CN103055209A - Appetizing chewing tablet and its preparation technology - Google Patents
Appetizing chewing tablet and its preparation technology Download PDFInfo
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- CN103055209A CN103055209A CN2013100059602A CN201310005960A CN103055209A CN 103055209 A CN103055209 A CN 103055209A CN 2013100059602 A CN2013100059602 A CN 2013100059602A CN 201310005960 A CN201310005960 A CN 201310005960A CN 103055209 A CN103055209 A CN 103055209A
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Abstract
The invention relates to an appetizing chewing tablet. The appetizing chewing tablet is prepared through using the following raw materials, by weight, 100-160 parts of a concentrate, 10-20 parts of haw powder, 30-50 parts of zinc gluconate, 3-5 parts of sorbitol, 1-3 parts of xylitol, 10-30 parts of maltodextrin, and 1-2 parts of magnesium stearate; and the raw drugs of the concentrate comprise the following drug materials, by weight, 55-85 parts of haw, 8-12 parts of malt, 9-11 parts of Radish Seed, 4-6 parts of white hyacinth bean, 10-20 parts of Chinese yam, 3-7 parts of dried orange peel and 350 parts of water. The appetizing chewing tablet has substantial food digestion, stomach strengthening, qi rectifying, spleen invigorating and appetite promoting efficacies, and can prevent the anorexia; the preparation technology has the advantages of simplicity and high efficiency; and the appetizing chewing tablet has the advantages of simple storage, convenient carrying and administration, good taste, and suitableness for the wide popularization and application.
Description
Technical field
The invention belongs to the Chinese patent medicine preparation field, relate generally to a kind of chewable tablet and preparation technology thereof, specifically a kind of appetizing chewable tablet and preparation technology thereof.
Background technology
In daily life, many people are arranged because overwork, the excessive anorexia, weakness of the spleen and stomach, breast flatulence of causing of stress be full, even long-term anorexia causes the health lassitude and weak, cisco unity malfunction; Also have a lot of children, because father and mother spoil, edible various snacks, sweets cause taste discomfort, disorder of function of stomach, anorexia etc., cause child's asthenic body how sick, unhealthful growth.In addition, people are when the treatment various diseases, no matter be adult or child, take various medicines after, be easy to cause taste discomfort, distension and fullness of the chest and abdomen, anorexia etc., have a strong impact on healthy, particularly the old people because can not get the conditioning on the diet after ill, causes prolonged constipation, the symptoms such as abdominal part distension, taste discomfort cause the health extremely feeble.Therefore, in time take the medicine of some spleen benefiting and stimulating the appetite, promote taste healthy, can alleviate the patient suffering, health can obtain rehabilitation early, but a lot of medicine is bitter, and some patients are displeased to take, and needs to use water delivery service, has brought inconvenience for some patients.
Summary of the invention
The present invention is directed to above-mentioned technical problem a kind of appetizing chewable tablet is provided, this appetizing chewable tablet promoting digestion and invigorating the stomach, regulating qi-flowing for strengthening spleen, orectic effect are remarkable, and can prevent the generation of apositia.
The present invention is that the technical scheme that addresses the above problem employing is: a kind of appetizing chewable tablet, and described appetizing chewable tablet is made by raw material concentrated solution, Fructus Crataegi powder, zinc gluconate and adjuvant sorbitol, xylitol, maltodextrin and magnesium stearate;
The parts by weight of each stock and adjunct are concentrated solution 100-160 part, Fructus Crataegi powder 10-20 part, zinc gluconate 30-50 part, sorbitol 3-5 part, xylitol 1-3 part, maltodextrin 10-30 part and magnesium stearate 1-2 part;
The crude drug of described concentrated solution is made by Fructus Crataegi, Fructus Hordei Germinatus, Semen Raphani, Semen Lablab Album, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae and water, and the parts by weight of each medical material are: 350 parts in Fructus Crataegi 55-85 part, Fructus Hordei Germinatus 8-12 part, Semen Raphani 9-11 part, Semen Lablab Album 4-6 part, Rhizoma Dioscoreae 10-20 part, Pericarpium Citri Reticulatae 3-7 part and water.
