CN101708242B - Traditional Chinese medicine prescription for preventing and treating spleen necrosis syndrome of meaty ducks - Google Patents
Traditional Chinese medicine prescription for preventing and treating spleen necrosis syndrome of meaty ducks Download PDFInfo
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- CN101708242B CN101708242B CN2009101770934A CN200910177093A CN101708242B CN 101708242 B CN101708242 B CN 101708242B CN 2009101770934 A CN2009101770934 A CN 2009101770934A CN 200910177093 A CN200910177093 A CN 200910177093A CN 101708242 B CN101708242 B CN 101708242B
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Abstract
The invention provides a traditional Chinese medicine prescription for preventing and treating the spleen necrosis syndrome of meaty ducks, which relates to the field of the production and the application of animal remedy preparations. The traditional Chinese medicine prescription comprises 15-25 parts of rhizoma atractylodis, 10-18 parts of officinal magnolia, 10-18 parts of tangerine peel, 10-17 parts of astragalus root, 8-15 parts of radix codonopsis pilosulae, 5-15 parts of wrinkled gianthyssop, 5-12 parts of hawthorn and 12-18 parts of licorice. The traditional Chinese medicine prescription is traditional Chinese medicine powder which is produced and prepared according to the production process of animal remedy medicinal powder, and the traditional Chinese medicine powder is used forfeeding meaty ducks by stirring the material or infusing and stewing the material with boiled water after decocting so as to prevent and treat the spleen necrosis syndrome of the meaty ducks. The prescription can also be produced and prepared into oral liquid according to the production process of animal remedy oral liquid, produced and prepared into granules according to the procedure of the production process of animal remedy granules and is of great significance for effectively reducing the use of antibacterials in the culture process of the meaty ducks and reducing the medicine residue.
Description
Technical field:
The present invention relates to veterinary drug preparation production and application, especially relates to a kind of Chinese medicine of preventing and treating spleen necrosis syndrome of meaty ducks.
Background technology:
Expansion along with the poultry farming scale, infectious disease more and more becomes the principal element of restriction culturing economic benefit, and because the abuse of antibacterials, when some commonly encountered diseases more and more are difficult to effectively control, the disease that also occurs some unknown causes in the poultry farming has often had a strong impact on the economic benefit of culturing.
Spring in 2007, foster duck such as Shandong, Jiangsu, Zhejiang, Fujian has occurred a kind of downright bad for mainly cuing open the duck disease that inspection changes with spleen than the area of comparatively dense in succession.This disease cause of disease complexity, and usually form mixed sense, between the mortality rate 2-80%, antibiotic and antiviral therapy commonly used often uncertain therapeutic efficacy is cut.Since 2009, this disease based on the spleen necrosis presents the trend that spreads among a small circle, and adding does not have specific Therapeutic Method, allows numerous raisers and the personnel that are engaged in clinical position feel to be stymied by.
General clinical symptoms: sick duck flocks together, and down in spirits, is squatted at necking down, and beak is dug earth with the snout, and two wings are sagging; The action of often shaking the head, eye and nose have secretions, rapid breathing.The morbidity duck is weak, shake severe patient paralysis.Morbidity duck colony searches for food and the decline of drinking water, and dysentery also has stench flavor, and common with yellow, white, green loose stool, the duck anus position of dying of illness has urate to adhere to more.The duckling mortality rate is higher, and mortality rate can be up to 80% when mixing other infection; Young duck, become duck to show as to become thin, paralyse, mortality rate is lower during no secondary infection more.
Cut open the inspection symptom: one or several Semen phaseoli radiati size petechias are arranged on the visible spleen of their early stage, occur the necrosis region of umbilicate Semen phaseoli radiati then to the Semen Glycines size.The later stage spleen further develops rubber-like or the soft mud sample that becomes brown, and spleen is atropurpureus, celadon or marble sample pathological changes, necrosis, and indivedual spleens have canescence ulcer kitchen range depression pathological changes; Glandular stomach mucosa, duodenum, mucous membrane of rectum are hemorrhage.The case of not having the sense of mixing does not have oromeningitis symptoms such as pericarditis, perihepatitis, airsacculitis.
At present, these sick pathology and pathogenic factor research are also lacked very much, because the generation of this disease mainly shows as the gradual necrosis of spleen, temporary called after " spleen necrosis syndrome ".This disease from since, the clinical antibacterials once on probation of basic unit, antiviral drugs and the treatment of antifungal medicine, but curative effect is all not obvious.
