ATE538120T1 - Regioselektive, metallkatalysierte synthese annelierter benzimidazole und azabenzimidazole - Google Patents
Regioselektive, metallkatalysierte synthese annelierter benzimidazole und azabenzimidazoleInfo
- Publication number
- ATE538120T1 ATE538120T1 AT08759157T AT08759157T ATE538120T1 AT E538120 T1 ATE538120 T1 AT E538120T1 AT 08759157 T AT08759157 T AT 08759157T AT 08759157 T AT08759157 T AT 08759157T AT E538120 T1 ATE538120 T1 AT E538120T1
- Authority
- AT
- Austria
- Prior art keywords
- regioselective
- azabenzimidazoles
- benzimidazoles
- metal
- annated
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- -1 N-substituted benzimidazoles Chemical class 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Measuring Oxygen Concentration In Cells (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290801 | 2007-06-26 | ||
| PCT/EP2008/004638 WO2009000412A1 (en) | 2007-06-26 | 2008-06-11 | A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538120T1 true ATE538120T1 (de) | 2012-01-15 |
Family
ID=39720505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08759157T ATE538120T1 (de) | 2007-06-26 | 2008-06-11 | Regioselektive, metallkatalysierte synthese annelierter benzimidazole und azabenzimidazole |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100216988A1 (https=) |
| EP (1) | EP2173747B1 (https=) |
| JP (1) | JP5492769B2 (https=) |
| KR (1) | KR20100033484A (https=) |
| CN (1) | CN101687865A (https=) |
| AT (1) | ATE538120T1 (https=) |
| AU (1) | AU2008267443A1 (https=) |
| BR (1) | BRPI0813273A2 (https=) |
| CA (1) | CA2693142A1 (https=) |
| IL (1) | IL202822A0 (https=) |
| WO (1) | WO2009000412A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9512125B2 (en) | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
| WO2007114926A2 (en) | 2006-04-04 | 2007-10-11 | The Regents Of The University Of California | Kinase antagonists |
| GB2467670B (en) | 2007-10-04 | 2012-08-01 | Intellikine Inc | Chemical entities and therapeutic uses thereof |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| EP3613743B1 (en) | 2008-01-04 | 2022-03-16 | Intellikine, LLC | Processes for the preparation of 1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives |
| US8637542B2 (en) | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
| US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
| US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
| JP5788316B2 (ja) | 2008-07-08 | 2015-09-30 | インテリカイン， エルエルシー | キナーゼインヒビターおよび使用方法 |
| US8703778B2 (en) | 2008-09-26 | 2014-04-22 | Intellikine Llc | Heterocyclic kinase inhibitors |
| WO2010045542A2 (en) | 2008-10-16 | 2010-04-22 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
| US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
| JP2010235575A (ja) * | 2009-03-09 | 2010-10-21 | Konica Minolta Holdings Inc | 含窒素縮合複素環化合物の製造方法 |
| EP2427195B1 (en) | 2009-05-07 | 2019-05-01 | Intellikine, LLC | Heterocyclic compounds and uses thereof |
| CA2771609C (en) | 2009-08-18 | 2018-10-02 | Ventirx Pharmaceuticals, Inc. | Substituted benzoazepines as toll-like receptor modulators |
| EP2467380B1 (en) | 2009-08-18 | 2016-11-30 | Ventirx Pharmaceuticals, Inc. | Substituted benzoazepines as toll-like receptor modulators |
| US8980899B2 (en) | 2009-10-16 | 2015-03-17 | The Regents Of The University Of California | Methods of inhibiting Ire1 |
| CA2799579A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| TW201307347A (zh) | 2010-11-01 | 2013-02-16 | Arqule Inc | 經取代苯並－咪唑並－吡啶並－二氮呯化合物 |
| JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環化合物及びその使用 |
| CN103313989B (zh) * | 2010-12-16 | 2016-05-04 | 霍夫曼-拉罗奇有限公司 | 三环pi3k抑制剂化合物和使用方法 |
| TWI674262B (zh) | 2011-01-10 | 2019-10-11 | 美商英菲尼提製藥股份有限公司 | 製備異喹啉酮之方法及異喹啉酮之固體形式 |
| US9295673B2 (en) | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
| MX2014000648A (es) | 2011-07-19 | 2014-09-25 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y sus usos. |
| WO2013012915A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| KR20140075693A (ko) | 2011-08-29 | 2014-06-19 | 인피니티 파마슈티칼스, 인코포레이티드 | 헤테로사이클릭 화합물 및 그의 용도 |
| MX370814B (es) | 2011-09-02 | 2020-01-08 | Univ California | Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas. |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| MX2015003874A (es) | 2012-09-26 | 2015-12-16 | Univ California | Modulacion de ire1. |
