CN101717693B - Artemisia frigida willd essential oil and preparation method and application thereof - Google Patents
Artemisia frigida willd essential oil and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to Artemisia frigida willd essential oil which is light yellow transparent liquid with heavy fragrance. The essential oil comprises terpene and enol and comprises the following main components by mass percent: 15-20% of dimethyl-methylene cycloheptyl, 15-20% of 3,3,6-trimethyl-1,5-heptadiene alcohol-2, 5-10% of 3,3,6-trimethyl-1,4-heptadiene alcohol-6, 3-8% of eucalyptol, 2-5% of 3,7-dimethyl-2,6-octadiene alcohol-1, 2-5% of santolina triene, 2-5% of 1-methyl-3-isopropyl benzene, 1-5% of bridged ring [2,2,1] terpene, 1-5% of camphor and 1-5% of myrcene. Meanwhile, the invention also discloses a preparation method of the essential oil, which is characterized by high extraction ratio and simple process flow. With antibacterial, inflammatory and antipruritic active components, the Artemisia frigida willd essential oil can be widely applied to pharmacy, cleaning supplies and cosmetics.
Description
Technical field
The present invention relates to an ESSENTIAL OIL, relate in particular to artemisia frigida willd essential oil, with.
Background technology
Prairie sagewort (Artemisia frigida Willd) has another name called small sievers wormwood herb, cold wormwood artemisia, is the composite family artemisia, the distinctive aromatic odour of tool artemisia.Be the medicinal material a kind of among the people that Tibetan, the Mongols use always, a Tibetan name Kan Ba, Mongolia Ah Gei by name, sweat cling to, look into dried-A Gei, sweat bundle.Mainly be distributed in NORTHWEST CHINA, North China, provinces and regions, northeast such as Qinghai, Xinjiang, Tibet, be born in sand ground, desert, grassland and the arid tailo of 2000～4200 meters of height above sea level, its property is bitter, cold.According to " brilliant pearl book on Chinese herbal medicine " record, the effect that it has hemostasis, dispels the wind, subsides a swelling.Modern study also shows, that composite family artemisia essential oil has is antibiotic, detoxify, be good for the stomach, anti-inflammatory effect, can be used for treatment flu, cough, is the single herbal medicine that has than obvious curative effects.
Volatile oil is the effective constituents in the Chinese medicine, distributes extensively in vegitabilia, and has multiple pharmacologically active and purposes widely.Along with the development of society, its development and utilization also receives relevant expert and scholar's concern day by day.
Go out a kind of new extractive of volatile oil so the present invention makes full use of the abundant prairie sagewort plant resource explorations in Qinghai-Tibet Platean, and it has been carried out useful exploration at medicine and washing cosmetic Application for Field.
Summary of the invention
Technical problem to be solved by this invention provides a kind of high-load artemisia frigida willd essential oil.
Another technical problem to be solved by this invention provides that a kind of technology is simple, effective component extraction rate is high, is easy to the preparation method of the artemisia frigida willd essential oil of suitability for industrialized production.
The 3rd technical problem to be solved by this invention provides artemisia frigida willd essential oil in pharmacy and washing cosmetic Application for Field.
For addressing the above problem, a kind of artemisia frigida willd essential oil of the present invention is characterized in that: this volatile oil is the light yellow transparent liquid that strong fragrance is arranged; Constitute by terpene, enol class, staple comprise the quality percentage composition be dimethyl--methylene basic ring enanthol of 15～20%, 15～20% 3,3; 6-trimethylammonium-1,3,3 of 5-heptadiene alcohol-2,5～10%; 6-trimethylammonium-1, the eucalyptus alcohol of 4-heptadiene alcohol-6,3～8%, 2～5% 3,7-dimethyl--2; 6-octadienol-1,2～5% santolina triolefin, 1-methyl-3-isopropyl benzene of 2～5%, 1～5% bridged ring [2,2,1] terpenes, 1～5% camphor and 1～5% myrcene.