The preparation method of described appetizing chewable tablet may further comprise the steps:
Step 1, pre-treatment: get raw material Fructus Hordei Germinatus, Pericarpium Citri Reticulatae and Semen Lablab Album, choose respectively decontamination, wash respectively again, dry, for subsequent use; Get the raw material Fructus Crataegi, choose enucleation behind the decontamination, then clean with clear water, place thermostatic drying chamber dry 5-9h under 40-80 ℃ of condition, for subsequent use; Get the raw material Semen Raphani, wash after choosing decontamination, dry, then place in the heat pot, fry 10-40min with slow fire, heave and cracker is arranged to little, take out, cooling, smash to pieces, for subsequent use; Get the raw material Rhizoma Dioscoreae, after cleaning up, be cut into the 5-10mm sheet, for subsequent use;
Step 2, lixiviate: Fructus Crataegi 55-85 part, Fructus Hordei Germinatus 8-12 part, Semen Raphani 9-11 part, Semen Lablab Album 4-6 part, Rhizoma Dioscoreae 10-20 part and the Pericarpium Citri Reticulatae 3-7 part of getting process pre-treatment in the step 1 place in the extraction pot, add for the first time 200 parts in water, add for the second time 150 parts in water, decoct 2 times, each 2h, collecting decoction also filters, filtrate places and leaves standstill 12h in the settling tank, getting supernatant concentration to relative density is 1.25, gets concentrated solution, for subsequent use;
Step 3, pulverizing: the residue Fructus Crataegi of the step 1 of learning from else's experience pre-treatment, pulverize with Chinese medicine grinder, cross 80 mesh sieves, make the Fructus Crataegi fine powder, place baking oven under 60 ℃ of conditions, to dry 3h, take out, using ball mill that the Fructus Crataegi fine powder is carried out micronizing, is that 300 r/min, ratio of grinding media to material are under 7 the condition at rotating speed, pulverizes 1 h, obtain the Fructus Crataegi powder of micronizing, for subsequent use;
Step 4, mixing, granulation: get the concentrated solution 100-160 part that obtains in the step 2 and place the efficient asymmetric mixer of V-type, then add zinc gluconate 30-50 part, sorbitol 3-5 part, xylitol 1-3 part, maltodextrin 10-30 part and process step 3 and process the ultra micro Fructus Crataegi fine powder 10-20 part that obtains, be to mix 3 times under the condition of 28r/min at speed of agitator, each 10min behind the mix homogeneously, crosses 14 mesh sieves and granulates, after the oven dry, with 16 mesh sieve granulate, get soft material, for subsequent use;
Step 5, tabletting, packing: add magnesium stearate 1-2 part in the soft material that makes to step 4, use the tablet machine tabletting behind the mix homogeneously, then plastic-aluminum packing or bottled, and with the C of 10MeV
60C
0Radiation gamma namely makes this appetizing chewable tablet after the radiation sterilization.
Wherein, Fructus Crataegi: sour, sweet, tepor, return spleen, stomach, Liver Channel, have the function of promoting digestion and invigorating the stomach, activating blood circulation to dissipate blood stasis, convergence dysentery relieving, to the long-pending phlegm retention of meat, feeling of fullness acid regurgitation,, children's's breast food stagnates etc. all effective in cure;
Fructus Hordei Germinatus: sweet, flat, return spleen, stomach warp, have spleen benefiting and stimulating the appetite, move back the effect of newborn relieving distension, be used for the symptoms such as food stagnation does not disappear, abdominal distention, insufficiency of the spleen lack of appetite;
Semen Raphani: hot, sweet, flat, return lung, spleen, stomach warp, having helps digestion removes function swollen, lowering the adverse-rising QI to resolve phlegm, is used for retention of food and drink, abdominal distention, stagnant dysentery etc.;
Rhizoma Dioscoreae: sweet in the mouth, property is flat, returns spleen, lung, kidney channel.Have the spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the effect of the kidney invigorating arresting seminal emission is used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.
Semen Lablab Album: sweet, tepor, return spleen, stomach warp, have the symptoms such as weakness of the spleen and stomach, inappetence, large loose stool are write, heat-damp in summer vomiting and diarrhoea, abdominal distention uncomfortable in chest;
Pericarpium Citri Reticulatae: bitter, hot, warm, return lung, spleen channel, have the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, be used for distension and fullness of the chest and abdomen, lack of appetite and vomiting, cough with copious phlegm;
Zinc gluconate: white crystals or particulate powder can be used for the symptoms such as malnutrition, apositia, growth retardation;
Sorbitol: sweeting agent, excipient;
Xylitol; Sweeting agent, anti-caries;
Magnesium stearate: fluidizer.
