CN101690777A - Formula of polygonatum chewable tablets and preparation method thereof - Google Patents
Formula of polygonatum chewable tablets and preparation method thereof Download PDFInfo
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- CN101690777A CN101690777A CN200910019436A CN200910019436A CN101690777A CN 101690777 A CN101690777 A CN 101690777A CN 200910019436 A CN200910019436 A CN 200910019436A CN 200910019436 A CN200910019436 A CN 200910019436A CN 101690777 A CN101690777 A CN 101690777A
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Abstract
The invention discloses a formula of polygonatum chewable tablets and a preparation method thereof. The formula comprises the following raw materials with drug effects in weight ratio: 20-50% of polygonatum, 10-50% of rhizoma polygonatum, 1-20% of medlar, 1-10% of hawthorn, 20-50% of mannitol, 8-30% of microcrystalline cellulose, 0.5-2% of vanillin and 0.1-1% of magnesium stearate. The polygonatum chewable tablets provided by the invention have good mouthfeel, can effectively improve the immunity of the organism, whiten the skins, delay senility, improve the anti-virus, anti-fatigue and anti-aging capacities of the organism, effectively improve myocardial ischemia and have obvious effect on adjusting hyperlipidemia and hyperglycaemia. The polygonatum chewable tablets are externally applied to treat traumatic injuries and facial freckles.
Description
Technical field
The present invention relates to the Chinese medicine and pharmacy field, specifically prescription of a kind of polygonatum chewable tablets and preparation method thereof.
Background technology
Rhizoma Polygonati Odorati is called as top grade in Compendium of Material Medica, and is sutable for men, women, and children, and its benefiting action can be compared with Radix Ginseng, the Radix Astragali.Rhizoma Polygonati Odorati, Polygonatum medicinal and edible Chinese medicine material, both all contain multiple active ingredient such as steroidal saponin, plant sterol, flavonoid, polysaccharide and abundant vitamin, various trace elements etc., function with nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, being used for the lung stomach-Yin hinders, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst, be conventional Chinese medicine, extensively used since ancient times by doctor family.Through experimental verification, Rhizoma Polygonati and Rhizoma Polygonati Odorati compatibility effect are better.
Summary of the invention
The invention provides prescription of a kind of polygonatum chewable tablets and preparation method thereof, this chewable tablet has plurality of health care functions, and suitable middle-aged and elderly people, hyperlipidemia, hyperglycemia, obese people, the personage that likes to be beautiful take.
At this prescription medication object based on middle-aged and elderly people, for the compliance that improves the patient is made chewable tablet.Chewable tablet has following advantage: the bioavailability height, and chewable tablet does not have disintegrating procedue, and after chewing in the oral cavity or sucking clothes, its surface area increases makes the medicine stripping rapid, absorbs fast; Taking convenience is particularly useful for the patient of difficulty that swallows; Easy to carry, steady quality; Chewable tablet absorbs by oral mucosa after chewing, and not only can reduce the gastrointestinal untoward reaction, can also play a role rapidly, and experimental results show that chewable tablet and conventional tablet have bioequivalence.
For achieving the above object, technical scheme of the present invention is as follows:
A kind of prescription of polygonatum chewable tablets is made up of the following pharmacodynamic raw material: Rhizoma Polygonati Odorati: 20%-50%; Rhizoma Polygonati: 10%-50%; Fructus Lycii: 1%-20%; Fructus Crataegi: 1%-10%; Mannitol: 20%-50%; Microcrystalline Cellulose: 8%-30%; Vanillin 0.5%-2%; Magnesium stearate: 0.1%-1%.
The preparation method of above-mentioned polygonatum chewable tablets, realized by following step:
1) gets material: take by weighing pharmacodynamic raw materials according to above-mentioned weight proportion;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: 1 mixed is even, after the pulverizing, with microwave lixiviate 3-20min, will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind the 80-200 mesh sieve that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 14-18 mesh sieve system soft material, it is interior in 40-60 ℃ of dry 0.5h-2.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed the 80-200 mesh sieve, with the above-mentioned wet grain mix homogeneously that makes, with 16-20 mesh sieve granulate, the debugging tablet machine carries out tabletting.
