CN108186900A - It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof - Google Patents

It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof Download PDF

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CN108186900A
CN108186900A CN201810189215.0A CN201810189215A CN108186900A CN 108186900 A CN108186900 A CN 108186900A CN 201810189215 A CN201810189215 A CN 201810189215A CN 108186900 A CN108186900 A CN 108186900A
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wormwood artemisia
burn
preparation
rice
parts
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CN108186900B (en
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赵雪梅
张萌
徐家鑫
黄昱
陈天德
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Shandong First Medical University and Shandong Academy of Medical Sciences
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Taishan Medical University
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Abstract

The invention discloses a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof, in terms of parts by weight, following raw material is included：Rice wormwood artemisia seed, garden burnet, dragon's blood, rheum officinale, frankincense, myrrh, greater celandine, Asian puccoon, the bletilla striata, beeswax, borneol and linseed oil, the present invention for burn and scald have apparent analgesic antiphlogistic, convergence, anti-corrosion, promote new granulation tissue growth and reduce burn and scald after scar hyperplasia the effect of.

Description

It is a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof
Technical field
The present invention relates to a kind of for rice wormwood artemisia compound preparation of burn and scald and preparation method thereof, belong to technical field of traditional Chinese medicines.
Background technology
According to available data, China's burn Annual occurence rate about 2%, general mortality rate about 1.35/10 ten thousand.Burn and scald traumatogenic reason It is increasingly sophisticated, other than the scalds such as common fire, boiling water, occur in recent years by chafing dish, scalds of motorcycle exhaust pipe, mostly IIth, III degree of wound, is not easy to fully recover, and incidence is on the rise.In Children Injury condition survey in 0~6 years old the result shows that： It is burn and scald to come deputy, and burn and scald ratio is 13.83%, is that children cause injury the main reason for disabling, causes children's body Heart developmental disorder, returns family and society brings heavy financial burden【Li Jiawei, Jing Lin, Xiong Ying, Pan Yujia, Jing Yuan rely Pretty, 0~6 years old children's health management service in Yu Wei rural areas is cured using present situation and full section of children's health problem investigation and analysis China It learns, 2014,17 (30)：3590-3593.】.The burn and scald of teenager and the elderly generally live burn, using light, moderate as It is main.There are about 5% burn and scald persons in China according to estimates to need hospitalization, and 95% light the wounded can be in family and treat-and-release.It burns in hospital Sick and wounded people is there are about the different degrees of deformity of 10% generation, and China is every year because of about 100,000 disabled person of burn and scald kainogenesis.
Burn wound is the source of the complication such as infection of burn, organ injury, how to be effectively facilitated wound healing, always It is the hot spot studied in burn treating.The drug of western medical treatment burn and scald is mainly antibiotic, and long-time service can not only make bacterium It generates drug resistance and induces suprainfection, can also reduce the immunity of human body.Chinese medicine is always one piece of field of Chinese medicine rare Treasured, Chinese medicine and its preparation in terms of burn and scald is treated using extensively, quickly grow, dosage form is enriched, have the Western medicine incomparable Advantage；Burn Chinese medicine also presents its unique curative effect in terms of anti-infective, wound healing.Chinese medicine is usually used in treatment burn Form of Chinese drug has：Finish, powder, film, aqueous solvent, spray, also has creme, film forming agent etc. at paste【Wang Xiaoni, Qiao Bin, week Moral is refined, the present Research of Zhang Jianchun Chinese medicine burn pastes and application prospect gansu science and technologies, 2016,5 (32)：124-126.】.Chinese medicine Burn paste occupies higher proportion in Chinese medicine burn medicine always due to its convenient, effective advantage.
Prove that Chinese medicine ointment has the effect of fine through pharmacology and clinical test, be burn it is outer control most common preparation it One.Ointment and plaster in externally used paste is very early in Chinese application,《The Yellow Emperor's Canon of Internal Medicine》Have in (Plain Questions) " a ulcer piece " and " dredge stone acupuncture needle It, is coated with pig cream " record.Chinese medicine burn paste is primarily adapted for use in I degree and II degree of burn, and paste is applied with affected part, both rich in stickiness Can avoid external irritant and bacterium infection, but can anti-inflammatory analgetic, improve local blood circulation, be conducive to wound tissue reparation and Regeneration, suitable for various burn wounds.
Invention content
There is apparent analgesic antiphlogistic for burn and scald the technical problem to be solved by the invention is to provide one kind, convergence, prevent Rice wormwood artemisia compound preparation that is rotten, promoting scar hyperplasia effect after new granulation tissue's growth and reduction burn and scald.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
A kind of rice wormwood artemisia compound preparation for burn and scald in terms of parts by weight, includes following raw material：Rice wormwood artemisia seed, garden burnet, Dragon's blood, rheum officinale, frankincense, myrrh, greater celandine, Asian puccoon, the bletilla striata, beeswax, borneol and linseed oil.
In terms of parts by weight, following raw material is included：20-30 parts of wormwood artemisia seed of rice, 4-6 parts of garden burnet, 2-3 parts of dragon's blood, rheum officinale 4-6 Part, 0.8-1.2 parts of frankincense, 0.8-1.2 parts of myrrh, 8-12 parts of greater celandine, 20-30 parts of Asian puccoon, 4-6 parts of the bletilla striata, 4-6 parts of beeswax, 70-110 parts of 2-3 parts of borneol and linseed oil.