Said staple chemical structural formula is following:
Dimethyl--methylene basic ring heptan 3,3,6-trimethylammonium-1,5-heptadiene alcohol-2 3,3,6-trimethylammonium-1,4-heptadiene alcohol-6
3,7-dimethyl--2,6-octadienol-1 santolina triolefin 1-methyl-3-isopropyl benzene eucalyptus alcohol
Bridged ring [2,2,1] terpenes camphor myrcene
A kind of preparation method of aforesaid artemisia frigida willd essential oil may further comprise the steps:
(1),, prairie sagewort is fully soaked into for broken section with 2～15 times of water loggings bubbles of its weight 2～10 hours with after the spray or the bright leaf removal of impurities of fresh prairie sagewort over-ground part, being cut to 0.5～4cm;
(2) broken section of prairie sagewort and the soak solution thereof with said step (1) gained carries out wet distillation, collects distillate;
(3) the distillate naturally cooling is got the upper strata or promptly got artemisia frigida willd essential oil for several times with extracted with diethyl ether.
Distillation temperature in the said step (2) is 80～120 ℃, and distillation time is 2～10h.
The application of aforesaid artemisia frigida willd essential oil in pharmacy is characterized in that: said artemisia frigida willd essential oil as antibiotic, anti-inflammatory, antibechic, relieving asthma, the application of antalgesic-antipruritic activeconstituents on treatment asthmatic bronchitis, chronic bronchitis, anemogenous headache and tetter.
Saidly be used to treat bronchitic pharmaceutical composition and form: artemisia frigida willd essential oil 20～40g, savoury rhododendron oil 5～15g and Radix Glycyrrhizae fluidextract 3～7g by following raw material; Or artemisia frigida willd essential oil 20～40g, spearmint oil 5～15g, Oleum Folium Artemisiae Argyi 3～7g and Radix Glycyrrhizae extractum 1～3g.
Usage and dosage: every day 2～3 times, each 2～4 (is example with the dripping pill).
Saidly be used to treat anemogenous headache and dermopathic pharmaceutical composition is made up of following raw material: artemisia frigida willd essential oil 50～150g, Peppermint Oil 50～150g, Oleum Folium Artemisiae Argyi 10～20g, Rhododendron oil 10～20g and Oleum Viticis Negundo 10～20g.
Usage and dosage: get and be applied in the affected part in right amount, every day 3～5 times (is example with the ointment).
In above-mentioned prescription, be equipped with medicinal stone and acceptable carrier pharmaceutically or on the physiology, be prepared into any formulation on the pharmaceutics by the Chinese medicine preparation technology of routine.
The application of aforesaid artemisia frigida willd essential oil in articles for washing and makeup is characterized in that: said artemisia frigida willd essential oil is as fragrance ingredient and antibiotic, anti-inflammatory, the application of antipruritic activeconstituents in articles for washing and makeup.
The present invention compared with prior art has the following advantages:
1, the artemisia frigida willd essential oil of gained of the present invention is found through gas chromatography-mass spectrometry, and this volatile oil has 106 kinds of chemical compositions, and mainly is terpene, enol class, like dimethyl--methylene basic ring heptan, 3; 3,6-trimethylammonium-1,5-heptadiene alcohol-2,3,3; 6-trimethylammonium-1,4-heptadiene alcohol-6, eucalyptus alcohol, 3,7-dimethyl--2; 6-octadienol-1, santolina triolefin, 1-methyl-3-isopropyl benzene, bridged ring [2,2,1] terpenes, camphor, myrcene etc.What wherein content was higher is dimethyl--methylene basic ring heptan (17.67%) and 3,3,6-trimethylammonium-1,5-heptadiene alcohol-2 (16.40%).(GC conditions: the GC temperature of vaporization chamber is 250 ℃, and column temperature, kept 30 minutes by 80 ℃ of temperature programmings to 290 ℃ with the temperature rise rate of 4 ℃/min, and carrier gas is 99.999% high-pure helium, and flow velocity is 30ml/min; The mass spectrum condition: mass ion source is the EI source, 230 ℃ of ion source temperatures, electron energy 70eV; Use America NI ST02L spectrum storehouse.)
