CN102961557A - Aqueous compound peganum harmala pharmaceutical composition and preparation method thereof - Google Patents
Aqueous compound peganum harmala pharmaceutical composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an aqueous compound peganum harmala pharmaceutical composition and a preparation method thereof. The aqueous compound peganum harmala pharmaceutical composition is composed of the following components: 19.0%-21.5% of peganum harmala, 10.5-13.5% of henbane, 6.5-9.0% of meadow saffron, 5.5-8.0% of cetyl alcohol and stearyl alcohol, 1.5-3.5% of albolene, 9.5-11.0% of liquid paraffin, 3.5-4.5% of glycerin monostearate, 0.05-0.15% of ethyl p-hydroxybenzoate, 15.5-17.5% of glyceride, 0.5-1.5% of lauryl sodium sulfate and 18.4-20.4% of purified water. The pharmaceutical composition provided by the invention mainly aims to treat diseases caused by raw such as joint sore, rheumatic arthritis, ischialgia, eczema and the like, and is good in stability, wettability and transdermal effect, low in toxic side effect and thrill, high in safety, simple to prepare, low in cost, obvious in effect and convenient for popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, especially a kind of aqueous compound recipe Semen pegani harmalae emulsifiable paste and preparation method thereof.
Background technology
By raw caused joint aches, rheumatic arthritis, sciatica, eczema, scabies, scabies etc. often occur clinically, and treatment cycle is long, easily recurrence, and be intractable condition.Market is existing for raw caused joint aches, rheumatic arthritis, sciatica, eczema, scabies, and the medicine of scabies etc. has multiple, Western medicine, Chinese medicine is arranged, also the Chinese medicine and western medicine mixing manufacture arranged.But the side effect that has is large or effect is not ideal, and treatment is long the course for the treatment of, needs life-time service.Therapeutic effect was not obvious after the plaster of the external of using at present used, and can only play the effect of temporary transient pain relieving.
The chemical constitution of the banisterine that contains in the Semen pegani harmalae (Peganum harmala L.) is similar to quinoline, thus poisonous to protozoons such as amebas, some Antimalarial is also arranged.Banisterine is similar to Santonin to the effect of ascarid, and antibacterial (particularly gram positive bacteria) is also had inhibitory action, and bactericidal action was namely arranged at external 1: 1 ten thousand.
Semen Hyoscyami (Hyoscyami Semen) cures mainly relieving spasm to stop pain, the analgesic therapy of calming the nerves; One is plant name, i.e. hyoscyami.Tibetan language claims " hyoscyami pool ", is plant of Solanaceae; Have spasmolytic, pain relieving, calm the nerves, the effect of parasite killing.Control demented ， Feng Epilepsy, migratory arthralgia is fainted bitterly, breathes with cough stomachache, chronic dysentery, chronic diarrhea, proctoptosis, toothache, carbuncle, malignant boil.
Colchicum autumnale (Colchicum autumnale) is Liliaceae Colchicum plant, just begin during 19th-century to use Effects of Colchicine In Treating sciatica and arthritis etc., found again afterwards that it had certain curative effect to the leukemia of breast carcinoma, cervical cancer, acute lymphoblastic.
Product commonly used is the ointment of Chinese medicine preparation now, chafe not, according to traditional Uygur medical science medicine for external use proved recipe, organized the mechanisms such as Xinjiang Medicine University, institute of materia medica, Xinjiang, Xinjiang medicine inspecting institute by country, the rare uighur ' s culture medicine medicine for external use that excavates, puts in order, researches and develops, its prescription is unique, determined curative effect.Dimension medical knowledge opinion is explained its effect and is: rush down clearly the black gallbladder matter of local anomaly, phlegmatic temperament, repellent antipruritic, loose gas pain relieving.Be used for raw caused joint aches, rheumatic arthritis, sciatica, eczema, scabies, scabies etc.The extensive Rheumatism Dept. of clinical practice (immune section), orthopaedics: treatment joint aches, rheumatic arthritis, sciatica etc.; Department of dermatologry: treatment eczema, scabies, scabies etc.The ointment formulation of this medicine is the larger product of oiliness, at the therapeutic effect in winter of cold or apparent in view, but the oils and fats of secreting owing to skin in the time of during the broiling summer is more, the oils and fats of adding medicine can stop up the pore generation scytitis of skin, and can hinder skin and perspire and dispel the heat, give the patient with uncomfortable sensation, affect therapeutic effect.