Summary of the invention:
The purpose of this invention is to provide a kind of Chinese medicine of preventing and treating spleen necrosis syndrome of meaty ducks, it is a pure Chinese medicinal preparation, and is significant to use, the minimizing drug residue of antibacterials in effective minimizing meat-type duck breeding process.
In order to solve the existing problem of background technology, the present invention is by the following technical solutions: it is by Rhizoma Atractylodis 15-25 part, Cortex Magnoliae Officinalis 10-18 part, Pericarpium Citri Reticulatae 10-18 part, Radix Astragali 10-17 part, Radix Codonopsis 8-15 part, Herba Pogostemonis 5-15 part, Fructus Crataegi 5-12 part, Radix Glycyrrhizae 12-18 part is formed, press the Chinese powder medicine that veterinary drug powder production technology is produced preparation, feed or boiled water dashes stewing, the meat-type duck of feeding after decocting by spice, with the control spleen necrosis syndrome of meaty ducks.
The present invention can produce by the veterinary drug oral liquid process and be prepared into oral liquid, also can produce the granule of preparation according to the veterinary drug granule technological process of production.
The present invention has following beneficial effect: is pure Chinese medicinal preparation, can prevents and treats spleen necrosis syndrome of meaty ducks, and significant to use, the minimizing drug residue of antibacterials in effective minimizing meat-type duck breeding process.
Description of drawings:
Fig. 1 is herbal mixture of the present invention and antibacterial therapy result schematic diagram;
Fig. 2 is the therapeutic test result schematic diagram of herbal mixture different dosage form of the present invention to spleen putrescence syndrome.
The specific embodiment:
The specific embodiment one: this specific embodiment by the following technical solutions: it is by Rhizoma Atractylodis 15-25 part, Cortex Magnoliae Officinalis 10-18 part, Pericarpium Citri Reticulatae 10-18 part, Radix Astragali 10-17 part, Radix Codonopsis 8-15 part, Herba Pogostemonis 5-15 part, Fructus Crataegi 5-12 part, Radix Glycyrrhizae 12-18 part is formed, and presses the Chinese powder medicine that veterinary drug powder production technology is produced preparation, feed or boiled water dashes stewing, the meat-type duck of feeding after decocting by spice, with the control spleen necrosis syndrome of meaty ducks.
The present invention can produce by the veterinary drug oral liquid process and be prepared into oral liquid, also can produce the granule of preparation according to the veterinary drug granule technological process of production.
This specific embodiment can be prevented and treated spleen necrosis syndrome of meaty ducks, and is significant to use, the minimizing drug residue of antibacterials in effective minimizing meat-type duck breeding process.
The specific embodiment two: it is by 25 parts of Rhizoma Atractylodis, 10 parts of Cortex Magnoliae Officinalis, 15 parts of Pericarpium Citri Reticulataes, 15 parts of the Radixs Astragali, 10 parts of Radix Codonopsis, 6 parts of Herba Pogostemoniss, 10 parts of Fructus Crataegis, 15 parts of compositions of Radix Glycyrrhizae; Each Chinese medicine is mixed pulverizing, cross 60 orders and revolve the sieve that shakes, thicker Chinese medicinal granule is pulverized once more, always mixes the Chinese medicine fine powder, is packed as the 1kg/ bag, promptly.By the Chinese powder medicine that this method is produced, generally the mode of feeding by spice is used for the prevention of spleen necrosis syndrome of meaty ducks, when being used for the treatment of, this powder doubly can being measured boiled water with 8-10 and dash supernatant drinking-water, medicinal residues spice stewing 30 minutes.
The specific embodiment three: it is by 20 parts of Rhizoma Atractylodis, 15 parts of Cortex Magnoliae Officinalis, 12 parts of Pericarpium Citri Reticulataes, 15 parts of the Radixs Astragali, 8 parts of Radix Codonopsis, 6 parts of Herba Pogostemoniss, 10 parts of Fructus Crataegis, 15 parts of compositions of Radix Glycyrrhizae; Each Chinese medicine is added 10 times of amount purified water soaked 5 hours, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches, add 8 times of amount purified water again and be heated to boiling, be incubated 1 hour, filter, merge filtrate twice, heating is concentrated into crude drug than being 0.5kg/L, add ethanol to 75%, precipitate 12 hours, supernatant heating recovery ethanol, and medicinal liquid is concentrated into crude drug than for 1kg/L, it is anticorrosion to add 0.3% sodium benzoate, and fill, gland are promptly.By the Chinese medicine oral liquid that this method is produced, can directly use by drinking-water, because Chinese medicine is handled through extracting, have onset characteristics rapidly.
