CN101695516A - Immunostimulant for aquatic animals and preparation method thereof - Google Patents
Immunostimulant for aquatic animals and preparation method thereof Download PDFInfo
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- CN101695516A CN101695516A CN200910307194A CN200910307194A CN101695516A CN 101695516 A CN101695516 A CN 101695516A CN 200910307194 A CN200910307194 A CN 200910307194A CN 200910307194 A CN200910307194 A CN 200910307194A CN 101695516 A CN101695516 A CN 101695516A
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Abstract
The invention provides an immunostimulant for aquatic animals and a preparation method thereof. The immunostimulant for the aquatic animals consists of the following components in part by weight: 150 to 250 parts of milkvetch, 150 to 250 parts of liquorice, 100 to 200 parts of mongolian dandelion herb, 200 to 300 parts of yeast, 30 to 80 parts of spirulina, and 100 to 200 parts of glucosan. The preparation method thereof comprises the steps of: taking the milkvetch, the liquorice and the mongolian dandelion herb for micronization, then adding the yeast, the spirulina and the glucosan, and stirring the mixture evenly to obtain the immunostimulant. The immunostimulant for the aquatic animals can obviously improve the immunity and disease resistance of the aquatic animals, effectively lower the death rate of the aquatic animals caused by various factors, can promote the growth of organisms and improve the survival rate of the organisms and the utilization rate of feed; and the preparation method thereof is simple and suitable for the need of mass industrial production.
Description
Technical field
The present invention relates to a kind of immunostimulant and preparation method thereof, especially a kind of immunostimulant that is used for aquatic animal and preparation method thereof.
Background technology
China is world aquaculture big country, and the breed of intensification has caused the aquatic animal resistance to descend, and the adaptability of poor environment is weakened, and very easily breaks out extensive disease, and production is caused tremendous loss.Present some chemicalses of anti-Zhiduo County to various diseases, but these chemicalses such as improper use meeting are developed immunity to drugs pathogenic microorganism, and can cause the reduction of animal body immunity, and the drug residue in the chemical drugs and the drug contamination of breeding water body also serious threat the health and safety of aquatic animal, therefore research and develop a kind ofly, have very important production practices meaning by stimulating the aquatic animal autoimmune response to improve the immunostimulant of animal resistance.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of immunostimulant that is used for aquatic animal.
Another technical problem to be solved by this invention is to provide the above-mentioned preparation method that is used for the immunostimulant of aquatic animal.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of immunostimulant that is used for aquatic animal, form by the Radix Astragali, Radix Glycyrrhizae, dandelion, yeast, spirulina and glucosan, by its parts by weight Radix Astragali 150-250 part, Radix Glycyrrhizae 150-250 part, dandelion 100-200 part, yeast 200-300 part, spirulina 30-80 part, glucosan 100-200 part.
Preferably, the above-mentioned immunostimulant that is used for aquatic animal is by 200 parts of its parts by weight Radixs Astragali, 200 parts in Radix Glycyrrhizae, 150 parts of dandelions, 250 parts in yeast, 50 parts of spirulinas, Dextran 150 part.
Preferably, the above-mentioned immunostimulant that is used for aquatic animal is by 150 parts of its parts by weight Radixs Astragali, 250 parts in Radix Glycyrrhizae, 200 parts of dandelions, 200 parts in yeast, 80 parts of spirulinas, 100 parts of glucosans.
Preferably, the above-mentioned immunostimulant that is used for aquatic animal is by 250 parts of its parts by weight Radixs Astragali, 150 parts in Radix Glycyrrhizae, 100 parts of dandelions, 300 parts in yeast, 30 parts of spirulinas, Dextran 200 part.
Preferably, the above-mentioned immunostimulant that is used for aquatic animal is by 170 parts of its parts by weight Radixs Astragali, 220 parts in Radix Glycyrrhizae, 120 parts of dandelions, 280 parts in yeast, 60 parts of spirulinas, 130 parts of glucosans.
Preferably, the above-mentioned immunostimulant that is used for aquatic animal is by 240 parts of its parts by weight Radixs Astragali, 170 parts in Radix Glycyrrhizae, 180 parts of dandelions, 210 parts in yeast, 70 parts of spirulinas, 180 parts of glucosans.
