CN101664467A - Microbial fermentation preparation of Jingfang toxicity-removing composition - Google Patents
Microbial fermentation preparation of Jingfang toxicity-removing composition Download PDFInfo
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- CN101664467A CN101664467A CN200810151221A CN200810151221A CN101664467A CN 101664467 A CN101664467 A CN 101664467A CN 200810151221 A CN200810151221 A CN 200810151221A CN 200810151221 A CN200810151221 A CN 200810151221A CN 101664467 A CN101664467 A CN 101664467A
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Abstract
The invention discloses a microbial fermentation preparation of Jingfang toxicity-removing composition. The preparation is prepared by the following method: (1) taking notopterygium roots, radix bupleuri, whiteflower hogfennel roots, doubleteeth pubescent angelica roots, bitter oranges, tuckahoe, fineleaf schizonepeta herbs, divaricate saposhnikovia roots, ballonflower and hemlock parsley as raw materials, adding water, decocting, filtering the obtained product and concentrating filtrate; (2) inoculating solution prepared in a step (1) with EM original liquid, fermenting the obtained product for 1 to 5 months at a temperature between 10 and 30 DEG C and preparing fermented liquid; and (3) separating, refining and sterilizing the fermented liquid to prepare the microbial fermentation preparation of Jingfang toxicity-removing composition. The invention introduces the EM original liquid into the Jingfang toxicity-removing composition for fermentation and metabolism, and reduces or removesheavy metals, pesticides and carcinogenic substances in medicinal materials through the biotransformation function of the EM original liquid. The preparation method has the advantages of metabolizingmacromolecular substances to be small-molecular active substances through microbial fermentation, improving bioavailability, ensuring quick complete absorption and reducing dosage.
Description
Technical field
The present invention relates to a kind of microbial fermentation preparation of Chinese medicine, particularly relate to a kind of microbial fermentation preparation of Jingfang toxicity-removing composition.
Background technology
Chinese medicine with traditional Chinese culture developing history in several thousand has been arranged, and the history of chemical synthetic drug has only more than 100 year, in the modern medical service system, and still chemical synthetic drug in the highest flight.Trace it to its cause, the characteristics of chemical synthetic drug are to be mostly the monomer medicine, and molecular weight is little, is easy to enter human body cell, therefore, instant effect more direct to the treatment of focus; And Chinese medicine is compound recipe (colony) medicine, and molecular weight is big, is the mixture of various chemical constituents, do not understand wherein function and the mechanism of action of each composition on cell and molecular level so far as yet, so it takes effect in treatment of diseases slowly.
Yet, adopt chemical synthetic drug treatment viral disease, so not only toxic and side effects is bigger, and particularly liver, the renal function to animal has certain influence, easily causes the animal drug disposition residual; Simultaneously also with environmental pollution, and medical expense is higher.
Traditional Antiphlogistic Powder of Schizonepetae and Ledebouriellae comes with some shortcomings, as impurity such as pesticide, heavy metal residue problem in the raw material of Chinese medicine.Harmful substance is residual does not solve for heavy metal in the raw material of Chinese medicine, pesticide, carcinogen etc., and the quality of Antiphlogistic Powder of Schizonepetae and Ledebouriellae is produced certain influence.Therefore, how providing that a kind of preparation technology is simple, pollution abatement is residual, the microbial fermentation preparation of the Jingfang toxicity-removing composition of good effect, instant effect, is that this technical field scientific research personnel needs one of new problem of exploitation badly.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of microbial fermentation preparation of Jingfang toxicity-removing composition is provided.
Technical scheme of the present invention is summarized as follows:
A kind of microbial fermentation preparation of Jingfang toxicity-removing composition is to make as follows:
(1) take by weighing by quality: the Radix Saposhnikoviae of the Poria of the Radix Angelicae Pubescentis of the Radix Bupleuri of the Rhizoma Et Radix Notopterygii of 2-8 part, 2-8 part, the Radix Peucedani of 2-8 part, 2-8 part, the Fructus Aurantii of 2-8 part, 2-8 part, the Herba Schizonepetae of 2-8 part, 2-8 part, the Radix Platycodonis of 2-8 part and the Rhizoma Chuanxiong of 2-8 part are raw material, adding raw material 2-8 quality water doubly decocts, filter, it is 0.2～2.0g/ml that filtrate is concentrated into concentration;
(2) be 1-3 by volume: 100 ratio, EM original solution is inoculated in the solution that described step (1) makes, 10～30 ℃, illumination condition bottom fermentation 1～5 month, make fermentation liquid;
(3) described fermentation liquid is separated, makes with extra care, sterilizes, make a kind of microbial fermentation preparation of Jingfang toxicity-removing composition.
