CN101716209A - Artemisia dalai-lamae Krasch. essential oil and preparation method and application thereof - Google Patents
Artemisia dalai-lamae Krasch. essential oil and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to Artemisia dalai-lamae Krasch. essential oil which is light yellow transparent liquid with heavy fragrance and is freely soluble in alcohols and liposoluble solvents. The essential oil comprises the following main chemical components: alcohol, alkane, alkene and ketone compounds and mainly comprises 20-30% of myrtenol, 5-15% of eucalyptol, 5-15% of 1,3-dimethyl-5-ethylbenzene, 5-15% of myrcene, 3-9% of (Z)-3,7-dimethyl-octatriene (1,5,7) alcohol-3, 3-9% of adamantine, 3-9% of 3,3,6-trimethyl-heptadiene (1,4) alcohol-6, 2-6% of 3,3,6-trimethyl-heptadiene (1,5) alcohol-4, 2-6% of 4-methyl-heptadiene (1,6) alcohol-4 and 2-6% of alpha-pinene by mass. Meanwhile, the invention also discloses a preparation method of the essential oil, which is characterized by high extraction ratio and simple process flow. With antibacterial, antineoplastic, expectorant and antitussive active components, the Artemisia dalai-lamae Krasch. essential oil can be applied to treating respiratory disorders.
Description
Technical field
The present invention relates to an ESSENTIAL OIL, relate in particular to a meter Artemisia volatile oil, with and its production and application.
Background technology
Along with human living standard's raising, the extensive application of antibiotics, chemicals causes some mushroom to develop immunity to drugs, and life has caused serious threat to human being's production for this.The countries in the world medical experts constantly are devoted to seek the control medicament that toxic and side effects is little, mushroom is difficult for developing immunity to drugs.China's Chinese herbal medicine resource is abundant, and high-efficiency low-toxicity is with low cost.Vast Chinese medicine worker has made a large amount of good tries to the activity of Chinese herbal medicine antibacterial and bacteriostatic, has accumulated many experiences.
Tumor is a kind of common disease.According to statistics, the annual total 1,000 ten thousand tumor new cases that surpass in the whole world, people's death of wherein about 60% needs the patient who looks after to surpass 2,000 ten thousand people.In the Asia, the tumor invasion number of China is higher than Japan, South Asia and West Asia far away.Traditional treatment of cancer means mainly are operation, lonizing radiation and chemotherapeutics.The operative treatment limitation is big, but and low even at a loss what to do to patient's treatment rate of tumor cell diffusion, even if perform a surgical operation, disability rate is also very high.The target of chemotherapeutics is to suppress cancer cell propagation, the synthetic antitumor drug specificity of common chemical is not strong now, also the normal cell to molecular marker for increased proliferation has certain influence in killing tumor cell, cause untoward reaction such as vomiting, diarrhoea, alopecia, bone marrow depression, cause suffering to the patient, influenced patient's life quality.Along with going deep into that natural product is studied, from natural animal and plant, seek toxicity anti-cancer agent low, that curative effect is high and have great potential.
Rice Artemisia (Artemisia dalai-lamae Krasch.) is the Compositae sagebruss, has another name called donkey donkey Artemisia, reaches Artemisia, is Qinghai-Tibet plant, the lobule shrub, the mountain region drought is given birth to the desert steppe kind, be distributed in mountain region, desert district more, mainly be distributed in Dragon Head Mountain, Gansu, Qinghai and Tibet one band.The Yang Fu congruence once adopted column chromatography method that its herb chemical constituent is separated and identified, isolated 5 chemical compounds altogether.
Volatile oil is the effective constituents in the Chinese medicine, and is widely distributed in plant kingdom, and have multiple pharmacologically active and purposes widely.Along with the development of society, its development and utilization also receives relevant expert and scholar's concern day by day.
Go out a kind of new extractive of volatile oil so the present invention makes full use of the abundant rice Artemisia plant resource explorations in Qinghai-Tibet Platean, and useful exploration has been carried out in its application in field of medicaments.
Summary of the invention
Technical problem to be solved by this invention provides a kind of high-load rice Artemisia volatile oil.
Another technical problem to be solved by this invention provides that a kind of technology is simple, effective component extraction rate is high, is easy to the preparation method of the rice Artemisia volatile oil of suitability for industrialized production.
The 3rd technical problem to be solved by this invention provides meter application of Artemisia volatile oil in pharmacy.