Beneficial effect of the present invention:
In one, the prescription, the equal spleen of Fructus Crataegi, Fructus Hordei Germinatus, Rhizoma Dioscoreae, Semen Lablab Album and Semen Raphani, stomach warp, effect with warming middle-JIAO nourishing the stomach, strengthening the spleen to promote digestion, and focus on warming the spleen, use mutually combines, treatment to symptoms such as weakness of the spleen and stomach, distension and fullness of the chest and abdomen, food stagnation do not disappear is evident in efficacy, adds Pericarpium Citri Reticulatae and helps regulating qi-flowing for strengthening spleen, the treatment distension and fullness of the chest and abdomen; Add zinc gluconate in the Chinese medicine, the Chinese and Western combination can not only replenish the zinc that needed by human body is wanted, and also can improve the human body sense of taste, strengthens medicine to the promotion of human body appetite, and can strengthen human body to the absorption of medicine; More than the mutual compatibility of several medical materials, both made the present invention have the effect of promoting digestion and invigorating the stomach, regulating qi-flowing for strengthening spleen, appetite stimulator, can effectively alleviate and treat the symptoms such as gastral cavilty distension, food stagnation do not disappear, weakness of the spleen and stomach, inappetence, also can prevent the generation of apositia.
They are two years old, Fructus Crataegi is as a kind of principal agent among the present invention, a part and Fructus Hordei Germinatus, Semen Lablab Album, Rhizoma Dioscoreae, Semen Raphani and Pericarpium Citri Reticulatae digestion obtain lixiviating solution, Fructus Crataegi and Fructus Hordei Germinatus in the lixiviating solution that obtains, Semen Lablab Album, Rhizoma Dioscoreae, Semen Raphani and Pericarpium Citri Reticulatae mutually combine, mutually promote, the warming middle-JIAO nourishing the stomach, the effect of strengthening the spleen to promote digestion is remarkable, another part obtains the Fructus Crataegi fine powder by pulverizing, mutually mix with lixiviating solution and adjuvant, promoting digestion and invigorating the stomach with Fructus Crataegi, activating blood circulation to dissipate blood stasis, the Function of convergence dysentery relieving arrives at utmost, again in conjunction with Fructus Hordei Germinatus in the lixiviating solution, Semen Lablab Album, Rhizoma Dioscoreae, the effect of Semen Raphani and Pericarpium Citri Reticulatae is alleviated the present invention and is treated the gastral cavilty distension, food stagnation does not disappear, weakness of the spleen and stomach, the effect of the symptoms such as inappetence is remarkable.
Three, among the present invention Fructus Crataegi powder is carried out micronizing, fully abolish cell wall, effective ingredient is fully come out, then be combined with other compositions, can improve utilization rate biology of Chinese crude drug, promote drug effect.
Four, preparation technology of the present invention is simple, efficient, and the tablet storage is simple, easy to carry and use, and the chewable tablet taste is better, need not use water delivery service, is suitable for wide popularization and application.
The specific embodiment
A kind of appetizing chewable tablet, described appetizing chewable tablet is made by raw material concentrated solution, Fructus Crataegi powder, zinc gluconate and adjuvant sorbitol, xylitol, maltodextrin and magnesium stearate;
The parts by weight of each stock and adjunct are concentrated solution 100-160 part, Fructus Crataegi powder 10-20 part, zinc gluconate 30-50 part, sorbitol 3-5 part, xylitol 1-3 part, maltodextrin 10-30 part and magnesium stearate 1-2 part;
The crude drug of described concentrated solution is made by Fructus Crataegi, Fructus Hordei Germinatus, Semen Raphani, Semen Lablab Album, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae and water, and the parts by weight of each medical material are: 350 parts in Fructus Crataegi 55-85 part, Fructus Hordei Germinatus 8-12 part, Semen Raphani 9-11 part, Semen Lablab Album 4-6 part, Rhizoma Dioscoreae 10-20 part, Pericarpium Citri Reticulatae 3-7 part and water.