Preferably, the above-mentioned immunostimulant that is used for aquatic animal is by 220 parts of its parts by weight Radixs Astragali, 160 parts in Radix Glycyrrhizae, 130 parts of dandelions, 230 parts in yeast, 40 parts of spirulinas, 170 parts of glucosans.
Preferably, the above-mentioned immunostimulant that is used for aquatic animal is by 210 parts of its parts by weight Radixs Astragali, 190 parts in Radix Glycyrrhizae, 140 parts of dandelions, 260 parts in yeast, 50 parts of spirulinas, 140 parts of glucosans.
The above-mentioned preparation method that is used for the immunostimulant of aquatic animal, concrete preparation process is as follows:
(1) Radix Astragali, Radix Glycyrrhizae, dandelion three flavor medical materials are carried out micronizing;
(2) packing after the above-mentioned parts by weight of eucalyptus globulus will mix with yeast, spirulina, glucosan, stir through three flavor medical materials of micronizing, promptly.
Use the immunostimulant that is used for aquatic animal that above-mentioned preparation method is made, add the amount of 30g by every 1kg bait and throw something and feed, 3 times on the one, even feeding 5-7 days is a course of treatment.
Beneficial effect of the present invention:
The above-mentioned immunostimulant that is used for aquatic animal can significantly improve aquatic animal resistance and premunition, effectively reduces the mortality rate of the aquatic animal that causes because of various factors, and can promote body growth, improves the survival rate of body and the utilization rate of feedstuff; Its preparation method is simple, is fit to requirements of large-scale industrial production.
The specific embodiment
Below in conjunction with specific embodiment technical scheme of the present invention is further described.
Embodiment 1
A kind of immunostimulant that is used for aquatic animal is made up of the Radix Astragali, Radix Glycyrrhizae, dandelion, yeast, spirulina and glucosan.
The above-mentioned preparation method that is used for the immunostimulant of aquatic animal, concrete preparation method is as follows:
(1) Radix Astragali, Radix Glycyrrhizae, dandelion three flavor medical materials are carried out micronizing;
(2) the eucalyptus globulus parts by weight will be through 150 parts of 200 parts in 200 parts of the Radixs Astragali, Radix Glycyrrhizae, the dandelions of the micronizing back packing of mixing, stir with 250 parts in yeast, 50 parts of spirulinas and Dextran 150 part, promptly.
Embodiment 2
A kind of immunostimulant that is used for aquatic animal is made up of the Radix Astragali, Radix Glycyrrhizae, dandelion, yeast, spirulina and glucosan.
The above-mentioned preparation method that is used for the immunostimulant of aquatic animal, concrete preparation method is as follows:
(1) Radix Astragali, Radix Glycyrrhizae, dandelion three flavor medical materials are carried out micronizing;
(2) the eucalyptus globulus parts by weight will be through 200 parts of 250 parts in 150 parts of the Radixs Astragali, Radix Glycyrrhizae, the dandelions of micronizing and 200 parts in yeast, 80 parts of spirulinas and 100 parts of back packings of mixing, stir of glucosan, promptly.
Embodiment 3
A kind of immunostimulant that is used for aquatic animal is made up of the Radix Astragali, Radix Glycyrrhizae, dandelion, yeast, spirulina and glucosan.
The above-mentioned preparation method that is used for the immunostimulant of aquatic animal, concrete preparation method is as follows:
(1) Radix Astragali, Radix Glycyrrhizae, dandelion three flavor medical materials are carried out micronizing;
(2) the eucalyptus globulus parts by weight will be through 100 parts of 150 parts in 250 parts of the Radixs Astragali, Radix Glycyrrhizae, the dandelions of the micronizing back packing of mixing, stir with 300 parts in yeast, 30 parts of spirulinas and Dextran 200 part, promptly.
Embodiment 4
A kind of immunostimulant that is used for aquatic animal is made up of the Radix Astragali, Radix Glycyrrhizae, dandelion, yeast, spirulina and glucosan.
The above-mentioned preparation method that is used for the immunostimulant of aquatic animal, concrete preparation method is as follows:
(1) Radix Astragali, Radix Glycyrrhizae, dandelion three flavor medical materials are carried out micronizing;
(2) the eucalyptus globulus parts by weight will be through 120 parts of 220 parts in 170 parts of the Radixs Astragali, Radix Glycyrrhizae, the dandelions of micronizing and 280 parts in yeast, 60 parts of spirulinas and 130 parts of back packings of mixing, stir of glucosan, promptly.