Step (1) is preferably: take by weighing by quality: 4.5 parts Rhizoma Et Radix Notopterygii, 4.5 parts Radix Bupleuri, 4.5 parts Radix Peucedani, 4.5 parts Radix Angelicae Pubescentis, 4.5 parts Fructus Aurantii, 4.5 parts Poria, 4.5 parts Herba Schizonepetae, 4.5 parts Radix Saposhnikoviae, 4.5 parts Radix Platycodonis and 4.5 parts Rhizoma Chuanxiong are raw material, adding raw material 4-6 quality water doubly decocts, filter, it is 1.0g/ml that filtrate is concentrated into concentration.
EM original solution contains bacillus cereus, lactobacillus, yeast, light and antibacterial.
The present invention combines modern biotechnology and Chinese medicine prescription, microorganism is incorporated into carries out fermentating metabolism in the Jingfang toxicity-removing composition, the utilization that biotransformation function by microorganism and idiotrophic are worth, in the mode of combination among the strong ones, the microbial fermentation preparation of preparation Jingfang toxicity-removing composition.
Antiphlogistic Powder of Schizonepetae and Ledebouriellae heat-clearing and toxic substances removing, dispelling wind damp eliminating, strengthening vital QI to eliminate pathogenic factors, antibiotic, antiviral, antiulcer, dysentery relieving.Particularly, drug effect is brought into play more fully by the EM original solution fermentation.
Chemical compound of the present invention is suitable for treatment: 1, the hyperpyrexia that causes such as chicken atypical newcastle disease, fowl flu, infectious bursal disease, colibacillosis, infectious bronchitis, infectious laryngotracheitis, fowl cholera, loss of appetite, spirit is depressed, the hat whisker is livid purple, yellow green is shed tears, arranged to a swollen swollen face, dyspnea, snore, watery nasal discharge or blackish green loose stool, egg drop reduction and salpingitis, peritonitis, oophoritis, rubber egg, abnormal-shape egg such as increase at disease.
2, swine flue, epidemic diarrhea, innominate high fever, HUANGBAI(sic) dysentery etc.
The present invention has the following advantages and effect:
1, impurity such as the pesticide of traditional Antiphlogistic Powder of Schizonepetae and Ledebouriellae existence, heavy metal are residual.Harmful substance residue problems such as the heavy metal in the Chinese crude drug, pesticide, carcinogen are not resolved always, influence taking for a long time of Antiphlogistic Powder of Schizonepetae and Ledebouriellae.The present invention is incorporated into EM original solution and carries out fermentating metabolism in the Jingfang toxicity-removing composition, and the biotransformation function by EM original solution is the heavy metal in the medical material, pesticide, and carcinogen reduces or removes.
2, owing to production technology, conventional formulation need add the molding of a large amount of adjuvants ability, so dose is big, bioavailability is low.Preparation method of the present invention is handled through microbial fermentation, is small-molecule active substance with the macromolecular substances metabolism, has improved bioavailability, and absorption is rapid, complete, and has reduced dose.
3, the microbial fermentation preparation for preparing after the EM original solution metabolism of Jingfang toxicity-removing composition, the effect at aspects such as enhance immunity obviously strengthens, and is better than traditional Antiphlogistic Powder of Schizonepetae and Ledebouriellae.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of microbial fermentation preparation of Jingfang toxicity-removing composition is to make as follows:
(1) take by weighing by quality: 4.5 parts Rhizoma Et Radix Notopterygii, 4.5 parts Radix Bupleuri, 4.5 parts Radix Peucedani, 4.5 parts Radix Angelicae Pubescentis, 4.5 parts Fructus Aurantii, 4.5 parts Poria, 4.5 parts Herba Schizonepetae, 4.5 parts Radix Saposhnikoviae, 4.5 parts Radix Platycodonis and 4.5 parts Rhizoma Chuanxiong are raw material, adding raw material 4 quality water doubly decocts, filter, it is 1.0g/ml that filtrate is concentrated into concentration;
(2) be 2: 100 ratio by volume, EM original solution is inoculated in the solution that described step (1) makes,, make fermentation liquid 20～30 ℃, illumination condition bottom fermentation 2 months;
(3) described fermentation liquid is separated, makes with extra care, sterilizes, make a kind of oral formulations of microbial fermentation of Jingfang toxicity-removing composition.The preferred purple nonsulfur bacteria of EM original solution section antibacterial.