Summary of the invention
The purpose of this invention is to provide the untoward reaction that a kind of use curative effect that makes this medicine when avoiding heat weakens and follows, make this medicine at all seasons efficacy stability and also can bring a kind of pharmaceutical composition for the treatment of raw caused various disease conditions of comfortable sensation and preparation method thereof to the patient.
For achieving the above object, aqueous compound recipe Semen pegani harmalae pharmaceutical composition provided by the invention is made by crude drug and adjuvant, and described crude drug comprises: Semen pegani harmalae 19.0%-21.5%; Semen Hyoscyami 10.5.0%-13.5%; Colchicum autumnale 6.5%-9.0%.Described adjuvant comprises: 16. octadecanol 5.5%-8.0%; White vaseline 1.5%-3.5%; Liquid Paraffin 9.5%-11.0%; Glyceryl monostearate 3.5%-4.5%; Ethylparaben 0.05%-0.15%; Glycerol 15.5%-17.5%; Sodium lauryl sulphate 0.5%-1.5%; Purified water 18.4%-20.4%.
Optimizing prescriptions is: Semen pegani harmalae 20%; Semen Hyoscyami 12%; Colchicum autumnale 8%; 16. octadecanol 6%; White vaseline 3%; Liquid Paraffin 10%; Glyceryl monostearate 4%; Ethylparaben 0.1%; Glycerol 16%; Sodium lauryl sulphate 1%; Purified water 19.9%.
The present invention also provides the preparation method of above-mentioned compound recipe Semen pegani harmalae pharmaceutical composition, and it comprises the steps:
(1). Semen pegani harmalae, Semen Hyoscyami, Colchicum autumnale are ground into fine powder;
(2). get the Semen pegani harmalae, Semen Hyoscyami, the Colchicum autumnale fine powder that crush, heating and refluxing extraction 1～3 time adds 95% ethanol of 4～5 times of weight of medical material at every turn, with hydrochloric acid adjust pH to 4, each reflux, extract, 2～4 hours, merge extractive liquid,, leave standstill, filter, get filtrate;
(3). get filtrate recycling ethanol, be concentrated into without the alcohol flavor;
(4). get oil phase 16. octadecanol, white vaseline, liquid Paraffin, glyceryl monostearate, be heated to 100 ± 5 ℃, be incubated 20～40 minutes, after insulation finishes, ethylparaben is dropped in the oil phase dissolving pan, to fully the dissolving after, be cooled to 80 ℃ for subsequent use;
(5). water intaking phase glycerol, purified water, when being heated to 100 ℃, be incubated 20～40 minutes, sodium lauryl sulphate is dropped in the aqueous phase dissolved pot; To fully the dissolving after, be cooled to 80 ℃ for subsequent use;
(6). successively suck in the vacuum emulsification pot through negative pressure by 200 mesh sieves water, oil phase; Keep 80 ℃, emulsifying 15～30 minutes was opened homogenizer 3～5 minutes; Continue to stir, when being cooled to 65 ℃, concentrated extractum is added in the vacuum emulsification pot, continue to stir, be cooled to below 50 ℃, namely get patent medicine.
The preparation method of preferred above-mentioned compound recipe Semen pegani harmalae pharmaceutical composition, it comprises the steps:
1. Semen pegani harmalae, Semen Hyoscyami, Colchicum autumnale are put into pulverizer, start pulverizer and be ground into fine powder.