Embodiment 5
A kind of immunostimulant that is used for aquatic animal is made up of the Radix Astragali, Radix Glycyrrhizae, dandelion, yeast, spirulina and glucosan.
The above-mentioned preparation method that is used for the immunostimulant of aquatic animal, concrete preparation method is as follows:
(1) Radix Astragali, Radix Glycyrrhizae, dandelion three flavor medical materials are carried out micronizing;
(2) the eucalyptus globulus parts by weight will be through 180 parts of 170 parts in 240 parts of the Radixs Astragali, Radix Glycyrrhizae, the dandelions of micronizing and 210 parts in yeast, 70 parts of spirulinas and 180 parts of back packings of mixing, stir of glucosan, promptly.
Embodiment 6
A kind of immunostimulant that is used for aquatic animal is made up of the Radix Astragali, Radix Glycyrrhizae, dandelion, yeast, spirulina and glucosan.。
The above-mentioned preparation method that is used for the immunostimulant of aquatic animal, concrete preparation method is as follows:
(1) Radix Astragali, Radix Glycyrrhizae, dandelion three flavor medical materials are carried out micronizing;
(2) the eucalyptus globulus parts by weight will be through 130 parts of 160 parts in 220 parts of the Radixs Astragali, Radix Glycyrrhizae, the dandelions of micronizing and 230 parts in yeast, 40 parts of spirulinas and 170 parts of back packings of mixing, stir of glucosan, promptly.
Embodiment 7
A kind of immunostimulant that is used for aquatic animal is made up of the Radix Astragali, Radix Glycyrrhizae, dandelion, yeast, spirulina and glucosan.
The above-mentioned preparation method that is used for the immunostimulant of aquatic animal, concrete preparation method is as follows:
(1) Radix Astragali, Radix Glycyrrhizae, dandelion three flavor medical materials are carried out micronizing;
(2) the eucalyptus globulus parts by weight will be through 140 parts of 190 parts in 210 parts of the Radixs Astragali, Radix Glycyrrhizae, the dandelions of micronizing and 260 parts in yeast, 50 parts of spirulinas and 140 parts of back packings of mixing, stir of glucosan, promptly.
In the above-mentioned immunostimulant, the Radix Astragali, Radix Glycyrrhizae and dandelion all meet " Chinese veterinary drug allusion quotation " version two ministerial standards in 2005, and yeast, spirulina and glucosan all meet the relevant industries standard.
The Radix Astragali in the above-mentioned immunostimulant, invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation has the enhancing human body immunity function, can strengthen cellular metabolism, regulate dna replication dna and RNA and proteinic synthetic, reinforce the kidney in addition in addition blood pressure lowering, protect the liver antiphlogistic function, astragalus polysaccharides is one of its main active substances, can be used as immunopotentiating agent or reinforcing agent, has effects such as antiviral, antitumor, defying age, radioprotective, anti-stress, antioxidation simultaneously; Radix Glycyrrhizae has detoxifcation, antiinflammatory, blood pressure lowering, analgesia, antiallergic action, plays all medicines of blending, increases the effect of drug effect; Herba Taraxaci, contain distinctive taraxol in its plant, taraxacin and choline, organic acid, inulin, glucose, vitamin, the active component of multiple health-nutrition such as carotene, contain abundant trace element simultaneously, the content of its calcium is 2.2 times of Fructus psidii guajavae immaturus, 3.2 times of Fructus Rosae Normalis, the content of ferrum is 4 times of Fructus Rosae Normalis, the more important thing is wherein to be rich in and have very that Johnson ﹠ Johnson manages active selenium element, having crucial threpsology is worth, and Herba Taraxaci is to staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae, meningococcus, diphtheria stalk bacterium, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi, micrococcus catarrhalises etc. all have killing action, to tubercule bacillus, some fungus and virus also have certain inhibitory action, therefore can replace antibiotic to use to a certain extent; Yeast, yeast cells biological activity height, nutritious, safeguard the intestinal microecology balance, suppress the breeding of harmful bacterium, enhancing immunity, antibiosis is have toleration, can excite, the immunity of enhancing body and premunition are to antibacterial, disease and transportation that fungus and virus cause, change the group, inoculation, the stress that climate