Wherein, rice wormwood artemisia (Artemisia dalai-lamae) is chrysanthemum mesh Asterales, composite family Asteraceae, artemisia Artemisia plants.Alias：Dalai wormwood artemisia, donkey donkey wormwood artemisia (Gansu, the Inner Mongol), alkali wormwood artemisia (Gansu), " Dalai-sand Lille day " (Mongolian Name).Pungent, bitter, property Great Cold is hidden, there is the effect of purging the lung of pathogenic fire Dingchuan, expelling phlegm and arresting coughing, line water detumescence, it being capable of eliminating phlegm relieving asthma, cardiac stimulant profit Urine, logical intestines profit are just.Rice wormwood artemisia seed sulfur-bearing glycosides (Myronate Potassium, sinigrin), fat oil, the oil being squeezed into is rice sagebrush oil, to chronic branch Tracheae has certain therapeutic efficiency；The rice distinctive acid of wormwood artemisia can stimulate the metabolism of body, containing a large amount of crude fibre, lead to Just it is with obvious effects.《Compendium of Materia Medica》：It is nontoxic.《Tibetan medicine》As just that is protected：Overground part is divided and ruled anthrax《Qinghai-Tibet medicine mirror》.Seed controls epidemic disease subcutaneous ulcer Medicine, town shouting pain《Chinese Tibetan medicine》.《Anaesthetic》Such as, Bi Le, Da Ruiya are not done one cloth of tribute map grid for Kazakhstan：Seed is used for gallbladder-heat, lung heat, blood Heat, meat poisoning, oedema, chest full of cough, sternal rib pain, cor pulmonale.Its pharmacological action shows：Rice wormwood artemisia seed has cardiac stimulant, profit Urine adjusts blood fat, inhibits inflammatory exudation, the effect of antibacterial, anticancer.It is clinically used for treatment thoracic cavity, abdominal cavity, hydropericardium；Treatment Lung's foam phlegm and abundant expectoration；Pulmonary heart disease chronic heart failure is treated, can also treat the chronic heart failure of other heart diseases；Treat articular cavity product Liquid.
Linseed oil is the oils that linseed squeezes, and linseed (flaxseed or linseed) is also known as flaxseed, is flax Section, annual or herbaceos perennial flax the seed of linum.Alpha-linolenic acid content is 53% in linseed oil, is had anti- The effects that tumour, antithrombotic, reducing blood lipid, nourishing brain cell, adjusting vegetative nerve；Also contain VE in linseed oil, be a kind of strong Effective free radical scavenger has anti-aging and oxidation resistant effect；Also containing a considerable number of higher aliphatic, sterol and Hydroxyl class etc..Linseed oil has following effect：(1) skin is gentle and demure glossy；(2) improve arthritis；(3) improve organ-tissue inflammation； (4) promote cell health；(5) a variety of effects such as cholesterol are reduced.Wherein alpha-linolenic acid and lignan have in burn and scald and disappear Effect that is scorching, eliminating scar.Therefore linseed oil was not only used as matrix in this Chinese medicine preparation prescription, but also with preferable Therapeutic effect.
Greater celandine (Chelidonium majus) is one kind under Papaveraceae Chelidonium.Come from《Herbal for Relief of Famines》, entirely Grass is used as medicine.It is cool in nature, bitter；It is slightly poisonous.With town disease, cough-relieving, diuresis, removing toxic substances and other effects.It cures mainly：Town disease, cough-relieving, diuresis, solution Poison.Main stomachache, abdominal pain, enteritis；Dysentery, chronic bronchitis, pertussis, cough, jaundice, oedema, ascites, mange sore swells, snake Insect bite.《Middle traditional Chinese medicines plant will》：Control gastrointestinal distress and ulcer.External application is mange medicine and repellent, it is coated with to give birth to juice.Containing more Kind alkaloid, wherein having Chelidonine 41%, Biflorine 22%, talatisamine 17%；Also containing chelidonic acid, malic acid, lemon Lemon acid, succinic acid, choline, methylamine, histamine, tyrasamine, saponin(e, flavonols, celidoniol, also containing cardiac glycoside, volume vitamin C. Contained Chelidonine category protopine is a kind of, stronger to the effect of tip, and then weaker to maincenter, can benumb feeling and movement Nerve endings, but to nerve cord without effect.Especially suitable in external preparation, playing the role of detumescence, analgesic.
Garden burnet (Sanguisorba officinalis L.) is rose family burnet herbaceos perennial.Garden burnet root enters Medicine, cold in nature, bitter acid are nontoxic；Return liver, lung, kidney and large intestine channel.There is cooling blood and hemostasis, it is clearing heat and detoxicating, train clear yin-nourishing, healing up sore and subduing swelling And other effects.Contain a variety of tannin compositions in root：Sour dilactone is stolen on sanguiin (sanguiin), ground (sanguisorbicaciddilactone) etc.；Also contain 2 kinds of nutgall acyl hamamelose derivatives：5,2 '-bis--O- are not eaten Sub- acyl hamamelose (5,2 '-di-O-galloylhamamelose), 2 ', 3,5- tri--O- nutgall acyl-D- furans witch hazels Sugar.Modern medicine study proves：Garden burnet there is blood-stanching and blood-cooling, clearing heat and detoxicating, astringing to arrest diarrhea and inhibit a variety of pathogenic microorganisms and The effect of tumour, can treat haematemesis, bloody flux, burn wound, eczema, upper gastrointestinal bleeding, canker massive haemorrhage, have blood in stool, uterine bleeding, knot The diseases such as nuclearity purulence ulcer and chronic osteomyelitis.《Detailed outline》Described in：Garden burnet except lower burnt heat, controls stool and urine blood trouble.Hemostasis, takes Cut off piece fry use, the tip then can promoting circulation of blood, can not know.Yang Shiying cloud：All sore pain persons add garden burnet, and the person of itching adds radix scutellariae.《Book on Chinese herbal medicine choosing Purport》Described in：Garden burnet, with hemostasis, take cut fry use.With promoting circulation of blood, remove and cut raw use.Blood is held back with it, then is reached the same goal, Chinese herbaceous peony.With Heat-clearing, then reach the same goal, even.It is controlled wet, then reached the same goal, a kind of reed mentioned in ancient books with it.It is controlled in blood bitterly, then reached the same goal, cornel with it.With temperature warp and beneficial blood, It then reaches the same goal, ginger.On the whole acid holds back the agent of cold receipts, must mend, keep, must tremble with fear, coagulate, obtain warm and beneficial blood channel tropism, kind user it is contented it .《This warp》Metal-inflicted wound is treated again,《It does not record》Meaning stops purulence blood, and malignant sore herpes simplex can make metal-inflicted wound cream, all be the function of this cool blood of relieving inflammation or internal heat. 《Drug figure is examined》：Burn is dressed, infantile malnutrition due to digestive disturbances or intestinalparasites sore is festered.