The preparation method of described appetizing chewable tablet may further comprise the steps:
Step 1, pre-treatment: get raw material Fructus Hordei Germinatus, Pericarpium Citri Reticulatae and Semen Lablab Album, choose respectively decontamination, wash respectively again, dry, for subsequent use; Get the raw material Fructus Crataegi, choose enucleation behind the decontamination, then clean with clear water, place thermostatic drying chamber dry 5-9h under 40-80 ℃ of condition, for subsequent use; Get the raw material Semen Raphani, wash after choosing decontamination, dry, then place in the heat pot, fry 10-40min with slow fire, heave and cracker is arranged to little, take out, cooling, smash to pieces, for subsequent use; Get the raw material Rhizoma Dioscoreae, after cleaning up, be cut into the 5-10mm sheet, for subsequent use;
Step 2, lixiviate: Fructus Crataegi 55-85 part, Fructus Hordei Germinatus 8-12 part, Semen Raphani 9-11 part, Semen Lablab Album 4-6 part, Rhizoma Dioscoreae 10-20 part and the Pericarpium Citri Reticulatae 3-7 part of getting process pre-treatment in the step 1 place in the extraction pot, add for the first time 200 parts in water, add for the second time 150 parts in water, decoct 2 times, each 2h, collecting decoction also filters, filtrate places and leaves standstill 12h in the settling tank, getting supernatant concentration to relative density is 1.25, gets concentrated solution, for subsequent use;
Step 3, pulverizing: the residue Fructus Crataegi of the step 1 of learning from else's experience pre-treatment, pulverize with Chinese medicine grinder, cross 80 mesh sieves, make the Fructus Crataegi fine powder, place baking oven under 60 ℃ of conditions, to dry 3h, take out, using ball mill that the Fructus Crataegi fine powder is carried out micronizing, is that 300 r/min, ratio of grinding media to material are under 7 the condition at rotating speed, pulverizes 1 h, obtain the Fructus Crataegi powder of micronizing, for subsequent use;
Step 4, mixing, granulation: get the concentrated solution 100-160 part that obtains in the step 2 and place the efficient asymmetric mixer of V-type, then add zinc gluconate 30-50 part, sorbitol 3-5 part, xylitol 1-3 part, maltodextrin 10-30 part and process step 3 and process the ultra micro Fructus Crataegi fine powder 10-20 part that obtains, be to mix 3 times under the condition of 28r/min at speed of agitator, each 10min behind the mix homogeneously, crosses 14 mesh sieves and granulates, after the oven dry, with 16 mesh sieve granulate, get soft material, for subsequent use;
Step 5, tabletting, packing: add magnesium stearate 1-2 part in the soft material that makes to step 4, use the tablet machine tabletting behind the mix homogeneously, then plastic-aluminum packing or bottled, and with the C of 10MeV
60C
0Radiation gamma namely makes this appetizing chewable tablet after the radiation sterilization.
Embodiment 1:
A kind of appetizing chewable tablet, described appetizing chewable tablet is by 1 part of 30 parts of 160 parts of raw material concentrated solutions, 10 parts of Fructus Crataegi powder, zinc gluconate and 3 parts of adjuvant sorbitol, 1 part of xylitol, 10 parts of maltodextrins and magnesium stearate, the crude drug of described concentrated solution is comprised of Fructus Crataegi, Fructus Hordei Germinatus, Semen Raphani, Semen Lablab Album, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae and water, and the parts by weight of each medical material are: 350 parts in 85 parts of Fructus Crataegis, 8 parts in Fructus Hordei Germinatus, 9 parts of Semen Raphanis, 4 parts of Semen Lablab Albums, 10 parts of Rhizoma Dioscoreaes, 3 parts of Pericarpium Citri Reticulataes and water.
The preparation method of described appetizing chewable tablet may further comprise the steps:
Step 1, pre-treatment: get raw material Fructus Hordei Germinatus, Pericarpium Citri Reticulatae and Semen Lablab Album, choose respectively decontamination, wash respectively again, dry, for subsequent use; Get the raw material Fructus Crataegi, choose enucleation behind the decontamination, then clean with clear water, place thermostatic drying chamber dry 9h under 40 ℃ of conditions, for subsequent use; Get the raw material Semen Raphani, wash after choosing decontamination, dry, then place in the heat pot, fry 10min with slow fire, heave and cracker is arranged to little, take out, cooling, smash to pieces, for subsequent use; Get the raw material Rhizoma Dioscoreae, after cleaning up, be cut into the 5mm sheet, for subsequent use;
Step 2, lixiviate: get that Fructus Crataegi, Fructus Hordei Germinatus, Semen Raphani, Semen Lablab Album, Rhizoma Dioscoreae and the Pericarpium Citri Reticulatae through pre-treatment places in the extraction pot in the step 1 of above-mentioned formula ratio, add for the first time 200 parts in water, add for the second time 150 parts in water, decoct 2 times, each 2h, collecting decoction also filters, filtrate places and leaves standstill 12h in the settling tank, getting supernatant concentration to relative density is 1.25, gets concentrated solution, for subsequent use;
