CN101745027B - Preparation method of xiaokeling condensed pill - Google Patents

Preparation method of xiaokeling condensed pill Download PDF

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Publication number
CN101745027B
CN101745027B CN 201010102678 CN201010102678A CN101745027B CN 101745027 B CN101745027 B CN 101745027B CN 201010102678 CN201010102678 CN 201010102678 CN 201010102678 A CN201010102678 A CN 201010102678A CN 101745027 B CN101745027 B CN 101745027B
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Prior art keywords
radix
poria
rhizoma coptidis
cortex moutan
gypsum fibrosum
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CN101745027A (en
Inventor
袁芝
李玲
王英
李先
吕亚敬
李晓恩
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Anguo Tianen Medicinal Products Inspection Limited
Yaodu Pharmaceutical Group Co., Ltd.
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YAODU PHARMACEUTICAL GROUP CO Ltd
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Abstract

The invention relates to a preparation method of a xiaokeling condensed pill, which is improved on the basis of the prior art of 'a xiaokeling pill and a preparation method thereof' (the application No. of which is 03124439.4). The invention has the main improvements that (1) sieving with a sieve of 310 to 350 meshes is conducted after superfine comminution; and (2) the microwave drying temperature is from 40 to 45 DEG C. The invention has the advantages that (1) due to superfine comminution, granule size is smaller after comminution so as to facilitate the absorption after administration, the effect is taken fast and the curative effect is good; and (2) due to low temperature drying, active ingredients in the medicine are retained to the maximum extent, so the energy source is saved, the cost is reduced, and the curative effect is improved.

Description

The preparation method of xiaokeling condensed pill
Technical field
The present invention relates to a kind of preparation method of xiaokeling condensed pill, belong to the preparation method of Chinese patent medicine.
Background technology
Chinese patent discloses a kind of " disappear and drink clever ball and preparation method " (application number: 03124439.4), its preparation method is to carry out form improvement on the basis of tablet, the shortcoming of above-mentioned preparation method is that baking temperature is too high, diminishes the active ingredient in the medical material; In addition, the drug powder granule through pulverizing is thicker, absorbing after being unfavorable for taking.
Summary of the invention
Technical problem to be solved by this invention provides that a kind of active constituent content is higher, rapid-action, the preparation method of eutherapeutic xiaokeling condensed pill.
The technical solution adopted for the present invention to solve the technical problems:
A kind of preparation method of xiaokeling condensed pill, its step is as follows:
(1) with Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Cortex Moutan, the Radix Astragali, Rhizoma Coptidis, Poria, Radix Ginseng Rubra, Radix Trichosanthis, Gypsum Fibrosum, Fructus Lycii ten simply medical material clean respectively, it is for subsequent use to be up to the standards;
(2) it is as follows to take by weighing the above-mentioned medicine of respectively distinguishing the flavor of by the prescription drugs requirement:
Radix Rehmanniae: 579g; Fructus Schisandrae Chinensis: 43g; Radix Ophiopogonis: 289g; Cortex Moutan: 43g; The Radix Astragali: 289g; Rhizoma Coptidis: 28.9g; Poria: 49g; Radix Ginseng Rubra: 28.9g; Radix Trichosanthis: 289g; Gypsum Fibrosum: 145g; Structure Fructus Lycii: 289g;
(3) Poria, Radix Trichosanthis, Gypsum Fibrosum, Radix Ginseng Rubra, Rhizoma Coptidis, Cortex Moutan Six-element medicine are carried out micronizing, then cross the 310-350 mesh sieve;
(4) Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, the Radix Astragali, Fructus Lycii five tastes medical material are decocted with water twice, decocted 2-4 hour for the first time, decocted 2-3 hour for the second time, the front amount of water of twice decoction is respectively 8-15 and doubly measures, merge decoction liquor, left standstill 12 hours, getting supernatant, to be evaporated to relative density be 1.10-1.40g/cm 3The clear paste of (80 ℃);
(5) powder after the sieving of above-mentioned clear paste and Poria, Radix Trichosanthis, Gypsum Fibrosum, Radix Ginseng Rubra, Rhizoma Coptidis, Cortex Moutan is mixed into concentrated pill 1000g;
(6) upper concentrated pill is carried out microwave drying, baking temperature is 40-45 ℃; Then carry out polishing, screening, packing.
Beneficial effect of the present invention:
(1) owing to adopt micronizing, the degree after the pulverizing is less, the absorption after being convenient to take, rapid-action, good effect.
(2) owing to adopt cold drying, kept to greatest extent the active ingredient in the medicine, namely saved the energy, reduced again cost, and improved curative effect.
The specific embodiment
Embodiment 1:
A kind of preparation method of xiaokeling condensed pill, its step is as follows:
(1) with Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Cortex Moutan, the Radix Astragali, Rhizoma Coptidis, Poria, Radix Ginseng Rubra, Radix Trichosanthis, Gypsum Fibrosum, Fructus Lycii ten simply medical material clean respectively, it is for subsequent use to be up to the standards;
(2) it is as follows to take by weighing the above-mentioned medicine of respectively distinguishing the flavor of by the prescription drugs requirement:
Radix Rehmanniae: 579g; Fructus Schisandrae Chinensis: 43g; Radix Ophiopogonis: 289g; Cortex Moutan: 43g; The Radix Astragali: 289g; Rhizoma Coptidis: 28.9g; Poria: 49g; Radix Ginseng Rubra: 28.9g; Radix Trichosanthis: 289g; Gypsum Fibrosum: 145g; Fructus Lycii: 289g;
(3) Poria, Radix Trichosanthis, Gypsum Fibrosum, Radix Ginseng Rubra, Rhizoma Coptidis, Cortex Moutan Six-element medicine are carried out micronizing, then cross 320 mesh sieves;
(4) Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, the Radix Astragali, Fructus Lycii five tastes medical material are decocted with water twice, decocted 2-4 hour for the first time, decocted 2-3 hour for the second time, the front amount of water of twice decoction is respectively 8-15 and doubly measures, merge decoction liquor, left standstill 12 hours, getting supernatant, to be evaporated to relative density be 1.10-1.40g/cm 3The clear paste of (80 ℃);
(5) powder after the sieving of above-mentioned clear paste and Poria, Radix Trichosanthis, Gypsum Fibrosum, Radix Ginseng Rubra, Rhizoma Coptidis, Cortex Moutan is mixed into concentrated pill 1000g;
(6) upper concentrated pill is carried out microwave drying, baking temperature is 45 ℃; Then carry out polishing, screening, packing.
Embodiment 2:
Embodiment 2 crosses 310 mesh sieves after the micronizing as different from Example 1 and the microwave drying temperature is 40 ℃.
Embodiment 3:
Embodiment 3 crosses 350 mesh sieves after the micronizing as different from Example 1 and the microwave drying temperature is 43 ℃.

