CN106975049A - A kind of Yi nationality drug composition of reducing blood pressure and blood fat - Google Patents

Abstract

The present invention relates to a kind of Yi nationality's drug composition of reducing blood pressure and blood fat, it is characterised in that is made by following raw material：15 25 parts of finelydivided phtheirospermum root, 20 35 parts of Cymbaria dahurica, 5 10 parts of cattail pollen, 15 20 parts of the root bark of Chinese wolf-berry, 6 10 parts of rhizoma alismatis, 10 15 parts of HERBA SIPHONOSTEGIAE, 36 parts of turmeric, 12 15 parts of aleppo avens herb, 10 15 parts of Asian puccoon；The present composition has promoting blood circulation decompression, changes turbid lipid-loweringing, broken stasis of blood promoting the circulation of qi, inducing meastruation to relieve menalgia, qi-restoratives strengthening the essence, the function of soothing the liver nourishing heart, it is to be used to treat and prevent hypertension, hyperlipemia, atherosclerosis can effectively be prevented and treated, and composition production technique is simple, suitable for industrialized production and marketing application.

Description

A kind of Yi nationality drug composition of reducing blood pressure and blood fat

Technical field

The present invention relates to a kind of drug regimen with lowering blood pressure and blood fat function, particularly using ethnic drug to be main former The reducing blood pressure and blood fat Yi nationality drug composition of material.

Background technology

Yi Nationality Medicine experienced thousands of years time, understanding, the process put into practice, recognized again again, have accumulated abundant diseases prevention Cure the disease experience, develop into a huge treasure-house.State Council leader points out in national work of Chinese medicine meeting in 2004： " national medicine ensure body health of people in terms of also play an important role, conscientiously to carry out excavation, arrangement, summary, Work is improved, its development of making greater efforts to promote." 2005 years, State Council《Implement<The Law of the People's Republic of China on the Autonomy of Ethnic Minority Regions>It is some Regulation》In be just already indicated above：" people's governments at all levels should increase the input to national medicine cause, protection, support and development of national Medicine and pharmacology." it is all these be provided to effectively to protect with development of national medicine, make from it is national, protect national health money Source is able to develop and made full use of, while also embodying the great attention that country develops to national medicine.

With the continuous improvement of people's living standards, high protein, high cholesterol, higher unsaturated fatty acid, high salt, high heat are eaten The excessive intake of thing, and there is the bad life styles such as long-term smoking, anxiety, diet structure is destroyed so that blood pressure is inclined High, Hyperlipidemia turns into commonplace phenomenon, and the trend risen with rejuvenation is presented.It is reported that China is at present with height Blood pressure people surpasses 300,000,000, wherein 50% with dyslipidemia, high blood pressure influences each other with dyslipidemia, so as to further increase the heart The danger of vascular diseases.Therefore, preventing and treating of the control blood fat to cardiovascular and cerebrovascular diseases has great importance while decompression.

Conventional drug for hypertension mainly has calcium channel blocker, AngiotensionⅡ inhibitor and ACE-I tri- big at present Class, mainly based on Nimodipine, Telmisartan, captopril；Western medicine blood lipid-lowering medicine be based on Statins, but this A little medicine long-term takings can produce dependence and many adverse reaction and side effect, and such as Nimodipine can cause intestines and stomach The symptoms such as bleeding, decrease of platelet, skin irritation, it is bad anti-that captopril can produce injury of kidney and palpitaition, vomiting, faintness etc. Should, Statins easily causes the side effects such as rhabdomyolysis, myalgia, and can control blood fat while decompression without a Medicine, medical expense is higher.

Compared with Western medicine, the uniqueness such as the high security of traditional Chinese medicine, low adverse reaction, multicomponent, Mutiple Targets, wholistic therapy Advantage gradually shows, and Yi nationality's medicine as tcm field one greatly have national characters rarity, its potentiality and superiority are not sayed And explain, with boundless development prospect.