Step 3, pulverizing: the residue Fructus Crataegi of the step 1 of learning from else's experience pre-treatment, pulverize with Chinese medicine grinder, cross 80 mesh sieves, make the Fructus Crataegi fine powder, place baking oven under 60 ℃ of conditions, to dry 3h, take out, using ball mill that the Fructus Crataegi fine powder is carried out micronizing, is that 300 r/min, ratio of grinding media to material are under 7 the condition at rotating speed, pulverizes 1 h, obtain the Fructus Crataegi powder of micronizing, for subsequent use;
Step 4, mixing, granulation: get the concentrated solution that obtains in the step 2 of formula ratio and place the efficient asymmetric mixer of V-type, then add zinc gluconate, sorbitol, xylitol, maltodextrin and process step 3 and process the ultra micro Fructus Crataegi fine powder that obtains, be to mix 3 times under the condition of 28r/min at speed of agitator, each 10min behind the mix homogeneously, crosses 14 mesh sieves and granulates, after the oven dry, with 16 mesh sieve granulate, get soft material, for subsequent use;
Step 5, tabletting, packing: add magnesium stearate 1-2 part in the soft material that makes to step 4, use the tablet machine tabletting behind the mix homogeneously, then plastic-aluminum packing or bottled, and with the C of 10MeV
60C
0Radiation gamma namely makes this appetizing chewable tablet after the radiation sterilization.
Embodiment 2:
A kind of appetizing chewable tablet, described appetizing chewable tablet is by 2 parts of 50 parts of 100 parts of raw material concentrated solutions, 20 parts of Fructus Crataegi powder, zinc gluconate and 5 parts of adjuvant sorbitol, 3 parts of xylitol, 30 parts of maltodextrins and magnesium stearate, the crude drug of described concentrated solution is comprised of Fructus Crataegi, Fructus Hordei Germinatus, Semen Raphani, Semen Lablab Album, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae and water, and the parts by weight of each medical material are: 350 parts in 55 parts of Fructus Crataegis, 12 parts in Fructus Hordei Germinatus, 11 parts of Semen Raphanis, 6 parts of Semen Lablab Albums, 20 parts of Rhizoma Dioscoreaes, 7 parts of Pericarpium Citri Reticulataes and water.
The preparation method of described appetizing chewable tablet may further comprise the steps:
Step 1, pre-treatment: get raw material Fructus Hordei Germinatus, Pericarpium Citri Reticulatae and Semen Lablab Album, choose respectively decontamination, wash respectively again, dry, for subsequent use; Get the raw material Fructus Crataegi, choose enucleation behind the decontamination, then clean with clear water, place thermostatic drying chamber dry 5h under 80 ℃ of conditions, for subsequent use; Get the raw material Semen Raphani, wash after choosing decontamination, dry, then place in the heat pot, fry 40min with slow fire, heave and cracker is arranged to little, take out, cooling, smash to pieces, for subsequent use; Get the raw material Rhizoma Dioscoreae, after cleaning up, be cut into the 10mm sheet, for subsequent use;
Step 2, lixiviate: get that Fructus Crataegi, Fructus Hordei Germinatus, Semen Raphani, Semen Lablab Album, Rhizoma Dioscoreae and the Pericarpium Citri Reticulatae through pre-treatment places in the extraction pot in the step 1 of above-mentioned formula ratio, add for the first time 200 parts in water, add for the second time 150 parts in water, decoct 2 times, each 2h, collecting decoction also filters, filtrate places and leaves standstill 12h in the settling tank, getting supernatant concentration to relative density is 1.25, gets concentrated solution, for subsequent use;
Step 3, pulverizing: the residue Fructus Crataegi of the step 1 of learning from else's experience pre-treatment, pulverize with Chinese medicine grinder, cross 80 mesh sieves, make the Fructus Crataegi fine powder, place baking oven under 60 ℃ of conditions, to dry 3h, take out, using ball mill that the Fructus Crataegi fine powder is carried out micronizing, is that 300 r/min, ratio of grinding media to material are under 7 the condition at rotating speed, pulverizes 1 h, obtain the Fructus Crataegi powder of micronizing, for subsequent use;
Step 4, mixing, granulation: get the concentrated solution that obtains in the step 2 of formula ratio and place the efficient asymmetric mixer of V-type, then add zinc gluconate, sorbitol, xylitol, maltodextrin and process step 3 and process the ultra micro Fructus Crataegi fine powder that obtains, be to mix 3 times under the condition of 28r/min at speed of agitator, each 10min behind the mix homogeneously, crosses 14 mesh sieves and granulates, after the oven dry, with 16 mesh sieve granulate, get soft material, for subsequent use;
Step 5, tabletting, packing: add magnesium stearate 1-2 part in the soft material that makes to step 4, use the tablet machine tabletting behind the mix homogeneously, then plastic-aluminum packing or bottled, and with the C of 10MeV
60C
0Radiation gamma namely makes this appetizing chewable tablet after the radiation sterilization.
