CN104622937A - Plant mosquito-repelling itch-relieving external medicament, applications and preparation method thereof - Google Patents
Plant mosquito-repelling itch-relieving external medicament, applications and preparation method thereof Download PDFInfo
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- CN104622937A CN104622937A CN201310553377.5A CN201310553377A CN104622937A CN 104622937 A CN104622937 A CN 104622937A CN 201310553377 A CN201310553377 A CN 201310553377A CN 104622937 A CN104622937 A CN 104622937A
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Abstract
The invention discloses a plant mosquito-repelling itch-relieving external medicament, which comprises a mixture of volatile extracts of pelargonium graveolens and sedum spectabile boreau. The provided plant mosquito-repelling itch-relieving paste comprises volatile oil extracted from pelargonium graveolens and sedum spectabile boreau; each 100 mL of volatile oil is mixed with the following components by weight: 200 to 300 grams of white vaseline, 150 to 170 parts of octadecanol, 20 to 40 parts of monoglyceride stearate, 10 to 30 grams of sodium dodecyl sulfate, 130 to 150 grams of glycerin, 3 to 5 grams of ethyl p-hydroxybenzoate, and 1800 to 2200 mL of distilled water. The inventor discovers and utilizes the characteristics of pelargonium graveolens and sedum spectabile boreau such as mosquito repelling, itch relieving, swelling eliminating, and the like, to develop a formula of a pure natural mosquito-repelling itch-relieving external medicament. According to the simple formula, external drugs with functions of repelling mosquito and relieving itch such as pastes, sprays, liniments, and the like, can be prepared.
Description
Technical field
The present invention relates to one utilizes natural plant extracts to prepare topical agent, belong to biomedicine technical field medicine and cosmetics A61P: the therapeutic activity technical field of compound or pharmaceutical preparation.
Background technology
When arriving summer, mosquito bite becomes our a great problem of puzzlement already, hard to bear once be bitten with regard to very itching, and also easily causes the various diseases such as dengue fever, malaria, has a strong impact on our work, life.
At present conventional anophelifuge method has mosquito incense, floral water, mosquito does not sting, anophelifuge ring etc.Although this several method has certain repelling effect, igniting mosquito-repellent incense must in confined space effectively, and easy contaminated environment easily makes people produce allergic phenomena; Anophelifuge ring is only effective within the scope of 1cm around ring, and floral water, mosquito are not stung and easily produced stimulation to skin, and easily produce anaphylaxis.
Its toxic and side effects of current plant-originated repellent is little, not easily makes harmful organism develop immunity to drugs.But some current mosquito-expelling and antipruritic medicaments, synthetic containing various effect in its composition, its component is various, complicated, assort these components, just become certain difficulty, thus preparation cost is also very high, and for the extracting method of plant source active ingredient, its operating procedure is many and numerous, the fabrication and processing of medicament is carried out again after often needing to be extracted separately by effective ingredient one by one, thus seem simple not, industrial scale is produced and brings certain difficulty, efficiency is low, and the extractant itself used in some extracting method has stimulation to skin, if residue in finished product, also harmful effect can be produced to skin, affect the comfort of antipruritic medicament, thus also need to reduce to the greatest extent by some means the content maybe may removing these extractants.Prior reason is, not yet find at present the plant source anophelifuge of certain simple formulation have excellent, rapidly antipruritic and detumescence effect.
For solving the problems of the technologies described above, present invention employs and use only two kinds of comparatively common, to be easy to get plants, i.e. Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti, adopts unique component extracting method, and research makes a kind of not only anophelifuge but also the topical agent of the remarkable antipruritic effect of tool of pure natural.
Summary of the invention
Inventor, through screening for many years and research, selects and has screened two kind of plant Pelargonium gravelenss and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti, makes anophelifuge topical agent, can solve expelling mosquito, and by the antipruritic and detumescence problem after biting.
The invention discloses a kind of plant mosquito-expelling and antipruritic medicine for external use, it comprises the volatile oil extracted by Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti.
