CN108159153B - A compound preparation containing Artemisia Selengensis for treating burn and scald, and its preparation method - Google Patents

Abstract

The invention discloses a rice-wormwood compound preparation for burns and scalds and a preparation method thereof, wherein the formula of the preparation comprises the following raw materials: the composite material comprises the following raw materials in parts by weight: the invention relates to artemisia selengensis seed, garden burnet and linseed oil, which have obvious effects of relieving pain, diminishing inflammation, astringing, preventing corrosion, promoting the growth of granulation tissue and reducing scar hyperplasia after burn and scald.

Description

A compound preparation containing Artemisia Selengensis for treating burn and scald, and its preparation method

Technical Field

The invention relates to a rice-wormwood compound preparation for burns and scalds and a preparation method thereof, belonging to the technical field of traditional Chinese medicines.

Background

According to the existing data, the annual incidence rate of burn in China is about 2 percent, and the total death rate is about 1.35/10 ten thousand. The causes of burn and scald are increasingly complex, except for common burns, boiling water and the like, in recent years, burn caused by chafing dish and motorcycle exhaust pipe is generally II or III degree burn, the burn is not easy to cure, and the incidence rate is on the rise. The investigation result of the accidental injury condition of children aged 0-6 years shows that: the second place is burn and scald, the proportion of burn and scald is 13.83%, which is the main cause of children causing disability, causing physical and mental development disorder of children, and also bringing heavy economic burden to families and society [ Lijiawei, Jinglin, bear glume, Pangyou, Jingyujin, Liqian, and Yuwei ] rural 0-6 years old children health management service utilization current situation and children health problem investigation and analysis, Chinese general medicine, 2014, 17 (30): 3590 and 3593. The burns and scalds of teenagers and the elderly are generally life burns, mainly mild and moderate burns. It is estimated that about 5% of the people with burns and scalds in China need hospitalization, and 95% of the people with mild burns and scalds can be treated at home and in outpatient service. About 10 percent of hospitalized burn patients have disabilities of different degrees, and about 10 ten thousand of the patients with disabilities occur due to burns and scalds in China every year.

The burn wound is the source of complications such as burn infection and organ damage, and how to effectively promote the healing of the burn wound is always a hotspot of research in burn treatment. The western medicine for treating burns and scalds is mainly antibiotic, and long-term use of the western medicine not only can cause bacteria to generate drug resistance and induce superinfection, but also can reduce the immunity of human bodies. The traditional Chinese medicine is always a treasure in the field of traditional Chinese medicine, and the traditional Chinese medicine and the preparation thereof have wide use, rapid development and rich dosage form in the aspect of treating burns and scalds and have incomparable advantages compared with western medicines; the burn traditional Chinese medicine also shows unique curative effects on resisting infection and promoting wound healing. The traditional Chinese medicine commonly used for treating burn has the following dosage forms: current research situation and application prospect of traditional Chinese medicine burn cream [ wangxiane, arbobin, fudebbin, zhangjianchun ] gansu science and technology 2016, 5(32) ]: 124, 126. The traditional Chinese medicine burn ointment always occupies a higher proportion in the traditional Chinese medicine burn ointment due to the advantages of convenience and effectiveness.

Pharmacological and clinical tests prove that the traditional Chinese medicine oil solution and ointment have good curative effect and are one of the most common preparations for treating the burn by external application. Ointment and plaster in the externally applied ointment are applied in China very early, and the record of 'Shuangbi' is applied with pig ointment 'in Huangdi's inner meridian (Suzhou) 'carbuncle-abscess chapter'. The traditional Chinese medicine burn ointment is mainly suitable for I-degree and II-degree burns, is rich in viscosity, is externally applied to an affected part, can avoid external stimulation and bacterial infection, can diminish inflammation, relieve pain, improve local blood circulation, is beneficial to repair and regeneration of wound tissues, and is suitable for various burn wounds.

Disclosure of Invention

The invention aims to solve the technical problem of providing the artemisia selengensis compound preparation which has obvious effects of relieving pain, diminishing inflammation, astringing, preventing corrosion, promoting the growth of granulation tissue and reducing scar hyperplasia after burns and scalds.

In order to solve the technical problems, the technical scheme adopted by the invention is as follows:

a rice-wormwood compound preparation for burns and scalds comprises the following raw materials in parts by weight: artemisia seed, sanguisorba officinalis and linseed oil.