Rheum officinale is polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Maxim Rheum tanguticum The drying root and rhizome of Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..Bitter, it is cold in nature, it is nontoxic. With heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, promoting blood circulation and other effects.Belong to purgatives medicine, raw, ripe use stronger with discharge function Then discharge function relatively delays and is longer than purging intense heat and detonicating, eliminating dampness and heat；Wine work(arrogates to oneself promoting blood circulation, and is apt to the ripe of clear part of the body cavity above the diaphragm housing the heart and lungs blood system；It is normal to fry charcoal For cooling blood and hemostasis.It stagnates for treating enteron aisle, constipation, blood-head tells nosebleed, hot eyes, pharyngalgia, swelling and aching of gum, pathopyretic ulcer, Scald, blood stasis, traumatic injury, jaundice with damp-heat pathogen, heat gonorrhea.《Compendium of Materia Medica》：Control burn.It is ground with rheum officinale life, adjusts honey Painting is put on the skin, not only is relieved pain, and scar of going out【http://zhongyaocai360.com/】.Rheum officinale contains anthraquinone glycoside, also containing near 40% calcium oxalate, other compositions also have the rheum officinale tan of rheum emodin, colloid, resin, Rhein, aporetin and Bearberry Extract Acid.Modern pharmacology acts on：(1) to the influence of digestive system：1. discharge function：By stimulating colorectal mucosa, make intestines compacted Dynamic increase and under rushing down；In addition Na+, K+ on gut cell membrane-ATP enzyme are may also suppress, Na+ transhipments is hindered, makes enteral osmotic pressure liter Height retains large quantity of moisture, promote enterocinesia and under rushing down；2. cholagogic, liver protection；3. promote pancreatic secretion, inhibit enzymatic activity；4. resist Gastric and duodenal ulcer.(2) to the influence of hematological system：1. anastalsis；2. reducing blood lipid.(3) anti-infectious function：It is 1. disease-resistant Pathogenic microorganism acts on；2. anti-inflammatory, refrigeration function；3. immunological regulation；4. anti-aging antioxidation.
Asian puccoon (Lithospermumerythrorhizon Sieb.et Zucc.) is Boraginaceae Lithospermum perennial herb The dry root of plant.Nature and flavor：Hardship is trembled with fear.Major function：Cool blood, promoting blood circulation, heat-clearing, removing toxic substances.Warm macula is cured mainly, jaundice with damp-heat pathogen is purple Purplish or white patches on the skin spits, is defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, large carbuncle.《Haigoushen》：" control malignant sore, Guo tinea." mainization It studies point：Alkanet is containing naphthoquinone derivatives, aliphatic acid.Naphthoquinone derivatives have alkannin (shikonin, Shikonin), acetyl Asian puccoon Plain (Acetylshikonin), deoxyshikonin (Deoxyshikonin), isobutyl group alkannin (Isobutyshi-konin), Isovaleryl shikonin (Isovalerylshikonin), beta, beta-dimethyl acryloyl alkannin (β, β-Dimethyla- Crylshikonin) etc.；Aliphatic acid is mainly palmitic acid, oleic acid and linoleic acid etc..Pharmacological action：(1) antibacterial, anti-inflammatory effect： Asian puccoon can also inhibit to having inhibiting effect in capital section 68-1 virus test tubes, to staphylococcus aureus, Bacterium prodigiosum.Former Soviet Union's production is purple The tincture of grass has inhibiting effect to pyogenic baeceria, Escherichia coli；And epithelial growth and treatment burn can be accelerated.(2) to cyclic system The influence of system.(3) antitumor action.(4) contraceptive efficacy.(5) other are acted on：Arnebia euchroma decoction has rabbit the antipyretic of mitigation Effect, has rabbit isolated uterine and intestinal smooth muscle non-constant excitation, oral decoction can strengthen the tonicity of small intestine With contraction, intravenous injection is then reacted without this.The effects that Asian puccoon leaf extract can decline rabbit blood glucose, increase cavy intestinal tube tension.
