CN101695543B - 一种治疗心率失常的组合物及其制备方法 - Google Patents
一种治疗心率失常的组合物及其制备方法 Download PDFInfo
- Publication number
- CN101695543B CN101695543B CN2009101835553A CN200910183555A CN101695543B CN 101695543 B CN101695543 B CN 101695543B CN 2009101835553 A CN2009101835553 A CN 2009101835553A CN 200910183555 A CN200910183555 A CN 200910183555A CN 101695543 B CN101695543 B CN 101695543B
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- preparation
- composition
- ginseng
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 206010003119 arrhythmia Diseases 0.000 title abstract description 34
- 230000006793 arrhythmia Effects 0.000 title abstract description 33
- 241000208340 Araliaceae Species 0.000 claims abstract description 45
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 44
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 44
- 235000008434 ginseng Nutrition 0.000 claims abstract description 44
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims abstract description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 16
- 229930182490 saponin Natural products 0.000 claims abstract description 16
- 150000007949 saponins Chemical class 0.000 claims abstract description 16
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 239000007864 aqueous solution Substances 0.000 claims abstract description 8
- 238000010992 reflux Methods 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000002671 adjuvant Substances 0.000 claims abstract description 3
- 241000180649 Panax notoginseng Species 0.000 claims description 42
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 42
- 238000000034 method Methods 0.000 claims description 33
- 239000003814 drug Substances 0.000 claims description 25
- 230000006837 decompression Effects 0.000 claims description 14
- 239000000796 flavoring agent Substances 0.000 claims description 14
- 235000019634 flavors Nutrition 0.000 claims description 14
- 239000012567 medical material Substances 0.000 claims description 14
- -1 filter Substances 0.000 claims description 9
- 239000012141 concentrate Substances 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 238000011084 recovery Methods 0.000 claims description 7
- 238000004064 recycling Methods 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- 238000001291 vacuum drying Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 239000007901 soft capsule Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 5
- 240000002853 Nelumbo nucifera Species 0.000 abstract description 3
- 241000173529 Aconitum napellus Species 0.000 abstract 2
- 235000006508 Nelumbo nucifera Nutrition 0.000 abstract 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 abstract 2
- 240000002948 Ophiopogon intermedius Species 0.000 abstract 2
- 239000009759 San-Chi Substances 0.000 abstract 2
- 229940023019 aconite Drugs 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 45
- 229940039750 aconitine Drugs 0.000 description 38
- XFSBVAOIAHNAPC-XTHSEXKGSA-N 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@@]45C6[C@@H]([C@@]([C@H]31)(OC(C)=O)[C@@H](O)[C@@H]2OC)[C@H](OC)[C@@H]4[C@]([C@@H](C[C@@H]5OC)O)(COC)CN6CC)C(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-XTHSEXKGSA-N 0.000 description 37
- XFSBVAOIAHNAPC-UHFFFAOYSA-N Aconitin Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(OC(C)=O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-UHFFFAOYSA-N 0.000 description 37
- STDXGNLCJACLFY-UHFFFAOYSA-N aconitine Natural products CCN1CC2(COC)C(O)CC(O)C34C5CC6(O)C(OC)C(O)C(OC(=O)C)(C5C6OC(=O)c7ccccc7)C(C(OC)C23)C14 STDXGNLCJACLFY-UHFFFAOYSA-N 0.000 description 37
- 238000012360 testing method Methods 0.000 description 37
- 230000002861 ventricular Effects 0.000 description 29
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 26
- 230000004083 survival effect Effects 0.000 description 23
- VLPIATFUUWWMKC-UHFFFAOYSA-N mexiletine Chemical compound CC(N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-UHFFFAOYSA-N 0.000 description 18
- 229960001070 mexiletine hydrochloride Drugs 0.000 description 18
- 229940079593 drug Drugs 0.000 description 17
- 230000003203 everyday effect Effects 0.000 description 16