2, the artemisia frigida willd essential oil of gained of the present invention has antibacterial effect.
Tried bacterial classification: Staphylococcus albus, streptococcus aureus, kerekou pneumonia primary, Pseudomonas aeruginosa, Candida albicans, typhoid fever virus, intestinal bacteria (above bacterial classification provides by mikrobe teaching and research room of Henan Medical Univ.).
Experimental technique: the artemisia frigida willd essential oil of gained of the present invention is dissolved in 95% the ethanolic soln, is made into volume ratio and is 10% mother liquid medicine.Liquid nutrient medium is carried out autoclaving (121 ℃ 15min), and do not add medicine as blank with liquid nutrient medium.10 μ L evenly are inoculated in the substratum with bacteria suspension, and bacterium hatches 24h at 37 ℃.Judging with visual inspection that under the situation of not stirring solution is Clear & Transparent to be regarded as bacterium and not to grow fully, is minimum inhibitory concentration with the lowest drug concentration of the bacterium that do not grow fully.
The result shows that this artemisia frigida willd essential oil is tried bacterium to 7 kinds all has different restraining effect, and inhibition strength is followed successively by Pseudomonas aeruginosa, streptococcus aureus, Staphylococcus albus, Candida albicans, typhoid fever virus, intestinal bacteria, kerekou pneumonia primary.
When 3, the artemisia frigida willd essential oil of gained of the present invention is applied to treat in the pharmaceutical composition of asthmatic bronchitis, chronic bronchitis; Artemisia frigida willd essential oil wherein and savoury rhododendron oil bactericidal anti-inflammatory effect are remarkable, but equal expelling phlegm for arresting cough, and Radix Glycyrrhizae can be clearing heat and detoxicating; Moisten the lung and relieve the cough coordinating the actions of various ingredients in a prescription property; Artemisia frigida willd essential oil and the Oleum Folium Artemisiae Argyi tracheal smooth muscle that can directly relax; Tracheal smooth muscle spasm and asthma that antigen, vagusstoff and histamine are brought out all have provide protection; Also has anti-allergic effects; Can suppress the sensitization lung tissue and discharge slow reacting substance hypersensitive (SRS-A), and the effect of ability antagonism SRS-A and serotonin, spearmint oil can make skin or mucous membrane produce refrigerant sense to ease the pain.
Evident in efficacy, safe and effective through clinical experiment, all do not find obvious toxic-side effects (referring to table 1).
Table 1: the dripping pill clinical experiment that the artemisia frigida willd essential oil pharmaceutical composition is processed
| Divide into groups | The example number | Produce effects | Effectively | Invalid | Total obvious effective rate | Total effective rate |
| Asthmatic bronchitis | 150 | 113 | 34 | 3 | / | / |
| Chronic bronchitis | 139 | 102 | 32 | 5 | / | / |
| Amount to | 289 | 215 | 66 | 8 | 74.4％ | 97.2％ |
When 4, the artemisia frigida willd essential oil of gained of the present invention is applied to treat in anemogenous headache and the dermopathic pharmaceutical composition; Artemisia frigida willd essential oil wherein, Oleum Folium Artemisiae Argyi and Rhododendron oil all have the bactericidal antiphlogistic effect; Be applied to that the affected part can treat that uncinarial dermatitis, ulcer do not conform to, the open sore part coldly stagnates, a wind face sore, itching yellow water, eczema etc.; Spearmint oil can make skin or mucous membrane produce refrigerant sense cannot not alleviate suitablely sense and pain, and male sour jujube oil has calm antiinflammation.
Evident in efficacy, safe and reliable through clinical experiment, all do not find obvious toxic-side effects (referring to table 2).