The fertilizer comprises, by weight, 10-30 parts of artemisia selengensis seeds, 10-30 parts of sanguisorba officinalis and 30-90 parts of linseed oil.

Wherein the Artemisia (Artemisia Dalai-lamae) is plant of Asterales, Asteraceae, Artemisia of Compositae. Alias: tarragon, donkey-hide wormwood (Gansu, inner Mongolia), alkali wormwood (Gansu) and "daly-Shalieri" (Mongolian name). Is pungent and bitter, and cold in nature, has effects of purging lung, relieving asthma, eliminating phlegm, relieving cough, promoting diuresis, and relieving swelling, and can be used for eliminating phlegm, relieving asthma, tonifying heart, promoting urination, and moistening intestine. The seeds of Artemisia ordosica contain glucosinolate (sinapside) and fatty oil, and the squeezed oil is Artemisia ordosica oil, and has certain therapeutic effect on chronic bronchus; the peculiar pungent taste of the artemisia selengensis can stimulate the metabolic function of a body, contains a large amount of crude fiber, and has an obvious effect of relaxing the bowels. Compendium of materia Medica: is nontoxic. The Tibetan medicine is as follows: the above-ground part is responsible for anthrax, the Qinghai-Tibet medicine identification. Herbs for treating deep rooted carbuncle, Zhen Shao Tong (Tibetan Chinese medicine). Mongolian medicine, GongTuggeyibu, Hanbaile, Daruiya Gao: the seed can be used for treating gallbladder heat, lung heat, blood heat, botulism, edema, fullness sensation in chest, cough, distention and pain in chest and costal region, and pulmonary heart disease. The pharmacological action shows that: the seeds of Artemisia Selengensis have effects in tonifying heart, promoting urination, regulating blood lipid, inhibiting inflammatory exudation, inhibiting bacteria, and resisting cancer. The composition is clinically used for treating pleural effusion, abdominal cavity effusion and pericardial effusion; treating white foam phlegm and excessive phlegm in the lung; treating chronic heart failure of pulmonary heart disease, and chronic heart failure of other heart diseases; treating joint cavity effusion.

Linseed oil is the oil extracted from flaxseed, which is also known as flaxseed, and is the seed of flax, an annual or perennial herb of the flax family, genus linum. The content of alpha-linolenic acid in the linseed oil is 53%, and the linseed oil has the effects of resisting tumors and thrombi, reducing blood fat, nourishing brain cells, regulating vegetative nerves and the like; the linseed oil also contains VE, is a strong and effective free radical scavenger, and has the effects of delaying senility and resisting oxidation; also contains considerable amount of higher fatty alcohol, sterol, hydroxyl, etc. The linseed oil has the following effects: (1) the skin is tender and bright; (2) improving arthritis; (3) improving organ tissue inflammation; (4) promoting cell health; (5) reducing cholesterol, etc. Wherein the alpha-linolenic acid and the lignan have the functions of diminishing inflammation and eliminating scars in burns and scalds. Therefore, the flax seed oil in the formula of the traditional Chinese medicine preparation not only can be used as a substrate, but also has better treatment effect.

Sanguisorba officinalis L is a perennial herb of the genus Ulmus of the family Rosaceae. The sanguisorba root is used as a medicine, is cold in nature, is bitter in acid and is non-toxic; it enters liver, lung, kidney and large intestine meridians. Has the effects of cooling blood, stopping bleeding, clearing away heat and toxic materials, nourishing yin, relieving swelling and healing wound. The root contains a number of tannin components: sanguisorbatin (sanguisin), dilactone (sanguisorbicacidienone), and the like; also contains 2 galloylhamamelis sugar derivatives: 5,2 ' -bis-O-galloylhamamelose (5,2 ' -di-O-galloylhamamelose), 2 ', 3, 5-tri-O-galloyl-D-furamelose. Modern medical research proves that: radix Sangusorbae has effects of stopping bleeding, cooling blood, clearing away heat and toxic materials, astringing, relieving diarrhea, and inhibiting various pathogenic microorganisms and tumors, and can be used for treating hematemesis, bloody dysentery, burn, eczema, upper gastrointestinal hemorrhage, ulcer hemorrhage, hematochezia, metrorrhagia, tuberculous abscess and chronic osteomyelitis. The compendium records: sang Yu can remove heat from lower energizer and treat hematuria and stool. Stopping bleeding, the cut pieces are taken and stir-baked, and the tip of the cut pieces can move blood. Yang Shiyin cloud: radix Sangusorbae can be added for sore and pain, and Scutellariae radix can be added for itching. The Chinese herbal medicine selection records: sanguisorba root, which is used to stop bleeding, is taken and stir-baked. Take it down and take it off for unprocessed use. When the blood is collected, they are combined with Gui and Shao. For clearing heat, they are combined with Gui and Lian. For dampness, they are both Gui and Qin. For pain in blood, they are combined with Gui and Yu. They are both Gui and Jiang for warming meridians and tonifying blood. The strong sour and astringent cold-astringing herbs can tonify and keep the body, while the cold-astringing herbs can warm and nourish blood and enter meridians. For jin Jiang in Ben Jing, it can be used as jin Jiang Gao to treat jin Jiang in Bie Lu, which means that it can clear heat and cool blood. The picture examination of the medicine: it can be used for treating burn, scald, and infantile ulcer.

