CN111150815A - Compound external antibacterial lotion and preparation method thereof - Google Patents
Compound external antibacterial lotion and preparation method thereof Download PDFInfo
- Publication number
- CN111150815A CN111150815A CN202010206746.3A CN202010206746A CN111150815A CN 111150815 A CN111150815 A CN 111150815A CN 202010206746 A CN202010206746 A CN 202010206746A CN 111150815 A CN111150815 A CN 111150815A
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- Prior art keywords
- antibacterial lotion
- compound external
- compound
- fatty alcohol
- polyoxyethylene ether
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- 239000006210 lotion Substances 0.000 title claims abstract description 28
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 27
- 150000001875 compounds Chemical class 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims abstract description 15
- 229940051841 polyoxyethylene ether Drugs 0.000 claims abstract description 15
- 229920000056 polyoxyethylene ether Polymers 0.000 claims abstract description 15
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 15
- 239000011734 sodium Substances 0.000 claims abstract description 15
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims abstract description 15
- 230000000699 topical effect Effects 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 14
- 244000166124 Eucalyptus globulus Species 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 230000002147 killing effect Effects 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- 241000700605 Viruses Species 0.000 abstract description 3
- 244000052616 bacterial pathogen Species 0.000 abstract description 3
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 241000222122 Candida albicans Species 0.000 abstract description 2
- 241000192125 Firmicutes Species 0.000 abstract description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract description 2
- 229940095731 candida albicans Drugs 0.000 abstract description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 2
- 238000001228 spectrum Methods 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- -1 sodium fatty alcohol Chemical class 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 241000517307 Pediculus humanus Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 241001671204 Stemona Species 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 206010007882 Cellulitis Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 206010014881 enterobiasis Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A compound topical antibacterial lotion is prepared from radix Stemonae, folium Eucalypti Globueli, sodium fatty alcohol polyoxyethylene ether sulfate, sodium dodecylbenzenesulfonate, and DP 300. The invention is a pure Chinese medicinal preparation, and has wide sterilization spectrum: it has effects in killing and inhibiting gram-positive bacteria, gram-negative bacteria, pyococcus, Candida albicans, pathogenic bacteria in intestinal tract, yeast, and various viruses.
Description
Technical Field
The invention relates to a medicine and a preparation method thereof, in particular to a compound external antibacterial lotion and a preparation method thereof, belonging to the field of medicines.
Background
With the rapid increase of the human material wealth and the overall progress of the society, people are more and more concerned about self health and life quality. A large amount of bacteria, fungi and viruses exist in the living environment of people, can directly or indirectly cause various diseases, and cause great hidden danger and threat to the healthy life of people. The serious consequences of microorganisms on human production and life are not negligible. It has become a social consensus to prevent the effects and damage of harmful microorganisms to humans and to mitigate the adverse consequences thereof.
Therefore, the development of highly effective, low-toxicity and broad-spectrum antibacterial agents for killing and controlling the growth and reproduction of harmful pathogenic bacteria is a subject of common attention all over the world.
Disclosure of Invention
The invention aims to supplement the defects of antibacterial agents in the market, and provides a Chinese herbal medicine antibacterial lotion, which is a compound external antibacterial lotion with the characteristics of safety, effectiveness and convenience, and a preparation method thereof.
The technical scheme adopted by the invention for solving the problems is that the compound external antibacterial lotion comprises the following components: radix Stemonae, and folium Eucalypti Globueli;
the auxiliary materials of the compound external antibacterial lotion comprise: sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like.
Preferably, the compound external antibacterial lotion comprises the following components: 250 portions of radix stemonae and 500 portions of eucalyptus leaves;
the auxiliary materials of the compound external antibacterial lotion comprise: sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like.
Preferably, the compound external antibacterial lotion comprises the following components: 300g of radix stemonae and 500g of eucalyptus leaves;
the auxiliary materials of the compound external antibacterial lotion comprise: sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like.
Specifically, the effects of the raw materials in the invention are as follows:
radix Stemonae has effects of moistening lung, descending qi, relieving cough, killing parasite and killing louse. Can be used for treating chronic cough, pulmonary tuberculosis cough, and cough; it is used for treating head louse, body louse, enterobiasis, and pudendal pruritus.
The eucalyptus leaves have the effects of clearing heat, eliminating dampness, inhibiting bacteria and diminishing inflammation. Can be used for treating upper respiratory infection, pharyngolaryngitis, influenza, epidemic meningitis, cellulitis, furuncle, eczema, erysipelas, and skin pruritus.
The invention also discloses a preparation method of the compound external antibacterial lotion, which comprises the following steps:
(1) weighing the raw materials according to a formula;
(2) decocting radix Stemonae and folium Eucalypti Globueli in water twice, the first time with 8 times of water for 1.5 hr, and the second time with 6 times of water for 1 hr; and combining the two decoctions, filtering, concentrating the filtrate to thick paste of 1.20-1.30 (70 ℃), drying to obtain dry paste, crushing to fine powder, adding a proper amount of sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like, and preparing into granules to obtain the compound external antibacterial lotion.
The use method of the invention comprises the following steps:
the granule is dissolved in hot water according to the ratio of the mass (g) of the finished product to the volume (ml) of the hot water of 1:1000, stirred to be dissolved, rinsed or bathed or washed by hands, and then washed by clear water.