2. get the Semen pegani harmalae, Semen Hyoscyami, the Colchicum autumnale fine powder that crush, heating and refluxing extraction 2 times adds 95% ethanol (hydrochloric acid adjust pH to 4) of 5 times of amounts of medical material at every turn, each reflux, extract, 3 hours, merge extractive liquid, leaves standstill, filter (200 mesh sieve), get filtrate.
3. get filtrate recycling ethanol, being concentrated into relative density is the extractum (without the alcohol flavor) of 1.25～1.30 (20 ℃).
4. get oil phase 16. octadecanol, white vaseline, liquid Paraffin, glyceryl monostearate, be heated to about 100 ℃, be incubated 30 minutes, after insulation finishes, ethylparaben is dropped in the oil phase dissolving pan, to fully the dissolving after, be cooled to 80 ℃ for subsequent use.
5. water intaking phase glycerol, purified water when being heated to 100 ℃, are incubated 30 minutes, and sodium lauryl sulphate is dropped in the aqueous phase dissolved pot; To fully the dissolving after, be cooled to 80 ℃ for subsequent use.
6. water, oil phase are successively sucked in the vacuum emulsification pot by 200 mesh sieves through negative pressure.Keep 80 ℃, emulsifying 20 minutes.Opened homogenizer 3～5 minutes.Continue to stir, when being cooled to 65 ℃, concentrated extractum is added in the vacuum emulsification pot, continue to stir, be cooled to below 50 ℃, namely get patent medicine.
Cream preparation of the present invention adopts O/W type emulsifying agent adjuvant to make, when using throughout the year, be applied in the affected part, without greasy feeling, good with the coupling of skin, good absorbing, the ointment before having improved is unsuitable for the situation that hot weather uses, also increase simultaneously the stability of medicine, improved the curative effect of this medicine.
Clinical trial shows that emulsifiable paste has strengthened clinical efficacy in the disease for the treatment of eczema, has overcome the malaise symptoms that causes owing to heat, has also increased patient's receptance.Compound recipe Semen pegani harmalae emulsifiable paste of the present invention is easily accepted by the patient, and its preparation technology is simple, and the outward appearance silk is sliding, does not have larger oiliness, be applicable to weather throughout the year, be easy to absorb, zest reduces, and is easy to use, storage life is long, and cost is low, the advantage that the scope of application is wide.
Specific implementation method
Following examples further specify content of the present invention, but should not be construed as limitation of the present invention.Without departing from the spirit and substance of the case in the present invention, modification or replacement to the inventive method, step or condition are done all belong to scope of the present invention.
The percentage sign that relates among the present invention " % " if do not specify, refers to mass percent.If do not specialize, the conventional means that used technological means is well known to those skilled in the art among the embodiment.
Embodiment 1
Composition by prescription: Semen pegani harmalae 20%; Semen Hyoscyami 12%; Colchicum autumnale 8%; 16. octadecanol 6%; White vaseline 3%; Liquid Paraffin 10%; Glyceryl monostearate 4%; Ethylparaben 0.1%; Glycerol 16%; Sodium lauryl sulphate 1%; Purified water 19.9%, Semen pegani harmalae, Semen Hyoscyami, Colchicum autumnale are put into pulverizer, start pulverizer and be ground into fine powder, get the Semen pegani harmalae, Semen Hyoscyami, the Colchicum autumnale fine powder that crush, heating and refluxing extraction 2 times, each 95% ethanol (hydrochloric acid adjust pH to 4) that adds 5 times of amounts of medical material, each reflux, extract, 3 hours, merge extractive liquid,, leave standstill, filter (200 mesh sieve), get filtrate, get filtrate recycling ethanol, being concentrated into relative density is the extractum (without the alcohol flavor) of 1.25～1.30 (20 ℃); Get oil phase 16. octadecanol, white vaseline, liquid Paraffin, glyceryl monostearate, be heated to about 100 ℃, be incubated 30 minutes, after insulation finishes, ethylparaben is dropped in the oil phase dissolving pan, to complete dissolving, be cooled to 80 ℃ for subsequent use; Water intaking phase glycerol, purified water when being heated to 100 ℃, are incubated 30 minutes, and sodium lauryl sulphate is dropped in the aqueous phase dissolved pot; To fully the dissolving after, be cooled to 80 ℃ for subsequent use; Water, oil phase are successively sucked in the vacuum emulsification pot by 200 mesh sieves through negative pressure.Keep 80 ℃, emulsifying 20 minutes.Opened homogenizer 3～5 minutes.Continue to stir, when being cooled to 65 ℃, concentrated extractum is added in the vacuum emulsification pot, continue to stir, be cooled to below 50 ℃, namely get patent medicine.
