CN101687865A - 稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成 - Google Patents

稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成 Download PDF

Info

Publication number
CN101687865A
CN101687865A CN200880022154A CN200880022154A CN101687865A CN 101687865 A CN101687865 A CN 101687865A CN 200880022154 A CN200880022154 A CN 200880022154A CN 200880022154 A CN200880022154 A CN 200880022154A CN 101687865 A CN101687865 A CN 101687865A
Authority
CN
China
Prior art keywords
alkyl
base
substituted
pyridine
replacements
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880022154A
Other languages
English (en)
Chinese (zh)
Inventor
J·阿朗索
A·林登施密德
M·纳扎雷
O·勒克亚克
M·乌尔曼
N·哈兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SRL
Original Assignee
Sanofi Aventis SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis SpA filed Critical Sanofi Aventis SpA
Publication of CN101687865A publication Critical patent/CN101687865A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Measuring Oxygen Concentration In Cells (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880022154A 2007-06-26 2008-06-11 稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成 Pending CN101687865A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07290801.5 2007-06-26
EP07290801 2007-06-26
PCT/EP2008/004638 WO2009000412A1 (en) 2007-06-26 2008-06-11 A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

Publications (1)

Publication Number Publication Date
CN101687865A true CN101687865A (zh) 2010-03-31

Family

ID=39720505

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880022154A Pending CN101687865A (zh) 2007-06-26 2008-06-11 稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成

Country Status (11)

Country Link
US (1) US20100216988A1 (https=)
EP (1) EP2173747B1 (https=)
JP (1) JP5492769B2 (https=)
KR (1) KR20100033484A (https=)
CN (1) CN101687865A (https=)
AT (1) ATE538120T1 (https=)
AU (1) AU2008267443A1 (https=)
BR (1) BRPI0813273A2 (https=)
CA (1) CA2693142A1 (https=)
IL (1) IL202822A0 (https=)
WO (1) WO2009000412A1 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105017257A (zh) * 2014-04-30 2015-11-04 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
CN105968044A (zh) * 2016-05-11 2016-09-28 张加明 一种乙氧基喹啉的工业化生产方法
CN107635993A (zh) * 2015-03-18 2018-01-26 百时美施贵宝公司 取代的三环杂环化合物
CN108349987A (zh) * 2015-11-04 2018-07-31 出光兴产株式会社 苯并咪唑稠合杂芳族类
CN110003213A (zh) * 2018-01-04 2019-07-12 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN111217819A (zh) * 2018-11-27 2020-06-02 杭州科巢生物科技有限公司 乌帕替尼的合成方法
CN112552305A (zh) * 2020-11-26 2021-03-26 广东省测试分析研究所（中国广州分析测试中心） 一种新型苯并环庚烷并咪唑并吡啶类阻燃抗紫外线分子材料及其制备方法与应用
CN114423763A (zh) * 2019-05-09 2022-04-29 豪夫迈·罗氏有限公司 咪唑并[1,2-a]嘧啶的区域选择性合成