Embodiment 3:
A kind of appetizing chewable tablet, described appetizing chewable tablet is by 1.5 parts of 40 parts of 130 parts of raw material concentrated solutions, 15 parts of Fructus Crataegi powder, zinc gluconate and 4 parts of adjuvant sorbitol, 2 parts of xylitol, 20 parts of maltodextrins and magnesium stearate, the crude drug of described concentrated solution is comprised of Fructus Crataegi, Fructus Hordei Germinatus, Semen Raphani, Semen Lablab Album, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae and water, and the parts by weight of each medical material are: 350 parts in 70 parts of Fructus Crataegis, 10 parts in Fructus Hordei Germinatus, 10 parts of Semen Raphanis, 5 parts of Semen Lablab Albums, 15 parts of Rhizoma Dioscoreaes, 5 parts of Pericarpium Citri Reticulataes and water.
The preparation method of described appetizing chewable tablet may further comprise the steps:
Step 1, pre-treatment: get raw material Fructus Hordei Germinatus, Pericarpium Citri Reticulatae and Semen Lablab Album, choose respectively decontamination, wash respectively again, dry, for subsequent use; Get the raw material Fructus Crataegi, choose enucleation behind the decontamination, then clean with clear water, place thermostatic drying chamber dry 7h under 60 ℃ of conditions, for subsequent use; Get the raw material Semen Raphani, wash after choosing decontamination, dry, then place in the heat pot, fry 25min with slow fire, heave and cracker is arranged to little, take out, cooling, smash to pieces, for subsequent use; Get the raw material Rhizoma Dioscoreae, after cleaning up, be cut into the 7.5mm sheet, for subsequent use;
Step 2, lixiviate: get that Fructus Crataegi, Fructus Hordei Germinatus, Semen Raphani, Semen Lablab Album, Rhizoma Dioscoreae and the Pericarpium Citri Reticulatae through pre-treatment places in the extraction pot in the step 1 of above-mentioned formula ratio, add for the first time 200 parts in water, add for the second time 150 parts in water, decoct 2 times, each 2h, collecting decoction also filters, filtrate places and leaves standstill 12h in the settling tank, getting supernatant concentration to relative density is 1.25, gets concentrated solution, for subsequent use;
Step 3, pulverizing: the residue Fructus Crataegi of the step 1 of learning from else's experience pre-treatment, pulverize with Chinese medicine grinder, cross 80 mesh sieves, make the Fructus Crataegi fine powder, place baking oven under 60 ℃ of conditions, to dry 3h, take out, using ball mill that the Fructus Crataegi fine powder is carried out micronizing, is that 300 r/min, ratio of grinding media to material are under 7 the condition at rotating speed, pulverizes 1 h, obtain the Fructus Crataegi powder of micronizing, for subsequent use;
Step 4, mixing, granulation: get the concentrated solution that obtains in the step 2 of formula ratio and place the efficient asymmetric mixer of V-type, then add zinc gluconate, sorbitol, xylitol, maltodextrin and process step 3 and process the ultra micro Fructus Crataegi fine powder that obtains, be to mix 3 times under the condition of 28r/min at speed of agitator, each 10min behind the mix homogeneously, crosses 14 mesh sieves and granulates, after the oven dry, with 16 mesh sieve granulate, get soft material, for subsequent use;
Step 5, tabletting, packing: add magnesium stearate 1-2 part in the soft material that makes to step 4, use the tablet machine tabletting behind the mix homogeneously, then plastic-aluminum packing or bottled, and with the C of 10MeV
60C
0Radiation gamma namely makes this appetizing chewable tablet after the radiation sterilization.
The mouthfeel investigation
100 experimenters taste at the street corner random choose, and the present invention is done the mouthfeel investigation, by statistics, and shown in the following form of the result who obtains:
By form as can be known: think that the better and good percentage ratio of this herbal tea mouthfeel amounts to 91%, illustrate that the appetizing chewable tablet of making according to prescription of the present invention meets most people's mouthfeel demand, suits to promote in market.