The content of the invention

There is hypotensive activity it is an object of the invention to provide one kind, while Yi nationality's medicine combination of blood fat balance can be adjusted Thing, the problem of to solve to propose in background technology, the present invention carries out formula design based on Yi nationality's medicine, with finelydivided phtheirospermum root（It is puckery not all）、 Cymbaria dahurica（Machine can rise）, cattail pollen be monarch drug in a prescription, mental-tranquilization, promoting blood circulation decompression；With the root bark of Chinese wolf-berry（Closely can slag）, rhizoma alismatis, HERBA SIPHONOSTEGIAE（It is puckery It is blue or green）For ministerial drug, heat-clearing improving eyesight, damp-clearing pain-relieving, the turbid lipid-loweringing of change, while strengthening reducing blood pressure and blood fat effect, are worked along both lines；With ginger Yellow, aleppo avens herb（Miaow vegetarian）For adjutant, broken stasis of blood promoting the circulation of qi, inducing meastruation to relieve menalgia, enriching yin and nourishing kidney strengthen the work(of reducing blood pressure and blood fat Effect, while supplementing kidney qi；With Asian puccoon（The straight slag of cloth）To make medicine, priming enters pericardium channel, Liver Channel, and focus of going directly, each medicine gives full play to Monarch relation, promoting blood circulation is depressured, changes turbid lipid-loweringing, and qi-restoratives strengthening the essence, soothing the liver nourishing heart are adjusted comprehensively to body, more efficient Treat hypertension, hyperlipemia disease.

It is an object of the invention to carry forward Chinese TCM Culture, depth excavates Yi nationality's medicine value with national characters.

In order to realize foregoing invention purpose, the present invention provides following technical scheme：

There is promoting blood circulation decompression the invention provides one kind, change turbid lipid-loweringing, broken stasis of blood promoting the circulation of qi, inducing meastruation to relieve menalgia, qi-restoratives strengthening the essence, soothing the liver nourishing heart Function, Yi nationality's drug composition of safe and effective reducing blood pressure and blood fat, in parts by weight, it is made up of the following raw material：

Finelydivided phtheirospermum root（It is puckery not all）15-25 parts, Cymbaria dahurica（Machine can rise）20-35 parts, 5-10 parts of cattail pollen, the root bark of Chinese wolf-berry（Closely can slag）15- 20 parts, 6-10 parts of rhizoma alismatis, HERBA SIPHONOSTEGIAE（Puckery green grass or young crops）10-15 parts, 3-6 parts of turmeric, aleppo avens herb（Miaow vegetarian）12-15 parts, purple Grass（The straight slag of cloth）10-15 parts.

Effect of following taste Chinese medicine is introduced separately below and cures mainly disease：

It is puckery not all, Chinese medicine name finelydivided phtheirospermum root, alias moellendorf spikemoss herb, be Scrophulariaceae Pheheirospermum japonicum platymiscium (Phtheirospermum tenuisectum Bur. et Franch) perennial short and small draft, with root, all herbal medicine.Be distributed in Qinghai, Sichuan, Guizhou, Yunnan, Tibet, free translation are cardiopathic medicine, and document is recorded：Its mild-natured, pungent hardship.Thoughts of returning home warp, reposes with feeling at ease, hemostasis Effect.《Yi nationality's medicine book on Chinese herbal medicine》It is recorded to cure mainly：Nervous palpitaition, arrhythmia cordis, insomnia and dreamful sleep, vertigo, hypertension.

Machine can rise, Chinese medicine name Cymbaria dahurica, the big affine cudweed of alias, be composite family Gnaphalium (Gnaphalium affine D.Don) perennial herb, all herbal medicine is distributed mainly on the ground such as Yunnan, Sichuan,《Yi nationality's medicine book on Chinese herbal medicine》It is recorded to cure mainly outside Sense cough, tracheitis cough, document record its sweet, slight bitter, and property is pungent, puts down.With preventing phlegm from forming and stopping coughing, clearing heat and promoting diuresis, promoting blood circulation decompression Effect.

Cattail pollen, Typhaceae plant raupo cattailTypha angustifoliaL., typha orientalisTypha orientalisPreslOr the dry pollen of congener.It is sweet, mild-natured, Return liver, pericardium channel, tool hemostasis, stagnation resolvation is treating stranguria Effect.For spitting blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, uterine bleeding, traumatism and bleeding, closed dysmenorrhea, chest and abdomen shouting pain, tumbling and swelling, blood strangury and dry pain.Its Containing phytosterols such as sitosterol, stigmasterol, campesterols, zoopery also proves substantially suppress the exogenous courage of intestinal absorption Sterol, promotes it to be discharged in excrement, so as to play a part of reducing blood fat, and can have atherosclerosis and reduction blood Clear sterol.

