CN104274649B

CN104274649B - Medication for treating dental ulcer

Info

Publication number: CN104274649B
Application number: CN201410511622.0A
Authority: CN
Inventors: 周知航
Original assignee: Individual
Current assignee: Tengzhou Fangguan Enterprise Management Consulting Co ltd
Priority date: 2014-09-29
Filing date: 2014-09-29
Publication date: 2015-03-25
Anticipated expiration: 2034-09-29
Also published as: CN104274649A

Abstract

The invention discloses a medicine for oral ulcer, comprising an oral medicine and an externally applied medicine, wherein the oral medicine includes the bulk drugs such as radix scrophulariae, swimming bladder, prunella spike, lemon slices, okra complete stool, Barbados aloe, gallnut, rose, prunus mume, fomes fomentarius, lotus leaf, bunge cordalis herb, radix zanthoxyli, liquorice, centella, citrus chirocarpus, sweet potato leaf, dragon' blood or the like; and the externally applied medicine includes the bulk drugs such as centella, Chinese ilex leaf, radix zanthoxyli, persimmon frost, fructus forsythia, prunella spike, pearl powder, mint or the like. The inventive medicine is taken orally and external used at the same time, the principal and subordinate symptoms are simultaneously treated, and the medicine works fast. After patients take the medicine, it is fast to relieve swelling and pain, the ulceration healing time is short, and the curative effect is obvious.

Description

A kind of medicine for oral ulcer

Technical field

The present invention relates to a kind of medicine for oral ulcer, belong to Chinese medicine and preparing technical field thereof.

Background technology

Oral ulcer is a kind of commonly encountered diseases clinically and frequently-occurring disease, with oral mucosa limitation ulcerative lesions for main manifestations, has the feature of recurrent exerbation, causes certain puzzlement to the life of patient.Oral ulcer can occur in any position of oral mucosa, common with the mucosa at the places such as the lip in oral cavity, cheek, soft palate or gums, there is single or multiple circle of differing in size or oval ulcer, greyish white or the yellow pseudomembrane of surface coverage, concavity, clear border, surrounding mucosa is red and micro-swollen, ulcer local causalgia is obvious, has the feature of periodicity, recurrent, self limiting.

The cause of disease of oral ulcer is many-sided, and the regulate factors etc. between the immune state of body, genetic aspect, each tract may be all the pathogenic factor of oral ulcer, and in addition, the environmental factors residing for body also may cause ulcer.The medicine of current treatment oral ulcer has oral medicine and medicine for external use, and these medicines respectively have pluses and minuses.

Summary of the invention

The object of this invention is to provide a kind of medicine for oral ulcer, this medicine oral administration and externally carries out simultaneously, internal and external application, can play the effect relieving the pain, promote ulcer surface to heal of subsiding a swelling fast, evident in efficacy.

The concrete technical scheme of the present invention is as follows:

A kind of medicine for oral ulcer, be made up of oral medicine and medicine for external use, oral medicine comprises the crude drug of following weight portion: Radix Scrophulariae 10-25 part, Air Bladder pseudosciaenae seu Acipenser 20-50 part, Spica Prunellae 8-15 part, lemon tablet 10-20 part, Flos abelmoschi manihot Herb 18-25 part, Aloe 5-12 part, Galla Chinensis 12-20 part, Flos Rosae Rugosae 1-5 part, FLOS MUME 1-5 part, Fomes Fomentarius 5-15 part, Folium Nelumbinis 5-10 part, Herba Violae 5-10 part, Radix Zanthoxyli 1-5 part, Radix Glycyrrhizae 3-10 part, Herba Centellae 10-20 part, Fructus Citri Sarcodactylis 15-25 part, Radix Pachyrhizi Erosi leaf 20-30 part, Sanguis Draxonis 5-10 part; Medicine for external use comprises the crude drug of following weight portion: Herba Centellae 15-20 part, Folium Ilicis Purpureae 10-15 part, Radix Zanthoxyli 5-10 part, Mannosum Kaki 5-10 part, Fructus Forsythiae 1-5 part, Spica Prunellae 1-5 part, Margarita powder 3-5 part, Herba Menthae 1-2 part.