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 12
- 210000002784 stomach Anatomy 0.000 description 12
- 230000000144 pharmacologic effect Effects 0.000 description 11
- 241000283973 Oryctolagus cuniculus Species 0.000 description 8
- 239000013641 positive control Substances 0.000 description 8
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 7
- 229930182837 (R)-adrenaline Natural products 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 7
- 229910001626 barium chloride Inorganic materials 0.000 description 7
- 229960005139 epinephrine Drugs 0.000 description 7
- 230000002085 persistent effect Effects 0.000 description 7
- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 description 6
- 230000033764 rhythmic process Effects 0.000 description 5
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 208000037920 primary disease Diseases 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 244000273928 Zingiber officinale Species 0.000 description 2
- 235000006886 Zingiber officinale Nutrition 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 241000553759 Aconitum coreanum Species 0.000 description 1
- 206010003658 Atrial Fibrillation Diseases 0.000 description 1
- 206010003671 Atrioventricular Block Diseases 0.000 description 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000205571 Caulophyllum Species 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 241000209477 Nymphaeaceae Species 0.000 description 1
- 244000248557 Ophiopogon japonicus Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 1
- 206010034568 Peripheral coldness Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 208000000418 Premature Cardiac Complexes Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 241000594182 Sarcophaga sigma Species 0.000 description 1
- 208000007888 Sinus Tachycardia Diseases 0.000 description 1
- 206010040741 Sinus bradycardia Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 208000008510 paroxysmal tachycardia Diseases 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000008203 tachypnea Diseases 0.000 description 1
- 206010043089 tachypnoea Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 剂量 (g/Kg) | 发生时间(S) | 持续时间(S) |
生理盐水组 | - | 11.6±2.2 | 225.8±45.0 |
盐酸美西律 | 8.0×10-3 | 32.9±4.3** | 120.3±31.4** |
组别 | 剂量 (g/Kg) | 发生时间(S) | 持续时间(S) |
低剂量组 | 0.6 | 17.9±2.8** | 158.2±38.9* |
中剂量组 | 1.2 | 21.4±3.6** | 134.5±46.7** |
高剂量组 | 2.4 | 29.8±4.1** | 116.7±27.0** |
组别 | 剂量(g/Kg) | 发生时间(S) | 持续时间(min) |
生理盐水组 | - | 3.2±1.2 | 33.2±7.2 |
盐酸美西律 | 1.6×10-2 | 15.7±2.2** | 15.0±5.7** |
低剂量组 | 1.2 | 5.4±1.5** | 26.1±6.9* |
中剂量组 | 2.4 | 9.6±1.7** | 20.7±4.2** |
高剂量组 | 4.8 | 13.7±2.1** | 18.8±4.8** |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率 (%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
低剂量组 | 1.2 | 33.4±8.8* | 58.3* |
中剂量组 | 2.4 | 36.0±8.7** | 75.0** |
高剂量组 | 4.8 | 40.2±7.5** | 83.3** |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率(%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
实施1 | 2.8 | 32.2±6.9* | 58.3* |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率(%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
实施2 | 1.6 | 33.1±7.4* | 66.7* |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率(%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
实施3 | 2.4 | 32.9±6.9* | 58.3* |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率(%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
实施4 | 1.6 | 33.0±7.3* | 66.7* |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率(%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
实施5 | 2.4 | 32.4±7.7* | 58.3* |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率(%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
实施6 | 2.0 | 32.7±6.9* | 58.3* |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率(%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
实施7 | 2.4 | 33.0±7.5* | 58.3* |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率(%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
实施8 | 2.0 | 32.3±7.6* | 66.7* |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率(%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
实施9 | 2.4 | 32.4±8.4* | 58.3* |