The preparation is an oil preparation.

A preparation method of a artemisia selengensis compound preparation for burns and scalds comprises the following specific steps:

(1) baking the artemisia selengensis seeds in a preheating container according to the formula amount, and quickly stir-frying until the seeds have burst sound;

(2) cooling the baked artemisia selengensis seeds, and grinding the seeds into powder for later use;

(3) baking garden burnet with the formula amount in a preheated container until the garden burnet is burnt yellow;

(4) cooling the baked garden burnet, grinding into fine powder, and sieving for later use;

(5) taking the flaxseed oil according to the formula amount, heating, adding the sanguisorba powder obtained in the step (4) while the flaxseed oil is hot, cooling, adding the artemisia selengensis powder obtained in the step (2), and mixing to obtain paste.

The preheating temperature in the step (1) and the step (3) is 100 ℃.

And (4) sieving the sanguisorba officinalis powder with a 100-mesh sieve.

The invention achieves the following beneficial effects: in the invention, the artemisia selengensis seeds are firstly used in the traditional Chinese medicine preparation for treating burns and scalds, and are combined with the sanguisorba and the linseed oil for use, and the three components act together to promote the treatment effect.

Drawings

FIG. 1 is a graph showing the comparative effect of the control group, the single herb oil and the compound herb oil in the example after being administered to mice;

FIG. 2 is a comparison of pathological sections of skin of mice treated with normal skin, control group, single herb oil and compound herb oil.

Detailed Description

The invention is further described below with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.

1. A medicinal oil prepared from Artemisia Selengensis for treating burn and scald

The main raw materials are as follows: 20g of artemisia Miliacea seeds and 30ml of linseed oil.

The preparation method comprises the following steps: (1) taking 20g of artemisia scoparia seeds, putting the artemisia scoparia seeds on tiles which are heated to 100 ℃ in advance, baking the seeds for 3-5 seconds, and quickly stir-frying the seeds until the seeds are exploded;

(2) quickly transferring the baked artemisia selengensis seeds into a white porcelain plate, cooling, and grinding into powder in a mortar;

(3) adding 30ml of linseed oil into the ground artemisia selengensis powder, and blending into light brown yellow oily paste for later use.

2. Compound oil preparation of artemisia Miliacea for treating burns and scalds

The main raw materials are as follows: 20g of artemisia selengensis seeds, 20g of sanguisorba officinalis and about 60ml of linseed oil.

The preparation method comprises the following steps: (1) taking 20g of artemisia scoparia seeds, placing the seeds on tiles which are preheated to 100 ℃ for baking for 3-5 seconds, and simultaneously quickly stir-frying until the seeds have burst sound;

(2) quickly pouring baked artemisia selengensis seeds into a white porcelain plate, cooling, and grinding into powder in a mortar for later use;

(3) taking 20g of garden burnet, placing the garden burnet on a tile which is preheated to 100 ℃ for baking, and baking the tile to be brown;

(4) pouring the baked sanguisorba officinalis into a white porcelain plate, cooling, grinding into fine powder in a mortar, and sieving with a 100-mesh sieve for later use;

(5) heating 60ml of linseed oil to slight boiling, mixing the garden burnet powder while hot, and then cooling to room temperature; adding ground Artemisia Selengensis powder, and mixing to obtain brown paste.

3. Burn and scald model building experiment

3.1, subjects

BALB/c mice. Half male and half female, average weight 18-22g, clean grade feeding.