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1831225A2 (en) 2004-11-19 2007-09-12 The Regents of the University of California Anti-inflammatory pyrazolopyrimidines
WO2007114926A2 (en) 2006-04-04 2007-10-11 The Regents Of The University Of California Kinase antagonists
GB2467670B (en) 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
MX2010007419A (es) 2008-01-04 2010-11-12 Intellikine Inc Ciertas entidades quimicas, composiciones y metodos.
EP2252293B1 (en) 2008-03-14 2018-06-27 Intellikine, LLC Kinase inhibitors and methods of use
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
BRPI0915231A2 (pt) 2008-07-08 2018-06-12 Intellikine Inc compostos inibidores de quinase e métodos de uso
CA2738429C (en) 2008-09-26 2016-10-25 Intellikine, Inc. Heterocyclic kinase inhibitors
EP2358720B1 (en) 2008-10-16 2016-03-02 The Regents of The University of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
JP2010235575A (ja) * 2009-03-09 2010-10-21 Konica Minolta Holdings Inc 含窒素縮合複素環化合物の製造方法
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
RU2016108987A (ru) 2009-08-18 2018-11-26 Вентиркс Фармасьютикалз, Инк. Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора
CN105669553A (zh) 2009-08-18 2016-06-15 文蒂雷克斯药品公司 作为toll样受体调节剂的取代的苯并氮杂*
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
CA2799579A1 (en) 2010-05-21 2011-11-24 Intellikine, Inc. Chemical compounds, compositions and methods for kinase modulation
WO2012061342A2 (en) 2010-11-01 2012-05-10 Arqule, Inc. Substituted benzo-imidazo-pyrido-diazepine compounds
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
TW201500358A (zh) * 2010-12-16 2015-01-01 赫夫門羅氏藥廠股份有限公司 三環ｐｉ３ｋ抑制劑化合物及其使用方法
ES2637113T3 (es) 2011-01-10 2017-10-10 Infinity Pharmaceuticals, Inc. Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas
US9295673B2 (en) 2011-02-23 2016-03-29 Intellikine Llc Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
AR088218A1 (es) 2011-07-19 2014-05-21 Infinity Pharmaceuticals Inc Compuestos heterociclicos utiles como inhibidores de pi3k
HK1198443A1 (en) 2011-07-19 2015-04-24 无限药品股份有限公司 Heterocyclic compounds and uses thereof
MX2014002542A (es) 2011-08-29 2014-07-09 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
CA2846496C (en) 2011-09-02 2020-07-14 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
JP2015532287A (ja) 2012-09-26 2015-11-09 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア Ｉｒｅ１の調節
AU2013337717B2 (en) 2012-11-01 2018-10-25 Infinity Pharmaceuticals, Inc. Treatment of cancers using PI3 kinase isoform modulators
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PT3052485T (pt) 2013-10-04 2021-10-22 Infinity Pharmaceuticals Inc Compostos heterocíclicos e suas utilizações
MX382033B (es) 2014-03-19 2025-03-13 Infinity Pharmaceuticals Inc Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR101540198B1 (ko) * 2015-01-29 2015-07-29 성균관대학교산학협력단 팔라듐이 함유된 카본 나이트라이드 지지체를 이용한 메탄올과 일산화탄소의 카르보닐레이션 반응으로부터 아세트산을 제조하기 위한 촉매 및 이의 제조방법
WO2017048702A1 (en) 2015-09-14 2017-03-23 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
SG11201811237WA (en) 2016-06-24 2019-01-30 Infinity Pharmaceuticals Inc Combination therapies
CN110681362B (zh) * 2019-09-26 2020-09-11 浙江大学 以羧基和吲哚基为功能基团的混合模式层析介质
EP4146205A4 (en) 2020-05-05 2024-05-29 Nuvalent, Inc. HETEROAROMATIC MACROCYCLIC ETHERS AS CHEMOTHERAPEUTIC AGENTS
IL297832A (en) 2020-05-05 2023-01-01 Nuvalent Inc Macrocyclic heteroaromatic chemotherapeutic agents
CN113512068B (zh) * 2021-04-13 2022-05-31 山西大学 一种双配体的亚硝酰钌配合物及其制备方法和应用
US20230144528A1 (en) * 2021-09-30 2023-05-11 Prelude Therapeutics Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
TW202320768A (zh) 2021-10-01 2023-06-01 美商努法倫特公司 雜芳族大環醚化合物之固體形式、醫藥組成物及製備
CN114907421A (zh) * 2022-06-06 2022-08-16 河南师范大学 铑催化6-芳基嘌呤核苷和炔烃合成荧光多环嘌呤盐的方法
CN116943408B (zh) * 2023-06-30 2024-01-30 江苏创新石化有限公司 一种位阻胺复合脱硫剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049422A (en) * 1976-03-29 1977-09-20 United States Borax & Chemical Corporation Herbicidal morpholinobenzimidazoles
SU1587052A1 (ru) * 1988-06-27 1990-08-23 Всесоюзный научно-исследовательский институт химических средств защиты растений Способ получени 2,3-дигидро-1Н-пирроло [1,2- @ ]бензимидазол-6-сульфонамидов
EP0627433B1 (en) * 1992-12-07 2003-03-05 Eisai Co., Ltd. Process for producing imidazopyridine derivative and intermediate
WO2003106413A2 (en) * 2001-10-18 2003-12-24 Michigan State University Process for the preparation of oxazolidinones and method of use thereof
AU2005309606B2 (en) * 2004-11-29 2011-01-06 Merck Sharp & Dohme Corp. Fused aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105017257A (zh) * 2014-04-30 2015-11-04 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
CN105017257B (zh) * 2014-04-30 2017-05-24 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
CN107635993A (zh) * 2015-03-18 2018-01-26 百时美施贵宝公司 取代的三环杂环化合物
CN107635993B (zh) * 2015-03-18 2020-05-22 百时美施贵宝公司 取代的三环杂环化合物
CN108349987A (zh) * 2015-11-04 2018-07-31 出光兴产株式会社 苯并咪唑稠合杂芳族类
CN105968044A (zh) * 2016-05-11 2016-09-28 张加明 一种乙氧基喹啉的工业化生产方法
CN110003213A (zh) * 2018-01-04 2019-07-12 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN110003213B (zh) * 2018-01-04 2021-10-08 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN111217819A (zh) * 2018-11-27 2020-06-02 杭州科巢生物科技有限公司 乌帕替尼的合成方法
CN114423763A (zh) * 2019-05-09 2022-04-29 豪夫迈·罗氏有限公司 咪唑并[1,2-a]嘧啶的区域选择性合成
CN112552305A (zh) * 2020-11-26 2021-03-26 广东省测试分析研究所（中国广州分析测试中心） 一种新型苯并环庚烷并咪唑并吡啶类阻燃抗紫外线分子材料及其制备方法与应用