The present invention more provides a kind of plant mosquito-expelling and antipruritic cream, and its volatile oil extracted by Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti and unguentum adjuvant form.
Above-mentioned plant mosquito-expelling and antipruritic cream, comprise following component: the volatile oil that Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti extract, white vaseline 200-300g joined by every 100ml volatile oil, octadecanol 150 ~ 170g, glyceryl monostearate 20-40g, sodium lauryl sulphate 10-30g, glycerol 130-150g, ethylparaben 3-5g, distilled water 1800-2200ml.
Above-mentioned plant mosquito-expelling and antipruritic cream, comprises following component: every 100ml volatile oil joins white vaseline 250g, octadecanol 160g, glyceryl monostearate 30g, sodium lauryl sulphate 20g, glycerol 140g, ethylparaben 4g, distilled water 2000ml.
Plant mosquito-expelling and antipruritic medicine for external use of the present invention, is not limited to unguentum, all right liniment, spray, patch etc., and different dosage forms is that the volatile oil adopting corresponding adjuvant to coordinate Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti to extract is made.
The preparation method of one kind of plant mosquito-expelling and antipruritic medicine for external use, its active ingredient is the volatile oil extracted by Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti, and the extraction step of described Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti volatile oil is:
1) stock solution preparation:
1.1) collection Pelargonium gravelens stem and leaf, Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti blade clean respectively, dry;
1.2) Pelargonium gravelens stem and leaf, Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti blade are squeezed the juice;
1.3) thick worry, centrifugal treating, obtain juice stock solution;
2) stock solution preparation process is mixed:
2.1) get Pelargonium gravelens stock solution, Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti stock solution 1:1 mixes;
2.2) centrifugal treating is carried out to Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti mixed liquor, to remove the precipitate impurity in mixed liquor, collect centrifugal after liquid;
2.3) fine straining, by filtrate cold preservation;
3) volatile oil preparation process:
3.1) by step 2) Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti stock solution evaporation and concentration of gained is to less than 1/3 of stock solution volume;
3.2) by after concentrated solution filter paper filtering, be added to again in dehydrated alcohol and carry out dilution crystallization, the volumetric usage ratio of concentrated solution and dehydrated alcohol is 1:8, leave standstill and (be preferably more than 48 hours) after some hours, dissolved liquid is filtered, filtering crystallization, obtains the filtrate containing Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti mixture of volatile oil.
Dilution crystallization is by solute dissolves in water or other organic solvents, in crystalline solid, then add the dissolubility reduction that certain solvent makes solute in former solvent, thus the method for crystallising that solute is separated out fast.The solvent added is referred to as dissolved agent or precipitant, and dissolved agent can be gas, also can be liquid.
Above-mentioned topical agent is ointment, and the preparation process of described ointment is:
(1) get the raw materials ready: every 100ml volatile oil joins white vaseline 200-300g, octadecanol 150 ~ 170g, glyceryl monostearate 20-40g, sodium lauryl sulphate 10-30g, glycerol 130-150g, ethylparaben 3-5g, distilled water 1800-2200ml;
(2) ointment is prepared:
Get white vaseline, octadecanol and glyceryl monostearate and be placed in beaker, in bath temperature 70 ~ 80 DEG C, make it melt and obtain fluid; Sodium lauryl sulphate, glycerol, ethylparaben etc. are placed in another beaker with distilled water, bath temperature 70 ~ 80 DEG C, make it melt and obtain distilled water liquid.
Under equality of temperature, be added in fluid by distilled water liquid with thread, limit edged is stirred to condensation, obtains Water-In-Oil (O/W) type Emulsion, then adds the plant volatile oil obtained after filtration analysed by alcohol and stir.
(3) sterilization processing is carried out with Burdick lamp.
The volatile oil that present invention further teaches Pelargonium gravelens and the extraction of Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti is making the application in mosquito-expelling and antipruritic topical agent.
The present invention finds and utilizes the characteristic of Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti plant mixture tool anophelifuge, antipruritic, detumescence, invent a kind of formula preparing the antipruritic medicine for external use of pure natural mosquito-repellent, only use simple formula, just can prepare both can anophelifuge, medicine is smeared in external that again can be effectively antipruritic, such as unguentum, liniment, spray etc.
