CN101693040B - Medicament for treating onychomycosis and preparation method thereof - Google Patents
Medicament for treating onychomycosis and preparation method thereof Download PDFInfo
- Publication number
- CN101693040B CN101693040B CN2009101527779A CN200910152777A CN101693040B CN 101693040 B CN101693040 B CN 101693040B CN 2009101527779 A CN2009101527779 A CN 2009101527779A CN 200910152777 A CN200910152777 A CN 200910152777A CN 101693040 B CN101693040 B CN 101693040B
- Authority
- CN
- China
- Prior art keywords
- parts
- ointment
- acid
- medicament
- medicinal liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a medicament for treating onychomycosis and a preparation method thereof. The medicament comprises ointment for removing diseased nails and medicine liquor for killing fungi and hastening new nails, wherein the ointment comprises the following components in parts by weight: 300-600 parts of urea, 100-200 parts of boric acid, 200-400 parts of salicylic acid, 100-200 parts of benzoic acid, 60-100 parts of phenol, 10-15 parts of cocaine hydrochloride and 800 parts of vaseline; and the medicine liquor comprises the following components in parts by weight: 3-8 parts of pseudolarix, 3-8 parts of common cnidium fruit, 3-8 parts of radix sophorae flavescentis, 3-8 parts of chaulmoogra benevolence, 5-15 parts of salicylic acid, 5-15 parts of benzoic acid, 20-30 parts of glacial acetic acid, 2-4 parts of cantharis, 2-4 parts of camphor and 85 parts of alcohol with concentration of 75 percent. The invention removes the diseased nails by applying the ointment, kills the fungi and hastens the new nails by applying the medicine liquor with high curative ratio, can effectively suppress the recurrence of the onychomycosis and has the advantages of safety, no pain and no side effect.
Description
Technical field:
The present invention relates to a kind of medicament and this medicaments preparation method thereof for the treatment of tinea unguium, a kind of specifically medicament and this medicaments preparation method thereof that adopts external therapy for treating tinea unguium.
Background technology:
Tinea unguium claims tinea unguium again, is that the infected by microbes of fungus causes.Dermatophytosis most importantly wherein, this bacterium just existence as in the soil, on one's body the ground of bathing pool and swimming pool, animal (seeing cat, Canis familiaris L., pig etc.), and suffer from dermatophytes patient's the erythra with us.Common skin tinea bacterium is trichophyton, alpha fungus, acrothesium floccosum etc., and same first can infect two kinds of funguses.The symptom of tinea unguium generally begins morbidity with 1-2 fingernail, and the whole fingernails of weight person all can infect pathogenic.Fingernail thickens, gloss, surface are not uneven, first matter is crisp etc. all is the symptom performance of tinea unguium for variable color, deck.Tinea unguium is not treated the healthy growth that also might influence other fingernail for a long time, causes nail matrix seriously to be subjected to fungal damage, can't give birth to first.The method of treatment tinea unguium mainly can be divided three classes at present.
1, first is pulled out in operation: under local anesthesia, will suffer from first and pull out.This method wound surface is big, hemorrhage, easily causes infection.Generally can feel after the operation than pain, generally not ideal because " curing the symptoms, not the disease ", infection and recurrence again easily.And the patient of heart disease, hypertension, diabetes etc., unsuitable operative treatment.
2, oral drugs: take antifungal drug such as griseofulvin, fluconazol, itraconazole (itraconazole) etc. merely, certain curative effect is arranged, and convenient.But because this class medicine must reach fungus place, parasitic deck competence exertion antibacterial action, and the dissolubility in water is low waits a moment, it is very fast again to absorb metabolism, so dosage is big, administration time is long.In addition, oral medicine all has side effect, and easily recurrence after the drug withdrawal, so should not be as the conventional therapy medicine of tinea unguium.
