CN101653451B - Health product for keeping joint health and increasing bone density and preparation method thereof - Google Patents
Health product for keeping joint health and increasing bone density and preparation method thereof Download PDFInfo
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- CN101653451B CN101653451B CN2009101698113A CN200910169811A CN101653451B CN 101653451 B CN101653451 B CN 101653451B CN 2009101698113 A CN2009101698113 A CN 2009101698113A CN 200910169811 A CN200910169811 A CN 200910169811A CN 101653451 B CN101653451 B CN 101653451B
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Abstract
The invention discloses a health product for keeping joint health and increasing bone density and a preparation method thereof. The health product comprises the following active components: glucosamine, chondroitin sulfate, a calcium agent, a copper agent, a manganese agent and vitamins, wherein the glucosamine is glucosamine sulfate, hydrochloride, phosphate or the mixture; auxiliary materials comprise an excipient, a disintegrant, a lubricant, an adhesive, a wetting agent and a coating pre-mixing agent. The health product contains vitamin D3 which can be used for supplementing mineral matters, such as calcium and the like for human bodies and promoting absorption and have treating and preventing functions for rheumatoid arthritis, degenerative arthritis and damaged joint motion. A tablet prepared by the method has the advantages of good disintegrating performance, quick dissolution and effect taking, optimal proportion of use amount of raw materials and various auxiliary materials, product stability enhancement and high absorption utilization rate.
Description
Technical field
The invention belongs to glucosamine Medicines and Health Product technical field, be specifically related to a kind of health product that are used for joint care and bone density improving and preparation method thereof.
Background technology
Osteoarthritis is common a kind of chronic arthritis, and people are always at the medicine of seeking and explore the osteoarthritis PD for many years.The people is after getting into person in middle and old age, and sclerotin is lost gradually, along with bone loss speeds up, when bone density is reduced to a certain degree, just can not keep the complete of skeletal structure, even compression, and under very little external force, can fracture, and is osteoporosis.Because the osteoporotic fracture sickness rate is high, poor prognosis and expend hugely, it brings very big psychology and life stress for patient and family, causes serious financial burden to society.Therefore, osteoporosis has become global public health problem, about the prevention of osteoporosis and complication thereof and treatment are the focuses of research at present.In addition, glucosamine is the most important monosaccharide of poly-glucosamine and proteoglycan in the formation articular cartilage substrate, and it can block the pathological process of osteoarthritis, and the progress that wards off disease is improved joint motion, alleviating pain, and do not have significant side effects.But owing to adjunct ingredient, there are problems such as product efficacy is single, absorption rate is low in the existing glucosamine class health food.In addition, the most difficult work is the particulate preparation of D-glucosamine and confirms specific adjuvant combination and ratio that the major part that can implement is in theory write out a prescription, and in the reality screening, does not all reach the prescription of tablet.The consumption of raw material and the improper ratio of various adjuvants makes and draws moist increase greatly, has reduced the stability of product.
Summary of the invention
The purpose of this invention is to provide a kind of health product that are used for joint care and bone density improving and preparation method thereof; Mineral such as collection is replenished the calcium, manganese, copper and joint care are one; It has solved problems such as product efficacy is single in the existing glucosamine class health food, absorption rate is low; Creatively screen and confirm to have the preparation of specific composition, the stability of product is strengthened, meet people's medication requirement more.
Technical solution of the present invention is to comprise active component and adjuvant, and described active component is glucosamine, chondroitin sulfate, and glucosamine is glucosamine sulphate or hydrochlorate or phosphate or its mixture; Adjuvant comprises excipient, disintegrating agent, lubricant, binding agent, wetting agent and coating pre-mixing agent; Said excipient is one or more the combination in starch, microcrystalline Cellulose, sucrose, lactose, dextrin, mannitol, the calcium phosphate; Disintegrating agent is one or more the combination in crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, the cross-linking sodium carboxymethyl cellulose; Lubricant is one or both the combination in magnesium stearate, micropowder silica gel, the Pulvis Talci; Binding agent is one or more the combination in polyvinylpyrrolidone, sodium carboxymethyl cellulose, starch, the hydroxypropyl emthylcellulose; Wetting agent is water or dehydrated alcohol, and the component of coating pre-mixing agent solution is one or more the mixing in titanium dioxide, polyoxyethylene, Pulvis Talci, Polyethylene Glycol, hydroxypropyl emthylcellulose, the lecithin.
