CN101716237A - Traditional Chinese medicine composition for treating infantile diarrhea caused by rotavirus - Google Patents
Traditional Chinese medicine composition for treating infantile diarrhea caused by rotavirus Download PDFInfo
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- CN101716237A CN101716237A CN200810157650A CN200810157650A CN101716237A CN 101716237 A CN101716237 A CN 101716237A CN 200810157650 A CN200810157650 A CN 200810157650A CN 200810157650 A CN200810157650 A CN 200810157650A CN 101716237 A CN101716237 A CN 101716237A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating infantile diarrhea, prepared by extracting and concentrating traditional Chinese medicines of ash brak, coptis roots, Chinese bulbul, myrobalam and semen plantaginis as raw materials into pharmaceutically acceptable preparation forms, such as oral liquid, particle preparations, and the like. The medicament has the efficacy of clearing heat, drying damp, inducing diuresis and checking diarrhea, mainly treats the infantile diarrhea caused by rotavirus, is suitable for invasion damping of lower energizer, diarrhea due to more damp with less heat, illness defection frequency increase, diarrhea which causes yellow or tawny watery stools or egg drop stools without purulent matter or fishiness and accompanies a fall feeling or not, fever, white or yellowish thick fur and purple or red fingerprints. Proved by efficacy tests, the invention has remarkable treatment action without toxic and side effect.
Description
Technical field:
The present invention relates to the Chinese medicine composition of a kind of treatment by the infantile diarrhea due to the rotavirus, being specifically related to a kind of is the Chinese patent medicine of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology:
Rotavirus is the one of the main reasons that causes acute infantile diarrhea, and the four seasons all can fall ill, and autumn and winter, morbidity was more common, even reached more than 80% of infantile acute diarrhea inpatient.This disease is because onset is hurried, and progress easily merges a series of complication rapidly, makes the whole world have 500-1000 ten thousand people to die from diarrhoea approximately every year.
The traditional Chinese medical science, primary disease belong to has loose bowels, dialectical damp and hot, the cold-damp, wind heat, insufficiency of the spleen etc. of generally being divided into, especially with damp and hot for seeing more.The treatment ancient Chinese medicine doctor of having loose bowels has been accumulated rich experience, and its cause of disease, pathogenesis have been had detailed argumentation.Treat for many years on the clinical experience basis of viral diarrhea in summary, at the etiology and pathogenesis that causes that viral diarrhea is comparatively common, in Treatise on Febrile Diseases on the basis of " Radix Pulsatillae Decoction ", add to simplify and be cut into children's's abdomen peace oral liquid prescription, requirement according to the new Chinese medicine development, being developed into a kind of Chinese patent medicine for the treatment of safe and efficient, the taking convenience of viral diarrhea, improving children life quality, is very necessary.
The present invention is to cure mainly the Radix Pulsatillae Decoction of " diarrhea of heat type with tenesmus " in the treatise on Febrile Diseases, according to our Clinical Experience, adds to simplify and cuts out the new side who forms.The Fang Zhongyong Cortex Fraxini is monarch, and this product nature and flavor bitter cold has the merit of heat clearing and damp drying.Rhizoma Coptidis nature and flavor bitter cold, the function clearing away heat-damp and expelling toxic material can be led " intestinal is warded off the stomachache dysentery ", can " transfer the thick intestinal of stomach "; Radix Pulsatillae nature and flavor bitter cold, but both heat-clearing and toxic substances removing, kind again eliminating pathogenic heat from blood to cure dysentery can be prevented pathogenic heat deeply, the two mutually 5, with the power of principal drug assistance, be ministerial drug altogether.The acid of Pericarpium Papaveris nature and flavor is flat, has the distinguished service of relieving diarrhea with astringents.A large amount of Gus, new, proved recipe record: this product is harnessed the river and is rushed down incessantly, controls new of a specified duration vomiting and diarrhoea of children's, does not think breast and eats.So we help this product less, get its convergence healthy energy, relieving diarrhea with astringent, in case consumption impairment of QI liquid, YIN and YANG exhausted simultaneously, and the merit of relieving spasm to stop pain is arranged.Semen Plantaginis is sweet in flavor and cold in property, is the clearing away heat and promoting diuresis key medicine." end the heat-damp in summer dysentery." " part of the body cavity above the diaphragm housing the heart and lungs that disappears is burning hot, and sealing rushes down." we use it, can diuretic wet, and divide pure and impure and antidiarrheal, the i.e. meaning for the treatment of diarrhea by diuretics.Itself and Rhizoma Coptidis mutually 5, bowel relieving is purged heat, no matter be weight in wet base in heat, still thermogravimetric is in wet, all must it is suitable.So think assistant.All medicines share, and play clearing away heat-damp and promoting diuresis altogether, hold back intestinal antidiarrheal, the merit of relieving spasm to stop pain.