组别 | 剂量(g/Kg) | 发生时间(min) | 1h存活率(%) |
生理盐水组 | - | 23.4±9.8 | 16.7 |
盐酸美西律 | 1.6×10-2 | 38.7±7.2** | 83.3** |
实施10 | 1.4 | 32.5±8.0* | 58.3* |
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009101835553A CN101695543B (zh) | 2009-09-23 | 2009-09-23 | 一种治疗心率失常的组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009101835553A CN101695543B (zh) | 2009-09-23 | 2009-09-23 | 一种治疗心率失常的组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101695543A CN101695543A (zh) | 2010-04-21 |
CN101695543B true CN101695543B (zh) | 2011-08-10 |
Family
ID=42140695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009101835553A Withdrawn - After Issue CN101695543B (zh) | 2009-09-23 | 2009-09-23 | 一种治疗心率失常的组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101695543B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105560974A (zh) * | 2015-12-31 | 2016-05-11 | 王芳 | 一种抗心律失常产前干预药物的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1483422A (zh) * | 2002-09-19 | 2004-03-24 | 张利鹏 | 一种治疗糖尿病的药物 |
-
2009
- 2009-09-23 CN CN2009101835553A patent/CN101695543B/zh not_active Withdrawn - After Issue
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1483422A (zh) * | 2002-09-19 | 2004-03-24 | 张利鹏 | 一种治疗糖尿病的药物 |
Also Published As
Publication number | Publication date |
---|---|
CN101695543A (zh) | 2010-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN112057551A (zh) | 一种具有滋阴补肾功能的组合物及其制备方法和应用 | |
CN103768407A (zh) | 一种复方降糖胶囊及其制备方法 | |
CN107302996A (zh) | 一种辅助降脂溶栓抗动脉硬化的保健食品及其制备方法 | |
CN104161977B (zh) | 一种用于防治鸡传染性鼻炎的中药组合物及其制备方法 | |
CN103705725A (zh) | 一种清咽抗炎的中药组合物及其制备方法 | |
CN101695543B (zh) | 一种治疗心率失常的组合物及其制备方法 | |
CN102335358A (zh) | 一种治疗心律失常的中药制剂 | |
CN102068520B (zh) | 一种治疗心脑血管疾病的中药组合物及其制备方法 | |
CN107812115A (zh) | 一种治疗糖尿病的中药组合物 | |
CN1970050B (zh) | 一种治疗心率失常的药物组合物及其制备方法 | |
CN102940762B (zh) | 一种治疗痛风性关节炎的中药 | |
CN102120000B (zh) | 抗柯萨奇b病毒中药制剂有效部位的组合物及其制备方法 | |
CN102626471B (zh) | 一种具有防敏脱敏、修复再生作用的中药组合物 | |
CN104258260A (zh) | 一种肉苁蓉醇提取物、制备方法及其用途 | |
CN101199568A (zh) | 一种治疗心血管疾病的药物组合物及其制备方法 | |
CN103768116A (zh) | 三七粉袋泡型产品gmp生产工艺及其应用方法 | |
CN103479870A (zh) | 一种调理和治疗高血压的药膳包及其制备方法 | |
CN104055963A (zh) | 一种减脂中药组合物及制备方法 | |
CN104083469B (zh) | 一种用于治疗老年功能性便秘的中药 | |
CN103479868B (zh) | 一种治疗心虚胆怯型心律失常的中药及制备方法 | |
CN106376928A (zh) | 一种辅助降血糖的复方铁皮石斛保健品制备方法 | |
CN113229498A (zh) | 一种有助于降低血压药食同源组合物组方及其制备工艺 | |
CN113812613A (zh) | 一种抗尿酸功能性食品及其制备工艺 | |
CN104042772B (zh) | 一种增强免疫功能的中药组合物及制备方法 | |
CN116173176A (zh) | 一种抗疲劳的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: BEIJING JEWIM GUOKANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SUZHOU PAITENG BIOPHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20120206 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 215011 SUZHOU, JIANGSU PROVINCE TO: 100070 FENGTAI, BEIJING |
|
TR01 | Transfer of patent right |
Effective date of registration: 20120206 Address after: 100070, No. 9, Spark Road, 1, Beijing, Fengtai District Patentee after: Beijing jewim Pharmaceutical Co., Ltd. Address before: Suzhou City, Jiangsu Province, 215011 Suzhou high tech Development Zone Sunshine Holiday Garden Building 63, No. 1412 Patentee before: Suzhou Paiteng Biopharmaceutical Technology Co., Ltd. |
|
C56 | Change in the name or address of the patentee |
Owner name: HUARUN GUOKANG (BEIJING) PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: BEIJING JEWIM GUOKANG PHARMACEUTICAL CO., LTD. |
|
CP03 | Change of name, title or address |
Address after: 100070, Beijing, Fengtai District, Spark Road, No. 1, 9, 5 Patentee after: Huarun (Beijing) Pharmaceutical Co., Ltd. Address before: 100070, No. 9, Spark Road, 1, Beijing, Fengtai District Patentee before: Beijing jewim Pharmaceutical Co., Ltd. |
|
AV01 | Patent right actively abandoned | ||
AV01 | Patent right actively abandoned | ||
AV01 | Patent right actively abandoned |
Granted publication date: 20110810 Effective date of abandoning: 20210930 |
|
AV01 | Patent right actively abandoned |
Granted publication date: 20110810 Effective date of abandoning: 20210930 |
|
DD01 | Delivery of document by public notice | ||
DD01 | Delivery of document by public notice |
Addressee: Ma Qingyun Document name: Notification of conformity |