Active component according to the invention also comprises following one or more mixing: calcium preparation, copper agent, manganese agent, vitamin; Described calcium preparation is a kind of in calcium gluconate, calcium chloride, calcium phosphate, calcium lactate or the calcium carbonate; Described copper agent is a kind of in copper gluconate, curpic carbonate, lysine complex copper, copper citrate, the copper sulfate; Described manganese agent is a kind of in manganese gluconate, manganese citrate, manganese sulfate, the chelating amino acids manganese; Said vitamin is a vitamin D
3
The weight proportion of each component according to the invention is following: 200～500 parts of glucosamine, 100～400 parts of chondroitin sulfate, 10～200 parts of calcium preparation, copper agent, manganese agent; 1～5 part of vitamin, 1～100 part of excipient, 1～20 part of binding agent; 1～30 part of disintegrating agent; 1～10 part of lubricant, 1～20 part of coating pre-mixing agent, wetting agent is an amount of.
The method for preparing that the present invention is used for the health product of joint care and bone density improving is to carry out according to the following steps:
1) 1～25% of prepare adhesive aqueous solution fully is dissolved to clear;
2) glucosamine is pulverized, crossed 60～120 mesh sieves;
3) with preheating in glucosamine, the chondroitin sulfate input fluid bed boiling granulating machine 1～10 minute;
4) solution that sprays into binding agent is granulated, control EAT and temperature of charge, and drying is crossed 12～20 mesh sieves;
5) in step 4 gained granule, add calcium preparation, copper agent, manganese agent, vitamin, excipient, disintegrating agent, lubricant and fully mix, measure tabletting behind the intermediate content;
6) preparation coating pre-mixing agent solution, compound concentration is 1～18%, EAT, sheet bed tempertaure, leaving air temp during the control coating, the tablet made to step 5 carries out coating.
The vitamin D that the present invention contains mineral such as the calcium that can replenish human body and promotes calcium absorption
3, good curing and preventive effect arranged to rheumatic arthritis and degenerative osteoarthritis and joint motions are impaired; The disintegration of tablet performance that this method makes is good, and stripping is fast, and onset is rapid, and the consumption of raw material and various adjuvants reaches optimal proportion, and the stability of product strengthens, and has the high characteristics of absorption rate.
The specific embodiment
The effect of chondroitin sulfate comprises: 1, the effect of skeletonization.The formation of animal bone is on the fiber that Organic substances such as collagen protein form, and inorganic salts such as deposition calcium, phosphorus form.Chondroitin sulfate plays a part positive in the deposition process of calcium.Calcium in the bone often is that stripping limit, limit is sedimentary: promptly the calcium one side is dissolved out from bone; Calcium in absorbing blood and deposition and form new bone are in a kind of homeostasis process bone all the time.If the chondroitin sulfate rope is not enough, the deposition of the calcium in the blood on bone will receive certain influence.If can absorb calcium and chondroitin sulfate together, can make sclerotin solid and suppress the generation of osteopathia effectively to a certain extent; 2, the effect of protection cartilage.Be positioned at the joint of the connecting portion of bone and bone, promptly the top of bone is made up of cartilage, and cartilage then mainly is to be made up of II collagen type and a large amount of proteoglycans.In the gap in joint, filled up by joint fluid, when pressurizeing for the joint repeatedly or when moving back and forth, joint fluid plays a part lubricated joint and protection joint, undertaking what suck cartilage to joint fluid is exactly chondroitin sulfate.It is generally acknowledged that cartilage is in case destruction just is difficult to regeneration.
Calcium is to keep important nutrient of bone health and the main component that constitutes bone mineral, and calcium has important effect as the main composition element of bone in bone formation and bone resorption.Vitamin D
3Can promote the absorption and the utilization of calcium, prevention is fallen, and reduces old people's fracture.Vitamin D
3Lacking the main pathological change that causes osteoporosis and fracture is exactly that bone loss increases and the reduction of bone mineralization process.Chondroitin sulfate also plays a part actively in the deposition process of calcium, absorbs calcium and chondroitin sulfate together, can make sclerotin solid and suppress the generation of osteopathia effectively to a certain extent; Glucosamine is the necessary important component of synthetic proteins polysaccharide in the cartilage matrix, can form and repair cartilage, helps to recover being connected of cartilage through it, for osteoarthritis and senile osteoporosis good preventing and health-care effect is arranged all; Manganese is the indispensable composition of normal bone structure, and manganese is participated in the formation of chondroitin sulfate, and manganese is the necessary mineral element of normal development of skeleton; Copper is positioned at the active site of enzyme with the form of metalloenzyme, improves the activity of lysyloxidase, and collagen fiber toughness is strengthened, the insoluble increase of collagen, thus increase the intensity of bone, and stress stimulation promotes the generation of new bone, with callus formation substantial connection is arranged.