change etc. cause can produce non-specific immunity, has good palatability, suspension is strong, active high, advantage such as polluted water not, and can decompose organic matter in the water body, reduce harmful organism type and flora quantity, reduce dosage and residual level in culturing, yeast cell wall can improve animal disease resistant power and appetite strengthening, promotes growth; Spirulina, its protein content is up to 60～70%, be equivalent to 6 times of Semen Tritici aestivi, 4 times of Carnis Sus domestica, 3 times of the flesh of fish, 5 times of egg, 2.4 times of cheese, and digestibility is up to more than 95%, and its distinctive phycocyanin can improve lymphocyte activity, enhancing human body immunity power, vitamin and content of mineral substances are very abundant, comprise vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin E, vitamin K etc., and contain zinc, ferrum, potassium, calcium, magnesium, phosphorus, selenium, trace element such as iodine, carotenoid content is 1.5 times of Radix Dauci Sativae, vitamin B12 content is 4 times of Hepar Sus domestica, and iron content is 23 times of Herba Spinaciae, is the abundantest food of iron content, spirulina is at cholesterol reducing and blood fat, anticancer, fat-reducing, stomach is protected in nourishing the stomach, treatment anemia and trace element deficiency, hepatoprotective is promoted immunity, and all there is positive role aspects such as adjustment metabolism; Glucosan, enter in the animal body can with the special receptors bind of humoral factor and immunocyte, thereby activate intravital immune system, for Fish, glucosan is by promoting that macrophage shifts to focus, improve reactive oxygen free radical output and hemocytolysis effect, make the parasiticide of body, bactericidal activity, antiviral activity and stress ability improve, for crustacean and shellfish, glucosan produces activated phenol oxidase by activating pro-phenoloxidase system, participate in the defense reaction of body in several ways with approach, make immunization strengthen, excite complement, the activity of lysozyme and macrophage strengthens the fish and shrimp antibacterium, the ability that virus etc. infect, above-mentioned each component is shared, mutual synergism can significantly improve the rate of body weight gain of aquatic animal, survival rate, and reduce feed coefficient.
Clinical trial:
The Hangu District shrimp pool, Tianjin is the high-density breeding pond, the stocking rate of every mu of shrimp reaches more than 100,000 tails, main Penaeus vannamei and the oriental prawn of culturing, long behind 4-5cm shrimp, shrimp very easily falls ill, the embodiment 1 described immunostimulant of throwing something and feeding since mid-June, and consumption is every 1kg bait with this immunostimulant 30g, mixing bait throws something and feeds, 3 times on the one, threw something and fed continuously 5 days, stopped 10 days, threw something and fed again 5 days, during whole breed, especially at high temperature season, this shrimp pool is compared with the pond that contrasts the embodiment 1 described immunostimulant of not throwing something and feeding, seldom morbidity, and the body colour of shrimp is beautiful, vigor is very strong, and food ration is higher than the contrast pond, and the speed of growth is very fast, the long comparison of average body increases about 20% according to pond Prawn body is long when going out the pond, and body weight has also increased about 10%.
As seen, above-mentioned immunostimulant is by the mutual collaborative facilitation of each component, stimulate the aquatic animal autoimmune response, improve aquatic animal resistance and premunition, effectively reduce the mortality rate of the aquatic animal that causes because of various factors, and can promote body growth, improve the survival rate of body and the utilization rate of feedstuff.
Above-mentioned detailed description of this a kind of immunostimulant that is used for aquatic animal and preparation method thereof being carried out with reference to embodiment; be illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (9)
1. immunostimulant that is used for aquatic animal, it is characterized in that: form by the Radix Astragali, Radix Glycyrrhizae, dandelion, yeast, spirulina and glucosan, by its parts by weight Radix Astragali 150-250 part, Radix Glycyrrhizae 150-250 part, dandelion 100-200 part, yeast 200-300 part, spirulina 30-80 part, glucosan 100-200 part.