Table 2: the ointment clinical experiment that the artemisia frigida willd essential oil pharmaceutical composition is processed
| Divide into groups | The example number | Produce effects | Effectively | Invalid | Total obvious effective rate | Total effective rate |
| Eczema | 48 | 42 | 3 | 3 | / | / |
| Folliculitis | 33 | 29 | 2 | 2 | / | / |
| Impetigo herpetiformis | 29 | 20 | 4 | 5 | / | / |
| Psoriasis | 55 | 44 | 7 | 4 | / | / |
| Amount to | 165 | 135 | 16 | 14 | 81.8％ | 91.5％ |
5, because the artemisia frigida willd essential oil of gained of the present invention has fragrance ingredient and antibiotic, anti-inflammatory, antipruritic activeconstituents, therefore, also can be applicable in articles for washing and the makeup.
6, because preparation method of the present invention adopts steam distillation, and therefore, not only technical process is simple, equipment drops into little, and production cost is low, is easy to suitability for industrialized production, and the main pharmaceutical compound yield of volatile oil is high; Residual owing to the used medium unharmful substance simultaneously, so environmental pollution is little.
Embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in the restriction scope of the present invention; In addition, any with the institute similar content of putting down in writing or the equalization method and material all can be applicable among the present invention.The usefulness that preferable implementation method described in the literary composition and material only present a demonstration.
The preparation method of artemisia frigida willd essential oil:
The preparation method of 1 one kinds of artemisia frigida willd essential oils of embodiment may further comprise the steps:
(1) with after the spray or the bright leaf removal of impurities of the fresh prairie sagewort over-ground part of 1kg, being cut to 0.5～4cm, put into Shanghai with admiring the volatile oil extractor that biological medicine Science and Technology Ltd. produces, with 2 times of water loggings bubbles of its weight 2 hours, prairie sagewort is fully soaked into for broken section.
(2) volatile oil extractor that fills broken section of prairie sagewort and soak solution thereof in the step (1) is moved on the 98-1-B type electronic thermostatic electric mantle that Tianjin Tai Site Instr Ltd. produces carry out wet distillation; Distillation temperature is 80 ℃; Distillation time is 2h, and every 1h collects distillate once.
(3) with the distillate naturally cooling, natural layering discards water layer, gets the upper strata and promptly gets the 4.5ml artemisia frigida willd essential oil, and yield is 0.45%.
The preparation method of 2 one kinds of artemisia frigida willd essential oils of embodiment may further comprise the steps:
(1) with after the spray or the bright leaf removal of impurities of the fresh prairie sagewort over-ground part of 1kg, being cut to 0.5～4cm, puts into volatile oil extractor,, prairie sagewort is fully soaked into for broken section with 15 times of water loggings bubbles of its weight 10 hours.
(2) volatile oil extractor that fills broken section of prairie sagewort and soak solution thereof in the step (1) is moved on the 98-1-B type electronic thermostatic electric mantle carry out wet distillation, distillation temperature is 120 ℃, and distillation time is 10h, and every 1h collects distillate once.
(3) with the distillate naturally cooling, natural layering discards water layer, gets the upper strata and promptly gets the 9.4ml artemisia frigida willd essential oil, and yield is 0.94%.
The preparation method of 3 one kinds of artemisia frigida willd essential oils of embodiment may further comprise the steps:
(1) with after the spray or the bright leaf removal of impurities of the fresh prairie sagewort over-ground part of 1kg, being cut to 0.5～4cm, puts into volatile oil extractor,, prairie sagewort is fully soaked into for broken section with 8 times of water loggings bubbles of its weight 6 hours.
(2) volatile oil extractor that fills broken section of prairie sagewort and soak solution thereof in the step (1) is moved on the 98-1-B type electronic thermostatic electric mantle carry out wet distillation, distillation temperature is 100 ℃, and distillation time is 8h, and every 1h collects distillate once.
(3) with the distillate naturally cooling, natural layering discards water layer, gets the upper strata and promptly gets the 9.2ml artemisia frigida willd essential oil, and yield is 0.92%.