Nearly river slag, the Chinese medicine name root bark of Chinese wolf-berry, alias matrimony vine beans, Solanaceae (Lycium chinenseMill) overgrow undershrub, Root is taken to be used as medicine, document records its sweet-bitter flavor, cool in nature, returns liver and kidney channel, with qi-restoratives strengthening the essence, heat-clearing is quenched the thirst, the work(of dispelling pathogenic wind for improving eyesight Effect, be mainly used in main caused by liver and kidney deficiency, blurred vision, soreness and weakness of waist and knees, quench one's thirst draw drink etc. disease.《Yi nationality's medicine book on Chinese herbal medicine》Record it and cure mainly high blood Press, toothache caused by fire of deficiency type, the disease such as phlegm-accumulating vertigo.

Rhizoma alismatis, Notes On Alism At Aceae rhizoma alismatisAlisma orientale（Sam.）Juzep. dry tuber.It is sweet, light, It is cold in nature.Return kidney, bladder warp.With clearing damp and promoting diuresis, expel the heat-evil, change effect of turbid lipid-loweringing.For difficult urination, oedema turgor, diarrhea Oliguria, phlegmatic vertigo, puckery pain of heat gonorrhea, hyperlipidemia.Animal experiment study shows, hence it is evident that suppress rabbit aorta atherosclerotic plaque Formation and its cholesterolemia content, mouse intestines can be suppressed to cholesterol absorption and internal cholesterol biosynthesis, contribute to courage consolidate The operating and excretion of alcohol.Absorption, decomposition and Excretion with interference cholesterol.

Puckery green grass or young crops, Chinese medicine name HERBA SIPHONOSTEGIAE, alias siphonstegia chinensis, Scrophulariaceae siphonstegia chinensis category (Siphonostegia chinensis Benth) annual herb, all herbal medicine.Main product is in Jiangsu, Anhui, Zhejiang, Yunnan, Guangxi and other places.Document records that its is cold in nature, Slight bitter；With clearing heat and promoting diuresis, cooling blood and hemostasis, effect of stasis-dispelling and pain-killing, for treating jaundice, difficult urination, oedema abdominal distension falls damage Stasis caused pain, bloody flux, blood strangury, leukorrhea, irregular menstruation, a lump in the abdomen causing distension and pain, and postpartum stops stasis of blood stomachache.《Yi nationality's medicine book on Chinese herbal medicine》It is recorded to cure mainly： Icterepatitis, chronic cholecystitis, the disease such as Hypertension Complicated Headache.

Turmeric, zingiberaceous plant turmericCurcuma Longa L. dry rhizome.Pungent, hardship, it is warm-natured.Returns spleen, Liver Channel.Tool There are blood-breaking, inducing meastruation to relieve menalgia effect.For chest side of body shouting pain, chest is fought pained, and dysmenorrhoea Amenorrhea , Disorder lumps in the abdomen, rheumatism shoulder arm pain is fallen Flutter and swell and ache.Document, which records turmeric, can promote choleresis, and the blood courage that its extract can obviously reduce Experimental Hyperlipemia animal is consolidated Alcohol content.Turmeric alcohol extracting thing, volatile oil and curcumin play the role of reduction cholesterolemia, triglycerides and beta Lipoprotein, with Triglyceride reducing is most notable, and can reduce cholesterol, content of triglyceride in sustainer.

Miaow vegetarian, Chinese medicine name aleppo avens herb, alias dizziness medicine, aleppo avens, throatroot, rose family throatroot category (Geum japonicum Thbg.var.chinense F.Bolle) perennial herb, all herbal medicine.Document records its acrid-sweet flavor, property Temperature, with enriching yin and nourishing kidney, flat liver improving eyesight, promoting blood circulation and stopping pain, adjusting meridian and stopping leukorrhea, cures mainly main sore, carbuncle and painful swelling, aphtha pharyngalgia, injuries from falls as well, Under arthralgia pain due to rheumatism, diarrhea dysentery abdominal pain, irregular menstruation, uterine bleeding band, tinea pedis oedema, child convulsion.《Yi nationality's medicine book on Chinese herbal medicine》It is recorded to cure mainly：Head Confused dizzy, god declines physically weak, irregular menstruation, under uterine bleeding band, chronic hepatitis, chronic bronchitis, hypertension, low blood pressure, hypoglycemia.