Dragon's blood (Daemonorops draco Bl.) is the processed system of resin of babassu Sanguis Draxonis fruit exudation Into.With promoting blood circulation analgesic therapy, removing blood stasis and hemostasis, expelling pus and promoting granulation.For traumatic injury, trusted subordinate's stasis caused pain, traumatic hemorrhage, sore do not hold back.《This Grass is standby will》：Benefit and blood, sore.Gan Xian.Color it is red enter blood system.Bushing packet, deficiency of liver-blood, specially except blood pain, it is new to dissipate stasis of blood life, is and blood Panacea.It controls interior blood trouble to gather, metal-inflicted wound folding falls, and ulcerous nonunion relieves pain myogenic.It is impatient, can not make more, draw purulence (dragon's blood list enter blood system, Frankincense, myrrh it is simultaneous enter qi leel, all wooden fat).Go out south kind.Color is red, using the person that contaminates nail as it is true (false person is extra large female blood, and taste is salty greatly, There is stink smell).It is single to grind with (being smash with crowd's medicine, then fly as dirt)【http://zhongyaocai360.com/】.Chemical composition is：Dragon's blood Red pigment (dracorubin), dracorhodin (dracorhodin), demethyl dracorubin (nordracorubin), demethyl dragon's blood Plain (nordracorhodin), (2S) -5- methoxyl group -6- methyl flavane -7- alcohol, (2S) -5- methoxyl group knotweed alkane -7- alcohol, 2,4- Dihydroxy -5- methyl -6- methoxyl group ear ketone, dragon's blood flavane (dracoflavan) A, dragon's blood dioxa heptyl ether (dracooxepine), separately containing pimaric acid (pimaric acid), isodextropimaric acid (isopimaric acid), rosin acid (abietic acid), dehydrogenation rosin acid (dehydroabieticacid), sandaracopimaric acid (sandaracopimaric acid).Pharmacological action is：Antifungic action, anastalsis.With myrrh, the power of promoting blood circulation and breaking stagnation enhances, for traumatic injury, Blood stasis and swelling pain.With frankincense, blood activating and promoting tissue regeneration, and sore stretch muscle, therefore can be used for malignant sore ulcer, do not close up long, metal-inflicted wound bleeding, wound Do not conform to and wait diseases.
Frankincense (Boswellia carteri.) for olive subject plant Boswellia carterii Boswellia carterii Birdw. and The resin of congener Boswellia bhaurdajiana Birdw. barks exudation.Nature and flavor are pungent, bitter, temperature.With blood-activating and qi-promoting The effect of analgesic, detumescence and promoting granulation.Cure mainly chest impediment and cardialgia, gastral cavity pain, dysmenorrhoea Amenorrhea, postpartum stasis, abdominal mass abdominal pain, rheumatism numbness Bitterly, muscle arteries and veins contraction, traumatic injury, carbuncle swells sore.《Compendium of Materia Medica》：Married woman is controlled in all poison of the ulcer that disappears, Tuoli shield heart, analgesic therapy of invigorating blood circulation Difficult labour, injured.Frankincense perfume (or spice) is altered, and can enter the heart channel of Hang-Shaoyin, analgesic therapy of invigorating blood circulation, therefore is ulcer sores, pain in the chest and abdomen key medicine.... all sides of obstetrics are mostly used It, also takes the work(ear of its promoting blood circulation.《Mingyi Bielu》：It " treats geomantic omen poison to swell, removes bad odor." " treat urticaria poison of itching." chemical composition is： Resin 60%-70%, gummy 27%-35%, volatile oil 3%-8%.The main component of resin is free a, β-boswellic acid (a, β-boswellic acid) 33%, with reference to boswellic acid 13.5%；Olibanoresene (olibanoresene) 33%；Natural gum is The sour calcium salt of (arabic acid) of Arabic heteroglycan and magnesium salts 20%, bassorin (bassorin) 6%.In addition, still Containing amaroid 0.5% and volatile oil.Pharmacological action is mainly：(1) analgesic activity：Prove that Olibanum volatile oil has with hot plate method in mice Analgesic activity, the residue extracted after volatile oil are invalid.Analgesia in volatile oil mainly becomes acetic acid n-octyl.(2) anti-inflammatory anti-corrosion Effect：Frankincense can promote polynuclear leucocyte to increase, and with the blood cell and cell that phagocytosis is dead, improve metabolism, so as to play anti-inflammatory Effect.Shared with myrrh, realgar etc., can detumescence and promoting granulation, be ministerial drug.
Myrrh (Commiphora myrrha Engl.) is olive subject plant Chinese violet tree Commiphora myrrha Engl. or the dry resin of Chinese violet tree Commiphora molmol Engl. is breathed out.Acrid flavour, hardship, it is mild-natured.With scattered stasis pain, disappear The effect of swollen myogenic.It is usually used in chest impediment and cardialgia, gastral cavity pain, dysmenorrhoea Amenorrhea, postpartum stasis , Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, bruise The treatment of the illnesss such as damage, carbuncle swells sore.Chemical composition is：α-heerabomyrrholic acid and β-heerabomyrrholic acid (Heerabomyrrholic Acid), α-myrrholic acid, β-myrrholic acid and γ-myrrholic acid (Commiphoric acid), myrrh hypo acid (Commiphorinic Acid), α-heerabomyrrhol and β-heerabomyrrhol (α-Heerabomyrrhol, β-Heerabomyrrhol), heeraboresene (Heeraboresene)；Separately containing volatile oil, ingredient is Eugenol, phenyl methylcarbamate, cumaldehyde, cinnaldehydrum, heerabolene (Heerabolene) etc..Pharmacological action is：(1) myrrh flooding agent has inhibiting effect to dermatophytes such as trichophytons；(2) The volatile oil of myrrh also can slightly inhibit dermatophyte；(3) myrrh can also reduce the blood cholesterol levels of rabbit, rat and chicken, and There is anti-inflammatory effect.《Compendium of Materia Medica》：Frankincense is invigorated blood circulation, and myrrh dissipates blood, all can alleviating pain and detumescence, myogenic, therefore two medicines often mutually and and are used.