Embodiment 2:
Composition by prescription: Semen pegani harmalae 19.5%; Semen Hyoscyami 11.5%; Colchicum autumnale 9%; 16, octadecanol 6%; White vaseline 3%; Liquid Paraffin 10%; Glyceryl monostearate 4%; Ethylparaben 0.1%; Glycerol 16%; Sodium lauryl sulphate 1%; Purified water 19.9%, Semen pegani harmalae, Semen Hyoscyami, Colchicum autumnale are put into pulverizer, start pulverizer and be ground into fine powder, get the Semen pegani harmalae, Semen Hyoscyami, the Colchicum autumnale fine powder that crush, heating and refluxing extraction 2 times, each 95% ethanol (hydrochloric acid adjust pH to 4) that adds 5 times of amounts of medical material, each reflux, extract, 3 hours, merge extractive liquid,, leave standstill, filter (200 mesh sieve), get filtrate, get filtrate recycling ethanol, being concentrated into relative density is the extractum (without the alcohol flavor) of 1.25～1.30 (20 ℃); Get oil phase 16. octadecanol, white vaseline, liquid Paraffin, glyceryl monostearate, be heated to about 100 ℃, be incubated 30 minutes, after insulation finishes, ethylparaben is dropped in the oil phase dissolving pan, to complete dissolving, be cooled to 80 ℃ for subsequent use; Water intaking phase glycerol, purified water when being heated to 100 ℃, are incubated 30 minutes, and sodium lauryl sulphate is dropped in the aqueous phase dissolved pot; To fully the dissolving after, be cooled to 80 ℃ for subsequent use; Water, oil phase are successively sucked in the vacuum emulsification pot by 200 mesh sieves through negative pressure.Keep 80 ℃, emulsifying 20 minutes.Opened homogenizer 3～5 minutes.Continue to stir, when being cooled to 65 ℃, concentrated extractum is added in the vacuum emulsification pot, continue to stir, be cooled to below 50 ℃, namely get patent medicine.