The straight slag of cloth, Chinese medicine name Asian puccoon, alias purple grass, Boraginaceae radix onosmae category（Onosma paniculatum Bur.et Fr）Perennial herb, all herbal medicine, distribution Yunnan and Tibet, Sichuan.《Yi nationality's medicine book on Chinese herbal medicine》Record that its mainly for treating mammary gland inflammation Collapse is broken not to be received Mouthful, adult's treating child hyperpyrexia.Document records its sweet-salty, cold in nature, enters pericardium channel, Liver Channel, and with cool blood, promoting blood circulation, removing toxic substances is saturating Rash, anti-inflammatory analgetic.For blood-heat and toxin exuberance, measles without adequate eruption, the disease such as scald.Modern pharmacology clinical trial shows that it has very Good antihypertensive effect.

Yi nationality's drug composition of reducing blood pressure and blood fat of the present invention can be routinely Traditional Chinese medicine extraction method extract raw material activity Component, along with pharmaceutically acceptable auxiliary material, be made granule suitable in pharmacy, oral liquid, tablet, capsule, The common dosage forms such as pill.

Yi nationality's drug composition of reducing blood pressure and blood fat of the present invention, the extracting method of raw material can be used but is not limited to lower section Method：

Finelydivided phtheirospermum root, Cymbaria dahurica, cattail pollen, the root bark of Chinese wolf-berry, rhizoma alismatis, HERBA SIPHONOSTEGIAE, turmeric, aleppo avens herb, Asian puccoon are weighed by proportioning, is mixed Add water, amount of water is 8-10 times of composition quality, and 1-2h is handled at 60-70 DEG C, filter after conjunction, filter residue adds filter residue quality 8-10 Water again is reprocessed 1-2 times, merging filtrate, and 60 DEG C -70 DEG C of filtrate is concentrated into the clear cream that relative density is 1.20-1.30； Mass percent concentration 75-85% ethanol solution is added in clear cream, is stood, supernatant is taken, ethanol is removed, obtains refined liquid；Essence Liquid processed is concentrated and dried, and produces Yi nationality's drug composition.

Each component gives full play to monarch relation in Yi nationality's drug composition of reducing blood pressure and blood fat of the present invention, decompression of invigorating blood circulation, Change turbid lipid-loweringing, broken stasis of blood promoting the circulation of qi, qi-restoratives strengthening the essence, inducing meastruation to relieve menalgia, qi-restoratives strengthening the essence, soothing the liver nourishing heart are adjusted, more comprehensively to body Effectively treat hypertension, hyperlipemia disease；It is mainly used in hypertension, hyperlipemia, effectively prevents and treats atherosclerosis；Present invention production Product simple production process, can be made into various preparations, suitable for industrialization production and marketing application.

Embodiment

Below by embodiment, the present invention will be described in further detail, but the scope of the present invention be not limited to it is described Content.

Embodiment 1：Yi nationality's drug composition of this reducing blood pressure and blood fat is made by following raw material：Finelydivided phtheirospermum root 15g, Cymbaria dahurica 20g, cattail pollen 5g, root bark of Chinese wolf-berry 15g, rhizoma alismatis 6g, HERBA SIPHONOSTEGIAE 10g, turmeric 3g, aleppo avens herb 12g, Asian puccoon 10g；

Preparing for above-mentioned composition is as follows：

Finelydivided phtheirospermum root, Cymbaria dahurica, cattail pollen, the root bark of Chinese wolf-berry, rhizoma alismatis, HERBA SIPHONOSTEGIAE, turmeric, aleppo avens herb, Asian puccoon, group are weighed by proportioning Compound, which adds water, to be handled three times, adds 1.5h is handled at the water of 10 times of composition quality, 60 DEG C for the first time, and filtering filter residue adds filter for the second time The water that 8 times of slag amount, 8 times of 1h, filtering filter residue third time plus filter residue quality water are handled at 60 DEG C, 60 DEG C, 1h is handled, merges filter Liquid, 60 DEG C are concentrated into the clear cream that relative density is 1.30；The ethanol solution of mass percent concentration 80% is added in clear cream, it is quiet 12h is put, supernatant is taken, ethanol is removed, obtains refined liquid；Refined liquid is concentrated and dried, and produces Yi nationality's drug composition.