Mosquito-expelling and antipruritic medicine of the present invention only uses two kinds of common plants, and its drug effect material is pure plant source, and toxic and side effects is little, not easily makes harmful insect develop immunity to drugs.Its formula is simple; common being easy to of material obtains; thus preparation cost is low; again because " mixing stock solution dissolved method " of the present invention extracts the method for plant active ingredient very simply, operating procedure is few, uses alcohol as dissolved agent; a small amount of residual also non-stimulated to skin; also have effect that is antibacterial, that prevent finished product rotten, therefore the present invention's obtaining and preparing two major parts for material, is really very beneficial for large-scale industrial and produces.
Through inspection, the present invention is nontoxic to skin, harmless, non-stimulated, convenient, safety.
Accompanying drawing explanation
Fig. 1 is the comprehensive use sample survey results figure using itching-relieving cream effect of the present invention.
Fig. 2 is the antipruritic time sampling survey result figure using itching-relieving cream of the present invention.
Detailed description of the invention
the preparation example of mosquito-expelling and antipruritic cream:
1, stock solution preparation
Gather Pelargonium gravelens stem and leaf, clean piecewise with water, dry; Weigh.Gather Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti blade, clean piecewise with water, dry; Weigh.
Pelargonium gravelens spiral juice extractor is squeezed the juice (Lexen hand-rail type juice extractor), and by Pelargonium gravelens juice filter-cloth filtering, after coarse filtration, centrifugal treating, obtains juice stock solution, and juice is in green.The Pelargonium gravelens juice obtained after filtration is placed in beaker, and marks: " Pelargonium gravelens normal juice ", be placed in cold compartment of refrigerator and preserve.
Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti blade juice extractor is squeezed the juice, and by Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti juice filter-cloth filtering, juice, in green, be positioned among beaker, and mark: " Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti normal juice ", is placed in cold compartment of refrigerator and preserves.
2, stock solution preparation is mixed
From refrigerator, take out Pelargonium gravelens juice, Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti juice, implant in measuring cup by equivalent share, form 1:1 mixed solution, mixed liquor is yellow green.
Get mixed liquor and be placed in 4 centrifuge (LD-2A respectively, Hunan Xiang Yi Laboratory Instruments development corporation, Ltd.) centrifuge tube in, arrange rotating speed 3500 revs/min, the time is 15 minutes, centrifugal treating is carried out to Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti mixed liquor, to remove the precipitate impurity in mixed liquor.Centrifugal rear liquid color is orange-yellow, and precipitate is green.By the liquid collecting after centrifugal measuring cup in.
Select conical flask, glass funnel, each two covers of filter paper, filter the mixed liquor after centrifugal.
By obtain after filtering Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti mixed liquor is placed in vial, bottle marks: " Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti mixing stock solution ", is placed in cold compartment of refrigerator and preserves.
3, concentrated, the purification processes of plant extraction liquid
" Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti mixing stock solution " is installed in rotary evaporator (Shanghai Yarong Biochemical Instrument Plant) with flask, again temperature is adjusted to 115 DEG C, rotating speed is transferred to 80 revs/min, vacuum pump using circulatory water (Shanghai know reliable test technical device company limited) pressure adjusting concentrates to 0.05MP, be concentrated into less than 1/3 of former mixing stock solution volume, obtain mixed concentrated liquid.
After concentrated solution filter paper filtering, then add dehydrated alcohol (Beijing Chemical Plant) and carry out dissolved, the volumetric usage ratio of concentrated solution and ethanol is 1:8, leaves standstill 48 hours.Dissolved liquid is filtered, filtering crystal, obtain the filtrate containing Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti phytovolatilization oil mixture, for the processing and fabricating of ointment or its topical agent etc.