Embodiment 3
Composition by prescription: Semen pegani harmalae 21.5%; Semen Hyoscyami 10.5%; Colchicum autumnale 6.5%; 16. octadecanol 6.0%; White vaseline 3.5%; Liquid Paraffin 11.0%; Glyceryl monostearate 3.5%; Ethylparaben 0.05%; Glycerol 15.5%; Sodium lauryl sulphate 1.5%; Purification 20.45%, Semen pegani harmalae, Semen Hyoscyami, Colchicum autumnale are put into pulverizer, start pulverizer and be ground into fine powder, get the Semen pegani harmalae, Semen Hyoscyami, the Colchicum autumnale fine powder that crush, heating and refluxing extraction 2 times, each 95% ethanol (hydrochloric acid adjust pH to 4) that adds 5 times of amounts of medical material, each reflux, extract, 3 hours, merge extractive liquid,, leave standstill, filter (200 mesh sieve), get filtrate, get filtrate recycling ethanol, being concentrated into relative density is the extractum (without the alcohol flavor) of 1.25～1.30 (20 ℃); Get oil phase 16. octadecanol, white vaseline, liquid Paraffin, glyceryl monostearate, be heated to about 100 ℃, be incubated 30 minutes, after insulation finishes, ethylparaben is dropped in the oil phase dissolving pan, to complete dissolving, be cooled to 80 ℃ for subsequent use; Water intaking phase glycerol, purified water when being heated to 100 ℃, are incubated 30 minutes, and sodium lauryl sulphate is dropped in the aqueous phase dissolved pot; To fully the dissolving after, be cooled to 80 ℃ for subsequent use; Water, oil phase are successively sucked in the vacuum emulsification pot by 200 mesh sieves through negative pressure.Keep 80 ℃, emulsifying 20 minutes.Opened homogenizer 3～5 minutes.Continue to stir, when being cooled to 65 ℃, concentrated extractum is added in the vacuum emulsification pot, continue to stir, be cooled to below 50 ℃, namely get patent medicine.
Embodiment 4
Composition by prescription: Semen pegani harmalae 19.0%; Semen Hyoscyami 13.5%; Colchicum autumnale 7.5%; 16. octadecanol 8%; White vaseline 1.5%; Liquid Paraffin 9.5%; Glyceryl monostearate 4.5%; Ethylparaben 0.15%; Glycerol 17.5%; Sodium lauryl sulphate 0.5%; Purification 18.35%, Semen pegani harmalae, Semen Hyoscyami, Colchicum autumnale are put into pulverizer, start pulverizer and be ground into fine powder, get the Semen pegani harmalae, Semen Hyoscyami, the Colchicum autumnale fine powder that crush, heating and refluxing extraction 2 times, each 95% ethanol (hydrochloric acid adjust pH to 4) that adds 5 times of amounts of medical material, each reflux, extract, 3 hours, merge extractive liquid,, leave standstill, filter (200 mesh sieve), get filtrate, get filtrate recycling ethanol, being concentrated into relative density is the extractum (without the alcohol flavor) of 1.25～1.30 (20 ℃); Get oil phase 16. octadecanol, white vaseline, liquid Paraffin, glyceryl monostearate, be heated to about 100 ℃, be incubated 30 minutes, after insulation finishes, ethylparaben is dropped in the oil phase dissolving pan, to complete dissolving, be cooled to 80 ℃ for subsequent use; Water intaking phase glycerol, purified water when being heated to 100 ℃, are incubated 30 minutes, and sodium lauryl sulphate is dropped in the aqueous phase dissolved pot; To fully the dissolving after, be cooled to 80 ℃ for subsequent use; Water, oil phase are successively sucked in the vacuum emulsification pot by 200 mesh sieves through negative pressure.Keep 80 ℃, emulsifying 20 minutes.Opened homogenizer 3～5 minutes.Continue to stir, when being cooled to 65 ℃, concentrated extractum is added in the vacuum emulsification pot, continue to stir, be cooled to below 50 ℃, namely get patent medicine.
Embodiment 3 clinical trials
Trial drug: commercially available compound recipe Semen pegani harmalae ointment (z20063953), compound recipe Semen pegani harmalae emulsifiable paste of the present invention (embodiment 1);
Subjects: clinical definite is raw caused joint aches patient and raw caused eczema patients;
Test method: medicine is applied the affected part, 2 times on the one, observed 1 month.
Efficacy determination: 1, joint aches curative effect: recovery from illness: arthralgia disappears, and joint motion freely; Produce effects: arthralgia disappears substantially, joint motion freely; Effectively: arthralgia takes a turn for the better to some extent, and joint motion freely; Invalid: the treatment front and back are without significant change.2, eczema curative effect: recovery from illness: eczema all disappears, and does not recur in 4 months; Produce effects: eczema all disappears, and in 4 months recurrence is arranged; Effectively: eczema disappears to some extent; Invalid: the treatment front and back are without significant change.