For addressing the above problem, a kind of meter Artemisia volatile oil of the present invention, it is characterized in that: this volatile oil is the light yellow transparent liquid that strong fragrance is arranged, be soluble in pure and mild fat-soluble solvent, its main chemical compositions is an alcohol, alkane, alkene, ketone compounds, comprise that mainly the quality percentage composition is 20～30% myrtenol, 5～15% Eucalyptus alcohol, 5～15% 1,3-dimethyl-5-ethylo benzene, 5～15% myrcene, 3～9% (Z)-3,7-dimethyl-sarohornene (1,5,7) alcohol-3,3～9% diamantane (obsolete), 3～9% 3,3,6-trimethyl-heptadiene (1,4) alcohol-6,2～6% 3,3,6-trimethyl-heptadiene (1,5) alcohol-4, the australene of 4-methyl-heptadiene (1,6) alcohol-4 and 2～6% of 2～6%.
Described main component chemical structural formula is as follows:
Myrtenol Eucalyptus alcohol 1,3-dimethyl-5-ethylo benzene myrcene
(Z)-3,7-dimethyl-sarohornene (1,5,7) alcohol-3 diamantane (obsolete) 3,3,6-trimethyl-heptadiene (1,4) alcohol-6
3,3,6-trimethyl-heptadiene (1,5) alcohol-4 4-methyl-heptadiene (1,6) alcohol-4 australenes
A kind of preparation method of aforesaid rice Artemisia volatile oil may further comprise the steps:
(1),, makes broken section fully infiltration of meter Artemisia with 4～10 times of water loggings bubbles of its weight 2～5 hours with behind the twig of fresh rice Artemisia aerial parts or bright leaf remove impurity, cutting to the 0.5～3cm;
(2) broken section of Artemisia of rice and the soak thereof with described step (1) gained carries out vapor distillation, collects distillate;
(3) will get oil reservoir behind the distillate natural cooling, the weight ratio drying of pressing 1: 1～1: 8 with anhydrous sodium sulfate also promptly gets a rice Artemisia volatile oil behind the filtering solid.
Vapo(u)rizing temperature in the described step (2) is 80～120 ℃, and distillation time is 2～6h.
The application of aforesaid rice Artemisia volatile oil in pharmacy is characterized in that: described rice Artemisia volatile oil as antibiotic, antitumor, eliminate the phlegm, the application of antitussive activity composition on the treatment respiratory system disease.
Be equipped with acceptable carrier on medicinal stone and pharmaceutically various or the physiology in described rice Artemisia volatile oil, Chinese medicine preparation technology routinely is prepared into any dosage form on the pharmaceutics.
The present invention compared with prior art has the following advantages:
1, the invention provides a kind of new plant volatile oil, the rice Artemisia volatile oil of gained is found through gas chromatography-mass spectrometry, this volatile oil has chemical compound more than 51 kinds, what wherein content was the highest is myrtenol (24.591%), secondly be Eucalyptus alcohol (10.878%), 1,3-dimethyl-5-ethylo benzene (10.140%), myrcene (9.374%), (Z)-3,7-dimethyl-sarohornene (1,5,7) alcohol-3 (6.958%), diamantane (obsolete) (6.442%), 3,3,6-trimethyl-heptadiene (1,4) alcohol-6 (6.405%), 3,3,6-trimethyl-heptadiene (1,4) alcohol-4 (4.716%), 4-methyl-heptadiene (1,6) alcohol-4 (3.204%), australene (3.025%) etc.More than the content of 10 kinds of chemical compounds account for 85.533% of volatile oil total amount.(GC conditions: the GC temperature of vaporization chamber is 250 ℃, and column temperature, kept 30 minutes by 80 ℃ of temperature programmings to 290 ℃ with the heating rate of 4 ℃/min, and carrier gas is 99.999% high-pure helium, and flow velocity is 30ml/min; The mass spectrum condition: mass ion source is the EI source, 230 ℃ of ion source temperatures, electron energy 70eV; Use America NI ST02L spectrum storehouse.)
2, owing to main component in the rice Artemisia volatile oil of gained of the present invention has good biological activity, wherein myrtenol is the bicyclic diterpene compounds, has the excellent antibiotic activity; Eucalyptus alcohol has good antibiotic and anti-tumor activity; Myrcene have eliminate the phlegm, antitussive effect; Australene then has certain antibacterial activity.Therefore, the rice Artemisia volatile oil of gained of the present invention has effect antibiotic, antiinflammatory.
