CN101636223B - 制备晶体的方法 - Google Patents

制备晶体的方法 Download PDF

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Publication number
CN101636223B
CN101636223B CN200880008925.3A CN200880008925A CN101636223B CN 101636223 B CN101636223 B CN 101636223B CN 200880008925 A CN200880008925 A CN 200880008925A CN 101636223 B CN101636223 B CN 101636223B
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China
Prior art keywords
solvent
flow rate
flow
ultrasonic
rate ratio
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CN200880008925.3A
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English (en)
Chinese (zh)
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CN101636223A (zh
Inventor
J·罗宾逊
G·吕克罗夫特
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Niox Healthcare Ltd
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Prosonix Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/02—Crystallisation from solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00105—Controlling the temperature by indirect heating or cooling employing heat exchange fluids part or all of the reactants being heated or cooled outside the reactor while recycling
    • B01J2219/0011—Controlling the temperature by indirect heating or cooling employing heat exchange fluids part or all of the reactants being heated or cooled outside the reactor while recycling involving reactant liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00105—Controlling the temperature by indirect heating or cooling employing heat exchange fluids part or all of the reactants being heated or cooled outside the reactor while recycling
    • B01J2219/00114—Controlling the temperature by indirect heating or cooling employing heat exchange fluids part or all of the reactants being heated or cooled outside the reactor while recycling involving reactant slurries

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CN200880008925.3A 2007-03-19 2008-03-18 制备晶体的方法 Active CN101636223B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0705159.2A GB0705159D0 (en) 2007-03-19 2007-03-19 Process for making crystals
GB0705159.2 2007-03-19
PCT/GB2008/050191 WO2008114052A1 (en) 2007-03-19 2008-03-18 Process for making crystals

Publications (2)

Publication Number Publication Date
CN101636223A CN101636223A (zh) 2010-01-27
CN101636223B true CN101636223B (zh) 2015-09-16

Family

ID=38008612

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880008925.3A Active CN101636223B (zh) 2007-03-19 2008-03-18 制备晶体的方法

Country Status (11)

Country Link
US (2) US9162160B2 (enExample)
EP (1) EP2134457B1 (enExample)
JP (2) JP2010522154A (enExample)
CN (1) CN101636223B (enExample)
BR (1) BRPI0809275A2 (enExample)
CA (1) CA2680105C (enExample)
ES (1) ES2701728T3 (enExample)
GB (2) GB0705159D0 (enExample)
IL (1) IL200802A (enExample)
RU (1) RU2456066C2 (enExample)
WO (1) WO2008114052A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
MX2011000410A (es) * 2008-07-18 2011-03-24 Prosonix Ltd Proceso para mejorar la cristalinidad de particulas de fluticasona.
GB0900080D0 (en) * 2009-01-06 2009-02-11 Prosonix Ltd An apparatus and process for producing crystals
GB0918431D0 (en) 2009-10-21 2009-12-09 Prosonix Ltd Process for improving crystallinity
EP2360147A1 (en) 2010-02-22 2011-08-24 CHIESI FARMACEUTICI S.p.A. Process for preparing crystalline particles of a salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino] ethyl]-2(1H)-quinolinone (carmoterol)
BR112012024059B1 (pt) 2010-04-01 2021-06-01 Chiesi Farmaceutici S.P.A. Processo de preparo de um excipiente para composições farmacêuticas em pó para inalação, partículas carreadoras para uma formulação farmacêutica de pó seco, composição farmacêutica em forma de pó seco para inalação e inalador de pó seco
US9278867B2 (en) 2010-12-30 2016-03-08 Yava Technologies Inc. Transition metal compound particles and methods of production
EP2500072A1 (en) 2011-03-15 2012-09-19 LEK Pharmaceuticals d.d. A novel process of residual solvent removal
GB201113662D0 (en) 2011-08-08 2011-09-21 Prosonix Ltd Pharmaceutical compositions
ES2639815T3 (es) * 2011-11-28 2017-10-30 Nanomakers Procedimiento de utilización de un contenedor
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
PL3517541T3 (pl) 2012-05-08 2020-12-28 Nicox Ophthalmics, Inc. Postać polimorficzna propionianu flutykazonu
CN102872612B (zh) * 2012-10-15 2013-11-27 中国工程物理研究院化工材料研究所 超声结晶器
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
GB201301721D0 (en) * 2013-01-31 2013-03-20 Prosonix Ltd Pharmaceutical Preparations
EP2950792A1 (en) 2013-01-31 2015-12-09 Prosonix Limited Pharmaceutical compositions comprising multi-component crystalline particles suitable for use in inhalation therapy
CN103172476A (zh) * 2013-04-08 2013-06-26 中国工程物理研究院化工材料研究所 一种亚微米颗粒1-氧-二氨基-3，5-二硝基吡嗪炸药的制备方法
US9469548B2 (en) * 2015-02-20 2016-10-18 Hydro Dynamics, Inc. Continuous hydrodynamic cavitation crystallization
CN105037253A (zh) * 2015-05-27 2015-11-11 上海应用技术学院 一种超声逼晶法提纯化合物的方法
CN105664816B (zh) * 2016-03-17 2017-11-03 杭州成功超声设备有限公司 将基于振幅控制的超声波设备用于化工装置的三步式方法
EP3369468A1 (en) * 2017-02-23 2018-09-05 Covaris, Inc. Acoustic energy-based control of particle count in crystallization
US10583085B2 (en) 2017-05-17 2020-03-10 Chiesi Farmaceutici S.P.A. Carrier particles for dry powder formulations for inhalation
AU2019311268B2 (en) 2018-07-27 2025-01-16 Chiesi Farmaceutici S.P.A. Novel carrier particles for dry powder formulations for inhalation
CN110330335A (zh) * 2019-07-19 2019-10-15 中国工程物理研究院化工材料研究所 铋基卤化物陶瓷材料、制备方法及x射线探测器
US11925907B2 (en) 2019-07-22 2024-03-12 Canopy Growth Corporation Continuous crystallization of cannabinoids in a stirred-tank reactor
CN110773079B (zh) * 2019-11-18 2022-03-01 江苏博迁新材料股份有限公司 一种超声喷雾法制备超细粉球的方法
CN112972384B (zh) * 2019-12-02 2022-03-18 长风药业股份有限公司 一种格隆溴铵和茚达特罗原料药微粉混合物的制备方法
GB2599890A (en) 2020-08-18 2022-04-20 Ashe Robert Improved loop reactor
CN114307840B (zh) * 2022-01-08 2022-09-16 安徽省农业科学院棉花研究所 一种有机配方肥热返料设备
CN115634635B (zh) * 2022-10-20 2025-03-18 江苏瑞祥化工有限公司 一种高纯度粒状2,5-二氯苯胺的制备装置及制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1620333A (zh) * 2002-01-22 2005-05-25 葛兰素集团有限公司 制备结晶颗粒的设备和方法
WO2006108572A2 (en) * 2005-04-08 2006-10-19 Glaxo Group Limited Novel crystalline pharmaceutical product