The selection of disintegrating agent: disintegrating agent and kind and consumption are most important to disintegrate, the result of extraction of tablet, are the factors that at first will consider.The general disintegrating agent swellbility that requires to select for use is greater than 5ml/g, and the most frequently used have carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, a crospolyvinylpyrrolidone etc.On the consumption, should at first consider of the influence of the kind of disintegrating agent to the disintegration of tablet behavior, even but same disintegrating agent, the difference on the consumption also may produce diametrically opposite effect to the disintegrate behavior of tablet.As a kind of fast disintegrant efficiently, have good water absorption and dilatancy like carboxymethyl starch sodium, the back volume that fully expands can increase 200-300 doubly.When its consumption of control is in 7%; Can bring into play best disintegration; And in water, do not form stickiness solution and hinder tablet continuation disintegrate; Carboxymethyl starch sodium is bondd in water and form hydration shell and be higher than 8% consumption, stop the infiltration of moisture on the contrary, slow down the disintegrate of tablet in the sheet sub-surface.Test shows, prepare in the process and need grope at different pharmaceutical according to other adjuvant composition situation, for new medication preparation become tablet do not have can foundation ready-made composition proposal.
The selection of binding agent: some drugs itself or adjuvant mix afterwards inadhesion or stickiness is less; Can adopt the aqueous solution of hydrophilic polymeies such as polyvinylpyrrolidone and hydroxypropyl emthylcellulose is binding agent; Wherein commonly used with polyvinylpyrrolidone, seldom adopt starch slurry.It is bigger to adopt polyvinylpyrrolidone to do the particle surface hydrophilic that binding agent makes, and moisture is prone to infiltrate label and makes its quick disintegrate stripping behind the tabletting.The suitable composition and the ratio of considered binding agent are beneficial to the disintegrate of tablet during preparation.
The selection of other adjuvant: generally disintegrate in water of tablet; Suitable excipient can produce synergism to disintegrating agent; The normal good excipient of swellability that adopts like microcrystalline Cellulose, pregelatinized Starch and processing agar, can also be selected some lubricants such as magnesium stearate etc.
Through embodiment the present invention is done further specifying below, but be not limited only to following instance.
Embodiment: glucosamine 500g
Chondroitin sulfate 400g
Calcium preparation, copper agent, manganese agent 150g
Vitamin D
32.5g
Microcrystalline Cellulose 78.3g
Carboxymethyl starch sodium 30g
Polyvinylpyrrolidone 12g
Magnesium stearate 7.2g
Coating pre-mixing agent 20g
Prepare according to following step:
1) 10% of the configuration binding agent aqueous solution fully is dissolved to clear.
2) glucosamine is pulverized, crossed 120 mesh sieves.
3) with preheating in glucosamine, the chondroitin sulfate input fluidised bed granulator 10 minutes.
4) solution that sprays into binding agent is granulated, 45 ℃ of 60 ℃ of strict control EATs and temperature of charge, and drying is crossed 20 mesh sieves.
5) in step 4 gained granule, add calcium preparation, copper agent, manganese agent, vitamin D
3, excipient, disintegrating agent, lubricant fully mix, and measures tabletting behind the intermediate content by conventional method.
6) preparation coating pre-mixing agent solution, compound concentration is 15%, EAT, sheet bed tempertaure, leaving air temp during the control coating, the tablet made to step 5 carries out coating.
