CN101676717B - 一种中药制品的检测方法 - Google Patents
一种中药制品的检测方法 Download PDFInfo
- Publication number
- CN101676717B CN101676717B CN2008101514844A CN200810151484A CN101676717B CN 101676717 B CN101676717 B CN 101676717B CN 2008101514844 A CN2008101514844 A CN 2008101514844A CN 200810151484 A CN200810151484 A CN 200810151484A CN 101676717 B CN101676717 B CN 101676717B
- Authority
- CN
- China
- Prior art keywords
- peak
- chinese medicine
- unison
- finger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 89
- 239000003814 drug Substances 0.000 title abstract description 151
- 239000000203 mixture Substances 0.000 claims description 25
- 239000000126 substance Substances 0.000 claims description 20
- 238000003908 quality control method Methods 0.000 claims description 14
- 238000001514 detection method Methods 0.000 claims description 12
- 230000035945 sensitivity Effects 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 10
- 239000006187 pill Substances 0.000 claims description 10
- 230000000857 drug effect Effects 0.000 claims description 9
- 238000001228 spectrum Methods 0.000 claims description 9
- 230000009897 systematic effect Effects 0.000 claims description 7
- 230000001988 toxicity Effects 0.000 claims description 6
- 231100000419 toxicity Toxicity 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 4
- 239000009524 danshen dripping Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000004587 chromatography analysis Methods 0.000 claims description 3
- 240000003870 Ageratum houstonianum Species 0.000 claims description 2
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 claims description 2
- 241000202726 Bupleurum Species 0.000 claims description 2
- 208000012895 Gastric disease Diseases 0.000 claims description 2
- 235000011201 Ginkgo Nutrition 0.000 claims description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 2
- 244000194101 Ginkgo biloba Species 0.000 claims description 2
- 241000334160 Isatis Species 0.000 claims description 2
- 235000001667 Vitex agnus castus Nutrition 0.000 claims description 2
- 244000063464 Vitex agnus-castus Species 0.000 claims description 2
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 claims description 2
- 239000007938 effervescent tablet Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000008412 qishen yiqi Substances 0.000 claims description 2
- 238000010791 quenching Methods 0.000 claims description 2
- 230000000171 quenching effect Effects 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 208000018556 stomach disease Diseases 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000035922 thirst Effects 0.000 claims description 2
- 210000003462 vein Anatomy 0.000 claims description 2
- 230000006872 improvement Effects 0.000 abstract description 10
- 230000008901 benefit Effects 0.000 abstract description 7
- 239000000047 product Substances 0.000 description 70
- 238000011156 evaluation Methods 0.000 description 35
- 238000004364 calculation method Methods 0.000 description 28
- 229940079593 drug Drugs 0.000 description 25
- 238000004458 analytical method Methods 0.000 description 18
- 238000011160 research Methods 0.000 description 18
- 238000011524 similarity measure Methods 0.000 description 15
- 239000002398 materia medica Substances 0.000 description 14
- 238000010586 diagram Methods 0.000 description 13
- 239000000284 extract Substances 0.000 description 13
- 238000005259 measurement Methods 0.000 description 9