A kind of prescription of polygonatum chewable tablets is made up of the pharmacodynamic raw materials of following weight percentage ratio: Rhizoma Polygonati Odorati: 20%-35%; Rhizoma Polygonati: 10%-25%; Fructus Lycii: 1%-5%; Fructus Crataegi: 1%-5%; Mannitol: 40%-50%; Microcrystalline Cellulose: 10%-20%; Vanillin 0.5%-1%; Magnesium stearate: 0.5%-1%.
A kind of prescription of polygonatum chewable tablets is made up of the pharmacodynamic raw materials of following weight percentage ratio: Rhizoma Polygonati Odorati: 20%; Rhizoma Polygonati: 10%; Fructus Lycii: 2.5%; Fructus Crataegi: 3%; Mannitol: 45%; Microcrystalline Cellulose: 18%; Vanillin 0.5%; Magnesium stearate: 1%.
The pharmacological action of various pharmacodynamic raw materials is as follows:
Rhizoma Polygonati Odorati: a little less than the feeble QI, it is slightly sweet to distinguish the flavor of, toughness, greasiness, soft and moist edible, be longer than yin nourishing, mainly act on taste, so obey not imapirment of the spleen and stomach for a long time, cure mainly the few expectorant of dry cough due to the deficiency of lung-YIN, pharynx dryness of the tongue and epidemic febrile disease later stage, or the Tianjin that occurs because of hyperpyrexia consumption impairment of body fluid liquid is few thirsty, inappetence, diseases such as stomach discomfort, the complementary blood fat reducing of energy, blood pressure lowering and blood sugar lowering etc.
Rhizoma Polygonati: sweet in the mouth is flat.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.Be used for weakness of the spleen and stomach, fatigue and asthenia, the xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.Have multiple functions such as antibiotic, resisting pathogenic microbes, resisting fatigue, defying age and blood sugar lowering, blood fat reducing.
Fructus Lycii: be the liver and the kidney tonifying Chinese medicine commonly used simply, its color is scarlet, and its flavor is fragrant and sweet.Modern medicine study confirms that it contains nutritional labelings such as betanin, polysaccharide, crude fat, crude protein, carotene, vitamin A, vitamin C, vitamin B1, vitamin B2 and calcium, phosphorus, ferrum, zinc, manganese, linoleic acid, hemopoietic function there is facilitation, can also defying age, effect such as mutation, antitumor, anti-fatty liver and blood sugar lowering.
Fructus Crataegi: sweet, the slightly warm in nature of sour in the mouth, energy promoting digestion and invigorating the stomach, promoting flow of QI and blood, dysentery relieving blood pressure lowering.Fructus Crataegi is not only of great advantage to giving protection against cancer, and goes back cholesterol reducing, prevents and treats cardiovascular and cerebrovascular diseases such as hypertension, coronary heart disease, arteriosclerosis.The Fructus Crataegi decoct has extremely strong disease-resistant bacterium power, can treat diseases such as bacillary dysentery, enteritis.
Above-mentioned pharmacodynamic raw materials interacts, and mends and oiliness, cold not dry, so the tonification the five internal organs are arranged, nourishes QI and blood, and flat benefit the and moistening held concurrently and removed the merit of wind heat, have nourish calm neural, improve looks and brighten and cardiac stimulant effect.
Polygonatum chewable tablets good mouthfeel provided by the present invention, the effective human body immunity improving power of energy available energy, skin whitening, slow down aging, enhancing body antiviral, resisting fatigue and defying age ability, effectively improve myocardial ischemia, obvious to regulating hyperlipidemia and hyperglycemia effect, external coating treatment traumatic injury, face freckle.