Embodiment 2
A kind of microbial fermentation preparation of Jingfang toxicity-removing composition is to make as follows:
(1) take by weighing by quality: 2 parts Rhizoma Et Radix Notopterygii, 5 parts Radix Bupleuri, 8 parts Radix Peucedani, 4 parts Radix Angelicae Pubescentis, 2 parts Fructus Aurantii, 8 parts Poria, 4 parts Herba Schizonepetae, 2 parts Radix Saposhnikoviae, 3 parts Radix Platycodonis and 8 parts Rhizoma Chuanxiong are raw material, adding raw material 6 quality water doubly decocts, filter, it is 0.2g/ml that filtrate is concentrated into concentration;
(2) be 1: 100 ratio by volume, EM original solution is inoculated in the solution that described step (1) makes,, make fermentation liquid 25～28 ℃, illumination condition bottom fermentation 5 months;
(3) described fermentation liquid is separated, makes with extra care, sterilizes, make a kind of microbial fermentation tablet of Jingfang toxicity-removing composition.
EM original solution contains bacillus cereus, lactobacillus, yeast, light and antibacterial.
Embodiment 3
A kind of microbial fermentation preparation of Jingfang toxicity-removing composition is to make as follows:
(1) take by weighing by quality: 8 parts Rhizoma Et Radix Notopterygii, 2 parts Radix Bupleuri, 2 parts Radix Peucedani, 8 parts Radix Angelicae Pubescentis, 4 parts Fructus Aurantii, 2 parts Poria, 2 parts Herba Schizonepetae, 5 parts Radix Saposhnikoviae, 2 parts Radix Platycodonis and 2 parts Rhizoma Chuanxiong are raw material, adding raw material 2 quality water doubly decocts, filter, it is 2.0g/ml that filtrate is concentrated into concentration;
(2) be 3: 100 ratio by volume, EM original solution is inoculated in the solution that described step (1) makes,, make fermentation liquid 10～20 ℃, illumination condition bottom fermentation 1 month;
(3) described fermentation liquid is separated, makes with extra care, sterilizes, make a kind of microbial fermentation preparation of Jingfang toxicity-removing composition.
EM original solution contains bacillus cereus, lactobacillus, yeast, light and antibacterial.
Embodiment 4
A kind of microbial fermentation preparation of Jingfang toxicity-removing composition is to make as follows:
(1) take by weighing by quality: 6 parts Rhizoma Et Radix Notopterygii, 8 parts Radix Bupleuri, 4 parts Radix Peucedani, 2 parts Radix Angelicae Pubescentis, 8 parts Fructus Aurantii, 4 parts Poria, 8 parts Herba Schizonepetae, 8 parts Radix Saposhnikoviae, 8 parts Radix Platycodonis and 4 parts Rhizoma Chuanxiong are raw material, adding raw material 8 quality water doubly decocts, filter, it is 1.0g/ml that filtrate is concentrated into concentration;
(2) be 1: 100 ratio by volume, EM original solution is inoculated in the solution that described step (1) makes,, make fermentation liquid 20～30 ℃, illumination condition bottom fermentation 4 months;
(3) described fermentation liquid is separated, makes with extra care, sterilizes, make a kind of microbial fermentation preparation of Jingfang toxicity-removing composition.
EM original solution contains bacillus cereus, lactobacillus, yeast, light and antibacterial.
Embodiment 5
Swine influenza is a kind of acute, the height contagious infection disease of pig that swine influenza virus causes, with unexpected generation, bamboo telegraph is feature, often full mass-sending is sick in short-term (2～3 days), the equal easy infection of the pig of all ages and classes, sex and kind.Pilosity is born in late fall and early spring and the cold winter that there was an abrupt change in weather, sickness rate about 100%.
1 clinical symptoms sudden onset, Chang Quanqun almost infects simultaneously.Sick temperature of pig body is elevated to 40.3～41.5 ℃ suddenly, sometimes can be up to 42 ℃.Loss of appetite, spirit is extremely tired, can not lie prostrate, and cough, snivel have sneeze, argol, short urination is red, and dyspnea is the sitting position of dog gesture sometimes, and the conjunctiva flushing is shed tears for two.