The specific embodiment four: it is by 22 parts of Rhizoma Atractylodis, 10 parts of Cortex Magnoliae Officinalis, 15 parts of Pericarpium Citri Reticulataes, 12 parts of the Radixs Astragali, 15 parts of Radix Codonopsis, 12 parts of Herba Pogostemoniss, 8 parts of Fructus Crataegis, 18 parts in Radix Glycyrrhizae; Each Chinese medicine is added 10 times of amount purified water soaked 5 hours, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches, add 8 times of amount purified water again and be heated to boiling, be incubated 1 hour, filter, merge filtrate twice, heating is concentrated into crude drug than being 0.5kg/L, add ethanol to 75%, precipitate 12 hours, supernatant heating recovery ethanol, and medicinal liquid is concentrated into crude drug than for 5kg/L, and add an amount of sucrose or glucose, granulate, the granule that crude drug content is 1kg/kg is made in oven dry, and packing promptly.Characteristics such as by the Chinese medicine granules of this method preparation, the aquation of can heating during application is opened, and feeds by drinking-water, and it is rapid to have an onset, and accumulating is convenient.
Clinical trial:
1. materials and methods
1.1 test material
Chinese powder medicine is pressed embodiment 1 described method preparation; Chinese medicine oral liquid is pressed embodiment 2 described method preparations; Chinese medicine granules is pressed embodiment 3 described method preparations.
Positive control medicine: ceftiofur, astragalus polysaccharides
Experimental animal is the commodity meat-type duck of natural infection morbidity, makes a definite diagnosis through cuing open the inspection diagnosis.
1.2 test method
1.2.1 contrast therapy test: Fructus Pruni pseudocerasi paddy commodity meat-type duck 5909 plumages of 12 age in days natural infections morbidity, be diagnosed as spleen putrescence syndrome through cuing open inspection, be divided into 3 groups at random.Wherein, positive controls 1232 plumages, ceftiofur sodium are pressed the intramuscular injection of 2mg/kg body weight, and astragalus polysaccharides is pressed the administration of 0.3g/kg body weight drinking-water, and every day 1 time, logotype three days was a course of treatment.
Chinese powder medicine group morbidity duck 2245 plumages are pressed the 0.3g/kg body weight and are calculated dosage.Chinese medicine is directly admixed feedstuff and is fed, and every day 1 time, logotype 3 days was a course of treatment.
Chinese medicine oral liquid group and Chinese medicine granules group morbidity duck group are 2432 plumages and 2143 plumages, with the crude drug cubage, press the 0.3g/kg body weight and calculate dosage.Every day 1 time, logotype 3 days was a course of treatment.
1.2.2 checking therapeutic test: Fructus Pruni pseudocerasi paddy commodity meat-type duck 54000 plumages of natural infection morbidity, the morbidity age in days is between the 5-18 age in days.Chinese medicine oral liquid and Chinese medicine granules are pressed the 0.3g/kg body weight and are calculated dosage all with the crude drug cubage.The variation of statistics morbidity duck case fatality rate, feed intake during the treatment.
2. result of the test
2.1 contrast therapy test
The morbidity duck is supported the duck family from the high cities and towns one of Shandong Gaoqing.This raiser has 4 foster duck canopies, buys duckling 9000 plumages, raises to 7 ages in days to begin morbidity, by oromeningitis antibacterial therapy 5 days but can not control death, about every day dead 160 plumages.Be diagnosed as spleen putrescence syndrome through cuing open inspection, and 4 foster duck canopy incidences, mortality rate basically identical.By consulting, compare therapeutic test with the raiser.Mass-send the disease duck in view of this and used florfenicol, fluoroquinolones and aminoaglycon antibiotics early stage,, be aided with the antiviral drugs astragalus polysaccharides so the positive control medicine is selected ceftiofur sodium for use.Morbidity duck mortality rate, feed intake change as shown in Figure 1 in adding up 3 days.
This morbidity duck group has been owing to incured loss through delay best occasion for the treatment, and mortality rate reaches about 1.2% each duck shed day before going to a doctor, and mortality rate has trend of rising day by day.Positive controls treatment dead 21 plumages on the same day treats average mortality 1.0% in 3 days, though do not further develop, fail effectively control death, show that antibiotic combination antiviral therapy is invalid substantially.Answer this group that requires of raiser also to change treatment by Chinese herbs into after 3 days, controlled death very soon.Chinese powder medicine group, Chinese medicine oral liquid group and Chinese medicine granules group death all occurred in second day, the 3rd day in medication difference on the same day dead 12 plumages, 7 plumages and 6 plumages, and feed intake also returns to normal level, illustrates that treatment by Chinese herbs has good control action to this disease.