The specific embodiment:
Describe the present invention below in conjunction with specific embodiment:
Embodiment 1:
1) gets material: take by weighing Rhizoma Polygonati Odorati by weight proportion: 20%; Rhizoma Polygonati: 25%; Fructus Lycii: 3%; Fructus Crataegi: 10%; Mannitol: 20%; Microcrystalline Cellulose: 20%; Vanillin 1%; Magnesium stearate: 1%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: 1 mixed is even, and after the pulverizing, lixiviate 3min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 200 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 14 mesh sieve system soft materials, it is interior in 60 ℃ of dry 0.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed 200 mesh sieves,,, debug tablet machine and carry out tabletting with 16 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Embodiment 2:
1) gets material: take by weighing Rhizoma Polygonati Odorati by weight proportion: 50%; Rhizoma Polygonati: 15%; Fructus Lycii: 1%; Fructus Crataegi: 4%; Mannitol: 20%; Microcrystalline Cellulose: 8%; Vanillin 1.9%; Magnesium stearate: 0.1%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: 1 mixed is even, and after the pulverizing, microwave lixiviate 20min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 120 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 16 mesh sieve system soft materials, it is interior in 60 ℃ of dry 1.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: before tabletting, put into drying baker after vanillin, magnesium stearate crossed 120 mesh sieves,,, debug tablet machine and carry out tabletting with 18 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Embodiment 3:
1) gets material: take by weighing Rhizoma Polygonati Odorati by weight proportion: 20%; Rhizoma Polygonati: 40%; Fructus Lycii: 1%; Fructus Crataegi: 1%; Mannitol: 20%; Microcrystalline Cellulose: 16%; Vanillin 1.5%; Magnesium stearate: 0.5%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: 1 mixed is even, and after the pulverizing, microwave lixiviate 10min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 120 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 16 mesh sieve system soft materials, it is interior in 40 ℃ of dry 2.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed 120 mesh sieves,,, debug tablet machine and carry out tabletting with 18 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Embodiment 4:
1) gets material: take by weighing Rhizoma Polygonati Odorati by weight proportion: 35%; Rhizoma Polygonati: 15%; Fructus Lycii: 10%; Fructus Crataegi: 8%; Mannitol: 20%; Microcrystalline Cellulose: 10%; Vanillin 1.2%; Magnesium stearate: 0.8%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: 1 mixed is even, and after the pulverizing, microwave lixiviate 15min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 120 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 14 mesh sieve system soft materials, it is interior in 40 ℃ of dry 0.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed 120 mesh sieves,,, debug tablet machine and carry out tabletting with 16 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Embodiment 5:
1) gets material: take by weighing Rhizoma Polygonati Odorati by weight proportion: 20%; Rhizoma Polygonati: 25%; Fructus Lycii: 3%; Fructus Crataegi: 1%; Mannitol: 20%; Microcrystalline Cellulose: 30%; Vanillin: 0.9%; Magnesium stearate: 0.1%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: 1 mixed is even, and after the pulverizing, microwave lixiviate 10min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 200 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 16 mesh sieve system soft materials, it is interior in 45 ℃ of dry 2.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed 200 mesh sieves,,, debug tablet machine and carry out tabletting with 18 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Embodiment 6:
1) gets material: take by weighing Rhizoma Polygonati Odorati by weight proportion: 20%; Rhizoma Polygonati: 50%; Fructus Lycii: 1%; Fructus Crataegi: 1%; Mannitol: 20%; Microcrystalline Cellulose: 8%; Vanillin: 0.5%; Magnesium stearate: 0.5%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: after 1 mixed was pulverized, microwave lixiviate 15min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 200 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 14 mesh sieve system soft materials, it is interior in 50 ℃ of dry 1.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed 200 mesh sieves,,, debug tablet machine and carry out tabletting with 16 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Embodiment 7:
1) gets material: take by weighing material by weight proportion: take by weighing Rhizoma Polygonati Odorati by weight proportion: 40%; Rhizoma Polygonati: 10%; Fructus Lycii: 12%; Fructus Crataegi: 9%; Mannitol: 20%; Microcrystalline Cellulose: 8%; Vanillin 0.5%; Magnesium stearate: 0.5%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: 1 mixed is even, and after the pulverizing, microwave lixiviate 12min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 160 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 16 mesh sieve system soft materials, it is interior in 50 ℃ of dry 2h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed 180 mesh sieves,,, debug tablet machine and carry out tabletting with 20 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Embodiment 8:
