CN101678020B - 作为Janus激酶的酪氨酸激酶活性抑制剂的喹喔啉衍生物 - Google Patents

作为Janus激酶的酪氨酸激酶活性抑制剂的喹喔啉衍生物 Download PDF

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Publication number
CN101678020B
CN101678020B CN2008800193524A CN200880019352A CN101678020B CN 101678020 B CN101678020 B CN 101678020B CN 2008800193524 A CN2008800193524 A CN 2008800193524A CN 200880019352 A CN200880019352 A CN 200880019352A CN 101678020 B CN101678020 B CN 101678020B
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phenyl
quinoxaline
methyl
ylmethyl
morpholine
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CN101678020A (zh
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M·格施帕赫
P·菲雷
E·范格莱维灵格
C·皮索特索德曼
C·高尔
P·霍尔策
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Novartis AG
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Novartis AG
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
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  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2008800193524A 2007-06-08 2008-06-06 作为Janus激酶的酪氨酸激酶活性抑制剂的喹喔啉衍生物 Expired - Fee Related CN101678020B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07109880 2007-06-08
EP07109880.0 2007-06-08
EP07150266 2007-12-20
EP07150266.0 2007-12-20
PCT/EP2008/057058 WO2008148867A2 (en) 2007-06-08 2008-06-06 Quinoxaline derivatives as inhibitors of the tyrosine kinase activity of janus kinases

Publications (2)

Publication Number Publication Date
CN101678020A CN101678020A (zh) 2010-03-24
CN101678020B true CN101678020B (zh) 2012-08-15

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CN2008800193524A Expired - Fee Related CN101678020B (zh) 2007-06-08 2008-06-06 作为Janus激酶的酪氨酸激酶活性抑制剂的喹喔啉衍生物

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US (1) US8193189B2 (enExample)
EP (1) EP2155201B1 (enExample)
JP (1) JP5574957B2 (enExample)
KR (1) KR20100020465A (enExample)
CN (1) CN101678020B (enExample)
AR (1) AR066879A1 (enExample)
AU (1) AU2008258486B2 (enExample)
BR (1) BRPI0812893A2 (enExample)
CA (1) CA2690288A1 (enExample)
CL (1) CL2008001659A1 (enExample)
EA (1) EA200901608A1 (enExample)
ES (1) ES2392570T3 (enExample)
MX (1) MX2009013218A (enExample)
PA (1) PA8783501A1 (enExample)
TW (1) TW200904814A (enExample)
UY (1) UY31126A1 (enExample)
WO (1) WO2008148867A2 (enExample)

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CN105873914B (zh) * 2013-10-23 2018-10-19 拜耳作物科学股份公司 作为害虫防治剂的取代的喹喔啉衍生物
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JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
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TWI719960B (zh) 2015-02-10 2021-03-01 英商阿斯迪克治療公司 新穎組成物
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HUE050567T2 (hu) 2015-09-23 2020-12-28 Janssen Pharmaceutica Nv Triciklusos heterociklusok rák kezelésére
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CN108472298B (zh) 2015-11-24 2021-04-20 深圳阿拉丁医疗科技有限公司 选择性激酶抑制剂
MX383747B (es) * 2016-02-24 2025-03-14 Pfizer Derivados de pirazolo[1,5-a]pirazin-4-ilo como inhibidores de quinasas janus (jak)
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WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
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TWI865563B (zh) 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
CN110698418B (zh) * 2019-09-11 2022-07-01 广西师范大学 一种3-芳胺基喹喔啉-2-甲酰胺类衍生物及其制备方法和应用
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