Clinical testing data
Prove that by the clinical trial to the multidigit patient a kind of appetizing chewable tablet provided by the invention has the effect of promoting digestion and invigorating the stomach, regulating qi-flowing for strengthening spleen, appetite stimulator.
In the clinical trial, choose at random 100 routine patients, symptom is that gastral cavilty distension, food stagnation do not disappear, weakness of the spleen and stomach, inappetence etc.
Administrated method: chew the appetizing chewable tablet, 3 times on the one, one time 4, children's is cut down according to the circumstance, 5 days is a course for the treatment of.
Criterion of therapeutical effect:
Produce effects: the symptoms such as gastral cavilty distension, food stagnation do not disappear, weakness of the spleen and stomach, inappetence disappear substantially;
Effectively: the sx↓s such as gastral cavilty distension, food stagnation do not disappear, weakness of the spleen and stomach, inappetence;
Invalid: above symptom is showed no improvement.
The result shows: after medication course for the treatment of, in 100 routine patients with gastric disease, have 72 routine patients' gastral cavilty distension, food stagnation not disappear, the symptoms such as weakness of the spleen and stomach, inappetence disappear substantially, are produce effects; After using again a course for the treatment of, have 27 routine patients' gastral cavilty distension, food stagnation not disappear, the sx↓ such as weakness of the spleen and stomach, inappetence, for effectively; The above symptom of all the other 1 routine patients does not all alleviate, and it is invalid to be considered as.
Result of the test shows: a kind of appetizing chewable tablet, its obvious effective rate are 72%, effective percentage 27%, and inefficiency is 1%, total effective rate is 99%.Illustrate that this appetizing chewable tablet has the effect of promoting digestion and invigorating the stomach, regulating qi-flowing for strengthening spleen, appetite stimulator, can effectively treat and alleviate the symptoms such as gastral cavilty distension, food stagnation do not disappear, weakness of the spleen and stomach, inappetence.
Model case
Case 1: Wei, man, 12 years old, symptom is that food stagnation does not disappear, weakness of the spleen and stomach, inappetence, adopts medicine provided by the invention to treat, every day 3 times, after 5 days, food stagnation does not disappear, the symptom complete obiteration of weakness of the spleen and stomach, inappetence, and it is effective to take this appetizing chewable tablet.
Case 2: Wang, woman, 23 years old, symptom is gastral cavilty distension, weakness of the spleen and stomach, inappetence, adopts medicine provided by the invention to treat, every day 3 times, after 1 course for the treatment of, the transference cure of gastral cavilty distension, weakness of the spleen and stomach, inappetence, it is effective to take this appetizing chewable tablet.
Case 3: Lee, the woman, 44 years old, symptom was that gastral cavilty distension, food stagnation do not disappear, and adopts medicine provided by the invention to treat, every day 3 times, after 2 days, the transference cure that gastral cavilty distension, food stagnation do not disappear, it is effective to take this appetizing chewable tablet.
Case 4: Guo, the man, 60 years old, symptom was gastral cavilty distension, weakness of the spleen and stomach, adopted medicine provided by the invention to treat, every day 3 times, after 5 days, the transference cure of gastral cavilty distension, weakness of the spleen and stomach, it is effective to take this appetizing chewable tablet.
Claims (2)
- One kind the appetizing chewable tablet, it is characterized in that: described appetizing chewable tablet is made by raw material concentrated solution, Fructus Crataegi powder, zinc gluconate and adjuvant sorbitol, xylitol, maltodextrin and magnesium stearate;The parts by weight of each stock and adjunct are concentrated solution 100-160 part, Fructus Crataegi powder 10-20 part, zinc gluconate 30-50 part, sorbitol 3-5 part, xylitol 1-3 part, maltodextrin 10-30 part and magnesium stearate 1-2 part;The crude drug of described concentrated solution is made by Fructus Crataegi, Fructus Hordei Germinatus, Semen Raphani, Semen Lablab Album, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae and water, and the parts by weight of each medical material are: 350 parts in Fructus Crataegi 55-85 part, Fructus Hordei Germinatus 8-12 part, Semen Raphani 9-11 part, Semen Lablab Album 4-6 part, Rhizoma Dioscoreae 10-20 part, Pericarpium Citri Reticulatae 3-7 part and water.