In said medicine, oral medicine preferably includes the crude drug of following weight portion: Radix Scrophulariae 20 parts, 30 parts, Air Bladder pseudosciaenae seu Acipenser, Spica Prunellae 10 parts, lemon tablet 15 parts, Flos abelmoschi manihot Herb 20 parts, Aloe 10 parts, Galla Chinensis 15 parts, Flos Rosae Rugosae 2 parts, FLOS MUME 2 parts, Fomes Fomentarius 10 parts, 8 parts, Folium Nelumbinis, Herba Violae 8 parts, Radix Zanthoxyli 3 parts, 5 parts, Radix Glycyrrhizae, Herba Centellae 15 parts, Fructus Citri Sarcodactylis 20 parts, 25 parts, Radix Pachyrhizi Erosi leaf, Sanguis Draxonis 8 parts.

In said medicine, medicine for external use preferably includes the crude drug of following weight portion: Herba Centellae 18 parts, Folium Ilicis Purpureae 12 parts, Radix Zanthoxyli 8 parts, Mannosum Kaki 6 parts, Fructus Forsythiae 2 parts, Spica Prunellae 2 parts, Margarita powder 4 parts, Herba Menthae 1.5 parts.

Inventor is for etiological study and obtain above-mentioned formula, and in formula, each crude drug works in coordination with onset, can either adjust body internal medium, removes the cause of disease, focus of going directly again, and accelerate the healing of ulcer, above-mentioned each crude drug effect is as follows:

Radix Scrophulariae, clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens, for fever of the body, excessive thirst, crimson tongue, speckle, hectic fever due to YIN-deficiency chronic cough, constipation, puckery dim-sighted, the skin sore of order are not hindered in awake, Tianjin to fidgets due to deficiency.

Bolus for invigorating kidney and improving benefit essence, nourishing muscle arteries and veins, dissipating blood stasis for subsidence of swelling, hemostasis, skin Caring.

Spica Prunellae, there is the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis, be applicable to lymphoid tuberculosis, goiter, acute mastitis, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, metrorrhagia, leukorrhagia, Fiedeler's disease type hepatitis and bacillary dysentery etc.

Lemon tablet, containing saccharide, calcium, phosphorus, ferrum and the multiple nutritional components such as vitamin B1, B2, C, there is toxin expelling, slake thirst and help produce saliva, stomach invigorating, the effect such as pain relieving.

Flos abelmoschi manihot, has another name called swordweed, Abelmoschus esculentus, Radix Solani ferocis, and its Herb comprises the root of Flos abelmoschi manihot, leaf and fruit pod, and Flos abelmoschi manihot is rich in abundant vitamin, has the effect of clearing away heat-damp and promoting diuresis, the liver protecting, skin nutrition.

Aloe, containing compositions such as phenols, aloin, tinctura aloes, organic acid, mucopolysaccharide, vitamin, aminoacid, has the effect of detoxicating, relieving inflammation, stomach invigorating relieving constipation, strengthening vital QI to eliminate pathogenic factors, beauty and skin care.

Galla Chinensis, pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating stops blooding, and removing dampness sore, for chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, night sweat, quenches one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.

Flos Rosae Rugosae, promoting QI circulation for relieving depression, and blood, pain relieving, for stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menoxenia, falls and flutters the pain of injury.

FLOS MUME, soothing the liver, stomach function regulating, reduces phlegm.Control globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizzy, scrofula.

Fomes Fomentarius, also known as Pyropolyporus fomentarius (L.ex Fr.) Teng, for the sporophore of On Polyporaceae Fomes fomentarius, in hemispherical, the shape of a hoof or hang bell, stockless, perennial, be born on the broad-leaved trunks such as oak, birch, poplar, willow, Hibiscus syriacus, elm, Cortex Fraxini mandshuricae, pears, Lee, Fructus Mali pumilae or on timber, there is the effect of wind-evil dispelling and cold-evil expelling, relaxing muscles and tendons and activating QI and blood in the collateral, removing food stagnancy blood stasis dispelling.

Folium Nelumbinis, has summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, and effect of dissipating blood stasis hemostasis, cures mainly summer-heat excessive thirst, have a headache dizzy, edema, lack of appetite abdominal distention, dysentery, traumatic blood stasis.