| EP2914296B2 (en) | 2012-11-01 | 2021-09-29 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MX2021012208A (es) | 2013-10-04 | 2023-01-19 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos y usos de los mismos. |
| NZ724368A (en) | 2014-03-19 | 2023-07-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| CN105017257B (zh) * | 2014-04-30 | 2017-05-24 | 华东理工大学 | 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途 |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| KR101540198B1 (ko) * | 2015-01-29 | 2015-07-29 | 성균관대학교산학협력단 | 팔라듐이 함유된 카본 나이트라이드 지지체를 이용한 메탄올과 일산화탄소의 카르보닐레이션 반응으로부터 아세트산을 제조하기 위한 촉매 및 이의 제조방법 |
| CN107635993B (zh) * | 2015-03-18 | 2020-05-22 | 百时美施贵宝公司 | 取代的三环杂环化合物 |
| EP4585268A3 (en) | 2015-09-14 | 2025-10-15 | Twelve Therapeutics, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| KR20180079328A (ko) * | 2015-11-04 | 2018-07-10 | 이데미쓰 고산 가부시키가이샤 | 벤즈이미다졸 축합 헤테로아릴 |
| US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
| CN105968044A (zh) * | 2016-05-11 | 2016-09-28 | 张加明 | 一种乙氧基喹啉的工业化生产方法 |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| RU2754507C2 (ru) | 2016-06-24 | 2021-09-02 | Инфинити Фармасьютикалз, Инк. | Комбинированная терапия |
| CN110003213B (zh) * | 2018-01-04 | 2021-10-08 | 南京农业大学 | 苯并咪唑并三嗪酮类化合物、制备方法及应用 |
| CN111217819B (zh) * | 2018-11-27 | 2021-05-14 | 杭州科巢生物科技有限公司 | 乌帕替尼的合成方法 |
| WO2020227576A1 (en) * | 2019-05-09 | 2020-11-12 | Genentech, Inc. | Regio-selective synthesis of imidazo[1,2-a]pyrimidines |
| CN110681362B (zh) * | 2019-09-26 | 2020-09-11 | 浙江大学 | 以羧基和吲哚基为功能基团的混合模式层析介质 |
| KR102698413B1 (ko) | 2020-05-05 | 2024-08-26 | 뉴베일런트, 아이엔씨. | 헤테로방향족 거대환식 에터 화학치료제 |
| IL297832A (en) | 2020-05-05 | 2023-01-01 | Nuvalent Inc | Macrocyclic heteroaromatic chemotherapeutic agents |
| CN112552305B (zh) * | 2020-11-26 | 2021-11-30 | 广东省测试分析研究所（中国广州分析测试中心） | 一种苯并环庚烷并咪唑并吡啶类阻燃抗紫外线分子材料及其制备方法与应用 |
| CN113512068B (zh) * | 2021-04-13 | 2022-05-31 | 山西大学 | 一种双配体的亚硝酰钌配合物及其制备方法和应用 |
| US20230144528A1 (en) * | 2021-09-30 | 2023-05-11 | Prelude Therapeutics Incorporated | CDK Inhibitors And Their Use As Pharmaceuticals |
| IL311444A (en) | 2021-10-01 | 2024-05-01 | Nuvalent Inc | Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds |
| CN114907421A (zh) * | 2022-06-06 | 2022-08-16 | 河南师范大学 | 铑催化6-芳基嘌呤核苷和炔烃合成荧光多环嘌呤盐的方法 |
| CN116943408B (zh) * | 2023-06-30 | 2024-01-30 | 江苏创新石化有限公司 | 一种位阻胺复合脱硫剂及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4049422A (en) * | 1976-03-29 | 1977-09-20 | United States Borax & Chemical Corporation | Herbicidal morpholinobenzimidazoles |
| SU1587052A1 (ru) * | 1988-06-27 | 1990-08-23 | Всесоюзный научно-исследовательский институт химических средств защиты растений | Способ получени 2,3-дигидро-1Н-пирроло [1,2- @ ]бензимидазол-6-сульфонамидов |
| US5583229A (en) * | 1992-12-07 | 1996-12-10 | Eisai Co., Ltd. | Process for the preparation of imidazopyridine derivatives |
| JP2005519996A (ja) * | 2001-10-18 | 2005-07-07 | ミシガン ステイト ユニバーシティー | オキサゾリジノン類の製造方法及びその使用方法 |
| JP4999698B2 (ja) * | 2004-11-29 | 2012-08-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病の治療または予防用のジペプチジルペプチダーゼ−ｉｖ阻害剤としての縮合アミノピペリジン |
-
2008
- 2008-06-11 BR BRPI0813273-9A2A patent/BRPI0813273A2/pt not_active IP Right Cessation
- 2008-06-11 KR KR1020097026783A patent/KR20100033484A/ko not_active Withdrawn
- 2008-06-11 WO PCT/EP2008/004638 patent/WO2009000412A1/en not_active Ceased
- 2008-06-11 CA CA2693142A patent/CA2693142A1/en not_active Abandoned
- 2008-06-11 EP EP08759157A patent/EP2173747B1/en not_active Not-in-force
- 2008-06-11 CN CN200880022154A patent/CN101687865A/zh active Pending
- 2008-06-11 AU AU2008267443A patent/AU2008267443A1/en not_active Abandoned
- 2008-06-11 JP JP2010513709A patent/JP5492769B2/ja not_active Expired - Fee Related
- 2008-06-11 AT AT08759157T patent/ATE538120T1/de active
-
2009
- 2009-12-17 IL IL202822A patent/IL202822A0/en unknown
- 2009-12-22 US US12/644,379 patent/US20100216988A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL202822A0 (en) | 2010-06-30 |
| AU2008267443A1 (en) | 2008-12-31 |
| JP5492769B2 (ja) | 2014-05-14 |
| WO2009000412A1 (en) | 2008-12-31 |
| BRPI0813273A2 (pt) | 2014-12-30 |
| KR20100033484A (ko) | 2010-03-30 |
| EP2173747B1 (en) | 2011-12-21 |
| JP2010531312A (ja) | 2010-09-24 |
| EP2173747A1 (en) | 2010-04-14 |
| CN101687865A (zh) | 2010-03-31 |
| CA2693142A1 (en) | 2008-12-31 |
| US20100216988A1 (en) | 2010-08-26 |
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