Summary of the invention:
The purpose of this invention is to provide the Chinese medicine composition of a kind of treatment by the infantile diarrhea due to the rotavirus.
Purpose of the present invention adopts following technical proposals to realize, a kind of treatment is by the Chinese medicine composition of the infantile diarrhea due to the rotavirus, is primarily characterized in that the Chinese crude drug that it includes following weight proportion makes:
Cortex Fraxini 2060 weight portion Rhizoma Coptidis 10-50 weight portions
Fructus Chebulae's 2060 weight portion Semen Plantaginis 30-80 weight portions
Radix Pulsatillae 20-60 weight portion
A kind of treatment of the present invention is by the Chinese medicine composition of the infantile diarrhea due to the rotavirus, and said medicament is an acceptable dosage form on the various pharmaceuticss such as tablet, hard capsule, soft capsule, pill, powder, syrup, mixture, drop pill, granule, oral liquid.
A kind of treatment of the present invention is by the Chinese medicine composition of the infantile diarrhea due to the rotavirus, and its preparation method is as follows:
(1) Rhizoma Coptidis was soaked 4-8 hour with diluted acid water (0.5% hydrochloric acid), decoct with water 1-3 time, and each 1-3 hour, filter, collecting decoction is condensed into the thick paste shape, adds ethanol and makes and contain the alcohol amount and be 60%-75%, left standstill 12 hours, filtration, standby.
(2) Radix Pulsatillae is used steam distillation, collects the about 250ml of distillate, and device is preserved in addition.Medicinal residues are standby.
(3) three flavors such as above-mentioned medicinal residues and Semen Plantaginis decoct with water 1-3 time, each 1-3 hour, filter collecting decoction, be concentrated into the thick paste of relative density about 1.20 (80 ℃ of heat are surveyed), add ethanol while hot and make and contain alcohol amount and reach 60%-75%, left standstill 12 hours, filter, merge with the Rhizoma Coptidis alcohol deposit fluid again, filter, reclaim ethanol, be condensed into the thick paste of relative density 1.08～1.10 (80 ℃ of heat are surveyed).
(4) above-mentioned thick paste is added suitable adjuvant, make suitable dosage form, promptly.
Medicine of the present invention is through the experimental study safety non-toxic, and onset is rapid, and curative effect is reliable, and the infantile diarrhea due to the rotavirus is had good therapeutic effect.
The invention will be further described below in conjunction with embodiment and pharmacodynamics test.
Embodiment 1
(1) Rhizoma Coptidis was soaked 4 hours with diluted acid water (0.5% hydrochloric acid), decoct with water 2 times, and each 2 hours, filter, collecting decoction is condensed into the thick paste shape, adds ethanol and makes that to contain the alcohol amount be 60%, leaves standstill 12 hours, filters, and is standby.
(2) Radix Pulsatillae is used steam distillation, collects the about 250ml of distillate, and device is preserved in addition.Medicinal residues are standby.
(3) three flavors such as above-mentioned medicinal residues and Semen Plantaginis decoct with water 3 times, each 1 hour, filter collecting decoction, be concentrated into the thick paste of relative density about 1.20 (80 ℃ of heat are surveyed), add ethanol while hot and make and contain alcohol amount and reach 75%, left standstill 12 hours, filter, merge with the Rhizoma Coptidis alcohol deposit fluid again, filter, reclaim ethanol, be condensed into the thick paste of relative density 1.08～1.10 (80 ℃ of heat are surveyed).Added distillate and distilled water by 1: 2, stir evenly, left standstill 12 hours.
(4) get supernatant, add simple syrup, adjust total amount to 1000ml, filter, pressure sterilizing promptly gets oral liquid of the present invention.
Embodiment 2
(1) Rhizoma Coptidis was soaked 6 hours with diluted acid water (0.5% hydrochloric acid), decoct with water 3 times, and 1.5 hours for the first time, for the second time, each 1 hour for the third time, filter, collecting decoction is condensed into the thick paste shape, adds ethanol and makes that to contain the alcohol amount be 65%, leaves standstill 12 hours, filters, and is standby.