- 2. the preparation method of a kind of chewable tablet that whets the appetite as claimed in claim 1 is characterized in that: may further comprise the steps:Step 1, pre-treatment: get raw material Fructus Hordei Germinatus, Pericarpium Citri Reticulatae and Semen Lablab Album, choose respectively decontamination, wash respectively again, dry, for subsequent use; Get the raw material Fructus Crataegi, choose enucleation behind the decontamination, then clean with clear water, place thermostatic drying chamber dry 5-9h under 40-80 ℃ of condition, for subsequent use; Get the raw material Semen Raphani, wash after choosing decontamination, dry, then place in the heat pot, fry 10-40min with slow fire, heave and cracker is arranged to little, take out, cooling, smash to pieces, for subsequent use; Get the raw material Rhizoma Dioscoreae, after cleaning up, be cut into the 5-10mm sheet, for subsequent use;Step 2, lixiviate: Fructus Crataegi 55-85 part, Fructus Hordei Germinatus 8-12 part, Semen Raphani 9-11 part, Semen Lablab Album 4-6 part, Rhizoma Dioscoreae 10-20 part and the Pericarpium Citri Reticulatae 3-7 part of getting process pre-treatment in the step 1 place in the extraction pot, add for the first time 200 parts in water, add for the second time 150 parts in water, decoct 2 times, each 2h, collecting decoction also filters, filtrate places and leaves standstill 12h in the settling tank, getting supernatant concentration to relative density is 1.25, gets concentrated solution, for subsequent use;Step 3, pulverizing: the residue Fructus Crataegi of the step 1 of learning from else's experience pre-treatment, pulverize with Chinese medicine grinder, cross 80 mesh sieves, make the Fructus Crataegi fine powder, place baking oven under 60 ℃ of conditions, to dry 3h, take out, using ball mill that the Fructus Crataegi fine powder is carried out micronizing, is that 300 r/min, ratio of grinding media to material are under 7 the condition at rotating speed, pulverizes 1 h, obtain the Fructus Crataegi powder of micronizing, for subsequent use;Step 4, mixing, granulation: get the concentrated solution 100-160 part that obtains in the step 2 and place the efficient asymmetric mixer of V-type, then add zinc gluconate 30-50 part, sorbitol 3-5 part, xylitol 1-3 part, maltodextrin 10-30 part and process step 3 and process the ultra micro Fructus Crataegi fine powder 10-20 part that obtains, be to mix 3 times under the condition of 28r/min at speed of agitator, each 10min behind the mix homogeneously, crosses 14 mesh sieves and granulates, after the oven dry, with 16 mesh sieve granulate, get soft material, for subsequent use;Step 5, tabletting, packing: add magnesium stearate 1-2 part in the soft material that makes to step 4, use the tablet machine tabletting behind the mix homogeneously, then plastic-aluminum packing or bottled, and with the C of 10MeV 60C 0Radiation gamma namely makes this appetizing chewable tablet after the radiation sterilization.
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| CN103652729A (en) * | 2013-12-11 | 2014-03-26 | 罗永祺 | Chewable tablet containing schisandra chinensis, longan and lichee and preparation method thereof |
| CN103652916A (en) * | 2013-12-11 | 2014-03-26 | 罗永祺 | Fructus lycii and Chinese yam chewing tablet and preparation method thereof |
| CN103652727A (en) * | 2013-12-11 | 2014-03-26 | 罗永祺 | Chinese yam -semen juglandis chewable tablet and preparation method thereof |
| CN103652916B (en) * | 2013-12-11 | 2015-08-12 | 罗永祺 | A kind of fruit of Chinese wolfberry Chinese yam chewable tablet and preparation method |
| CN105558924A (en) * | 2015-12-29 | 2016-05-11 | 天津天狮生物发展有限公司 | Dietary fiber chewable tablet and preparation method thereof |
| CN107455755A (en) * | 2017-08-10 | 2017-12-12 | 郑州养了吗科技有限公司 | A kind of zinc-rich Chinese yam chewable tablet and preparation method thereof |
| CN107455755B (en) * | 2017-08-10 | 2021-01-15 | 广东亿超生物科技有限公司 | Zinc-rich Chinese yam chewable tablet and preparation method thereof |
| CN108925731A (en) * | 2018-08-31 | 2018-12-04 | 阜阳健诺生物科技有限公司 | A kind of appetizing chewing sugar and preparation method thereof |
| CN111700198A (en) * | 2020-07-27 | 2020-09-25 | 黑龙江仁合堂药业有限责任公司 | Composition and beverage for regulating intestines and stomach and promoting appetite and preparation method thereof |
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| CN103055209B (en) | 2015-02-04 |
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