2.2 checking therapeutic test
Be the further curative effect of verifying that herbal mixture is used in a big way, and compare the curative effect difference of oral liquid and granule, the duck group who possesses certain experimental condition natural infection morbidity has been carried out demonstration test.The morbidity duck group who is used to test amounts to about treatment morbidity duck 64000 plumages from 11 raisers, and the result as shown in Figure 2.
The therapeutic effect of two kinds of dosage form herbal mixtures does not have notable difference, and Chinese medicine is through after extracting processing, and onset is very fast, except that treatment had the part death same day, can control death fully in second day; With compare before the treatment, the jumpbogroup feed intake increases also very fast after the medication.
Claims (5)
1. Chinese medicine of preventing and treating spleen necrosis syndrome of meaty ducks, it is characterized in that it is by Rhizoma Atractylodis 15-25 part, Cortex Magnoliae Officinalis 10-18 part, Pericarpium Citri Reticulatae 10-18 part, Radix Astragali 10-17 part, Radix Codonopsis 8-15 part, Herba Pogostemonis 5-15 part, Fructus Crataegi 5-12 part, Radix Glycyrrhizae 12-18 part is formed, press the Chinese powder medicine that veterinary drug powder production technology is produced preparation, feed or boiled water dashes stewing, the meat-type duck of feeding after decocting by spice.
2. a kind of Chinese medicine of preventing and treating spleen necrosis syndrome of meaty ducks according to claim 1 is characterized in that it can be prepared into oral liquid by the production of veterinary drug oral liquid process, also can produce according to the veterinary drug granule technological process of production and be prepared into granule.
3. a kind of Chinese medicine of preventing and treating spleen necrosis syndrome of meaty ducks according to claim 1 is characterized in that it is by 25 parts of Rhizoma Atractylodis, 10 parts of Cortex Magnoliae Officinalis, 15 parts of Pericarpium Citri Reticulataes, 15 parts of the Radixs Astragali, 10 parts of Radix Codonopsis, 6 parts of Herba Pogostemoniss, 10 parts of Fructus Crataegis, 15 parts of compositions of Radix Glycyrrhizae; Each Chinese medicine is mixed pulverizing, cross 60 orders and revolve the sieve that shakes, thicker Chinese medicinal granule is pulverized once more, always mixes the Chinese medicine fine powder, is packed as the 1kg/ bag promptly.
4. a kind of Chinese medicine of preventing and treating spleen necrosis syndrome of meaty ducks according to claim 1 is characterized in that it is by 20 parts of Rhizoma Atractylodis, 15 parts of Cortex Magnoliae Officinalis, 12 parts of Pericarpium Citri Reticulataes, 15 parts of the Radixs Astragali, 8 parts of Radix Codonopsis, 6 parts of Herba Pogostemoniss, 10 parts of Fructus Crataegis, 15 parts of compositions of Radix Glycyrrhizae; Each Chinese medicine is added 10 times of amount purified water soaked 5 hours, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches, add 8 times of amount purified water again and be heated to boiling, be incubated 1 hour, filter, merge filtrate twice, heating is concentrated into crude drug than being 0.5kg/L, add ethanol to 75%, precipitate 12 hours, supernatant heating recovery ethanol, and medicinal liquid is concentrated into crude drug than for 1kg/L, it is anticorrosion to add 0.3% sodium benzoate, and fill, gland are promptly.
5. a kind of Chinese medicine of preventing and treating spleen necrosis syndrome of meaty ducks according to claim 1 is characterized in that it is by 25 parts of Rhizoma Atractylodis, 10 parts of Cortex Magnoliae Officinalis, 15 parts of Pericarpium Citri Reticulataes, 12 parts of the Radixs Astragali, 15 parts of Radix Codonopsis, 12 parts of Herba Pogostemoniss, 8 parts of Fructus Crataegis, 18 parts in Radix Glycyrrhizae; Each Chinese medicine is added 10 times of amount purified water soaked 5 hours, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches, add 8 times of amount purified water again and be heated to boiling, be incubated 1 hour, filter, merge filtrate twice, heating is concentrated into crude drug than being 0.5kg/L, add ethanol to 75%, precipitate 12 hours, supernatant heating recovery ethanol, and medicinal liquid is concentrated into crude drug than for 5kg/L, and add an amount of sucrose or glucose, granulate, the granule that crude drug content is 1kg/kg is made in oven dry, and packing promptly.
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