The bletilla striata (Bletilla striata (Thunb.) Reichb.F.) also known as Lian Jicao, Gan Gen, give free of charge, indocalamus is blue, Zhu Lan (《Presbyopic glasses》), purple blue, purple a species of orchid, hundred large bamboo hats with a conical crown and broad brim.Belong to perennial herb bulbous plant (root tuber).Stop blooding good medicine, it is bitter in taste, sweet it is puckery, be slightly cold, It is nontoxic.Function astringing to arrest bleeding, detumescence and promoting granulation.Cure mainly interior traumatic hemorrhage.It spits blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, skin Chap；Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Stem tuber is mainly containing Bibenzyl compound, Dioxophenanthrene class compound, the luxuriant and rich with fragrance class chemical combination of connection Object, double luxuriant and rich with fragrance ether compounds, dihydro phenanthro- pyran compounds, the phenanthrene derivatives for having spirolactone, luxuriant and rich with fragrance class glycoside compounds, its His luxuriant and rich with fragrance class compound, benzyl class compound, anthracene compound, acrylic component, aldehydes ingredient；Fresh tuber separately contains bletilla mannan (bletillamannan).《Sheng Nong's herbal classic》：" main carbuncle swells, malignant sore lose subcutaneous ulcer, the dead flesh of impairment of yin, perverse trend in stomach.”《Herbal guiding principle Mesh》：" smell (root) is bitter, flat, nontoxic." ethnomedicines：【Was's medicine】The bletilla striata, Bai Ji：Bulb is used for pulmonary tuberculosis hemoptysis, and stomach goes out Blood is scalded, burn《Middle Was's medicine》.【Yi nationality's medicine】The big bletilla striata：Root tuber treatment tuberculosis spitting of blood, gold create blood, and scald is burnt, trick chap 《Sad jail》.Pseudobulb is fractured for trick《Yunnan province will》.A Tuluobo：Treatment pulmonary tuberculosis, pertussis, bronchiectasis, silicosis, Gastric and duodenal ulcer acute perforation, Tuberculous impotence pipe, burn and surgery wound, anal fissure etc.《Medicine is planted by Yi nationality》.【Mulao's medicine】Greatly Stammerer：Stem tuber controls the inside and outside wound of bruise《Osmanthus medicine is compiled》.【Jingpo medicine】Lahoiban：The same De'ang nationality of function《Dehong medicine is recorded》.Paving is bought (or sell) on credit It does：Rhizome is used for pulmonary tuberculosis, bronchiectasis hemoptysis, and gastric ulcer is spitted blood, and hematuria is had blood in stool, traumatic hemorrhage, burn, impotence《Yunnan medicine Record》.【Local medicine】Gram if (rofkevyler)：Rhizome treatment tuberculosis disease, hemoptysis are had blood in stool, chapped skin, burn《Tujia's medicine》.
Beeswax, also known as yellow wax, beeswax.Beeswax is the one kind being secreted by 4 pairs of wax glands of worker bee abdomen of the right age in bee colony Fatty matter.Nature and flavor are sweet, tepor.With inducing astrigency, sore, myogenic relieves pain, conditioning.Outside for unhealing ulcer, ulcer on the shank is rotten to the corn, Wound, burn.Often make patent medicine excipients and ointment bases.Its main component can be divided into 4 major class, i.e., esters, free acids, Free alcohols and hydro carbons；Additionally containing micro volatile oil and pigment；It is said that still containing a kind of armaticity coloring matter, entitled insect wax Plain (Cerolein).Pharmacological action：(1) active ammonia scavenging effect；(2) other effects, beeswax and its emulsion have antibacterial and anti- Corruption effect.《Explaining abstruseness of the canon of materia medica》：Paste sore myogenic pain relieving.《This warp》：Main diarrhea purulence blood, bowl spares continue wound absolutely, metal-inflicted wound, QI invigorating.《Doctor Woods collection will》、《Wang Zhong exerts oneself Empirical formula》、《Qianjin Yi Fang》In control the records such as burn sore.
Borneol also known as borneol (《It does not record》), brain (《Sea side》), borneol (《Bencao Tujing》), plum blossom brain (《Children Medicine demonstrate,proves straight rhymed formula》), plum blossom piece brain (《Smooth heavily fortified point will》), piece brain (《Longevity domain god side》), plum blossom brain, borneol brain (《Detailed outline》), Borneolum, plum Ice.It is through steam distillation and to be recrystallized and obtained by composite family Blumea balsamifera cauline leaf or canella borneol camphor tree branches and leaves.Gas faint scent, property It is pungent, bitter, it is slightly cold.With Delicate fragrance a surname dissipate, there is the effect of inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison, removing nebula, cure mainly pyreticosis high fever god Dusk, apoplexy coma due to blocking of the respiratory system shies epilepsy, summer-heat and damp blinds clear key, throat deafness, aphtha tooth swells, sore carbuncle infantile malnutrition due to digestive disturbances or intestinalparasites hemorrhoid, red eye, swell pain, pterygium. Liaoning《Chinese herbal medicine new therapy that combines both Chinese and Western medical practices data is selected and compile》It records borneol and controls boiling hot, burn.《Medical center bun will》：" borneol master dissipates stagnated fire, can be deep Heat controls frightened epilepsy, phlegm confusing heart, larynx numbness, and tongue is swollen, toothache, deafness, breath, hot eyes are floated screen, acne poison invagination, desinsection, hemorrhoid, expedited the emergence of, and property is walked It, also can myogenic pain relieving without keeping.It so dissipates and easily exhausts, be cold sensation of the genitalia after all." clinical practice：(1) pediatric burn is treated：Treatment altogether 216, wherein 46 compared with system by observing, as a result Superficial bums are averaged curative day about 10 days, and deepⅱdegreeburn is average Curative day about 24 days.(2) ulcerative stomatitis is treated.(3) it is scorching to treat chronic nasal cavity.(4) otitis media suppurative is treated.(5) Treat enterobiasis.(6) treatment chronic bronchitis etc..