Also Published As

Publication number Publication date
US20100216988A1 (en) 2010-08-26
IL202822A0 (en) 2010-06-30
EP2173747B1 (en) 2011-12-21
JP5492769B2 (ja) 2014-05-14
EP2173747A1 (en) 2010-04-14
AU2008267443A1 (en) 2008-12-31
ATE538120T1 (de) 2012-01-15
JP2010531312A (ja) 2010-09-24
WO2009000412A1 (en) 2008-12-31
BRPI0813273A2 (pt) 2014-12-30
CA2693142A1 (en) 2008-12-31
KR20100033484A (ko) 2010-03-30

Similar Documents

Publication Publication Date Title
CN101687865A (zh) 稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成
CN101490014B (zh) 苯并咪唑和氮杂苯并咪唑的区域选择性钯催化合成
TWI783057B (zh) 製備6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈的方法
US8735586B2 (en) Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
CA3081790C (en) Macrocyclic compounds as trk kinase inhibitors and uses thereof
EP2424858B1 (en) Cxcr3 receptor antagonists
KR20150072412A (ko) Gdf-8 억제제
IL203533A (en) Lactam-containing tetrahydro-pyrazolo [3,4-c] pyridine compounds useful as factor xa inhibitors and pharmaceutical compositions comprising the same for treating thromboembolic disorders
EP1124822A1 (en) Thrombin inhibitors
CN117355523A (zh) 血浆激肽释放酶的多环抑制剂
CN108191834B (zh) 一种苯并稠合n-杂环化合物的制备方法
HK1142895A (en) A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
RU2330853C2 (ru) АЗАИНДОЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Xa
HK1133880A (en) A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
HK1142894A (en) A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1142895

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20100331

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1142895

Country of ref document: HK