Claims (1)

1. the preparation method of an xiaokeling condensed pill is characterized in that its step is as follows:
(1) with Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Cortex Moutan, the Radix Astragali, Rhizoma Coptidis, Poria, Radix Ginseng Rubra, Radix Trichosanthis, Gypsum Fibrosum, Fructus Lycii ten simply medical material clean respectively, it is for subsequent use to be up to the standards;
(2) it is as follows to take by weighing the above-mentioned medicine of respectively distinguishing the flavor of by the prescription drugs requirement:
Radix Rehmanniae: 579g; Fructus Schisandrae Chinensis: 43g; Radix Ophiopogonis: 289g; Cortex Moutan: 43g; The Radix Astragali: 289g; Rhizoma Coptidis: 28.9g; Poria: 49g; Radix Ginseng Rubra: 28.9g; Radix Trichosanthis: 289g; Gypsum Fibrosum: 145g; Fructus Lycii: 289g;
(3) Poria, Radix Trichosanthis, Gypsum Fibrosum, Radix Ginseng Rubra, Rhizoma Coptidis, Cortex Moutan Six-element medicine are carried out micronizing, then cross the 310-350 mesh sieve;
(4) Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, the Radix Astragali, Fructus Lycii five tastes medical material are decocted with water twice, decocted 2-4 hour for the first time, decocted 2-3 hour for the second time, the front amount of water of twice decoction is respectively 8-15 and doubly measures, merge decoction liquor, left standstill 12 hours, getting supernatant, to be evaporated to relative density be 1.10-1.40g/cm 3Clear paste;
(5) powder after the sieving of above-mentioned clear paste and Poria, Radix Trichosanthis, Gypsum Fibrosum, Radix Ginseng Rubra, Rhizoma Coptidis, Cortex Moutan is mixed into concentrated pill 1000g;
(6) upper concentrated pill is carried out microwave drying, baking temperature is 40-45 ℃; Then carry out polishing, screening, packing.
CN 201010102678 2010-01-29 2010-01-29 Preparation method of xiaokeling condensed pill Active CN101745027B (en)

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103432157A (en) * 2013-09-06 2013-12-11 兰州理工大学 Preparation method of concentrated pills of angelica sinensis and astragalus membranaceus polysaccharide
CN108403935A (en) * 2017-12-19 2018-08-17 宁夏多维药业有限公司 A kind of preparation method of Bushen Pills

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* Cited by examiner, † Cited by third party
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CN1456140A (en) * 2003-03-21 2003-11-19 毛友昌 Preparation of Xiaokeling granules
CN1739729A (en) * 2005-08-30 2006-03-01 郭小波 Xiaokeling prepn for treating diabetes and its prepn process

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Inventor after: Yuan Zhi

Inventor after: Li Ling

Inventor after: Wang Ying

Inventor after: Li Xian

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Inventor after: Li Xiaoen

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Free format text: CORRECT: INVENTOR; FROM: LI XIAOEN TO: YUAN ZHI LI LING WANG YING LI XIAN LV YAJING LI XIAOEN

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Owner name: ANGUO TIANEN MEDICINAL PRODUCTS INSPECTION LIMITED

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Address after: 071200 Anguo City in Hebei Province Bo Road No. 99.

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C53 Correction of patent for invention or patent application
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Inventor after: Wang Ying

Inventor after: Li Xian

Inventor after: Lv Yajing

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