder;
C) with filtrate with water extraction or alcohol extraction, be condensed into fluid extract, master stream extractum is made in oven dry in drying baker;
D) dry extract is broken into the active ingredient that powder must the invention medicine.
3. preparation method for preparing the described medicine of claim 1 is characterized in that it may further comprise the steps:
A) take by weighing each crude drug, standby;
B) decoct with water 5 times after Endothelium Corneum Gigeriae Galli, Rhizoma Dioscoreae, Semen Euryales, Fructus Crataegi, Cortex Cinnamomi, Fructus Mume, Semen Lablab Album, Fructus Amomi and the Rhizoma Zingiberis 9 flavor medicine water purification flushings with described weight proportion, add water at every turn and be not advisable, merge 5 times decoction liquor, filter to get filtrate 1 to have powder;
C) filtrate is suitably concentrated, handle, directly make the oral liquid of effective ingredient through corrosion-proof and sterilization.
4. preparation method according to claim 2 is characterized in that step 2d) with the effective ingredient of dry extract 110 ℃ incapsulate after the sterilization cooling in 10 minutes down capsule.
5. according to right 3 described process for preparing medicine, it is characterized in that step 3c) effective ingredient of oral liquid invention medicine is mixed with adjuvant commonly used, make oral liquid.
6. preparation method according to claim 2 is characterized in that step 2d) effective ingredient of dry extract and tablet adjuvant commonly used are mixed, tabletting becomes tablet.
7. preparation method according to claim 2 is characterized in that step 2d) effective ingredient of dry extract and granule adjuvant commonly used are mixed the acquisition granule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940858A (en) * | 2012-05-04 | 2013-02-27 | 饶帮华 | Edible traditional Chinese medicine composition and preparation method thereof |
| CN104352893A (en) * | 2014-11-07 | 2015-02-18 | 万鹏波 | Traditional Chinese medicine composition for treating chronic diarrhea |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695675A (en) * | 2005-05-19 | 2005-11-16 | 李春光 | Chinese traditional medicine for treating diarrhea of infant and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695675A (en) * | 2005-05-19 | 2005-11-16 | 李春光 | Chinese traditional medicine for treating diarrhea of infant and preparation method |
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| Title |
|---|
| 《中国中医药信息杂志》 20070228 刘丽等 小儿迁延性腹泻辨治3法 70-71 1-7 第14卷, 第2期 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940858A (en) * | 2012-05-04 | 2013-02-27 | 饶帮华 | Edible traditional Chinese medicine composition and preparation method thereof |
| CN104352893A (en) * | 2014-11-07 | 2015-02-18 | 万鹏波 | Traditional Chinese medicine composition for treating chronic diarrhea |
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