The rice wormwood artemisia preparation formulation is paste.
A kind of preparation method of rice wormwood artemisia compound preparation for burn and scald, includes step in detail below：
(1) the rice wormwood artemisia seed for weighing formula ratio bakes in the container of preheating, and quick stir-frying will be baked to there is explosion sound Rice wormwood artemisia seed cool, crush, it is spare；
(2) it weighs the dragon's blood of formula ratio, after rheum officinale fries charcoal, crushes, sieve for subsequent use；
(3) it weighs the frankincense of formula ratio, after myrrh crushes, sieves for subsequent use；
(4) greater celandine of formula ratio is weighed, is extracted using 80% ethyl alcohol, filtrate is concentrated into medicinal extract shape, spare；
(5) it weighs the Asian puccoon of formula ratio, after the bletilla striata crushes, adds in appropriate linseed oil and heat, filter while hot, take filter Oil, it is spare；
(6) garden burnet for weighing formula ratio bakes in the container of preheating, bakes to coke yellow, and the garden burnet baked is put It is cool, it crushes, sieves for subsequent use；
(7) Radix Sangusorbae powder in step (6) is taken, the beeswax of formula ratio is added in the oil strain boiled in step (5) and stirred, drop Temperature adds in the borneol of the dragon blood powder and formula ratio in step (2), stirs to borneol and dissolve, put spare to room temperature；
(8) it takes the frankincense powder in step (3) and does not have medicinal powder, add in appropriate linseed oil and mix and stir, by itself and step (2) In Rhubarb Powder add in the standby material in step (7), stir evenly, it is spare；
(9) the rice wormwood artemisia powder in step (1) is added in remaining linseed oil, mixed and stirred, it is spare to obtain meter wormwood artemisia paste；
(10) the rice wormwood artemisia paste prepared in the greater celandine medicinal extract in step (4) and step (9) is added to the spare of step (8) In material, stir evenly to get rufous paste-like preparation.
Preheating temperature is 100 DEG C in step (1), is baked 3-5 seconds.
Frankincense, myrrh are placed in 120 DEG C of baking 2h in step (3), are cooled to room temperature, then crush.
Powder sieves with 100 mesh sieve in step (2), (3) and (6).
Greater celandine is extracted twice with 80% alcohol reflux in step (4), extracts 2h, second of extraction 1.5h for the first time, point It does not filter, merging filtrate.
Linseed oil is heated to 115 DEG C in step (5), heating time 30min.
Step is cooled to 56 DEG C in (7), adds the borneol of the dragon blood powder and formula ratio in step (2).
The advantageous effect that the present invention is reached：In the present invention, rice wormwood artemisia seed is used to treat to the Chinese medicine system of burn and scald for the first time In agent, itself and other Chinese medicines or Chinese medical extract are applied in combination, therapeutic effect can be promoted, be made into paste, is had equal The characteristics of even property, ductility, adsorptivity, fibre forming property and good hygroscopicity and modest viscosity.
Description of the drawings
Fig. 1 is control group in embodiment, rice wormwood artemisia folk prescription finish and rice wormwood artemisia compound paste to therapeutic effect after mouse medication Comparison diagram；
Fig. 2 is that mouse normal skin in embodiment, control group, rice wormwood artemisia folk prescription finish and rice wormwood artemisia compound paste are used to mouse Dermal pathology is sliced comparison diagram after medicine.
Specific embodiment
The invention will be further described below in conjunction with the accompanying drawings.Following embodiment is only used for clearly illustrating the present invention Technical solution, and be not intended to limit the protection scope of the present invention and limit the scope of the invention.
1st, a kind of rice wormwood artemisia folk prescription finish for burn and scald
Primary raw material is：Rice wormwood artemisia seed 20g, linseed oil 30ml.
Preparation method：(1) a meter wormwood artemisia seed 20g is taken, is put in and is previously heated to bake on 100 DEG C of tile 3-5 seconds, while fast Speed stir-frying is to there is explosion sound；
(2) the rice wormwood artemisia seed baked is transferred to rapidly in ceramic whiteware disk and cooled, is ground into powder in mortar；
(3) 30ml linseed oil is taken, is added in ground rice wormwood artemisia powder, mix is spare into sundown oily lotion.
2nd, a kind of rice wormwood artemisia compound paste for burn and scald
Primary raw material is：Rice wormwood artemisia seed 25g, garden burnet 5g, dragon's blood 2.5g, rheum officinale 5g, frankincense 1g, myrrh 1g, greater celandine 10g, Asian puccoon 25g, bletilla striata 5g, beeswax 5g, borneol 2.5g, linseed oil about 90ml.