3, external therapy: generally should select the external curing tinea unguium,, mainly contain immersion, local application and package and cut Therapeutic Method according to the medicament difference.Need cooperate during treatment and remove sick first, thus generally there is not interior oral administration to make things convenient for, but safety, no pain, have no side effect.But be to use medicament in the market, not only treatment time long, and be difficult to the radical cure, tend to after half a year, recur.
Summary of the invention:
The objective of the invention is to defective and deficiency, for people provide a kind of safety, no pain, have no side effect, are difficult for the medicament of the treatment tinea unguium of recurrence and this medicaments preparation method at above-mentioned prior art.
The invention provides a kind of medicament for the treatment of tinea unguium for achieving the above object, this medicament comprises the ointment and the medicinal liquid that is used to kill fungus and expedite the emergence of new first that is used to remove the disease first, and ointment and medicinal liquid are used.
The composition of ointment and weight proportion: carbamide 300-600 part, boric acid 100-200 part, salicylic acid 200-400 part, benzoic acid 100-200 part, 800 parts in phenol 60-100 part, cocaine hydrochloride 10-15 part and vaseline.
The composition of medicinal liquid and weight proportion: Cortex Pseudolaricis 3-8 part, Fructus Cnidii 3-8 part, Radix Sophorae Flavescentis 3-8 part, Semen Hydnocarpi 3-8 part, salicylic acid 5-15 part, benzoic acid 5-15 part, glacial acetic acid 20-30 part, Mylabris 2-4 part, 85 parts of Camphora 2-4 part and 75% ethanol.
The optimum weight proportioning of ointment composition: 400 parts in carbamide, 150 parts of boric acid, 300 parts of salicylic acid, 150 parts in benzoic acid, 80 parts of phenol, 12 parts of cocaine hydrochlorides, 800 parts in vaseline.
The optimum weight proportioning of medicinal liquid composition: 5 parts of Cortex Pseudolaricis, 5 parts of Fructus Cnidiis, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Semen Hydnocarpi, 10 parts of salicylic acid, 10 parts in benzoic acid, 25 parts of glacial acetic acids, 3 parts of Mylabris, 85 parts of 3 parts of Camphoras and 75% ethanol.
The method for preparing the medicament of this treatment tinea unguium
The preparation of ointment: carbamide, boric acid, salicylic acid, benzoic acid, phenol, cocaine hydrochloride and vaseline are mixed stirring, be mixed into paste, fermenting made ointment after 24 hours.
The preparation of medicinal liquid: Cortex Pseudolaricis, Fructus Cnidii, Radix Sophorae Flavescentis, Semen Hydnocarpi, Mylabris and Camphora are worn into powder, put into 75% ethanol then together, sealing infusion 2 was by 3 months, and then adding salicylic acid, benzoic acid and glacial acetic acid, after fully fused medicinal residues are filtered, make medicinal liquid.
The present invention removes the disease first by smearing ointment earlier, kills fungus and expedites the emergence of new first by smearing medicinal liquid again, and the new first after growing up to is smooth, smooth, the cure rate height.Because medicinal liquid directly contacts with fungus, can kill fungus fast, contain the tinea unguium recurrence effectively, the advantage that have safety, no pain, have no side effect, cost is low has good market prospect.
The specific embodiment:
The composition of ointment and weight proportion: carbamide 300-600 part, boric acid 100-200 part, salicylic acid 200-400 part, benzoic acid 100-200 part, 800 parts in phenol 60-100 part, cocaine hydrochloride 10-15 part and vaseline.The optimum weight proportioning of its Chinese medicinal ointment composition: 400 parts in carbamide, 150 parts of boric acid, 300 parts of salicylic acid, 150 parts in benzoic acid, 80 parts of phenol, 12 parts of cocaine hydrochlorides, 800 parts in vaseline.
The preparation ointment
Embodiment 1: take by weighing carbamide 30 grams, and boric acid 10 grams, salicylic acid 20 grams, benzoic acid 10 restrains, phenol 6 grams, cocaine hydrochloride 10 grams, vaseline 80 grams are put into container and are mixed stirring, until being mixed into paste, body of paste natural fermentation are made ointment after 24 hours.