- 239000013598 vector Substances 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 238000011161 development Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- 244000111489 Gardenia augusta Species 0.000 description 6
- 235000018958 Gardenia augusta Nutrition 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000010835 comparative analysis Methods 0.000 description 6
- 239000000470 constituent Substances 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000012797 qualification Methods 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000002131 composite material Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- 238000012850 discrimination method Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000001303 quality assessment method Methods 0.000 description 2
- 238000011158 quantitative evaluation Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 241001269238 Data Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000002567 autonomic effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000007621 cluster analysis Methods 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 238000000556 factor analysis Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000024053 secondary metabolic process Effects 0.000 description 1
- 238000004379 similarity theory Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Images
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008101514844A CN101676717B (zh) | 2008-09-19 | 2008-09-19 | 一种中药制品的检测方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008101514844A CN101676717B (zh) | 2008-09-19 | 2008-09-19 | 一种中药制品的检测方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101676717A CN101676717A (zh) | 2010-03-24 |
CN101676717B true CN101676717B (zh) | 2013-12-04 |
Family
ID=42029356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008101514844A Active CN101676717B (zh) | 2008-09-19 | 2008-09-19 | 一种中药制品的检测方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101676717B (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101975845A (zh) * | 2010-09-21 | 2011-02-16 | 成都中医药大学 | 中药品质自动检测系统 |
CN102441058B (zh) * | 2010-10-14 | 2014-12-24 | 天士力制药集团股份有限公司 | 一种养血清脑颗粒的气相色谱指纹图谱检测方法 |
CN102608240B (zh) * | 2011-01-23 | 2014-10-29 | 复旦大学 | 一种多波长组合的指纹图谱检测方法及其用途 |
CN102841152A (zh) * | 2011-12-31 | 2012-12-26 | 山西振东泰盛制药有限公司 | 舒血宁注射液的指纹图谱的检测方法 |
CN103115973B (zh) * | 2013-01-25 | 2014-07-02 | 山东大学 | 一种用于中药批次一致性的判断方法 |
CN103278591B (zh) * | 2013-05-16 | 2015-08-26 | 江苏师范大学 | 一种色谱指纹图谱相似度计算方法 |
CN104749158B (zh) * | 2013-12-27 | 2020-12-11 | 同方威视技术股份有限公司 | 珠宝玉石鉴定方法及装置 |
CN104458632B (zh) * | 2014-11-27 | 2017-11-24 | 山东大学 | 一种相同品质中药的检测判别方法 |
CN105496974A (zh) * | 2016-01-28 | 2016-04-20 | 李兴惠 | 注射用益气复脉冻干粉针剂指纹图谱检测方法和制剂 |
CN106153791B (zh) * | 2016-09-29 | 2017-12-22 | 天津中医药大学 | 基于指纹图谱技术优化β‑环糊精提取复方血脂宁处方的方法 |
CN108398516B (zh) * | 2017-02-04 | 2020-12-15 | 北京蓝标一成科技有限公司 | 一种流苏石斛的质量检测方法 |
CN106990214B (zh) * | 2017-05-08 | 2019-11-15 | 云南民族大学 | 一种评价中药材质量的方法 |
CN107941997A (zh) * | 2017-11-15 | 2018-04-20 | 江苏中烟工业有限责任公司 | 一种外引烤烟品种种植区域遴选和验证的方法 |
CN109324014B (zh) * | 2018-10-08 | 2021-09-24 | 华东理工大学 | 一种自适应的原油性质近红外快速预测方法 |
US11443854B2 (en) | 2020-02-24 | 2022-09-13 | International Business Machines Corporation | Identifying potential medicinal interactions for online clinical trial study groups |
CN113029979B (zh) * | 2021-02-10 | 2023-03-24 | 河南中烟工业有限责任公司 | 一种用于检验卷烟纸质量稳定性的方法 |
CN113466361A (zh) * | 2021-06-18 | 2021-10-01 | 广西壮族自治区中医药研究院 | 一种肠胃散的质量评价方法 |