4, ointment preparation
Balance weighs (Shanghai Hua Litai electronic scale company limited), white vaseline (Nanchang white clouds medicinal liquid company limited) 200-300g is joined according to every 100ml plant volatile oil, octadecanol (Chemical Reagent Co., Ltd., Sinopharm Group) 150 ~ 170g, glyceryl monostearate 20-40g, sodium lauryl sulphate 10-30g, glycerol (Chemical Reagent Co., Ltd., Sinopharm Group) 130-150g, ethylparaben 3-5g, distilled water 1800-2200ml prepares each batching;
Get white vaseline, octadecanol and glyceryl monostearate and be placed in beaker, water-bath (Yuyao City east electric instrument factory) set temperature 70 ~ 80 DEG C, makes it melt and obtains fluid; Sodium lauryl sulphate, glycerol, ethylparaben and distilled water are placed in another beaker, and water-bath set temperature 70 ~ 80 DEG C, makes it melt and obtains distilled water liquid.
Under equality of temperature, be added in fluid by distilled water liquid with thread, limit edged is stirred to condensation, obtains Water-In-Oil (O/W) type Emulsion, then add alcohol analyse filtration after Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti plant volatile oil stir.
From factory's customization cream toilet ware box, carry out sterilization processing with Burdick lamp.Pour in box by the mastic prepared, screw lid, labelled, prepared by finished product.
Finished product plant mosquito-repellent paste through the inspection of Centers For Disease Control And Prevention In Beijing center Institute for Toxicology, to toxic and side effects such as skin are non-stimulated.
mosquito-expelling and antipruritic cream result of use checking example:
Provide questionnaire and use itching-relieving cream 500 parts, return effective questionnaire 300 parts, selection male, women respectively account for 50%, age is between 13-55 one full year of life, logical oversampling acquisition 30 increment originally, result " comprehensive use sample survey results figure " as shown in Figure 1, and " the antipruritic time sampling survey result figure " shown in Fig. 2.
As seen from Figure 1, in sample survey sample, repelling effect effective percentage is 88%, and antipruritic effect effective percentage is 88.6%; Biting rear number of times of on average smearing is 2.17 recoveries from illness.As seen from Figure 2, smear plant mosquito-expelling and antipruritic cream average 11 minutes relieving itching and eliminating swelling effects after biting to manifest.Be 96% to this plant mosquito-expelling and antipruritic cream overall assessment.
Claims (9)
1. a kind of plant mosquito-expelling and antipruritic medicine for external use, it comprises by the mixture of volatile oil extracted in Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti.
2. plant mosquito-expelling and antipruritic medicine for external use as claimed in claim 1, it is characterized in that, described medicine for external use is plant mosquito-expelling and antipruritic cream, and its mixture of volatile oil extracted by Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti and unguentum adjuvant form.
3. plant mosquito-expelling and antipruritic medicine for external use as claimed in claim 2, it is characterized in that, described plant mosquito-expelling and antipruritic cream, comprises following component: the volatile oil that Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti extract, and white vaseline 200-300g joined by every 100ml volatile oil, octadecanol 150 ~ 170g, glyceryl monostearate 20-40g, sodium lauryl sulphate 10-30g, glycerol 130-150g, ethylparaben 3-5g, distilled water 1800-2200ml.
4. plant mosquito-expelling and antipruritic medicine for external use as claimed in claim 3, it is characterized in that, described plant mosquito-expelling and antipruritic cream, comprise following component: every 100ml volatile oil joins white vaseline 250g, octadecanol 160g, glyceryl monostearate 30g, sodium lauryl sulphate 20g, glycerol 140g, ethylparaben 4g, distilled water 2000ml.
5. plant mosquito-expelling and antipruritic medicine for external use as claimed in claim 1, it is characterized in that, described plant mosquito-expelling and antipruritic medicine for external use is unguentum, liniment, spray or patch.
6. Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti mixture of volatile oil, for making the purposes of mosquito-expelling and antipruritic topical agent, is characterized in that: containing as the mixture of volatile oil extracted in the Pelargonium gravelens of effective ingredient and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti in mosquito-expelling and antipruritic medicine for external use.