The preparation method of 4 one kinds of artemisia frigida willd essential oils of embodiment may further comprise the steps:
(1) with after the spray or the bright leaf removal of impurities of the fresh prairie sagewort over-ground part of 1.5kg, being cut to 0.5～4cm, puts into volatile oil extractor,, prairie sagewort is fully soaked into for broken section with 4 times of water loggings bubbles of its weight 2 hours.
(2) volatile oil extractor that fills broken section of prairie sagewort and soak solution thereof in the step (1) is moved on the 98-1-B type electronic thermostatic electric mantle carry out wet distillation, distillation temperature is 120 ℃, and distillation time is 4h, and every 1h collects distillate once.
(3) distillate is put into separating funnel with extracted with diethyl ether for several times; Combined ether layer; Adopt GZX-9146MBE type electric drying oven with forced convection that capital, Shanghai worker Industrial Co., Ltd. produces, under 50 ℃, fling to ether, promptly get the 13.0ml artemisia frigida willd essential oil, yield is 0.87%.
The artemisia frigida willd essential oil of the foregoing description 1～4 gained is the light yellow transparent liquid that strong fragrance is arranged, constitute by terpene, enol class, staple comprise the quality percentage composition be 15～20% dimethyl--methylene basic ring heptan, 15～20% 3; 3,6-trimethylammonium-1,3 of 5-heptadiene alcohol-2,5～10%; 3,6-trimethylammonium-1, the eucalyptus alcohol of 4-heptadiene alcohol-6,3～8%, 2～5% 3; 7-dimethyl--2; 6-octadienol-1,2～5% santolina triolefin, 1-methyl-3-isopropyl benzene of 2～5%, 1～5% bridged ring [2,2,1] terpenes, 1～5% camphor and 1～5% myrcene.Wherein the staple chemical structural formula is following
Dimethyl--methylene basic ring heptan 3,3,6-trimethylammonium-1,5-heptadiene alcohol-2 3,3,6-trimethylammonium-1,4-heptadiene alcohol-6
3,7-dimethyl--2,6-octadienol-1 santolina triolefin 1-methyl-3-isopropyl benzene eucalyptus alcohol
Bridged ring [2,2,1] terpenes camphor myrcene
The application example of artemisia frigida willd essential oil in medicine:
Embodiment 1 artemisia frigida willd essential oil 20～40g, savoury rhododendron oil 5～15g, Radix Glycyrrhizae fluidextract 3～7g; Or artemisia frigida willd essential oil 20～40g, spearmint oil 5～15g, Oleum Folium Artemisiae Argyi 3～7g, Radix Glycyrrhizae extractum 1～3g are equipped with medicinal stone and are prepared into any formulation on the pharmaceutics with the Chinese medicine preparation technology of routine.This prescription eliminates the phlegm, cough-relieving, antiasthmatic effect, applicable to the treatment of asthmatic bronchitis, chronic bronchitis.
Embodiment 2 takes by weighing artemisia frigida willd essential oil 30g, savoury rhododendron oil 10g, Radix Glycyrrhizae fluidextract 5g and polyoxyethylene glycol (4000) 315g.Earlier polyoxyethylene glycol (4000) is placed in the heating container, be heated to molten state; Add artemisia frigida willd essential oil, savoury rhododendron oil, Radix Glycyrrhizae fluidextract respectively, stir, the dripping pill machine that adopts the safe pharmaceutical machine of Taizhou City gold ltd to produce; Make the water dropper temperature of dripping pill machine remain on 60～85 ℃, and the thermograde that makes condensing agent is (30～15) ℃-(5～-5) ℃, under this state; With the water dropper of fused material through the dripping pill machine; Dropwise splash in the methyl-silicone oil, the dripping pill that shrinks moulding is taken out, remove the condensing agent on surface; Drying gets final product dripping pill with stomach enteric solubility dressing pre-mixture 20g dressing.
