CN107260846A - A kind of ointment for treating onychomycosis - Google Patents

A kind of ointment for treating onychomycosis Download PDF

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Publication number
CN107260846A
CN107260846A CN201710609430.7A CN201710609430A CN107260846A CN 107260846 A CN107260846 A CN 107260846A CN 201710609430 A CN201710609430 A CN 201710609430A CN 107260846 A CN107260846 A CN 107260846A
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ointment
mixed
paste
bitter
mentioned
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杜玉雷
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
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Abstract

The present invention provides a kind of ointment for treating onychomycosis, wherein described ointment is made up of the component of following portions by weight：6 ~ 8g of salicylic acid, 4 ~ 6g of benzoic acid, 7 ~ 9g of kuh-seng, 3 ~ 5g of the root bark of shaggy-fruited dittany, 2 ~ 3g of bitter alum, 2 ~ 4g of gleditsia sinensis, 2 ~ 3g of corydalis tuber, 2 ~ 3g of pillworm, 1 ~ 2g of muskmelon pedicel, 1 ~ 2g of balsamine；Above-mentioned medicament is pulverized and mixed, paste is mixed into vaseline；Advantage is：Drug effect is balanced, lasting, and good effect, treatment cost are low, have no toxic side effect.

Description

A kind of ointment for treating onychomycosis
Technical field
The present invention relates to treatment onychomycosis technical field, more particularly, to a kind of ointment for treating onychomycosis.
Background technology
Onychomycosis is that, by fungus-caused common disease, frequently-occurring disease, lesion starts from first distal end, and lateral margin or first pleat portion show as referring to First color and paramophia；And if the fungi of nail superficial infection prevents or killed not in time, deep skin infection can be caused.Cause And, cause the fungi for infecting onychomycosis to be more difficult in killing, work, life, social inconvenience are brought to patient.Onychomycosis has a variety of Type.One kind shows as white first, Chang Xiancong nail roots and started, and deck shows small particles and gradually expanded, and causes deck to soften and sink.Separately One kind infringement first since free margin of nail and side wall, makes deck lower recess or transverse furrows of the nail occur, and gradually development causes deck to become fragile, easily It is broken, thicken in interior brown.Under first talus accumulation Chang Yi make first it is emptying, tilt separated with nail matrix.Deck surface is uneven, coarse Tarnish, in addition when the imprudence pin in live and work or finger nail are injured, has hindered nail root and nail matrix, had not sterilized, disappears at that time Charcoal processing, slowly nail blackening, in purple, nail turns yellow, slowly forms empty first, and then slant borough chief inside inside or outside, Time length becomes to suppurate, and is changed into nail groove charcoal, very painful.Before nail both sides borough chief inside, first class end tilt, back down Sunken, nail is less and less, and slight or moderate, depth atrophy occurs in deck, and normalizing purulence is, it is necessary to often take first.
At present, although the externally applied drug for the treatment of onychomycosis is a lot, some externally applied drug therapeutic effects are undesirable, some medicine pairs Effect is big, and what is had easily causes allergic adverse reaction of Denging, and what is had cures the symptoms, not the disease, and has some external use liquids due to being applied to trouble Be dried soon behind place, drug effect can not it is balanced, persist to affected part and cause curative effect to be decreased obviously, then side effect is big for Western medicine, medicine valency Lattice are high, seriously endanger health, and the treatment cost of patient is high.
The content of the invention
It is an object of the invention to be solution the deficiencies in the prior art, and provide a kind of ointment for treating onychomycosis.
The new technical scheme of the present invention is：A kind of ointment for treating onychomycosis, described ointment is by following portions by weight Component is constituted：6 ~ 8g of salicylic acid, 4 ~ 6g of benzoic acid, 7 ~ 9g of kuh-seng, 3 ~ 5g of the root bark of shaggy-fruited dittany, 2 ~ 3g of bitter alum, 2 ~ 4g of gleditsia sinensis, corydalis tuber 2 ~ 3g, 2 ~ 3g of pillworm, 1 ~ 2g of muskmelon pedicel, 1 ~ 2g of balsamine, above-mentioned medicament is pulverized and mixed, paste is mixed into vaseline.
The optimum proportioning of the ointment is：Salicylic acid 7g, benzoic acid 5g, kuh-seng 8g, root bark of shaggy-fruited dittany 4g, bitter alum 3g, gleditsia sinensis 3g, Corydalis tuber 3g, pillworm 3g, muskmelon pedicel 2g, balsamine 2g, above-mentioned medicament is pulverized and mixed, paste is mixed into vaseline.
The preparation method of the ointment is：Kuh-seng, the root bark of shaggy-fruited dittany, bitter alum, gleditsia sinensis, corydalis tuber, pillworm, muskmelon pedicel, balsamine is clear Wash after weighing, be developed into and then can be well mixed the above-mentioned raw materials for being ground into fine powder, in 50 DEG C of rings by the fine powders of 120 mesh sieves After being fermented 12 ~ 15 under border, it is mixed in proportion with crossing salicylic acid and benzoic acid after trailing plants, cream is mixed into vaseline Shape.
The application method of the ointment is：It is uniform to be applied to affected part, then will be applied with medical proof fabric either shangshi zhitong plaster, shangshi zhitong gao Smear the paste mixture in affected part to wrap up together with the finger either toe in affected part, medicine is attached to affected part and is difficult in short-term Between it is dry；Parcel is attached, and once, it is a course for the treatment of that continuous parcel, which attaches 3 times, for dressing in 3 days；Each course for the treatment of interval time is 45.
The beneficial effects of the invention are as follows：Drug effect is balanced, lasting, and good effect, treatment cost are low, have no toxic side effect.
Embodiment
A kind of ointment for treating onychomycosis, described ointment is made up of the component of following portions by weight：6 ~ 8g of salicylic acid, benzene 4 ~ 6g of formic acid, 7 ~ 9g of kuh-seng, 3 ~ 5g of the root bark of shaggy-fruited dittany, 2 ~ 3g of bitter alum, 2 ~ 4g of gleditsia sinensis, 2 ~ 3g of corydalis tuber, 2 ~ 3g of pillworm, 1 ~ 2g of muskmelon pedicel, phoenix Celestial being spends 1 ~ 2g, and above-mentioned medicament is pulverized and mixed, paste is mixed into vaseline.