1) gets material: take by weighing Rhizoma Polygonati Odorati by weight proportion: 20%; Rhizoma Polygonati: 14%; Fructus Lycii: 5%; Fructus Crataegi: 5%; Mannitol: 25%; Microcrystalline Cellulose: 25%; Vanillin 0.7%; Magnesium stearate: 0.3%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: 1 mixed is even, and after the pulverizing, microwave lixiviate 15min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 160 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 16 mesh sieve system soft materials, it is interior in 55 ℃ of dry 1.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed 160 mesh sieves,,, debug tablet machine and carry out tabletting with 18 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Embodiment 9:
1) gets material: take by weighing Rhizoma Polygonati Odorati by weight proportion: 20%; Rhizoma Polygonati: 10%; Fructus Lycii: 1%; Fructus Crataegi: 1%; Mannitol: 50%; Microcrystalline Cellulose: 16.5%; Vanillin 0.5%; Magnesium stearate: 1%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: 1 mixed is even, and after the pulverizing, microwave lixiviate 5min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 80 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 18 mesh sieve system soft materials, it is interior in 40 ℃ of dry 1.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed 80 mesh sieves,,, debug tablet machine and carry out tabletting with 20 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Embodiment 10:
1) gets material: take by weighing Rhizoma Polygonati Odorati by weight proportion: 30%; Rhizoma Polygonati: 10%; Fructus Lycii: 4%; Fructus Crataegi: 4.4%; Mannitol: 40%; Microcrystalline Cellulose: 10%; Vanillin: 0.6%; Magnesium stearate: 1%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: after 1 mixed was pulverized, microwave lixiviate 20min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 80 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 18 mesh sieve system soft materials, it is interior in 60 ℃ of dry 1.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed 80 mesh sieves,,, debug tablet machine and carry out tabletting with 20 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Embodiment 11:
1) gets material: take by weighing Rhizoma Polygonati Odorati by weight proportion: 20%; Rhizoma Polygonati: 10%; Fructus Lycii: 2.5%; Fructus Crataegi: 3%; Mannitol: 45%; Microcrystalline Cellulose: 18%; Vanillin 0.5%; Magnesium stearate: 1%;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: 1 mixed is even, and after the pulverizing, microwave lixiviate 18min will obtain extractum after the supernatant concentration;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind 180 mesh sieves that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 16 mesh sieve system soft materials, it is interior in 50 ℃ of dry 2h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed 160 mesh sieves,,, debug tablet machine and carry out tabletting with 20 mesh sieve granulate with the above-mentioned wet grain mix homogeneously that makes.
Claims (4)
1. the prescription of a polygonatum chewable tablets is characterized in that, is made up of the pharmacodynamic raw materials of following weight percentage ratio: Rhizoma Polygonati Odorati: 20%-50%; Rhizoma Polygonati: 10%-50%; Fructus Lycii: 1%-20%; Fructus Crataegi: 1%-10%; Mannitol: 20%-50%; Microcrystalline Cellulose: 8%-30%; Vanillin 0.5%-2%; Magnesium stearate: 0.1%-1%.
2. the preparation method of a polygonatum chewable tablets as claimed in claim 1 is characterized in that, is realized by following step:
1) gets material: take by weighing pharmacodynamic raw materials according to above-mentioned percentage by weight;
2) preparation extractum: Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii and Fructus Crataegi were pressed 6: 2: 1: after 1 mixed is pulverized,, will obtain extractum after the supernatant concentration with microwave lixiviate 3-20min;
3) granulate: at first mannitol, microcrystalline Cellulose are crossed behind the 80-200 mesh sieve that ground and mixed evenly obtains adjuvant in mortar, then Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Crataegi are mixed through micronizing, obtaining micropowder adds in the gained adjuvant, with the above-mentioned extractum that makes as binding agent, adopt 14-18 mesh sieve system soft material, it is interior in 40-60 ℃ of dry 0.5h-2.5h to be placed on drying baker after the granulation, obtains wet grain;
4) tabletting: put into drying baker after vanillin, magnesium stearate crossed the 80-200 mesh sieve, with the above-mentioned wet grain mix homogeneously that makes, with 16-20 mesh sieve granulate, the debugging tablet machine carries out tabletting.
3. the prescription of polygonatum chewable tablets according to claim 1 is characterized in that, is made up of the pharmacodynamic raw materials of following weight percentage ratio: Rhizoma Polygonati Odorati: 20%-35%; Rhizoma Polygonati: 10%-25%; Fructus Lycii: 1%-5%; Fructus Crataegi: 1%-5%; Mannitol: 40%-50%; Microcrystalline Cellulose: 10%-20%; Vanillin 0.5%-1%; Magnesium stearate: 0.5%-1%.
4. according to the prescription of claim 1 and 3 described polygonatum chewable tablets, it is characterized in that, form by the pharmacodynamic raw materials of following weight percentage ratio: Rhizoma Polygonati Odorati: 20%; Rhizoma Polygonati: 10%; Fructus Lycii: 2.5%; Fructus Crataegi: 3%; Mannitol: 45%; Microcrystalline Cellulose: 18%; Vanillin 0.5%; Magnesium stearate: 1%.
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2009
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