(2) Radix Pulsatillae is used steam distillation, collects the about 250ml of distillate, and device is preserved in addition.Medicinal residues are standby.
(3) three flavors such as above-mentioned medicinal residues and Semen Plantaginis decoct with water 2 times, and 2 hours for the first time, 1 hour for the second time, filter, collecting decoction is concentrated into the thick paste of relative density about 1.20 (80 ℃ of heat are surveyed), adds ethanol while hot and makes and contain the alcohol amount and reach 75%, left standstill 12 hours, filter, merge with the Rhizoma Coptidis alcohol deposit fluid again, filter, reclaim ethanol, be condensed into the thick paste of relative density 1.08～1.10 (80 ℃ of heat are surveyed).Drying under reduced pressure gets dry extract, is ground into fine powder.
(4) with above-mentioned fine powder with 80% ethanol moistening, the system soft material is crossed 14 mesh sieves, 40 ℃ of oven dry, granulate is made 1000g, packing promptly gets granule of the present invention.
Above embodiment is only for the present invention is further illustrated, and scope of the present invention is not subjected to the limitation of illustrated embodiment.
A kind of treatment provided by the invention is by the Chinese medicine composition of the infantile diarrhea due to the rotavirus, and for proving its therapeutic effect, the inventor uses the oral liquid for preparing by the method that provides in the foregoing description to carry out pharmacodynamics test, and result of study is as follows:
Give mouse stomach oral liquid concentrated solution of the present invention 80ml/kg in (1) one day, be calculated as 211.2g/kg observation mice generally in order by containing the crude drug amount, observed none death of animal continuously seven days, be equivalent to more than 484 times of clinical children's's per kilogram of body weight consumption per day, this product low toxicity, safety are described.
(2) oral liquid of the present invention is to the refrigeration function of typhoid fever one paratyphoid fever, second triple vaccine pyrogenicity rabbit.Irritate stomach oral liquid high and low dose of the present invention 1.62g/kg, 0.81g/kg to rabbit.The result shows all 30 minutes performance refrigeration functions behind medicine of medicine high and low dose, the utmost point reduces the rising of 1.5 hours body temperature behind the medicine significantly, and obvious antagonism heating peak, with the high dose best results, with matched group in various degree significant difference is arranged more respectively in 6 hours behind the medicine.
(3) mice administration oral liquid high and low dose of the present invention 4.50g/kg, 2.25g/kg, the result shows that the medicine high dose group can reduce its trap very significantly and with blank group significant differences (P＜0.01) be arranged relatively, point out this medicine can reduce capillary permeability, ooze out in early days thereby suppress acutely inflamed.
(4) press the administration of 0.25ml/10g dosage mice, medicine high and low dose group has the obvious suppression effect to white mice in body small intestinal peristalsis as a result, can obviously suppress the charcoal end in enteral propelling rate.
(5) press the Xu Shi method
[4]The stripped intestinal segment of conventional preparation, every section about 2cm is with DC-001 type isolated organ analyzer record intestinal official activity, tyrode's solution is 30ml in the bath, be subjected to the reagent substrate concentration to amount to the crude drug amount to be: 320mg/ml, 160mg/ml, add dose and be 1ml, end level is respectively 10.7mg/ml, 5.3mg/ml.37.538.5 ℃ of water temperature control.Measurement result high and low dose of the present invention does not have tangible influence to the normal intestine in vitro shrinkage amplitude of rabbit, contraction frequency, only presents certain inhibitory action trend; The enhancing that Ach is caused rabbit intestine in vitro shrinkage amplitude all has utmost point significant inhibitory effect; Ach is caused that rabbit intestine in vitro contraction frequency obviously increases, and has reduction effect in various degree; To BaCl
2Cause that increasing of rabbit intestine in vitro shrinkage amplitude has tangible reduction effect.
(6) according to HRV diarrhoea model in autumn, oral liquid of the present invention can obviously improve heating, the symptom of diarrhea due to the HRV-Wa strain infecting mouse; Improve heating, symptom of diarrhea due to the clinical model case fecal infection mice.Can generate by obvious stimulation intestinal secretion type IgA, and enzyme mark ELASA result is turned out cloudy.
Claims (5)
1. a treatment is characterized in that by the Chinese medicine composition of the infantile diarrhea due to the rotavirus it is the medicament of being made by the following weight proportion raw material:
Cortex Fraxini 20-60 weight portion Rhizoma Coptidis 10-50 weight portion
Fructus Chebulae 20-60 weight portion Semen Plantaginis 30-80 weight portion
Radix Pulsatillae 20-60 weight portion.