Claims (2)
1. health product that are used for joint care and bone density improving comprise active component and adjuvant, it is characterized in that each component and weight proportion thereof are following:
2. a kind of method for preparing that is used for the health product of joint care and bone density improving according to claim 1 is characterized in that carrying out according to the following steps:
1) 10% of prepare adhesive aqueous solution fully is dissolved to clear;
2) glucosamine is pulverized, crossed 120 mesh sieves;
3) with preheating in glucosamine, the chondroitin sulfate input fluidised bed granulator 10 minutes;
4) solution that sprays into binding agent is granulated, 45 ℃ of 60 ℃ of strict control EATs and temperature of charge, and drying is crossed 20 mesh sieves;
5) in step 4 gained granule, add calcium preparation, copper agent, manganese agent, vitamin D3, excipient, disintegrating agent, lubricant and fully mix, measure tabletting behind the intermediate content by conventional method;
6) preparation coating pre-mixing agent solution, compound concentration is 15%, EAT, sheet bed tempertaure, leaving air temp during the control coating, the tablet made to step 5 carries out coating.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101698113A CN101653451B (en) | 2009-09-04 | 2009-09-04 | Health product for keeping joint health and increasing bone density and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101698113A CN101653451B (en) | 2009-09-04 | 2009-09-04 | Health product for keeping joint health and increasing bone density and preparation method thereof |
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| CN101653451A CN101653451A (en) | 2010-02-24 |
| CN101653451B true CN101653451B (en) | 2012-07-18 |
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| CN2009101698113A Active CN101653451B (en) | 2009-09-04 | 2009-09-04 | Health product for keeping joint health and increasing bone density and preparation method thereof |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104621432A (en) * | 2013-11-12 | 2015-05-20 | 江苏艾兰得营养品有限公司 | Glucosamine composite tablets and preparation method thereof |
| CN104623120A (en) * | 2013-11-12 | 2015-05-20 | 江苏艾兰得营养品有限公司 | Weight reducing and liver protecting health product and preparation method thereof |
| CN103960669A (en) * | 2014-05-26 | 2014-08-06 | 苏州力谷生物科技有限公司 | Glucosamine health product capable of increasing bone nutrition and improving bone mineral density and preparation method of glucosamine health product |
| CN106138085A (en) * | 2015-03-25 | 2016-11-23 | 烟台宝备生物技术有限公司 | A kind of have medicine or the health food increasing bone density effect |
| CN104873534A (en) * | 2015-04-03 | 2015-09-02 | 广东先强药业有限公司 | Glucosamine chondroitin tablets and preparation technology thereof |
| CN111297932A (en) * | 2019-12-30 | 2020-06-19 | 江苏雅博动物健康科技有限责任公司 | Joint maintenance composite tablet for pets and preparation method thereof |
| CN114259042A (en) * | 2020-09-16 | 2022-04-01 | 山东荆卫生物科技有限公司 | Health food for increasing bone density and preventing and treating osteoarthritis and preparation method and application thereof |
| CN114224860B (en) * | 2021-11-06 | 2023-04-28 | 山东润德生物科技有限公司 | Glucosamine calcium tablet preparation and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1439313A (en) * | 2003-04-02 | 2003-09-03 | 李安虎 | Joint healthy beverage or food and preparation thereof |
| CN1562073A (en) * | 2003-05-07 | 2005-01-12 | 汤毅 | Non-injection preparation containing medium and/or low molecular weight chondroitin sulfate |
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2009
- 2009-09-04 CN CN2009101698113A patent/CN101653451B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1439313A (en) * | 2003-04-02 | 2003-09-03 | 李安虎 | Joint healthy beverage or food and preparation thereof |
| CN1562073A (en) * | 2003-05-07 | 2005-01-12 | 汤毅 | Non-injection preparation containing medium and/or low molecular weight chondroitin sulfate |
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| CN101653451A (en) | 2010-02-24 |
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Application publication date: 20100224 Assignee: Jiangsu Aland Nourishment Co.,Ltd. Assignor: Jiangshan Pharmaceutical Co., Ltd., Jiangsu Prov. Contract record no.: 2013320000489 Denomination of invention: Health product for keeping joint health and increasing bone density and preparation method thereof Granted publication date: 20120718 License type: Exclusive License Record date: 20130604 |
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Owner name: JIANGSU ALAND NOURISHMENT CO., LTD. Free format text: FORMER OWNER: JIANGSHAN PHARMACEUTICAL CO., LTD., JIANGSU PROV. Effective date: 20131022 |
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Effective date of registration: 20131022 Address after: 214500, Jiangshan Road, Jiangsu, Jingjiang 20 Patentee after: Jiangsu Aland Nourishment Co.,Ltd. Address before: 214500, Jiangshan Road, Jiangsu, Jingjiang 20 Patentee before: Jiangshan Pharmaceutical Co., Ltd., Jiangsu Prov. |