Herba Violae, another name Herba corydalis edulis (Plants of Beijing will, Inner Mongol flora), Peng Shi Herba corydalis edulis (Plants of Beijing will), Bu Shi Herba Violae (northeast medicinal plants figure will) etc.It is irritated that heat-clearing and toxic substances removing is used for the high heat of epidemic febrile disease, influenza, infectious hepatitis, nephritis, scrofula, parotitis, furuncle and other pyogenic infection.

Radix Zanthoxyli, promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral, the traumatic injury caused for qi depression to blood stasis, rheumatic arthralgia, stomachache, toothache, venom.

Radix Glycyrrhizae, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of institute's abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Herba Centellae, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, for jaundice due to damp-heat, heatstroke is suffered from diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.

Fructus Citri Sarcodactylis, liver-smoothing, qi-regulating, and stomach and alleviating pain, for stagnation of liver-QI and stomach-QI. and distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.

Radix Pachyrhizi Erosi leaf, relieving constipation diuresis, slow down aging, enhancing immunologic function, enhances metabolism.

Sanguis Draxonis, removing blood stasis and relieving pain, hemostasia and promoting granulation, loses for falling to flutter, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury.

Folium Ilicis Purpureae, containing protocatechuic acid, volatile oil, flavones ingredient, has good bacteriostasis, can be used for treatment burn, ulcer of the lower limb, leprelcosis, orthopaedics infection, upper respiratory tract infection.

Mannosum Kaki, the white Refined Mercurous chloride that when fruit (Fructus Kaki) for Ebenaceae plant Fructus Kaki makes Fructus kaki Siccus, appearance is given birth to, have heat clearing away, moisturize, the effect of reducing phlegm, can be used for dry pharynx, aphtha of the mouth and tongue etc.

Fructus Forsythiae, has antibacterial, antiinflammatory, the effect such as antipyretic, town is told, diuresis heart tonifying, anti-liver damage, analgesia, antiviral, blood pressure lowering, antiendotoxin.

Margarita powder, arresting convulsion of calming the nerves, heat clearing away YIN nourishing, except nebula improving eyesight, convergence granulation promoting, removing toxic substances, for palpitation with a distress feeling of palpitating with fear, epilepsy infantile convulsion, conjunctival congestion and swelling pain, throat rots, aphtha of the mouth and tongue, ulcer do not close up for a long time.

Herba Menthae, dispelling wind-heat, refresh oneself, rash, for anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, order skin ulcer, rubella, measles, breast the side of body feeling of distension and oppression.

Inventor to be caused a disease the cause of disease in conjunction with oral ulcer, through large quantity research and experiment, obtains medicine of the present invention.Endo-medicine removing toxic substances and promoting subsidence of swelling, the removing heat from blood that relieves inflammation or internal heat, depressed liver-energy dispersing and QI regulating, the pain relieving of convergence granulation promoting, from interior removing old complaint.Medicine for external use anti-inflammation, removing heat from blood sore, reducing swelling and alleviating pain, heat clearing away and internal heat reducing, through focus.By the coordinated of crude drug each in formula, for oral administration and external is carried out simultaneously, and giving consideration to both the incidental and fundamental, onset is rapid.In the present invention, oral medicine can be worn into fine powder and be taken as powder, also decoction can be become to take with decocting, also can conventionally make the different dosage forms such as granule, capsule, tablet by after the concentration of liquid medicine of water extraction, drying.Medicine for external use can be worn into fine powder and be overlying on ulcer place as powder, and also available water is cooked into solution and gargles.

Medicine oral administration and externally of the present invention carries out simultaneously, treating both the principal and secondary aspects of a disease, and onset is rapid, and patient takes that rear reducing swelling and alleviating pain is quick, healing is short, evident in efficacy.

Detailed description of the invention

Below by specific embodiment, the present invention will be described in detail, it is to be understood that following explanation is only to explain the present invention, do not limit its content.If no special instructions, following raw material medicaments is weight portion.

embodiment 1

Oral medicine formula is: Radix Scrophulariae 20 parts, 30 parts, Air Bladder pseudosciaenae seu Acipenser, Spica Prunellae 10 parts, lemon tablet 15 parts, Flos abelmoschi manihot Herb 20 parts, Aloe 10 parts, Galla Chinensis 15 parts, Flos Rosae Rugosae 2 parts, FLOS MUME 2 parts, Fomes Fomentarius 10 parts, 8 parts, Folium Nelumbinis, Herba Violae 8 parts, Radix Zanthoxyli 3 parts, 5 parts, Radix Glycyrrhizae, Herba Centellae 15 parts, Fructus Citri Sarcodactylis 20 parts, 25 parts, Radix Pachyrhizi Erosi leaf, Sanguis Draxonis 8 parts.