2. a kind of immunostimulant that is used for aquatic animal according to claim 1 is characterized in that: by 200 parts of its parts by weight Radixs Astragali, 200 parts in Radix Glycyrrhizae, 150 parts of dandelions, 250 parts in yeast, 50 parts of spirulinas, Dextran 150 part.
3. a kind of immunostimulant that is used for aquatic animal according to claim 1 is characterized in that: by 150 parts of its parts by weight Radixs Astragali, 250 parts in Radix Glycyrrhizae, 200 parts of dandelions, 200 parts in yeast, 80 parts of spirulinas, 100 parts of glucosans.
4. a kind of immunostimulant that is used for aquatic animal according to claim 1 is characterized in that: by 250 parts of its parts by weight Radixs Astragali, 150 parts in Radix Glycyrrhizae, 100 parts of dandelions, 300 parts in yeast, 30 parts of spirulinas, Dextran 200 part.
5. a kind of immunostimulant that is used for aquatic animal according to claim 1 is characterized in that: by 170 parts of its parts by weight Radixs Astragali, 220 parts in Radix Glycyrrhizae, 120 parts of dandelions, 280 parts in yeast, 60 parts of spirulinas, 130 parts of glucosans.
6. a kind of immunostimulant that is used for aquatic animal according to claim 1 is characterized in that: by 240 parts of its parts by weight Radixs Astragali, 170 parts in Radix Glycyrrhizae, 180 parts of dandelions, 210 parts in yeast, 70 parts of spirulinas, 180 parts of glucosans.
7. a kind of immunostimulant that is used for aquatic animal according to claim 1 is characterized in that: by 220 parts of its parts by weight Radixs Astragali, 160 parts in Radix Glycyrrhizae, 130 parts of dandelions, 230 parts in yeast, 40 parts of spirulinas, 170 parts of glucosans.
8. according to the described a kind of immunostimulant that is used for aquatic animal of one of claim 1-7, it is characterized in that: by 210 parts of its parts by weight Radixs Astragali, 190 parts in Radix Glycyrrhizae, 140 parts of dandelions, 260 parts in yeast, 50 parts of spirulinas, 140 parts of glucosans.
9. the described preparation method that is used for the immunostimulant of aquatic animal of claim 1-8 is characterized in that: concrete preparation process is as follows:
(1) Radix Astragali, Radix Glycyrrhizae, dandelion three flavor medical materials are carried out micronizing;
(2) packing after the above-mentioned parts by weight of eucalyptus globulus will mix with yeast, spirulina, glucosan, stir through three flavor medical materials of micronizing, promptly.
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| CN200910307194A CN101695516A (en) | 2009-09-17 | 2009-09-17 | Immunostimulant for aquatic animals and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100911A (en) * | 2010-09-21 | 2011-06-22 | 淮海工学院 | Preparation method of Cynoglossus semilaevis vibrio anguillarum vaccine |
| CN108143776A (en) * | 2017-12-15 | 2018-06-12 | 浙江海洋大学 | A kind of preparation method of Larimichthys crocea non-specific immunostimulating agents |
| CN108157678A (en) * | 2017-12-29 | 2018-06-15 | 磐安县派普特生物科技有限公司 | A kind of preparation method containing Auricularia polysaccharide preparing grass carp feed additive |
| CN110074283A (en) * | 2019-06-03 | 2019-08-02 | 中国水产科学研究院黄海水产研究所 | Improve compound formulation and the preparation of ocean bivalve shellfish maturity of fish gonads and immunity |
-
2009
- 2009-09-17 CN CN200910307194A patent/CN101695516A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100911A (en) * | 2010-09-21 | 2011-06-22 | 淮海工学院 | Preparation method of Cynoglossus semilaevis vibrio anguillarum vaccine |
| CN108143776A (en) * | 2017-12-15 | 2018-06-12 | 浙江海洋大学 | A kind of preparation method of Larimichthys crocea non-specific immunostimulating agents |
| CN108157678A (en) * | 2017-12-29 | 2018-06-15 | 磐安县派普特生物科技有限公司 | A kind of preparation method containing Auricularia polysaccharide preparing grass carp feed additive |
| CN110074283A (en) * | 2019-06-03 | 2019-08-02 | 中国水产科学研究院黄海水产研究所 | Improve compound formulation and the preparation of ocean bivalve shellfish maturity of fish gonads and immunity |
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Application publication date: 20100421 |