Embodiment 2: take by weighing carbamide 40 grams, and boric acid 15 grams, salicylic acid 30 grams, benzoic acid 15 restrains, phenol 8 grams, cocaine hydrochloride 1.2 grams, vaseline 80 grams are put into container and are mixed stirring, until being mixed into paste, body of paste natural fermentation are made ointment after 24 hours.
Embodiment 3: take by weighing carbamide 60 grams, and boric acid 20 grams, salicylic acid 40 grams, benzoic acid 20 restrains, phenol 10 grams, cocaine hydrochloride 1.5 grams, vaseline 80 grams are put into container and are mixed stirring, until being mixed into paste, body of paste natural fermentation are made ointment after 24 hours.
The composition of medicinal liquid and weight proportion: Cortex Pseudolaricis 3-8 part, Fructus Cnidii 3-8 part, Radix Sophorae Flavescentis 3-8 part, Semen Hydnocarpi 3-8 part, salicylic acid 5-15 part, benzoic acid 5-15 part, glacial acetic acid 20-30 part, Mylabris 2-4 part, 85 parts of Camphora 2-4 part and 75% ethanol.The optimum weight proportioning of its herb liquid composition: 5 parts of Cortex Pseudolaricis, 5 parts of Fructus Cnidiis, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Semen Hydnocarpi, 10 parts of salicylic acid, 10 parts in benzoic acid, 25 parts of glacial acetic acids, 3 parts of Mylabris, 85 parts of 3 parts of Camphoras and 75% ethanol.
The preparation medicinal liquid
Embodiment 1: 75% the ethanol of measuring 1000 milliliters is standby (because 75% alcoholic acid density is about 0.85 grams per milliliter, therefore 1000 milliliters 75% ethanol is equivalent to 850 grams), take by weighing Cortex Pseudolaricis 30 grams again, Fructus Cnidii 30 grams, Radix Sophorae Flavescentis 30 grams, Semen Hydnocarpi 30 grams, Mylabris 20 grams, Camphora 20 grams, mix and wear into powder, put into 75% ethanol then, infusion 2 was by 3 months, taking by weighing salicylic acid 50 gram, benzoic acid 50 grams and glacial acetic acid 200 grams at last, to put into solution fully fused, medicinal residues filtered promptly make medicinal liquid.
Embodiment 2: 75% the ethanol of measuring 1000 milliliters is standby, take by weighing Cortex Pseudolaricis 50 grams again, Fructus Cnidii 50 grams, Radix Sophorae Flavescentis 50 grams, Semen Hydnocarpi 50 grams, Mylabris 30 grams, Camphora 30 grams mix and wear into powder, put into 75% ethanol then, infusion 2 is by 3 months, and taking by weighing salicylic acid 100 grams, benzoic acid 100 grams and glacial acetic acid 250 grams at last, to put into solution fully fused, medicinal residues filtered promptly make medicinal liquid.
Embodiment 3: 75% the ethanol of measuring 1000 milliliters is standby, take by weighing Cortex Pseudolaricis 80 grams again, Fructus Cnidii 80 grams, Radix Sophorae Flavescentis 80 grams, Semen Hydnocarpi 80 grams, Mylabris 40 grams, Camphora 40 grams mix and wear into powder, put into 75% ethanol then, infusion 2 is by 3 months, and taking by weighing salicylic acid 150 grams, benzoic acid 150 grams and glacial acetic acid 300 grams at last, to put into solution fully fused, medicinal residues filtered promptly make medicinal liquid.
Using method
1. the use of ointment
(1) sick first be soaked in the warm water dry about 10 minutes, then with blade with the sick first of scraping, repair sick first thin.
(2) be closed around the sick first with rubber glue, only expose fingernail, with the protection surrounding skin.