Recipe of external-use medicine is: Herba Centellae 18 parts, Folium Ilicis Purpureae 12 parts, Radix Zanthoxyli 8 parts, Mannosum Kaki 6 parts, Fructus Forsythiae 2 parts, Spica Prunellae 2 parts, Margarita powder 4 parts, Herba Menthae 1.5 parts.

Preparation method is:

1, by each for oral medicine crude drug mixing, grind to form fine powder, pack for subsequent use.

2, by each for medicine for external use crude drug mixing, grind to form fine powder, pack for subsequent use.

embodiment 2

Oral medicine formula is: Radix Scrophulariae 10 parts, 50 parts, Air Bladder pseudosciaenae seu Acipenser, Spica Prunellae 8 parts, lemon tablet 20 parts, Flos abelmoschi manihot Herb 18 parts, Aloe 12 parts, Galla Chinensis 12 parts, Flos Rosae Rugosae 5 parts, FLOS MUME 1 part, Fomes Fomentarius 15 parts, 5 parts, Folium Nelumbinis, Herba Violae 10 parts, Radix Zanthoxyli 1 part, 10 parts, Radix Glycyrrhizae, Herba Centellae 10 parts, Fructus Citri Sarcodactylis 25 parts, 20 parts, Radix Pachyrhizi Erosi leaf, Sanguis Draxonis 10 parts.

Recipe of external-use medicine is: Herba Centellae 15 parts, Folium Ilicis Purpureae 15 parts, Radix Zanthoxyli 5 parts, Mannosum Kaki 10 parts, Fructus Forsythiae 1 part, Spica Prunellae 5 parts, Margarita powder 3 parts, Herba Menthae 2 parts.

Preparation method is with embodiment 1.

embodiment 3

Oral medicine formula is: Radix Scrophulariae 25 parts, 20 parts, Air Bladder pseudosciaenae seu Acipenser, Spica Prunellae 15 parts, lemon tablet 10 parts, Flos abelmoschi manihot Herb 25 parts, Aloe 5 parts, Galla Chinensis 20 parts, Flos Rosae Rugosae 1 part, FLOS MUME 5 parts, Fomes Fomentarius 5 parts, 10 parts, Folium Nelumbinis, Herba Violae 5 parts, Radix Zanthoxyli 5 parts, 3 parts, Radix Glycyrrhizae, Herba Centellae 20 parts, Fructus Citri Sarcodactylis 15 parts, 30 parts, Radix Pachyrhizi Erosi leaf, Sanguis Draxonis 5 parts.

Recipe of external-use medicine is: Herba Centellae 20 parts, Folium Ilicis Purpureae 10 parts, Radix Zanthoxyli 10 parts, Mannosum Kaki 5 parts, Fructus Forsythiae 5 parts, Spica Prunellae 1 part, Margarita powder 5 parts, Herba Menthae 1 part.

Preparation method is with embodiment 1.

comparative example

Oral medicine formula is: Radix Scrophulariae 20 parts, 30 parts, Air Bladder pseudosciaenae seu Acipenser, Spica Prunellae 10 parts, lemon tablet 15 parts, Flos abelmoschi manihot Herb 20 parts, Aloe 10 parts, Galla Chinensis 15 parts, Flos Rosae Rugosae 2 parts, FLOS MUME 2 parts, Fomes Fomentarius 10 parts, 8 parts, Folium Nelumbinis, Herba Violae 8 parts, Radix Zanthoxyli 3 parts, 5 parts, Radix Glycyrrhizae.

Recipe of external-use medicine is with embodiment 1.