The invention has the beneficial effects that:
(1) the invention is a pure Chinese medicinal preparation, and has wide sterilization spectrum: it has effects in killing and inhibiting gram-positive bacteria, gram-negative bacteria, pyococcus, Candida albicans, pathogenic bacteria in intestinal tract, yeast, and various viruses.
(2) The invention is a Chinese medicinal granule, has the advantages of convenient carrying and storage, etc.; also has the advantages of high efficiency, small irritation, no toxicity, safety, easy water solubility, good stability, etc.
(3) The invention can be made into different specifications according to actual requirements, such as 5 g/bag, 10 g/bag and the like; it can also be made into different dosage forms, such as lotion, spray, ointment, etc., according to different people's needs.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The formula is as follows: 300g of stemona root, 500g of eucalyptus leaf, sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like
The preparation method comprises the following steps: weighing the raw materials according to a formula;
decocting radix Stemonae and folium Eucalypti Globueli in water twice, the first time with 8 times of water for 1.5 hr, and the second time with 6 times of water for 1 hr; and combining the two decoctions, filtering, concentrating the filtrate to thick paste of 1.20-1.30 (70 ℃), drying to obtain dry paste, crushing to fine powder, adding a proper amount of sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like, and preparing into granules to obtain the compound external antibacterial lotion.
Example 2
The formula is as follows: 250g of stemona root, 400g of eucalyptus leaf, proper amount of sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like
The preparation method comprises the following steps: weighing the raw materials according to a formula;
decocting radix Stemonae and folium Eucalypti Globueli in water twice, the first time with 8 times of water for 1.5 hr, and the second time with 6 times of water for 1 hr; and combining the two decoctions, filtering, concentrating the filtrate to thick paste of 1.20-1.30 (70 ℃), drying to obtain dry paste, crushing to fine powder, adding a proper amount of sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like, and preparing into granules to obtain the compound external antibacterial lotion.
Example 3
The formula is as follows: 280g of radix stemonae, 450g of eucalyptus leaves, a proper amount of sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like
The preparation method comprises the following steps: weighing the raw materials according to a formula;
decocting radix Stemonae and folium Eucalypti Globueli in water twice, the first time with 8 times of water for 1.5 hr, and the second time with 6 times of water for 1 hr; and combining the two decoctions, filtering, concentrating the filtrate to thick paste of 1.20-1.30 (70 ℃), drying to obtain dry paste, crushing to fine powder, adding a proper amount of sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like, and preparing into granules to obtain the compound external antibacterial lotion.
The compound external antibacterial lotion adopts common traditional Chinese medicinal materials as raw materials, has scientific formula, adopts the dosage form of granules, is convenient to carry, quickly reaches the disease, obviously improves the curative effect, treats both principal and secondary aspects of diseases, and has safe clinical application.
The above-mentioned serial numbers of the embodiments of the present invention are merely for description and do not represent the merits of the embodiments.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (5)
1. A compound external antibacterial lotion is characterized by comprising: radix Stemonae, and folium Eucalypti Globueli;
the auxiliary materials of the compound external antibacterial lotion comprise: sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like.
2. The compound antibacterial lotion for external use according to claim 1, characterized by comprising: 250 portions of radix stemonae and 500 portions of eucalyptus leaves;
the auxiliary materials of the compound external antibacterial lotion comprise: sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like.
3. The compound external antibacterial lotion according to claim 2, characterized by comprising: 300g of radix stemonae and 500g of eucalyptus leaves;
the auxiliary materials of the compound external antibacterial lotion comprise: sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like.
4. The preparation method of the compound external antibacterial lotion according to claim 2 or 3 is characterized by comprising the following main steps:
(1) weighing the raw materials according to a formula;
(2) decocting radix Stemonae and folium Eucalypti Globueli in water twice, the first time with 8 times of water for 1.5 hr, and the second time with 6 times of water for 1 hr; and combining the two decoctions, filtering, concentrating the filtrate to thick paste of 1.20-1.30 (70 ℃), drying to obtain dry paste, crushing to fine powder, adding a proper amount of sodium fatty alcohol-polyoxyethylene ether sulfate, sodium dodecyl benzene sulfonate, DP300 and the like, and preparing into granules to obtain the compound external antibacterial lotion.
5. The compound topical antibacterial lotion of claim 1 or 2 or 3 or 4, wherein the product particles are dissolved in hot water at a ratio of finished product mass (g) to hot water volume (ml) of 1:1000, stirred to dissolve, rinsed or bathed systemically or by hand washing, and rinsed with clear water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010206746.3A CN111150815A (en) | 2020-03-23 | 2020-03-23 | Compound external antibacterial lotion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010206746.3A CN111150815A (en) | 2020-03-23 | 2020-03-23 | Compound external antibacterial lotion and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111150815A true CN111150815A (en) | 2020-05-15 |
Family
ID=70567863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010206746.3A Withdrawn CN111150815A (en) | 2020-03-23 | 2020-03-23 | Compound external antibacterial lotion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111150815A (en) |
-
2020
- 2020-03-23 CN CN202010206746.3A patent/CN111150815A/en not_active Withdrawn
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Application publication date: 20200515 |