2. treatment according to claim 1 is characterized in that by the Chinese medicine composition of the infantile diarrhea due to the rotavirus described medicament is a said dosage form on any pharmaceutics.
3. a kind of treatment according to claim 2 is characterized in that by the Chinese medicine composition of the infantile diarrhea due to the rotavirus described medicament is tablet, hard capsule, soft capsule, pill, powder, syrup, mixture, drop pill, granule, oral liquid or the like.
4. a kind of treatment according to claim 3 be may further comprise the steps by the preparation method of the Chinese medicine composition of the infantile diarrhea due to the rotavirus:
(1) Rhizoma Coptidis was soaked 4-8 hour with diluted acid water (0.5% hydrochloric acid), decoct with water 1-3 time, and each 1-3 hour, filter, collecting decoction is condensed into the thick paste shape, adds ethanol and makes and contain the alcohol amount and be 60%-75%, left standstill 12 hours, filtration, standby.
(2) Radix Pulsatillae is used steam distillation, collects the about 250ml of distillate, and device is preserved in addition.Medicinal residues are standby.
(3) three flavors such as above-mentioned medicinal residues and Semen Plantaginis decoct with water 1-3 time, each 1-3 hour, filter collecting decoction, be concentrated into the thick paste of relative density about 1.20 (80 ℃ of heat are surveyed), add ethanol while hot and make and contain alcohol amount and reach 60%-75%, left standstill 12 hours, filter, merge with the Rhizoma Coptidis alcohol deposit fluid again, filter, reclaim ethanol, be condensed into the thick paste of relative density 1.08～1.10 (80 ℃ of heat are surveyed).
(4) above-mentioned thick paste is added suitable adjuvant, make suitable dosage form, promptly.
5. cure mainly and indication by the function of the Chinese medicine composition of the infantile diarrhea due to the rotavirus according to claim 1,2,3,4 one kind of treatment, it is characterized in that: have heat clearing and damp drying, the effect of diuretic antidiarrheal.Cure mainly the infantile diarrhea due to the rotavirus.Be applicable to damp invasion of lower energizer, weight in wet base is had loose bowels in heat, and disease sees that times of defecation increases, and diarrhoea is watery stool or egg style just, and yellow or yellowish-brown generally do not have pus and blood and stench, when rushing down can with or do not have bearing down, crissum is rubescent or not red, thirsty not polydipsia, short urination is red.Companion's vomiting, heating, white and greasy fur or little Huang are thick, and fingerprint is purple or red.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101576501A CN101716237B (en) | 2008-10-09 | 2008-10-09 | Traditional Chinese medicine composition for treating infantile diarrhea caused by rotavirus |
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| CN2008101576501A CN101716237B (en) | 2008-10-09 | 2008-10-09 | Traditional Chinese medicine composition for treating infantile diarrhea caused by rotavirus |
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| CN101716237B CN101716237B (en) | 2012-02-22 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697934A (en) * | 2012-06-25 | 2012-10-03 | 陈慧婷 | Golden cypress traditional Chinese medicine preparation for treating diarrhea and preparation method for preparation |
| CN104971283A (en) * | 2015-06-30 | 2015-10-14 | 谭清平 | Traditional Chinese medicine capsule used for treating infant rotaviral enteritis |
| CN105031459A (en) * | 2015-06-30 | 2015-11-11 | 谭清平 | Traditional Chinese medicinal capsules for treating autumn diarrhea in children |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474216B (en) * | 2014-10-13 | 2018-04-20 | 潘艳艳 | A kind of Chinese medicine composition for being used to treat baby diarrhea |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101099785A (en) * | 2007-07-20 | 2008-01-09 | 孙坤元 | Traditional Chinese medicine capsule for treating diarrhea and dysentery |
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2008
- 2008-10-09 CN CN2008101576501A patent/CN101716237B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697934A (en) * | 2012-06-25 | 2012-10-03 | 陈慧婷 | Golden cypress traditional Chinese medicine preparation for treating diarrhea and preparation method for preparation |
| CN104971283A (en) * | 2015-06-30 | 2015-10-14 | 谭清平 | Traditional Chinese medicine capsule used for treating infant rotaviral enteritis |
| CN105031459A (en) * | 2015-06-30 | 2015-11-11 | 谭清平 | Traditional Chinese medicinal capsules for treating autumn diarrhea in children |
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| CN101716237B (en) | 2012-02-22 |
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Granted publication date: 20120222 Termination date: 20211009 |