Preparation method is with embodiment 1.

in order to determine therapeutic effect of the present invention, now carry out clinical trial, to verify its therapeutic effect for the medicine of embodiment 1,2,3 and comparative example gained.

case is originated

Extract from this city large hospital the patient that 435 examples suffer from oral ulcer disease to test, wherein, man 225 example, female 210 example, the age 10-62 year between, 40.4 years old mean age.Ulcer spot: lip 135 example, buccal 115 example, lingual surface 98 example, palatine 87 example.Patient is all medical in 48h after ulcer morbidity, all with causalgia in various degree, anorexia, sialorrhea, pronounce indistinctly.

therapeutic Method

Patient is equally divided into 5 groups, each group patient no difference of science of statistics.Front four groups of patients use the medicine of embodiment 1,2,3 and comparative example to treat respectively, and using method is: oral medicine and medicine for external use use simultaneously, wherein oral medicine every day 3 times, each 3g, medicine for external use 3-6 time on the one, at every turn in right amount.The 5th group of oral medicine only using embodiment 1, does not use medicine for external use, as a control group.

criterion of therapeutical effect

Cure: ulcer heals completely, pain disappears;

Effective: pain is obviously alleviated or disappeared, and ulcer surface reduces over half;

Effective: alleviate in pain 3-4 days or disappear, ulcer surface reduces more than 1/3;

Invalid: pain was alleviated without obvious in 4 days, and ulcer surface reduces below 1/3.

therapeutic outcome

Continuous treatment is after 6 days, and each group patient ulcer healing situation sees the following form 1.

Treatments period respectively organizes patient, and to cure number as shown in table 2 below:

As can be seen from the above table, the present composition is rapid-action, and treatment time is short, and oral administration and externally effect is more remarkable than alone endo-medicine.And from therapeutic effect, the compositions therapeutic effect of embodiment 1 is best.

Claims

1. the medicine for oral ulcer, it is characterized in that: be made up of oral medicine and medicine for external use, oral medicine is made up of the crude drug of following weight portion: Radix Scrophulariae 10-25 part, Air Bladder pseudosciaenae seu Acipenser 20-50 part, Spica Prunellae 8-15 part, lemon tablet 10-20 part, Flos abelmoschi manihot Herb 18-25 part, Aloe 5-12 part, Galla Chinensis 12-20 part, Flos Rosae Rugosae 1-5 part, FLOS MUME 1-5 part, Fomes Fomentarius 5-15 part, Folium Nelumbinis 5-10 part, Herba Violae 5-10 part, Radix Zanthoxyli 1-5 part, Radix Glycyrrhizae 3-10 part, Herba Centellae 10-20 part, Fructus Citri Sarcodactylis 15-25 part, Radix Pachyrhizi Erosi leaf 20-30 part, Sanguis Draxonis 5-10 part;

Medicine for external use is made up of the crude drug of following weight portion: Herba Centellae 15-20 part, Folium Ilicis Purpureae 10-15 part, Radix Zanthoxyli 5-10 part, Mannosum Kaki 5-10 part, Fructus Forsythiae 1-5 part, Spica Prunellae 1-5 part, Margarita powder 3-5 part, Herba Menthae 1-2 part.

2. medicine according to claim 1, is characterized in that: oral medicine is made up of the crude drug of following weight portion: Radix Scrophulariae 20 parts, 30 parts, Air Bladder pseudosciaenae seu Acipenser, Spica Prunellae 10 parts, lemon tablet 15 parts, Flos abelmoschi manihot Herb 20 parts, Aloe 10 parts, Galla Chinensis 15 parts, Flos Rosae Rugosae 2 parts, FLOS MUME 2 parts, Fomes Fomentarius 10 parts, 8 parts, Folium Nelumbinis, Herba Violae 8 parts, Radix Zanthoxyli 3 parts, 5 parts, Radix Glycyrrhizae, Herba Centellae 15 parts, Fructus Citri Sarcodactylis 20 parts, 25 parts, Radix Pachyrhizi Erosi leaf, Sanguis Draxonis 8 parts.

3. medicine according to claim 1 and 2, is characterized in that: medicine for external use is made up of the crude drug of following weight portion: Herba Centellae 18 parts, Folium Ilicis Purpureae 12 parts, Radix Zanthoxyli 8 parts, Mannosum Kaki 6 parts, Fructus Forsythiae 2 parts, Spica Prunellae 2 parts, Margarita powder 4 parts, Herba Menthae 1.5 parts.