Preparation method：(1) rice wormwood artemisia seed is placed in and is previously heated to bake on 100 DEG C of tile 3-5 seconds, while turned over rapidly It fries to there is explosion sound；
(2) the rice wormwood artemisia seed baked is poured into rapidly in ceramic whiteware disk and cooled, is ground into powder in mortar, it is spare；
(3) dragon's blood, rheum officinale fry carbon, are ground into powdery；It sieves with 100 mesh sieve respectively, it is spare；
(4) frankincense, myrrh are placed in 120 DEG C of baking 2h, are cooled to room temperature, are ground into powdery, sieve with 100 mesh sieve, it is spare；
(5) greater celandine 10g is taken, respectively with 80% ethyl alcohol heating and refluxing extraction 2h, is filtered to get filtrate；Filter residue is again with 80% second Alcohol heating and refluxing extraction 1.5h, filtering, merging filtrate are concentrated into medicinal extract shape；
(6) Asian puccoon 25g, the bletilla striata 5g after crushing are taken respectively, adds in 50ml linseed oil, are heated 30min at 115 DEG C, are taken advantage of Heat filtering obtains oil strain, spare；
(7) garden burnet dries, is milled, and sieves with 100 mesh sieve；It takes in the oil strain (6) that Radix Sangusorbae powder 5g, beeswax 5g addition are boiled, stirring, 56 DEG C are placed into, is separately added into dragon blood powder 2.5g, borneol 2.5g, stirs to borneol and dissolves；Holding chamber warm standby is used；
(8) frankincense powder 1g is taken respectively, does not have medicinal powder 1g, and it is uniform to be added to mix in 10ml linseed oil；Again with Rhubarb Powder 5g, It is added in (7), stirs evenly, it is spare；
(9) rice wormwood artemisia powder 25g is heated in 30ml linseed oil, mix is uniform, and it is spare to obtain meter wormwood artemisia paste；
(10) rice wormwood artemisia prepared by the greater celandine concentrate prepared (5) and (9) is pasted, and is added in (8), after stirring and evenly mixing, Obtain the paste-like preparation of rufous.
3rd, burn and scald modeling is tested
3.1st, experimental subjects
BALB/c mouse.Half male and half female, average weight 18-22g, cleaning grade raising.
3.2nd, experiment material
LKTC-L, CONTROLLE thermostat water bath (Jintan area west city Xin Rui instrument plants), surgical forceps, scissors, 10g counterweights (Xiang Yi balance equipments factory), timer, cord, grainer.
3.3rd, prepared by model
Thermostat water bath is heated to 100 DEG C and constant temperature, will fasten the 10g counterweights of cord, has been positioned in water-bath and preheats about 10min, mouse back are lost hair or feathers with grainer, after etherization, carry out back blanching 5s with the counterweight of preheating, same position is continuous Blanching burns the round scald area of diameter 1cm, as II grade scald twice, in mouse back.
3.4th, model is administered
Mouse is randomly divided into 3 groups, i.e. control group, rice wormwood artemisia folk prescription finish group and rice wormwood artemisia compound paste group, in dividing in the morning, afternoon and evening Not Yong swab stick scald position coating, daily medication is three times.Control group mice skin of back smears auxiliary material linseed oil daily, together Medication group operates.Mouse is put to death in medication after 7 days, its injured cutaneous tissue and surrounding normal skin histology are taken respectively, in 4% poly 2 days are fixed in formaldehyde, paraffin embedding, HE dyeing carries out histological observation.
4th, therapeutic effect
As shown in Figure 1, for control group, rice wormwood artemisia folk prescription finish and rice wormwood artemisia compound paste to therapeutic effect pair after mouse medication Than observation is found：The skin trauma part of control group mice scald occurs scald property and festers, and organizes serious swelling, cellular morphology Fuzzy variation, while there is partial necrosis, color is white with red and swollen, and striking contrast is organized the formation of with all Zhou Zhengchang；Medication After group mouse medication, one layer of different degrees of reddish violet of surface of a wound knot does scab；Wherein rice wormwood artemisia compound paste medication effect is significantly better than Rice wormwood artemisia folk prescription finish starts to form a scab with the 2nd day scald skin after compound paste treatment；After medication 4 days, one layer of thicker depth is formed Aubergine does scab, while swollen tissue is substantially reduced；After medication 6 days, royal purple, which does scab, becomes drying, scalds adjacent margins knot Scab tilts；After medication 7 days, around there is granulation tissue ingrowing, tissue still has the incrustation that a thick layer is dried, wound above Area is obviously reduced.
As shown in Fig. 2, for mouse normal skin, control group, rice wormwood artemisia folk prescription finish and rice wormwood artemisia compound paste are used to mouse Dermal pathology is sliced after medicine, tectology Microscopic observation, compared with normal mouse skin tissue, control group mice scald skin Coagulation necrosis occurs for structure, and mesocuticle and dermis damage are serious；Portion of tissue comes off, and scald depth reaches corium depth Layer, in deep II degree of scald feature；After medication group mouse medication 7 days, scald skin histology level structure is restored, rice wormwood artemisia compound paste Skin texture restores significantly better than rice wormwood artemisia folk prescription finish group after treatment, and skin texture is clear, produces mast cell, huge Phagocyte is assembled, while is generated with fibroblast, Collagen material, and deep structure sweat gland, hair follicle gland restore substantially, epidermis Secondary structure is increasingly complete, and skin is in recovery state, and epidermis is almost complete.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, without departing from the technical principles of the invention, several improvement and deformation can also be made, these are improved and deformation Also it should be regarded as protection scope of the present invention.

Claims (10)

1. a kind of rice wormwood artemisia compound preparation for burn and scald, it is characterized in that, in terms of parts by weight, include following raw material：Rice wormwood artemisia kind Son, garden burnet, dragon's blood, rheum officinale, frankincense, myrrh, greater celandine, Asian puccoon, the bletilla striata, beeswax, borneol and linseed oil.