The optimum proportioning of the ointment is：Salicylic acid 7g, benzoic acid 5g, kuh-seng 8g, root bark of shaggy-fruited dittany 4g, bitter alum 3g, gleditsia sinensis 3g, Corydalis tuber 3g, pillworm 3g, muskmelon pedicel 2g, balsamine 2g, above-mentioned medicament is pulverized and mixed, paste is mixed into vaseline.
The preparation method of the ointment is：Kuh-seng, the root bark of shaggy-fruited dittany, bitter alum, gleditsia sinensis, corydalis tuber, pillworm, muskmelon pedicel, balsamine is clear Wash after weighing, be developed into and then can be well mixed the above-mentioned raw materials for being ground into fine powder, in 50 DEG C of rings by the fine powders of 120 mesh sieves After being fermented 12 ~ 15 under border, it is mixed in proportion with crossing salicylic acid and benzoic acid after trailing plants, cream is mixed into vaseline Shape.
The application method of the ointment is：It is uniform to be applied to affected part, then will be applied with medical proof fabric either shangshi zhitong plaster, shangshi zhitong gao Smear the paste mixture in affected part to wrap up together with the finger either toe in affected part, medicine is attached to affected part and is difficult in short-term Between it is dry；Parcel is attached, and once, it is a course for the treatment of that continuous parcel, which attaches 3 times, for dressing in 3 days；Each course for the treatment of interval time is 45.
Salicylic acid, is a kind of white powder, belongs to one kind of tartaric acid, is that a kind of can remove the natural goods of skin keratin Matter, multiple dermatosis good therapeutic effect of this material to human body.
Benzoic acid, is disinfection preservative, with antibacterial actions；In sour environment, there is bacteriostasis.
Kuh-seng, it is bitter, trembles with fear.There are heat-clearing and damp-drying drug, desinsection, the work(of diuresis.For hot dysentery, have blood in stool, jaundice renal shutdown, red leukorrhea Under, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy controls trichomonas vaginitis outside.
The root bark of shaggy-fruited dittany, with heat-clearing and damp-drying drug, the effect of wind-dispelling is detoxified.《Haigoushen》：" control all heat toxin wind, foul wind, wind sore, Mange is red rotten, and eyebrow hair is de- crisp, and musculus cutaneus is anxious, high fever aversion to cold；Principal solution heat Huang, wine Huang, acute febrile, paddy Huang, labor Huang etc..”
Alumen, there is dissolving phlegm, eliminating dampness, antidiarrheal, hemostasis, removing toxic substances, desinsection.
Gleditsia sinensis, its is warm-natured, pungent.Cure mainly detumescence eliminating toxic, apocenosis, desinsection.For ulcer from the beginning of or purulenceization do not burst；Control scabies outside Tinea leprosy, more in treatment acne, sty is used during movable blood soft hard dissipating bind.
Corydalis tuber, warm-natured, pungent hardship, enters the heart, spleen, liver, lung, is promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain quality goods, especially with the work(of analgesic Imitate and be world-famous for.Li Shizhen (1518-1593 A.D.) exists《Compendium of Materia Medica》Middle conclusion corydalis tuber has " promoting blood circulation, sharp gas, analgesic, diuresis " four large effects, and High praise corydalis tuber " stasis in the stagnation of the circulation of vital energy, gas in energy promoting circulation of blood, therefore specially control all pains above and below the whole body ".
Pillworm, property is sour, cool, has and relievings asthma, diuresis, detoxifies, analgesic, calm effect.External application has foaming effect, available for controlling Treat asthma, difficult urination, blood strangury, Amenorrhea, infantile convulsion summarized mouth, sore swells, the disease such as chronic malaria fever and chills.
Muskmelon pedicel, bitter cold, work(, which specially gushes, to be let out.Smouldered in the heart available for phlegm heat, send out shy for epilepsy it is mad, or place food, poisonous substance stop gathering in Gastral cavilty and cause chest gastral cavity ruffian firmly wait card., can clearing damp removing jaundice if grinding nasal insufflation.
Balsamine, dispelling wind and eliminating dampness；Promoting blood circulation and stopping pain；Detoxify desinsection.Main rheumatism disabled wilted limbs；Waist coerces pain；Women closes stomachache； Postpartum blood stasis is not most；Traumatic injury；Fracture；Skin sore；Venomous snake bite；Leukorrhea；The fungal infection of the hand；Onychomycosis.Invigorate blood circulation, wind-dispelling Analgesic, external application removing toxic substances.For amenorrhoea, traumatic injury, blood stasis and swelling pain, rheumatic arthritis, carbuncle furuncle furunculosis, snake bite, the tinea manuum.
The lighter patient of symptom, 1 course for the treatment of just can fully recover；Heavier patient's two courses for the treatment of of needs of symptom, serious symptom patient, 3 courses for the treatment of just can fully recover.
The present invention is through 5000 clinical experiments have proved that its cure rate 100%, without any side effects.
The several allusion quotation row cases treated using the present invention are set forth below：
Wu, female, 40 years old, ten fingers suffered from onychomycosis, and deck is in canescence, and finger tip hair is empty, and deck cutin comes off, adopted With one course for the treatment of effect of present invention treatment substantially, symptom disappears.
Chen, man, 48 years old, horn accumulation was obvious under first, and the cutin thickened comes off, and causes deck to be separated with nail matrix, adopts With one course for the treatment of effect of present invention treatment substantially, after 45 days, treat again after a course for the treatment of, recovery from illness.
Zhang, female, 63 years old, deck was thinning, reduce, and deck is totally disrupted, only remained on a small quantity on nail matrix, uses One course for the treatment of effect of present invention treatment substantially, after 45 days, is treated after a course for the treatment of, grows new nail again, after 45 days, re-treatment one The individual course for the treatment of is reached, recovery from illness.