For trying strain: hemophilus influenza, streptococcus pneumoniae, alpha streptococcus and neisser's coccus (above strain transforms seminar by Dalian Chemical Physics Research Institute's biomass efficient and provides)
Experimental technique: it is 10% mother liquid medicine that the rice Artemisia volatile oil of gained of the present invention is made into volume ratio with glycerol, water, ethanol.Fluid medium is carried out autoclaving (121 ℃ 15min), and do not add medicine as blank with fluid medium.10 μ L evenly are inoculated in the culture medium with bacteria suspension, and antibacterial hatches 24h at 37 ℃.Judging with perusal that under the situation of not stirring solution is Clear ﹠ Transparent to be considered as antibacterial and not to grow fully, is minimum inhibitory concentration with the lowest concentration of drug of the bacterium that do not grow fully.
The result shows that this meter Artemisia volatile oil is tried bacterium to 4 kinds all different inhibitory action, and inhibition strength is followed successively by streptococcus pneumoniae, neisser's coccus, alpha streptococcus, hemophilus influenza.
3, the rice Artemisia volatile oil treatment respiratory system disease clinical trial of gained of the present invention.
Be the clinical efficacy of definite this meter of evaluation Artemisia volatile oil and the safety of medicine, the Benexate Hydrochloride made from rice Artemisia volatile oil carries out clinical trial, sum up chronic bronchitis 87 examples, acute bronchitis 90 examples, chronic retardancy bronchitis 25 examples, acute respiratory infection 90 examples, acute sinusitis 74 examples, chronic pulmonary respectively and blocked 28 examples, evident in efficacy through clinical experiment, the produce effects case reaches 337 examples, safe and effective, all do not find obvious toxic-side effects (referring to table 1).
Table 1: rice Artemisia volatile oil treatment respiratory system disease clinical trial
| Grouping | The example number | Produce effects | Effectively | Invalid | Total obvious effective rate | Total effective rate |
| Chronic bronchitis | ??87 | ??70 | ??14 | ??3 | ??/ | ??/ |
| Acute bronchitis | ??90 | ??81 | ??7 | ??2 | ??/ | ??/ |
| Chronic retardancy bronchitis | ??25 | ??16 | ??5 | ??4 | ??/ | ??/ |
| Acute respiratory infection | ??90 | ??87 | ??2 | ??1 | ??/ | ??/ |
| Acute sinusitis | ??74 | ??66 | ??4 | ??4 | ??/ | ??/ |
| Chronic pulmonary is blocked | ??28 | ??17 | ??7 | ??4 | ??/ | ??/ |
| Amount to | ??394 | ??337 | ??39 | ??18 | ??85.5％ | ??95.4％ |
4, the rice Artemisia volatile oil of gained of the present invention has antitumor action.
Method: set up S180 tumors in vivo model, it is 5% mother liquid medicine that rice Artemisia volatile oil is made into volume ratio with glycerol, water, ethanol, and check and analysis rice Artemisia volatile oil is to the influence of tumour inhibiting rate, thymus index, index and spleen index, superoxide dismutase (SOD), malonaldehyde (MDA), nitric oxide (NO) and the tumor tissues Change of Ultrastructure of each group (rice Artemisia basic, normal, high dosage of volatile oil drug solution and cyclophosphamide, normal saline) tumor-bearing mice.
The result: the tumour inhibiting rate of rice Artemisia basic, normal, high dosage group of volatile oil drug solution and cyclophosphamide (CTX) group is respectively: 8.78%, 30.22%, 47.53%, 63.65%.The middle and high dosage group of drug solution thymus index is respectively (2.54 ± 0.39) mlg-1, (2.63 ± 0.67) mlg-1, than normal saline group [(2.20 ± 0.23) mgg-1] increase (P＜0.05).Rice Artemisia volatile oil drug solution high dose group index and spleen index (6.38 ± 0.89) mgg-1 is than normal saline group [(5.47 ± 0.99) mgg-1] increase (P＜0.05).Rice Artemisia volatile oil drug solution middle and high dosage group SOD numerical value is respectively: (305.45 ± 12.78) U/mL, (317.34 ± 16.56) U/mL, and than normal saline group [(279.55 ± 9.83) U/mL] increase (P＜0.05).Rice Artemisia volatile oil drug solution basic, normal, high dosage group MDA numerical value is respectively (6.77 ± 0.65) nmol/mL, (6.32 ± 1.41) nmol/mL, (5.62 ± 0.79) nmol/mL, than normal saline group [(7.47 ± 0.84) nmol/mL] decrease (P＜0.05).Rice Artemisia volatile oil drug solution basic, normal, high dosage group NO numerical value is respectively (57.32 ± 6.60) μ mol/L, (51.15 ± 9.88) μ mol/L, (47.06 ± 6.45) μ mol/L, than normal saline group [(65.04 ± 3.25) μ mol/L] also decrease (P＜0.05).