For because the clinical comparison checking one of the disease of raw caused joint aches:
Compound recipe Semen pegani harmalae ointment (commercially available, the accurate word z20063953 of traditional Chinese medicines), case 27 people, 15 people that fully recover, produce effects 3 people, effective 7 people, invalid 2 people, total effective rate 66.7%.
Compound recipe Semen pegani harmalae emulsifiable paste (embodiment 1), case 27 people, 18 people that fully recover, produce effects 6 people, effective 2 people, invalid 1 people, total effective rate 88.9%.
Above-mentioned two groups of contrasts, its conclusion is: what confirmed fully that the effect of emulsifiable paste on the disease for the treatment of joint aches will be more than ointment is effective.
For because the clinical comparison checking two of the disease of raw caused eczema:
Compound recipe Semen pegani harmalae ointment, case 27 people, 14 people that fully recover, produce effects 4 people, effective 8 people, invalid 1 people, total effective rate 66.7%.
Compound recipe Semen pegani harmalae emulsifiable paste (embodiment 1), case 27 people, 19 people that fully recover, produce effects 6 people, effective 2 people, invalid 0 people, total effective rate 92.6%.
Above-mentioned two groups of contrasts, its conclusion is: confirmed that fully emulsifiable paste has strengthened clinical efficacy in the disease for the treatment of eczema, overcome the malaise symptoms that causes owing to heat, also increased patient's receptance.
All obtained better effect according to the emulsifiable paste of the formula preparation of embodiment 2～4 with comparing on treatment joint aches and eczema according to the ointment of conventional method preparation according to same prescription.
Claims (5)
1. aqueous compound recipe Semen pegani harmalae pharmaceutical composition, it is made by crude drug and adjuvant, and described crude drug comprises the raw material of following weight ratio: Semen pegani harmalae 19.0%-21.5%; Semen Hyoscyami 10.5.0%-13.5%; Colchicum autumnale 6.5%-9.0%.
2. pharmaceutical composition according to claim 1 is characterized in that, said composition is emulsifiable paste, and described adjuvant comprises the composition of following weight ratio: 16. octadecanol 5.5%-8.0%; White vaseline 1.5%-3.5%; Liquid Paraffin 9.5%-11.0%; Glyceryl monostearate 3.5%-4.5%; Ethylparaben 0.05%-0.15%; Glycerol 15.5%-17.5%; Sodium lauryl sulphate 0.5%-1.5%; Purified water 18.4%-20.4%.
3. Semen pegani harmalae pharmaceutical composition according to claim 1 and 2, its raw material by following weight ratio is made: Semen pegani harmalae 20%; Semen Hyoscyami 12%; Colchicum autumnale 8%; 16. octadecanol 6%; White vaseline 3%; Liquid Paraffin 10%; Glyceryl monostearate 4%; Ethylparaben 0.1%; Glycerol 16%; Sodium lauryl sulphate 1%; Purified water 19.9%.
4. the preparation method of each described Semen pegani harmalae pharmaceutical composition of claim 1～3 is characterized in that may further comprise the steps:
(1) Semen pegani harmalae, Semen Hyoscyami, Colchicum autumnale are ground into fine powder;
(2) get Semen pegani harmalae, Semen Hyoscyami, the Colchicum autumnale fine powder that crushes, heating and refluxing extraction 1～3 time adds 95% ethanol of 4～5 times of weight of medical material at every turn, with hydrochloric acid adjust pH to 4, each reflux, extract, 2～4 hours, merge extractive liquid,, leave standstill, filter, get filtrate;
(3) get filtrate recycling ethanol, be concentrated into without the alcohol flavor;
(4) get oil phase 16. octadecanol, white vaseline, liquid Paraffin, glyceryl monostearate, be heated to 100 ± 5 ℃, be incubated 20～40 minutes, after insulation finishes, ethylparaben is dropped in the oil phase dissolving pan, to fully the dissolving after, be cooled to 80 ℃ for subsequent use;
(5) water intaking phase glycerol, purified water when being heated to 100 ℃, are incubated 20～40 minutes, and sodium lauryl sulphate is dropped in the aqueous phase dissolved pot; To fully the dissolving after, be cooled to 80 ℃ for subsequent use;
(6) successively suck in the vacuum emulsification pot through negative pressure by 200 mesh sieves water, oil phase; Keep 80 ℃, emulsifying 15～30 minutes was opened homogenizer 3～5 minutes; Continue to stir, when being cooled to 65 ℃, concentrated extractum is added in the vacuum emulsification pot, continue to stir, be cooled to below 50 ℃, namely get patent medicine.