(3) smearing ointment is being repaiied the ointment that evenly covers the 2-3 millimeters thick on the thin sick first.
(4) on finger, twine the 3-4 circle with plastic sheeting, guarantee ointment is encased fully, but can not twine too tight, reuse rubber glue fixes plastic sheeting, such wrapping method can be avoided into water, can prevent the ointment volatilization again, helps drug effect and is fully absorbed by fingernail.
(5) wrapping was thrown off rubber glue and plastic sheeting after 48 hours, dried about 10 minutes with warm water soaking, and this seasonal disease first is turned white, and fluff, deliquescing, gently scrape with blade and can make the disease onychoptosis, expose redness or peach soft textive.
Points for attention: may have mild pain in wrapping after 12 hours, belong to normal reflection.If the state of an illness is heavier, can not disposablely remove the disease first fully, can repeat above step 1 to twice, come off fully until sick first.
2. the use of medicinal liquid
(1) medicinal liquid is applied in the affected part, every day 2-3 time, each 3 minutes, continue about 10 days, come off for the second time until sick first, the quarter deck smooth surface that comes off does not have any meal beetle, and the fingernail of perk need pare off in the therapeutic process.
(2) etc. smear every three days 1 time or 2 times after sick first comes off for the second time, each 3 minutes, generally fingernail grows in 45 days, new first after growing up to is slightly higher than normal nail, and white stripes can appear in the new first of minority, and that is because the new first poor quality of harsh length, grow with time, fingernail is because of the increase in density attenuation, and white stripes reduces, and fingernail is smooth, smooth.
Points for attention: after using ointment to remove the disease first, just can smear medicinal liquid every two hours, and smear medicinal liquid for the first time and can feel slight twinge, utmost point individual patient sick first in therapeutic process can flow yellow fluid, and this need not in alarm for the medicinal liquid reflection.
Clinical trial
1, ointment test
Choose 150 tinea unguium patients, the patient age scope is in 25-75 year, and the ointment that three embodiment of the present invention are prepared from gives 50 tinea unguium patients respectively according to the using method of ointment and uses.
The ointment of embodiment 1 preparation: 43 patients sick onychoptosis after 48 hours is arranged, expose red or peach soft textive; Other has, and sick first can't come off in 7 patients 48 hours, and after using ointment for the second time, red or peach soft textive are exposed in sick onychoptosis after 96 hours.50 patients are all reflected no obvious pain during the treatment.
The ointment of embodiment 2 preparations: 50 all sick onychoptosis after 48 hours of patient, expose red or peach soft textive, and no obvious pain during all reflection is treated.
The ointment of embodiment 3 preparations: 50 all sick onychoptosis after 48 hours of patient, expose red or peach soft textive, but have 8 patients to represent during the treatment obvious paroxysmal pain is arranged.
2, medicinal liquid test
The medicinal liquid that three embodiment of the present invention are prepared from gives 50 respectively according to the using method of medicinal liquid and uses the tinea unguium patients behind the ointment to use.
The medicinal liquid of embodiment 1 preparation: 50 patients all grew new first at 36-45 days, did not have obvious pain during treatment, but the new first that has 13 patients to grow is second-rate, and white stripes is more, and has a people to recur after 7 months.
The medicinal liquid of embodiment 2 preparations: 50 patients all grew new first at 35-45 days, did not have obvious pain during treatment, and the new first quality that grows is better, and white stripes is less, does not have the patient to recur.
The medicinal liquid of embodiment 3 preparations: 50 patients all grew new first at 32-40 days, but had 15 patients to represent to have pain when treatment is in earlier stage smeared medicinal liquid, and the new first that grows is second-rate, and white stripes is more, does not have the patient to recur.
The medicinal liquid effect of the ointment of embodiment 2 preparations and embodiment 2 preparations is better in sum, and side effect is little.