Embodiment 3 artemisia frigida willd essential oils 50～150g, Peppermint Oil 50～150g, Oleum Folium Artemisiae Argyi 10～20g, Rhododendron oil 10～20g, Oleum Viticis Negundo 10～20g, paraffin 150～250g, beeswax 50～100g, Vaseline 100～300g; Ammonia solution (10%) 5～10ml is mixed and made into ointment by common process.
This prescription is applicable to various treating for skin disease for the external preparation for skin medicine of bactericidal antiphlogistic, antalgesic-antipruritic.
The application example of artemisia frigida willd essential oil in daily necessities and makeup:
Embodiment 1 contains the washing powder (weight is gram) of artemisia frigida willd essential oil by following formulation
Sodium alkyl benzene sulfonate 16 water glass 10 yellow soda ash 3
Xylo-Mucine 1 sodium sulfate 52.5 artemisia frigida willd essential oil 0.5ml
Tripoly phosphate sodium STPP 17
Embodiment 2 contains the soap (weight is gram) of artemisia frigida willd essential oil by following formulation
Sodium soap 60 salt 0.6 glycerine 0.2
Free alkali 0.2 water 27 artemisia frigida willd essential oil 0.5ml
Embodiment 3 contains the soap (weight is gram) of artemisia frigida willd essential oil by following formulation
Sodium soap 75 salt 0.3 glycerine 0.2
Free alkali 0.2 water 19 artemisia frigida willd essential oils 5
Embodiment 4 contains the enzyme-containing toothpaste (weight is gram) of artemisia frigida willd essential oil by following formulation
N-sodium lauroyl sareosine 5 secondary calcium phosphates 50 seaweed gels 0.8
Sodium lauryl sulfate 0.6 glycerine 25 spices 1.3
Artemisia frigida willd essential oil 0.5 proteinase-10 .5 water 20
Embodiment 5 contains the washing composition (weight is gram) of artemisia frigida willd essential oil by following formulation
Sodium dioctyl sulfosuccinate 6.5 sodium lauryl sulphate 20
Artemisia frigida willd essential oil 0.5 water 73
Embodiment 6 contains the bathing agents (weight is gram) of artemisia frigida willd essential oil by following formulation
C12-16 alkyl dimethyl benzyl ammonium chloride 8 alkylphenol-polyethenoxies (10) ether 18
YD 30 1.4 monoethanolamines 0.6
Artemisia frigida willd essential oil 5 water 67
Embodiment 7 contains the skin care item (weight is gram) of artemisia frigida willd essential oil by following formulation
Artemisia frigida willd essential oil 50 paraffin 210 Vaseline 100 glycerine 50
Claims (1)
1. the application of artemisia frigida willd essential oil in pharmacy is characterized in that: be used to treat bronchitic pharmaceutical composition and be made up of following raw material: artemisia frigida willd essential oil 20～40g, savoury rhododendron oil 5～15g and Radix Glycyrrhizae fluidextract 3～7g; Or artemisia frigida willd essential oil 20～40g, spearmint oil 5～15g, Oleum Folium Artemisiae Argyi 3～7g and Radix Glycyrrhizae extractum 1～3g;
The preparation method of said artemisia frigida willd essential oil may further comprise the steps:
(1) with after the spray or the bright leaf removal of impurities of the fresh prairie sagewort over-ground part of 1kg, being cut to 0.5～4cm, puts into volatile oil extractor,, prairie sagewort is fully soaked into for broken section with 15 times of water loggings bubbles of its weight 10 hours;
(2) volatile oil extractor that fills broken section of prairie sagewort and soak solution thereof in the step (1) is moved on the 98-1-B type electronic thermostatic electric mantle carry out wet distillation, distillation temperature is 120 ℃, and distillation time is 10h, and every 1h collects distillate once;
(3) with the distillate naturally cooling, natural layering discards water layer, gets the upper strata and promptly gets artemisia frigida willd essential oil.
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