Embodiment 2：Yi nationality's drug composition of this reducing blood pressure and blood fat is made by following raw material：Finelydivided phtheirospermum root 20g, Cymbaria dahurica 25g, Cattail pollen 10g, root bark of Chinese wolf-berry 17g, rhizoma alismatis 10g, HERBA SIPHONOSTEGIAE 15g, turmeric 6g, aleppo avens herb 13g, Asian puccoon 15g；

Preparing for above-mentioned composition is as follows：

Finelydivided phtheirospermum root, Cymbaria dahurica, cattail pollen, the root bark of Chinese wolf-berry, rhizoma alismatis, HERBA SIPHONOSTEGIAE, turmeric, aleppo avens herb, Asian puccoon, group are weighed by proportioning Compound, which adds water, to be handled three times, the water of 10 times of first time plus composition quality, and 65 DEG C of processing 1.5h, filtering filter residue adds filter residue for the second time The water of 9 times of the water that 9 times of quality, 65 DEG C of processing 1h, filtering filter residue third time plus filter residue quality, 65 DEG C of processing 1h, merging filtrate, 70 DEG C it is concentrated into the clear cream that relative density is 1.2；The ethanol solution of mass percent concentration 75% is added in clear cream, 12h is stood, Supernatant is taken, ethanol is removed, obtains refined liquid；Refined liquid is concentrated and dried, and produces Yi nationality's drug composition.

Embodiment 3：Yi nationality's drug composition of this reducing blood pressure and blood fat is made by following raw material：Finelydivided phtheirospermum root 25g, Cymbaria dahurica 35g, Cattail pollen 8g, root bark of Chinese wolf-berry 20g, rhizoma alismatis 9g, HERBA SIPHONOSTEGIAE 12g, turmeric 5g, aleppo avens herb 15g, Asian puccoon 13g；

Preparing for above-mentioned composition is as follows：

Finelydivided phtheirospermum root, Cymbaria dahurica, cattail pollen, the root bark of Chinese wolf-berry, rhizoma alismatis, HERBA SIPHONOSTEGIAE, turmeric, aleppo avens herb, Asian puccoon, group are weighed by proportioning Compound, which adds water, to be handled three times, the water of 10 times of first time plus composition quality, and 60 DEG C of processing 2h, filtering filter residue adds filter residue matter for the second time The water of 8 times of the water of 8 times of amount, 60 DEG C of processing 1.5h, filtering filter residue third time plus filter residue quality, 60 DEG C of processing 1h, merging filtrate, 65 DEG C it is concentrated into the clear cream that relative density is 1.30；The ethanol solution of mass percent concentration 85% is added in clear cream, 12h is stood, Supernatant is taken, ethanol is removed, obtains refined liquid；Refined liquid is concentrated and dried, and produces Yi nationality's drug composition.

Pharmacological experiment：

Experiment material：Yi nationality's drug composition made from above-described embodiment；Amlodipine besylate tablets, purchased from Pfizer；0.9% life Manage salt solution.

Laboratory apparatus：0.25mm " Ω " shapes silver brain clip (Ke Yuan Medical Devices Co., Ltd.s), big mouse non-invasive blood pressure instrument Softron BP-98A；

Experimental animal：SPF grades of rats (Beijing Vital River Experimental Animals Technology Co., Ltd.) 40, male and female half and half, body weight 200 ± 35g, sub-cage rearing, per 1, cage, 22~24 DEG C of room temperature, ad lib is drunk water 1 week.Goldblatt methods replicate two kidneys One folder Renovascular Hypertension Rats, that is, stabilize (5mg/kg)+ketamine (50mg/kg) anesthesia, and dissociate the left side arteria renalis, uses Internal diameter 0.25mm " Ω " shape silver brain clip is clamped, and offside kidney is not touched.Rat feeds high lipid food (basal feed 82.3%, cholesterol 2.0%th, cholate, 0.5%, lard 10%, yolk powder 5%, propylthiouracil 0.2%), continue to that experiment terminates, postoperative 6 weeks rat blood pressures are considered as modeling success up to more than 160mmHg.