Claims (4)
1. a medicament for the treatment of tinea unguium is characterized in that this medicament comprises the ointment and the medicinal liquid that is used to kill fungus and expedite the emergence of new first that is used to remove the disease first, and ointment and medicinal liquid are used;
The composition of ointment and weight proportion: carbamide 300-600 part, boric acid 100-200 part, salicylic acid 200-400 part, benzoic acid 100-200 part, phenol 60-100 part, 800 parts in cocaine hydrochloride 10-15 part and vaseline;
The composition of medicinal liquid and weight proportion: Cortex Pseudolaricis 3-8 part, Fructus Cnidii 3-8 part, Radix Sophorae Flavescentis 3-8 part, Semen Hydnocarpi 3-8 part, salicylic acid 5-15 part, benzoic acid 5-15 part, glacial acetic acid 20-30 part, Mylabris 2-4 part, 85 parts of Camphora 2-4 part and 75% ethanol.
2. a kind of medicament for the treatment of tinea unguium according to claim 1 is characterized in that the optimum weight proportioning of ointment composition: 400 parts in carbamide, 150 parts of boric acid, 300 parts of salicylic acid, 150 parts in benzoic acid, 80 parts of phenol, 12 parts of cocaine hydrochlorides, 800 parts in vaseline.
3. a kind of medicament for the treatment of tinea unguium according to claim 1 and 2, the optimum weight proportioning that it is characterized in that the medicinal liquid composition: 5 parts of Cortex Pseudolaricis, 5 parts of Fructus Cnidiis, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Semen Hydnocarpi, 10 parts of salicylic acid, 10 parts in benzoic acid, 25 parts of glacial acetic acids, 3 parts of Mylabris, 85 parts of 3 parts of Camphoras and 75% ethanol.
4. a method for preparing the medicament of the described treatment tinea unguium of claim 1-3 is characterized in that
The preparation of ointment: carbamide, boric acid, salicylic acid, benzoic acid, phenol, cocaine hydrochloride and vaseline are mixed stirring, be mixed into paste, fermenting made ointment after 24 hours;
The preparation of medicinal liquid: Cortex Pseudolaricis, Fructus Cnidii, Radix Sophorae Flavescentis, Semen Hydnocarpi, Mylabris and Camphora are worn into powder, put into 75% ethanol then together, sealing infusion 2 was by 3 months, and then adding salicylic acid, benzoic acid and glacial acetic acid, after fully fused medicinal residues are filtered, make medicinal liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101527779A CN101693040B (en) | 2009-10-14 | 2009-10-14 | Medicament for treating onychomycosis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101527779A CN101693040B (en) | 2009-10-14 | 2009-10-14 | Medicament for treating onychomycosis and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101693040A CN101693040A (en) | 2010-04-14 |
| CN101693040B true CN101693040B (en) | 2011-05-18 |
Family
ID=42092065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101527779A Expired - Fee Related CN101693040B (en) | 2009-10-14 | 2009-10-14 | Medicament for treating onychomycosis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101693040B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912556B (en) * | 2010-08-11 | 2012-04-25 | 叶正文 | Formula for treating tinea and preparation method thereof |
| CN102058633B (en) * | 2010-12-23 | 2012-02-08 | 王运生 | External medicine for treating tinea unguium |
| CN103830215A (en) * | 2013-01-31 | 2014-06-04 | 张雪峰 | Skin-disease targeted medicine adopting acetic acid and vaseline as main components |
| CN105878531A (en) * | 2016-05-27 | 2016-08-24 | 廖鲜芳 | Matching agent for treating paronychia |
| CN105878515A (en) * | 2016-05-27 | 2016-08-24 | 廖鲜芳 | Matching agent for treating onychomycosis |
| CN107260846A (en) * | 2017-07-25 | 2017-10-20 | 杜玉雷 | A kind of ointment for treating onychomycosis |
| CN107929372A (en) * | 2017-12-29 | 2018-04-20 | 浙江吉龙生物科技有限公司 | Treat Chinese medicine composition of onychomycosis and its preparation method and application |