2. a kind of rice wormwood artemisia compound preparation for burn and scald according to claim 1, it is characterized in that, in terms of parts by weight, Include following raw material：20-30 parts of wormwood artemisia seed of rice, 4-6 parts of garden burnet, 2-3 parts of dragon's blood, 4-6 parts of rheum officinale, 0.8-1.2 parts of frankincense, myrrh 0.8-1.2 parts, 8-12 parts of greater celandine, 20-30 parts of Asian puccoon, 4-6 parts of the bletilla striata, 4-6 parts of beeswax, 2-3 parts of borneol and linseed oil 70-110 parts.
3. a kind of rice wormwood artemisia compound preparation for burn and scald according to claim 2, it is characterized in that, the rice wormwood artemisia preparation agent Type is paste.
4. a kind of preparation method of rice wormwood artemisia compound preparation for burn and scald according to claim 3, it is characterized in that, comprising Step in detail below：
(1) the rice wormwood artemisia seed for weighing formula ratio bakes in the container of preheating, and quick stir-frying is to there is explosion sound, the rice that will have been baked Wormwood artemisia seed cools, and crushes, spare；
(2) it weighs the dragon's blood of formula ratio, after rheum officinale fries charcoal, crushes, sieve for subsequent use；
(3) it weighs the frankincense of formula ratio, after myrrh crushes, sieves for subsequent use；
(4) greater celandine of formula ratio is weighed, is extracted using 80% ethyl alcohol, filtrate is concentrated into medicinal extract shape, spare；
(5) it weighs the Asian puccoon of formula ratio, after the bletilla striata crushes, adds in appropriate linseed oil and heat, filter while hot, take oil strain, it is standby With；
(6) garden burnet for weighing formula ratio bakes in the container of preheating, bakes to coke yellow, the garden burnet baked is cooled, powder It is broken, it sieves for subsequent use；
(7) it takes in the oil strain boiled in the beeswax addition step (5) of the Radix Sangusorbae powder in step (6), formula ratio and stirs, cool down, add Enter the borneol of the dragon blood powder and formula ratio in step (2), stir to borneol and dissolve, put spare to room temperature；
(8) take the frankincense powder in step (3) and do not have medicinal powder, add in appropriate linseed oil and mix and stir, by its in step (2) Rhubarb Powder is added in the standby material in step (7), is stirred evenly, spare；
(9) the rice wormwood artemisia powder in step (1) is added in remaining linseed oil, mixed and stirred, it is spare to obtain meter wormwood artemisia paste；
(10) the rice wormwood artemisia paste prepared in the greater celandine medicinal extract in step (4) and step (9) is added to the standby material of step (8) In, it stirs evenly to get rufous paste-like preparation.
5. a kind of preparation method of rice wormwood artemisia compound preparation for burn and scald according to claim 4, it is characterized in that, step (1) preheating temperature is 100 DEG C in, is baked 3-5 seconds.
6. a kind of preparation method of rice wormwood artemisia compound preparation for burn and scald according to claim 4, it is characterized in that, step (3) frankincense, myrrh are placed in 120 DEG C of baking 2h in, are cooled to room temperature, then crush.
7. a kind of preparation method of rice wormwood artemisia compound preparation for burn and scald according to claim 4, it is characterized in that, step (2), powder sieves with 100 mesh sieve in (3) and (6).
8. a kind of preparation method of rice wormwood artemisia compound preparation for burn and scald according to claim 4, it is characterized in that, step (4) greater celandine is extracted twice with 80% alcohol reflux in, extracts 2h for the first time, and second of extraction 1.5h filters, merge filter respectively Liquid.
9. a kind of preparation method of rice wormwood artemisia compound preparation for burn and scald according to claim 4, it is characterized in that, step (5) linseed oil is heated to 115 DEG C in, heating time 30min.
10. a kind of preparation method of rice wormwood artemisia compound preparation for burn and scald according to claim 4, it is characterized in that, step Suddenly 56 DEG C are cooled in (7), add the borneol of the dragon blood powder and formula ratio in step (2).
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943248A (en) * 1974-11-04 1976-03-09 Shulman Max J Methods of treating burns using colophony containing preparations
CN1075877A (en) * 1992-05-10 1993-09-08 株洲市财贸职工医院 A kind of preparation method of burn ointment
CN1432378A (en) * 2002-01-17 2003-07-30 傅元庆 Medicine for treating burns and scalds and its prepn process
CN1772145A (en) * 2005-11-01 2006-05-17 黄绍恒 Medicine ointment for treating burns and scalds and its prepn
CN101716209A (en) * 2009-12-02 2010-06-02 中国科学院西北高原生物研究所 Artemisia dalai-lamae Krasch. essential oil and preparation method and application thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943248A (en) * 1974-11-04 1976-03-09 Shulman Max J Methods of treating burns using colophony containing preparations
CN1075877A (en) * 1992-05-10 1993-09-08 株洲市财贸职工医院 A kind of preparation method of burn ointment
CN1432378A (en) * 2002-01-17 2003-07-30 傅元庆 Medicine for treating burns and scalds and its prepn process
CN1772145A (en) * 2005-11-01 2006-05-17 黄绍恒 Medicine ointment for treating burns and scalds and its prepn
CN101716209A (en) * 2009-12-02 2010-06-02 中国科学院西北高原生物研究所 Artemisia dalai-lamae Krasch. essential oil and preparation method and application thereof

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