Experiment packet and administration

By the successful hypertension of above-mentioned modeling with hyperlipemia rat 40,5 groups are randomly divided into, every group 8,5 groups of experimental groups are set, 1st group be model group, 0.9% physiological saline gavage, once in the morning and once at night, each 3mL；2nd group is Amlodipine Besylate Tablet group, benzene Sulfonic acid amlodipine daily 5mg/, gavage；3rd, 4,5 groups be respectively the composition of embodiment 1,2,3, given low is every Secondary 2g/kg, 3 times a day.

All rat ad libs and drinking-water, are administered 4 weeks.Daily observation diet and active situation, measurement body weight, and according to Body weight adjusts drug dose, and an arteria caudalis blood pressure measurement is carried out every two weeks.After experiment terminates, abdominal aortic is extracted in anesthesia Blood, TC, TG, HDL-C, LDL-C are determined with ELISA method.

Experimental result：Statistical procedures are carried out with SPSS19.0 statistical analysis softwares, experimental data carries out variance analysis, As a result represented with x ± s.

Influence result (n=8) of each group of table 1 to rat blood pressure, unit：mmHg

；

Compared with model group：* P ＜ 0.05, above-described embodiment composition group can efficiently reduce the blood pressure of Hypertensive Rats, poor It is different that there is statistical significance.

After experiment terminates above, TC, TG, HDL-C, LDL-C level of each group rat are measured.Statistical result see the table below；

；

Compared with model group, P ＜ 0.05, above-described embodiment composition group can effectively reduce rat model blood fat, difference has Statistical significance.

By daily to rat it has been observed that 1,3,4,5 groups of signs it is normal, activity is normal, and 2 groups have 1 rat to go out Existing oedema phenomenon.Experiment proves that above-described embodiment composition group can effectively reduce the hypertension, hyperlipemia of rat.

Clinically screening hypertension is equally divided into 2 groups, control group is conventional treatments with hyperlipemic patients 128, Treatment group's tablet made from the composition conventional method in above-described embodiment（Composition accounts for the 71.6% of tablet quality）, often It 3 times, 3~5 every time, 60 days are even served, wherein control group there are 2 people, treatment group has 1 people not adhere to, and it is invalid to be designated as, and patient is general Often occur the diseases such as headache, tinnitus, palpitation, extremity numbness, dizziness, blood pressure detects that blood fat is with channel collateral instrument with conventional blood pressure instrument The heart channel of Hang-Shaoyin and pericardium channel are detected, as a result be see the table below：

；

Typical case is as follows：

Zhang, female, 69 years old, people from Chuxiong.It is diagnosed as hypertension, One's spirits are drooping, headache, palpitation, 2013 in March, 2012 June in year starts to take above-described embodiment composite preparation, takes headache relief after 5 days, continues to take after 3 courses for the treatment of, is discontinued, with Visit is not recurred so far.

Zeng, female, 50 years old, Chuxiong Yuanmou County people started headache tinnitus, dizziness occur for 2013, the situation such as palpitaition, sometimes Also with extremity numbness, after diagnosing with hypertension, symptom mitigation after above-described embodiment composite preparation, 1 course for the treatment of is taken, after Continuous take is discontinued after 2 courses for the treatment of, and follow-up is not recurred so far.

Yang, man, 42 years old, with hypertension, high fat of blood, often there is head and hangs dizzy, palpitaition ear in Chuxiong people from Nanhua County Ring, the symptom of extremity numbness, start to take symptom after above-described embodiment composite preparation, 1 course for the treatment of for 2014 and mitigate significantly, essence God recovers, and continues to take and is discontinued after 3 courses for the treatment of.

Claims (1)

1. Yi nationality's drug composition of a kind of reducing blood pressure and blood fat, it is characterised in that be made by following raw material：Finelydivided phtheirospermum root 15-25 Part, 20-35 parts of Cymbaria dahurica, 5-10 parts of cattail pollen, 15-20 parts of the root bark of Chinese wolf-berry, 6-10 parts of rhizoma alismatis, 10-15 parts of HERBA SIPHONOSTEGIAE, turmeric 3-6 Part, 12-15 parts of aleppo avens herb, 10-15 parts of Asian puccoon.