| CN110876756A (en) * | 2019-12-17 | 2020-03-13 | 罗香英 | Ointment for treating onychomycosis |
| CN112107675A (en) * | 2020-11-05 | 2020-12-22 | 赵垒垒 | Chinese herbal medicine ointment for preventing and treating onychomycosis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634234A (en) * | 2004-11-12 | 2005-07-06 | 梁东蓓 | Chinese herbal liquor for treating manus tenea, pedes tenea, onychomycosis and its preparation process |
| CN1785257A (en) * | 2005-09-27 | 2006-06-14 | 杨发祥 | Tincture for trenting fungus dermatosis |
-
2009
- 2009-10-14 CN CN2009101527779A patent/CN101693040B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634234A (en) * | 2004-11-12 | 2005-07-06 | 梁东蓓 | Chinese herbal liquor for treating manus tenea, pedes tenea, onychomycosis and its preparation process |
| CN1785257A (en) * | 2005-09-27 | 2006-06-14 | 杨发祥 | Tincture for trenting fungus dermatosis |
Non-Patent Citations (2)
| Title |
|---|
| 杜丽等.中医药治疗甲癣的研究进展.《甘肃中医》.2008,第21卷(第12期),第7-8页. * |
| 黄有彬.斑蝥虫的临床运用举隅.《中医外治杂志》.2004,第13卷(第5期),43. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101693040A (en) | 2010-04-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101693040B (en) | Medicament for treating onychomycosis and preparation method thereof | |
| EP1663104B1 (en) | Spongilla-based therapeutic compositions for treating and preventing acne | |
| CN110882207B (en) | Preparation process and method of essence for skin repair | |
| CN106420565A (en) | Preparation method of Chinese herbal medicine mask | |
| US20080138446A1 (en) | Herbal Composition | |
| CN108815111A (en) | A kind of traditional Chinese medicine freckle-removing whitening remediation composition and preparation method thereof | |
| CN108524887A (en) | A kind of onychomycosis ointment and preparation method thereof | |
| CN107789282B (en) | Skin care product containing dendrobium officinale extract and plant whitening agent as well as preparation method and application of skin care product | |
| WO2018113200A1 (en) | External traditional chinese medicine preparation for diminishing inflammation, relieving pain and promoting fast healing, and preparation method therefor | |
| CN105434743A (en) | Milk cow hoof-care ointment and preparation method thereof | |
| KR101057017B1 (en) | Anti-hair loss soap containing natural extract | |
| CN101991037B (en) | Angelica-aronia melanocarpa pill and manufacturing method thereof | |
| CN104138499A (en) | Traditional Chinese medicine composition for tinea unguium as well as preparation method and application thereof | |
| CN106038423B (en) | A kind of anti-acne, except scar gel and preparation method thereof | |
| CN107929624A (en) | A kind of ointment for treating tinea pedis and preparation method thereof | |
| CN110448512B (en) | Preparation method of mask cream based on sugarcane vinegar | |
| CN112704720A (en) | Pharmaceutical composition with nail-dissolving effect and application thereof | |
| CN112656907A (en) | External liquid preparation for treating pet fungal dermatosis | |
| CN104984177A (en) | Leuconychia compound medicine and preparation method thereof | |
| CN117085059A (en) | External Mongolian medicine for treating psoriasis | |
| CN118252886A (en) | Externally-applied herbal essence capable of improving skin itch | |
| CN111298008A (en) | External medicine for treating beriberi and preparation method thereof | |
| CN117180343A (en) | Traditional Chinese medicine composition for treating dermatophytosis and application thereof | |
| CN100411654C (en) | Medicien for treating ulcerative stomatitis | |
| CN108653696A (en) | It is a kind of treat tinea of feet and hands, onychomycosis ointment and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110518 Termination date: 20151014 |
|
| EXPY | Termination of patent right or utility model |