CN114298578A (zh) * | 2021-12-30 | 2022-04-08 | 中国兵器装备集团自动化研究所有限公司 | 火工品装配过程质量管控方法、系统、电子装置及介质 |
CN114792213B (zh) * | 2022-06-23 | 2022-09-02 | 辰欣佛都药业(汶上)有限公司 | 一种颗粒药品质量稽查方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1588050A (zh) * | 2004-07-09 | 2005-03-02 | 清华大学 | 一种利用特征图谱对药材进行鉴别的方法 |
CN1602830A (zh) * | 2004-11-09 | 2005-04-06 | 清华大学 | 一种对中药生产工艺进行实时监控的方法 |
-
2008
- 2008-09-19 CN CN2008101514844A patent/CN101676717B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1588050A (zh) * | 2004-07-09 | 2005-03-02 | 清华大学 | 一种利用特征图谱对药材进行鉴别的方法 |
CN1602830A (zh) * | 2004-11-09 | 2005-04-06 | 清华大学 | 一种对中药生产工艺进行实时监控的方法 |
Non-Patent Citations (2)
Title |
---|
徐永群等.阵列相关系数比对法在中药鉴别中的应用研究.《光谱学与光谱分析》.2007,第27卷(第11期),2239-2242. |
阵列相关系数比对法在中药鉴别中的应用研究;徐永群等;《光谱学与光谱分析》;20071130;第27卷(第11期);2239-2242 * |
Also Published As
Publication number | Publication date |
---|---|
CN101676717A (zh) | 2010-03-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101676717B (zh) | 一种中药制品的检测方法 | |
CN106990214B (zh) | 一种评价中药材质量的方法 | |
CN102138985B (zh) | 一种白芍制剂的质量检测方法 | |
CN103472025B (zh) | 紫檀香品质鉴定的方法 | |
CN103728387A (zh) | 参芪降糖制剂hplc标准指纹图谱及其构建方法 | |
CN103376242A (zh) | 一种芍药苷的检测方法 | |
CN103364506A (zh) | 一种化橘红有效部位及其制剂的质量控制方法 | |
CN106645508B (zh) | 风热感冒颗粒hplc特征图谱的构建方法 | |
CN109765319A (zh) | 一种六神丸hplc指纹图谱检测方法 | |
CN101791331B (zh) | 一种快速测定丹参提取液中鞣质含量的方法 | |
CN107356691A (zh) | 建曲指纹图谱的检测方法 | |
Liu et al. | Monitoring and evaluating the quality consistency of compound bismuth aluminate tablets by a simple quantified ratio fingerprint method combined with simultaneous determination of five compounds and correlated with antioxidant activities | |
CN103115973B (zh) | 一种用于中药批次一致性的判断方法 | |
Pan et al. | Identification of Forsythia suspensa (Thunb.) Vahl in different harvest periods using intelligent sensory technologies, HPLC characteristic fingerprint coupled with chemometrics | |
Liu et al. | Chemometric analysis based on HPLC multi-wavelength fingerprints for prediction of antioxidant components in Turpiniae Folium | |
CN104849375B (zh) | 橘红痰咳制剂的检测方法 | |
CN102175629B (zh) | 一种基于生物活性检测的熟地黄品质评价方法 | |
CN102592043A (zh) | 一种基于整体观模式中药质量优劣yzl值数字化评价新模式及其建立方法和应用 | |
CN105784951A (zh) | 一种六味地黄丸浓缩丸生药粉多指标快速检测方法 | |
CN115472236B (zh) | 一种利用“印迹模板”成分簇动力学与热力学平衡原理确定、表征与评价药效物质的方法 | |
CN107036997A (zh) | 利用近红外光谱法快速检测气滞胃痛颗粒的制备过程的方法及应用 | |
CN106770785B (zh) | 一种建立茜草藤药材的指纹图谱的方法 | |
CN105954311A (zh) | 美洲大蠊及其提取物的1h-nmr指纹图谱的构建方法 | |
CN106093229B (zh) | 一种基于uplc指纹图谱模式识别鉴别何首乌的方法及其应用 | |
AU2021106279A4 (en) | Method for establishing hplc-elsd fingerprints of shenlingbaizhu pills and standard fingerprints thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent for invention or patent application | ||
CB02 | Change of applicant information |
Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Applicant after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Applicant before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: TIANJIN TIANSHILI PHARMACEUTICAL CO., LTD. TO: TASLY PHARMACEUTICAL GROUP CO., LTD. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 (city of the modern Chinese Medicine) Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170911 Address after: 300402 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee after: Tianjin Tasly Modern Chinese Medicine Resource Co., Ltd. Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 (city of the modern Chinese Medicine) Patentee before: Tasly Pharmaceutical Group Limited by Share Ltd |