5. the preparation method of Semen pegani harmalae pharmaceutical composition according to claim 4 is characterized in that may further comprise the steps:
(1) Semen pegani harmalae, Semen Hyoscyami, Colchicum autumnale are put into pulverizer, it is ground into fine powder;
(2) get Semen pegani harmalae, Semen Hyoscyami, the Colchicum autumnale fine powder that crushes, heating and refluxing extraction 2 times adds 95% ethanol of 5 times of weight of medical material at every turn, with hydrochloric acid adjust pH to 4, each reflux, extract, 3 hours, merge extractive liquid,, leave standstill, 200 mesh sieves filter, and get filtrate;
(3) get filtrate recycling ethanol, be concentrated into 20 ℃ of lower relative densities and be 1.25～1.30 without alcohol flavor extractum;
(4) get oil phase 16. octadecanol, white vaseline, liquid Paraffin, glyceryl monostearate, be heated to 100 ± 5 ℃, be incubated 30 minutes, after insulation finishes, ethylparaben is dropped in the oil phase dissolving pan, to fully the dissolving after, be cooled to 80 ℃ for subsequent use;
(5) water intaking phase glycerol, purified water when being heated to 100 ℃, are incubated 30 minutes, and sodium lauryl sulphate is dropped in the aqueous phase dissolved pot; To fully the dissolving after, be cooled to 80 ℃ for subsequent use;
(6) successively suck in the vacuum emulsification pot through negative pressure by 200 mesh sieves water, oil phase; Keep 80 ℃, emulsifying 20 minutes was opened homogenizer 3～5 minutes; Continue to stir, when being cooled to 65 ℃, concentrated extractum is added in the vacuum emulsification pot, continue to stir, be cooled to below 50 ℃, namely get patent medicine.
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| CN104622937A (en) * | 2013-11-08 | 2015-05-20 | 马丽霞 | Plant mosquito-repelling itch-relieving external medicament, applications and preparation method thereof |
| CN107625938A (en) * | 2017-08-24 | 2018-01-26 | 木拉提·阿不都热合曼 | A kind of henbane seed analgesic ointment and preparation method thereof |
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| CN101780123A (en) * | 2009-11-13 | 2010-07-21 | 日照金禾生化集团有限公司 | Peganum harmala L extract chewable tablets and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622937A (en) * | 2013-11-08 | 2015-05-20 | 马丽霞 | Plant mosquito-repelling itch-relieving external medicament, applications and preparation method thereof |
| CN107625938A (en) * | 2017-08-24 | 2018-01-26 | 木拉提·阿不都热合曼 | A kind of henbane seed analgesic ointment and preparation method thereof |
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Effective date of registration: 20160229 Address after: 234000 north side of Jin Jiang Road, Suzhou economic and Technological Development Zone, Anhui Applicant after: SUZHOU E-FAN PHARMACEUTICAL CO., LTD. Address before: 836400 the Xinjiang Uygur Autonomous Region Aletai Fuhai County Fuhai Industrial Park North No. 02 Applicant before: Xinjiang Xiwang Pharmaceutical Co., Ltd. |
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