The microbial fermentation preparation of Jingfang toxicity-removing composition of the present invention is adopted in 2 treatments, and 30g/ days/pigs are divided clothes 2 times, serve on 3～4 days.
3 results adopt microbial fermentation preparation treatment swine influenza 63 examples of Jingfang toxicity-removing composition of the present invention, recovery from illness 60 examples after 5 days, and recovery from illness 2 examples after 7 days, 1 example is because of concurrent pneumonia death, and effect is very satisfied.
Claims (3)
1. the microbial fermentation preparation of a Jingfang toxicity-removing composition is characterized in that making as follows:
(1) take by weighing by quality: the Radix Saposhnikoviae of the Poria of the Radix Angelicae Pubescentis of the Radix Bupleuri of the Rhizoma Et Radix Notopterygii of 2-8 part, 2-8 part, the Radix Peucedani of 2-8 part, 2-8 part, the Fructus Aurantii of 2-8 part, 2-8 part, the Herba Schizonepetae of 2-8 part, 2-8 part, the Radix Platycodonis of 2-8 part and the Rhizoma Chuanxiong of 2-8 part are raw material, adding raw material 2-8 quality water doubly decocts, filter, it is 0.2～2.0g/ml that filtrate is concentrated into concentration;
(2) be 1-3 by volume: 100 ratio, EM original solution is inoculated in the solution that described step (1) makes, 10～30 ℃, illumination condition bottom fermentation 1～5 month, make fermentation liquid;
(3) described fermentation liquid is separated, makes with extra care, sterilizes, make a kind of microbial fermentation preparation of Jingfang toxicity-removing composition.
2. the microbial fermentation preparation of a kind of Jingfang toxicity-removing composition according to claim 1, it is characterized in that described step (1) is: take by weighing by quality: 4.5 parts Rhizoma Et Radix Notopterygii, 4.5 parts Radix Bupleuri, 4.5 parts Radix Peucedani, 4.5 parts Radix Angelicae Pubescentis, 4.5 parts Fructus Aurantii, 4.5 parts Poria, 4.5 parts Herba Schizonepetae, 4.5 parts Radix Saposhnikoviae, 4.5 parts Radix Platycodonis and 4.5 parts Rhizoma Chuanxiong are raw material, adding raw material 4-6 quality water doubly decocts, filter, it is 1.0g/ml that filtrate is concentrated into concentration.
3. the microbial fermentation preparation of a kind of Jingfang toxicity-removing composition according to claim 1 is characterized in that described EM original solution contains bacillus cereus, lactobacillus, yeast, light and antibacterial.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103463225A (en) * | 2013-09-11 | 2013-12-25 | 丁玉兰 | Traditional Chinese medicine micro-ecologic preparation for preventing and treating newcastle disease and preparation method thereof |
| CN112353863A (en) * | 2020-09-23 | 2021-02-12 | 鲁南制药集团股份有限公司 | Application of Jingfang preparation in preparation of medicine for treating gastric ulcer and preparation method of Jingfang preparation |
| CN114073731A (en) * | 2020-08-14 | 2022-02-22 | 鲁南制药集团股份有限公司 | A Chinese medicinal composition for treating abdominal pain and diarrhea |
| CN114146122A (en) * | 2020-09-08 | 2022-03-08 | 鲁南制药集团股份有限公司 | Traditional Chinese medicine composition for treating anorexia |
-
2008
- 2008-09-03 CN CN200810151221A patent/CN101664467A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103463225A (en) * | 2013-09-11 | 2013-12-25 | 丁玉兰 | Traditional Chinese medicine micro-ecologic preparation for preventing and treating newcastle disease and preparation method thereof |
| CN114073731A (en) * | 2020-08-14 | 2022-02-22 | 鲁南制药集团股份有限公司 | A Chinese medicinal composition for treating abdominal pain and diarrhea |
| CN114146122A (en) * | 2020-09-08 | 2022-03-08 | 鲁南制药集团股份有限公司 | Traditional Chinese medicine composition for treating anorexia |
| CN112353863A (en) * | 2020-09-23 | 2021-02-12 | 鲁南制药集团股份有限公司 | Application of Jingfang preparation in preparation of medicine for treating gastric ulcer and preparation method of Jingfang preparation |
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Open date: 20100310 |