Electron microscope showed: the tumor cell gap increase after the effect of rice Artemisia volatile oil drug solution, mitochondrial vacuolar degeneration in the kytoplasm, chromatin margination in the nuclear, kernel concentrates or is cracked, and the mitochondrial crista fusion is the early apoptosis sign.
Conclusion: rice Artemisia volatile oil drug solution has obvious antineoplastic, and its mechanism may realize by raise immunity, antioxidation, the apoptosis-induced grade.
5, because preparation method of the present invention adopts steam distillation, and therefore, not only technological process is simple, equipment drops into little, and production cost is low, is easy to suitability for industrialized production, and the main medicinal ingredient yield of volatile oil height; While is not owing to not with an organic solvent, so environmental pollution is little.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention; In addition, any method similar or impartial to described content and material all can be applicable among the present invention.The usefulness that preferable implementation method described in the literary composition and material only present a demonstration.
The preparation method of 1 one kinds of rice Artemisias of embodiment volatile oil may further comprise the steps:
(1) with behind the twig of the fresh rice of 500g Artemisia aerial parts or bright leaf remove impurity, cutting to the 0.5～3cm, put into Shanghai with admiring the volatile oil extractor that biological medicine Science and Technology Ltd. produces, with 4 times of water loggings bubbles of its weight 5 hours, make broken section fully infiltration of meter Artemisia.
(2) volatile oil extractor that fills broken section of meter Artemisia and soak thereof in the step (1) is moved on the 98-1-B type electronic thermostatic electric jacket that Tianjin Tai Site Instr Ltd. produces and carry out vapor distillation, vapo(u)rizing temperature is 80 ℃, distillation time is 2h, collects distillate.
(3) with the distillate natural cooling, natural layering discards water layer, gets oil reservoir, with the weight ratio drying of anhydrous sodium sulfate by 1: 1, promptly gets rice Artemisia volatile oil behind the filtering solid, and yield is 0.88%.
The preparation method of 2 one kinds of rice Artemisias of embodiment volatile oil may further comprise the steps:
(1) with behind the twig of the fresh rice of 1kg Artemisia aerial parts or bright leaf remove impurity, cutting to the 0.5～3cm, puts into volatile oil extractor,, make broken section fully infiltration of meter Artemisia with 10 times of water loggings bubbles of its weight 2 hours.
(2) volatile oil extractor that fills broken section of meter Artemisia and soak thereof in the step (1) is moved on the 98-1-B type electronic thermostatic electric jacket carry out vapor distillation, vapo(u)rizing temperature is 120 ℃, and distillation time is 6h, collects distillate.
(3) with the distillate natural cooling, natural layering discards water layer, gets oil reservoir, with the weight ratio drying of anhydrous sodium sulfate by 1: 8, promptly gets rice Artemisia volatile oil behind the filtering solid, and yield is 0.94%.
The preparation method of 3 one kinds of rice Artemisias of embodiment volatile oil may further comprise the steps:
(1) with behind the twig of the fresh rice of 2kg Artemisia aerial parts or bright leaf remove impurity, cutting to the 0.5～3cm, puts into volatile oil extractor,, make broken section fully infiltration of meter Artemisia with 7 times of water loggings bubbles of its weight 4 hours.
(2) volatile oil extractor that fills broken section of meter Artemisia and soak thereof in the step (1) is moved on the 98-1-B type electronic thermostatic electric jacket carry out vapor distillation, vapo(u)rizing temperature is 100 ℃, and distillation time is 4h, collects distillate.
(3) with the distillate natural cooling, natural layering discards water layer, gets oil reservoir, with the weight ratio drying of anhydrous sodium sulfate by 1: 5, promptly gets rice Artemisia volatile oil behind the filtering solid, and yield is 0.90%.