7. the preparation method of a kind of plant mosquito-expelling and antipruritic medicine for external use, wherein the active ingredient of medicine for external use is the mixture of volatile oil extracted by Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti, and the extraction step of described Pelargonium gravelens and Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti mixture of volatile oil is:
Prepared by stock solution:
Collection Pelargonium gravelens stem and leaf, Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti blade clean respectively, dry;
Pelargonium gravelens stem and leaf, Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti blade are squeezed the juice;
Thick worry, centrifugal treating, obtain juice stock solution respectively;
Mixing stock solution preparation process:
2.1) Pelargonium gravelens stock solution, the mixing of Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti stock solution is got;
2.2) centrifugal treating is carried out to Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti mixed liquor, to remove the precipitate impurity in mixed liquor, collect centrifugal after liquid;
2.3) fine straining, obtains Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti stock solution filtrate;
3) volatile oil preparation process:
3.1) by step 2) Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti stock solution filtrate evaporation and concentration of gained is to less than 1/3 of stock solution volume;
3.2) by after concentrated solution filter paper filtering, then be added in dehydrated alcohol in concentrated solution and carry out dilution crystallization, leave standstill some hours, by the crystal filtering in dissolved liquid, obtain the filtrate containing Pelargonium gravelens-Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti mixture of volatile oil.
8. the preparation method of plant mosquito-expelling and antipruritic medicine for external use as claimed in claim 7, described medicine for external use is ointment, and the preparation process of described ointment is:
(1) get the raw materials ready: every 100ml plant volatile oil joins white vaseline 200-300g, octadecanol 150 ~ 170g, glyceryl monostearate 20-40g, sodium lauryl sulphate 10-30g, glycerol 130-150g, ethylparaben 3-5g, distilled water 1800-2200ml;
(2) ointment is prepared:
Get white vaseline, octadecanol and glyceryl monostearate and be placed in beaker, in bath temperature 70-80 DEG C, make it melt and obtain fluid; Sodium lauryl sulphate, glycerol, ethylparaben and distilled water are placed in another beaker, bath temperature 70-80 DEG C, make it melt and obtain distilled water liquid;
Under equality of temperature, be added in fluid by distilled water liquid with thread, limit edged is stirred to condensation, obtains Water-In-Oil (O/W) type Emulsion, then adds the plant volatile oil obtained after filtration analysed by alcohol and stir;
(3) sterilization processing is carried out with Burdick lamp.
9. the preparation method of plant mosquito-expelling and antipruritic medicine for external use as claimed in claim 7, is characterized in that, step 3.2) in the dehydrated alcohol that the uses 8 times of volumes that are concentrated solution.
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| CN105343144A (en) * | 2015-12-03 | 2016-02-24 | 河北大学 | Preparation method and application of anti-bacterial and anti-inflammation sow thistle ointment |
| CN105726362A (en) * | 2016-02-25 | 2016-07-06 | 河北美荷药业有限公司 | Cow repellent compound ointment and preparation method thereof |
| CN113648338A (en) * | 2021-08-26 | 2021-11-16 | 柯永胜 | Preparation method of rhodiola crenulata gel |
| CN114146112A (en) * | 2020-09-07 | 2022-03-08 | 湖州新活医疗科技有限公司 | Traditional Chinese medicine composition for relieving swelling and itching or diminishing inflammation and relieving itching, preparation method and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343144A (en) * | 2015-12-03 | 2016-02-24 | 河北大学 | Preparation method and application of anti-bacterial and anti-inflammation sow thistle ointment |
| CN105726362A (en) * | 2016-02-25 | 2016-07-06 | 河北美荷药业有限公司 | Cow repellent compound ointment and preparation method thereof |
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| CN114146112A (en) * | 2020-09-07 | 2022-03-08 | 湖州新活医疗科技有限公司 | Traditional Chinese medicine composition for relieving swelling and itching or diminishing inflammation and relieving itching, preparation method and application thereof |
| CN113648338A (en) * | 2021-08-26 | 2021-11-16 | 柯永胜 | Preparation method of rhodiola crenulata gel |
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