3.2 Experimental materials

LKTC-L, control constant temperature water bath (instrument factory, new rui, west, altar), surgical forceps, scissors, 10g weight (balance instrument factory, xiang instrument), timer, string, and depilator.

3.3 preparation of the model

Heating a constant-temperature water bath kettle to 100 ℃ and keeping the temperature constant, placing a string-tied weight of 10g in the water bath kettle for preheating for about 10min, depilating the back of a mouse by using a depilator, performing ether anesthesia, then performing back blanching for 5s by using the preheated weight, continuously blanching the same part twice, and scalding the back of the mouse to form a circular scalding area with the diameter of 1cm, namely the second-level scald.

3.4 model administration

The mice were randomly divided into 3 groups, namely a control group, a single oil solution group of Artemisia Selengensis and a compound oil solution group of Artemisia Selengensis, and the medicine is applied to the scalded part with cotton sticks in the morning, noon and evening, three times per day. The back skin of the control mice was coated with linseed oil every day, and the operation was performed in the same manner as the drug group. The mice were sacrificed 7 days after administration, and the injured skin tissue and the surrounding normal skin tissue were taken respectively, fixed in 4% paraformaldehyde for 2 days, embedded in paraffin, HE-stained, and histologically observed.

4. Therapeutic effects

As shown in fig. 1, the comparison of the treatment effect of the control group, the single artemisia rice oil and the compound artemisia rice oil after being applied to mice shows that: the skin wound part of the scald of the control group of mice has scald ulceration, severe tissue swelling, fuzzy variation of cell morphology, partial necrosis, white and red swelling in color and bright contrast with the normal tissues around the week; after the mice in the drug group are used, the wound surface is scabbed red and purple dry scab with different degrees, wherein the drug effect of the compound oil solution group of the artemisia selengensis is obviously better than that of the single oil solution group of the artemisia selengensis, the scab begins on the 2 nd day of the drug application, a thick deep purple red dry scab is formed 6 days after the drug application, and the edge of the scalded part is scabbed and tilted; after 7 days, granulation tissues grow inwards around the wound, a thick layer of scab still exists on the tissues, and the wound surface is reduced.

As shown in fig. 2, after the control group, the single artemisia rice oil and the compound artemisia rice oil are applied to the normal skin of the mouse, the pathological section of the skin of the mouse is observed under a histomorphism mirror, and compared with the skin tissue of the normal mouse, the control group of the mouse burns the skin structure to generate coagulation necrosis, wherein the damage of the epidermis and the dermis structure is serious; part of tissues fall off, and the scald depth reaches the deep dermis and is characterized by deep II-degree scald; after the medicine is taken by mice in the medicine group for 7 days, the skin tissue hierarchical structure is recovered after being scalded, the skin hierarchical structure is recovered after the treatment of the artemisia selengensis compound oil preparation is obviously better than the treatment effect of the artemisia selengensis single oil preparation, the skin tissue structure is clear, fat cells and macrophages are generated and gathered, meanwhile, fibroblasts and collagen substances are generated, sweat glands and hair follicle glands in deep structures are recovered, the epidermis hierarchical structure is gradually complete, and the skin is in a recovery state.

The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.

Claims (3)

1. The rice-wormwood compound preparation for burns and scalds is characterized by comprising the following raw materials in parts by weight: 10-30 parts of artemisia selengensis seeds, 10-30 parts of garden burnet and 30-90 parts of linseed oil, wherein the burn and scald is a second-level burn and scald;

the preparation method of the artemisia selengensis compound preparation comprises the following specific steps:

(1) baking the artemisia selengensis seeds in a preheating container according to the formula amount, and quickly stir-frying until the seeds have burst sound;

(2) cooling the baked artemisia selengensis seeds, and grinding the seeds into powder for later use;

(3) baking the garden burnet with the formula amount in a preheated container until the garden burnet is burnt yellow;

(4) cooling the baked garden burnet, grinding into fine powder, and sieving for later use;

(5) taking the flaxseed oil according to the formula amount, heating, adding the sanguisorba powder obtained in the step (4) while the flaxseed oil is hot, cooling, adding the artemisia selengensis powder obtained in the step (2), and mixing to obtain paste.

2. The compound preparation of artemisia rice field as claimed in claim 1, wherein the preheating temperature in step (1) and step (3) of the preparation method is 100 ℃.

3. The compound preparation of artemisia selengensis as claimed in claim 1, wherein the sanguisorba officinalis powder in step (4) of the preparation method is sieved by a 100-mesh sieve.

Images