Rice Artemisia volatile oil in the foregoing description 1～3 is to have the light yellow transparent liquid of strong fragrance to be soluble in pure and mild fat-soluble solvent, its main chemical compositions is an alcohol, alkane, alkene, ketone compounds, comprise that mainly the quality percentage composition is 20～30% myrtenol, 5～15% Eucalyptus alcohol, 5～15% 1,3-dimethyl-5-ethylo benzene, 5～15% myrcene, 3～9% (Z)-3,7-dimethyl-sarohornene (1,5,7) alcohol-3,3～9% diamantane (obsolete), 3～9% 3,3,6-trimethyl-heptadiene (1,4) alcohol-6,2～6% 3,3,6-trimethyl-heptadiene (1,5) alcohol-4, the australene of 4-methyl-heptadiene (1,6) alcohol-4 and 2～6% of 2～6%.Wherein the main component chemical structural formula is as follows:
Myrtenol Eucalyptus alcohol 1,3-dimethyl-5-ethylo benzene myrcene
(Z)-3,7-dimethyl-sarohornene (1,5,7) alcohol-3 diamantane (obsolete) 3,3,6-trimethyl-heptadiene (1,4) alcohol-6
3,3,6-trimethyl-heptadiene (1,5) alcohol-4 4-methyl-heptadiene (1,6) alcohol-4 australenes
In this meter Artemisia volatile oil, be equipped with medicinal stone and be prepared into any dosage form on the pharmaceutics, can be used as antibiotic, antitumor, eliminate the phlegm, the antitussive activity composition pharmaceutically using with the Chinese medicine preparation technology of routine.
The application example of rice Artemisia volatile oil in medicine:
The preparation of 1 meter Artemisia volatile oil beta cyclodextrin inclusion complex of embodiment is in order to the treatment acute/chronic bronchitis.
Take by weighing beta-schardinger dextrin-8g, add the equivalent distilled water, stir evenly clockwise with Glass rod, 1ml dropwise adds with rice Artemisia volatile oil, and the limit edged stirs clockwise, adds the back and continues to stir 30 minutes, in 40 ℃ of following vacuum dryings, promptly gets Benexate Hydrochloride 8g.
The preparation of 2 meters Artemisia volatile oil of embodiment granule is used for the treatment of lung and blocks.
Get meter Artemisia volatile oil 1ml, a Benexate Hydrochloride 10g, add starch 90g, mix homogeneously, technology is after granulating, sieve, drying routinely, and granulate, pack, dress box get final product.
The preparation of 3 meters Artemisia volatile oil of embodiment spray is used for the treatment of sinusitis.
Get 1～2g rice Artemisia volatile oil, add 20%～40% ethanol and 10%～30% Polyethylene Glycol, technology is dispersed into the solution shape routinely, adds water 200～400ml, is distributed into oral spray and gets final product.
The preparation of 4 meters Artemisia volatile oil of embodiment injection is used for the treatment of chronic retardancy bronchitis.
100ml rice Artemisia volatile oil is added in the 300g injection Oleum Glycines, stir, be oil phase; In addition 60g injection phospholipid is added in 30ml water for injection and the 40g glycerol, high-speed stirred makes abundant mixing, is water; Under high-speed stirred, oil phase is added aqueous phase makes emulsion, transferring to pH value with 0.1 molar sodium hydroxide solution is 6.8～7.2, reuse water for injection quantitatively arrives 1000ml, after filtration, after the fill, sterilization promptly.
The preparation of 5 meters Artemisia soft capsules of volatile oil of embodiment is used for the treatment of lung and blocks.
In gelatin 300g and placing of agar 300g glue jar, after adding the 1000g deionized water and being made into glue, be pressed into soft capsule with the RJNJ22 encapsulating machine, control the heavy 0.5g of every ball, include a meter Artemisia volatile oil 0.1ml, promptly get 1000 of meter Artemisia soft capsules of volatile oil.
The preparation of 6 meters Artemisia volatile oil of embodiment suppository is used for the treatment of sinusitis.
Elder generation with an amount of dissolve with ethanol, adds 100ml rice Artemisia volatile oil, the abundant mixing of 75g polyoxyethylene sorbitan monoleate with the 20g Borneolum Syntheticum then.In addition 1500g polyoxyethylene 8 stearate fat is put in the water-bath and melted, add above-mentioned medicinal liquid, fully stir evenly, pour in the suppository mold, take out the cooling back, makes 1000 and get final product.
Claims (6)
1. rice Artemisia volatile oil, it is characterized in that: this volatile oil is the light yellow transparent liquid that strong fragrance is arranged, be soluble in pure and mild fat-soluble solvent, its main chemical compositions is an alcohol, alkane, alkene, ketone compounds, comprise that mainly the quality percentage composition is 20～30% myrtenol, 5～15% Eucalyptus alcohol, 5～15% 1,3-dimethyl-5-ethylo benzene, 5～15% myrcene, 3～9% (Z)-3,7-dimethyl-sarohornene (1,5,7) alcohol-3,3～9% diamantane (obsolete), 3～9% 3,3,6-trimethyl-heptadiene (1,4) alcohol-6,2～6% 3,3,6-trimethyl-heptadiene (1,5) alcohol-4, the australene of 4-methyl-heptadiene (1,6) alcohol-4 and 2～6% of 2～6%.