Claims (4)

1. a kind of ointment for treating onychomycosis, it is characterised in that：Described ointment is made up of the component of following portions by weight：Bigcatkin willow 6 ~ 8g of acid, 4 ~ 6g of benzoic acid, 7 ~ 9g of kuh-seng, 3 ~ 5g of the root bark of shaggy-fruited dittany, 2 ~ 3g of bitter alum, 2 ~ 4g of gleditsia sinensis, 2 ~ 3g of corydalis tuber, 2 ~ 3g of pillworm, melon 1 ~ 2g of the base of a fruit, 1 ~ 2g of balsamine, above-mentioned medicament is pulverized and mixed, paste is mixed into vaseline.
2. a kind of ointment for treating onychomycosis according to claim 1, it is characterised in that：The optimum proportioning of above-mentioned ointment For：Salicylic acid 7g, benzoic acid 5g, kuh-seng 8g, root bark of shaggy-fruited dittany 4g, bitter alum 3g, gleditsia sinensis 3g, corydalis tuber 3g, pillworm 3g, muskmelon pedicel 2g, phoenix are celestial Flower 2g, above-mentioned medicament is pulverized and mixed, paste is mixed into vaseline.
3. a kind of ointment for treating onychomycosis according to claim 1, it is characterised in that：The preparation method of above-mentioned ointment For：After kuh-seng, the root bark of shaggy-fruited dittany, bitter alum, gleditsia sinensis, corydalis tuber, pillworm, muskmelon pedicel, balsamine cleaning are weighed, being developed into can be by 120 mesh The above-mentioned raw materials for being ground into fine powder, are then well mixed by the fine powder of sieve, after being fermented 12 ~ 15 under 50 DEG C of environment, with crossing after trailing plants Salicylic acid and benzoic acid be mixed in proportion, be mixed into paste with vaseline.
4. a kind of ointment for treating onychomycosis according to claim 1, it is characterised in that：The application method of above-mentioned ointment For：It is uniform to be applied to affected part, then the paste mixture in affected part will be applied to together with trouble with medical proof fabric either shangshi zhitong plaster, shangshi zhitong gao The finger at place either toe parcel, makes medicine be attached to affected part and is difficult short time hair shaft；Parcel is attached, dressing one in 3 days Secondary, it is a course for the treatment of that continuous parcel, which attaches 3 times,；Each course for the treatment of interval time is 45.
CN201710609430.7A 2017-07-25 2017-07-25 A kind of ointment for treating onychomycosis Pending CN107260846A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101693040A (en) * 2009-10-14 2010-04-14 许保通 Medicament for treating onychomycosis and preparation method thereof
CN106177069A (en) * 2015-05-10 2016-12-07 王芳 The thickener for the treatment of tinea unguium

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101693040A (en) * 2009-10-14 2010-04-14 许保通 Medicament for treating onychomycosis and preparation method thereof
CN106177069A (en) * 2015-05-10 2016-12-07 王芳 The thickener for the treatment of tinea unguium

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杜青云: "复方姜黄酊及其制备方法", 《华西药学杂志》 *

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Application publication date: 20171020