2. rice Artemisia volatile oil as claimed in claim 1, it is characterized in that: described main component chemical structural formula is as follows:
Myrtenol Eucalyptus alcohol 1,3-dimethyl-5-ethylo benzene myrcene
(Z)-3,7-dimethyl-sarohornene (1,5,7) alcohol-3 diamantane (obsolete) 3,3,6-trimethyl-heptadiene (1,4) alcohol-6
3,3,6-trimethyl-heptadiene (1,5) alcohol-4 4-methyl-heptadiene (1,6) alcohol-4 australenes.
3. the preparation method of a rice as claimed in claim 1 Artemisia volatile oil may further comprise the steps:
(1),, makes broken section fully infiltration of meter Artemisia with 4～10 times of water loggings bubbles of its weight 2～5 hours with behind the twig of fresh rice Artemisia aerial parts or bright leaf remove impurity, cutting to the 0.5～3cm;
(2) broken section of Artemisia of rice and the soak thereof with described step (1) gained carries out vapor distillation, collects distillate;
(3) will get oil reservoir behind the distillate natural cooling, the weight ratio drying of pressing 1: 1～1: 8 with anhydrous sodium sulfate also promptly gets a rice Artemisia volatile oil behind the filtering solid.
4. the preparation method of rice Artemisia volatile oil as claimed in claim 3, it is characterized in that: the vapo(u)rizing temperature in the described step (2) is 80～120 ℃, distillation time is 2～6h.
5. the application of rice as claimed in claim 1 Artemisia volatile oil in pharmacy is characterized in that: described rice Artemisia volatile oil as antibiotic, antitumor, eliminate the phlegm, the application of antitussive activity composition on the treatment respiratory system disease.
6. the application of rice Artemisia volatile oil as claimed in claim 5 in pharmacy, it is characterized in that: be equipped with acceptable carrier on medicinal stone and pharmaceutically various or the physiology in described rice Artemisia volatile oil, Chinese medicine preparation technology routinely is prepared into any dosage form on the pharmaceutics.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104327952A (en) * | 2014-10-27 | 2015-02-04 | 山西大学 | Pelargonium odoratissimum essential oil and extraction method and application of essential oil |
| CN108159103A (en) * | 2018-03-08 | 2018-06-15 | 泰山医学院 | It is a kind of for rice wormwood artemisia preparation of burn and scald and preparation method thereof |
| CN108159153A (en) * | 2018-03-08 | 2018-06-15 | 泰山医学院 | It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof |
| CN108186901A (en) * | 2018-03-08 | 2018-06-22 | 泰山医学院 | It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof |
| CN108186900A (en) * | 2018-03-08 | 2018-06-22 | 泰山医学院 | It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof |
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2009
- 2009-12-02 CN CN200910117637A patent/CN101716209A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104327952A (en) * | 2014-10-27 | 2015-02-04 | 山西大学 | Pelargonium odoratissimum essential oil and extraction method and application of essential oil |
| CN108159103A (en) * | 2018-03-08 | 2018-06-15 | 泰山医学院 | It is a kind of for rice wormwood artemisia preparation of burn and scald and preparation method thereof |
| CN108159153A (en) * | 2018-03-08 | 2018-06-15 | 泰山医学院 | It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof |
| CN108186901A (en) * | 2018-03-08 | 2018-06-22 | 泰山医学院 | It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof |
| CN108186900A (en) * | 2018-03-08 | 2018-06-22 | 泰山医学院 | It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof |
| CN108186901B (en) * | 2018-03-08 | 2020-12-01 | 山东第一医科大学(山东省医学科学院) | A compound preparation containing Artemisia Selengensis for treating burn and scald, and its preparation method |
| CN108186900B (en) * | 2018-03-08 | 2020-12-01 | 山东第一医科大学(山东省医学科学院) | A compound preparation containing Artemisia Selengensis for treating burn and scald, and its preparation method |
| CN108159153B (en) * | 2018-03-08 | 2021-08-24 | 山东第一医科大学(山东省医学科学院) | A compound preparation containing Artemisia Selengensis for treating burn and scald, and its preparation method |
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