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2033254C1 (ru) * 1988-02-23 1995-04-20 Александр Петрович Пляскин Способ обработки материалов и устройство для его осуществления
GB9310030D0 (en) * 1993-05-15 1993-06-30 Scras Dry processed particles and process for the preparation of the same
US5874029A (en) * 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
DE69813254T2 (de) * 1997-08-05 2004-04-01 Microfluidics International Corp., Newton Hochdruck mischer-reaktor mit mehrfachströmen
US6465015B1 (en) * 1998-02-24 2002-10-15 Arch Chemicals, Inc. Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
AU755470B2 (en) * 1999-01-29 2002-12-12 Bristol-Myers Squibb Company Sonic impinging jet crystallization apparatus and process
GB9919693D0 (en) 1999-08-19 1999-10-20 Rhone Poulenc Rorer Ltd Process
GB9925934D0 (en) * 1999-11-03 1999-12-29 Glaxo Group Ltd Novel apparatus and process
US6620351B2 (en) * 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
GB0016040D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
GB0016002D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
GB0015981D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
JP2004530545A (ja) * 2001-05-05 2004-10-07 アクセンタス パブリック リミテッド カンパニー 微小結晶の形成方法および装置
US20030049323A1 (en) * 2001-08-29 2003-03-13 Hitt James E. Process to precipitate drug particles
GB0125604D0 (en) 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0219815D0 (en) * 2002-08-24 2002-10-02 Accentus Plc Preparation of small crystals
US20040197275A1 (en) * 2002-10-17 2004-10-07 Ecole Polytechnique Federale De Lausanne Process for the manufacture of powders of inhalable medicaments
GB0300339D0 (en) * 2003-01-08 2003-02-05 Bradford Particle Design Ltd Particle formation
CA2516733C (en) * 2003-02-21 2011-09-27 The University Of Bath Process for the production of particles
US20080194868A1 (en) * 2003-03-04 2008-08-14 Kozyuk Oleg V Hydrodynamic cavitation crystallization device and process
US7041144B2 (en) * 2003-03-04 2006-05-09 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization process
JP2004276334A (ja) 2003-03-13 2004-10-07 Ricoh Co Ltd 感熱記録材料
JP5207432B2 (ja) 2003-04-29 2013-06-12 エム・エス・ディー・オス・ベー・フェー アンチ溶媒凝固プロセス
US20060150892A1 (en) * 2003-04-29 2006-07-13 Akzo Nobel N.V. Processes Involving the Use of Antisolvent Crystallisation
GB0319797D0 (en) * 2003-08-26 2003-09-24 Leuven K U Res & Dev Particle size reduction of poorly soluble drugs
US7208106B2 (en) * 2003-10-24 2007-04-24 Ferro Corporation Method of forming particles
EP1688169A4 (en) * 2003-11-28 2008-10-01 Mitsubishi Chem Corp PROCESS FOR PRODUCING FINE PARTICLES OF AN ORGANIC COMPOUND
JP2005177746A (ja) * 2003-11-28 2005-07-07 Mitsubishi Chemicals Corp 有機化合物微粒子の製造方法
EP1993513A4 (en) * 2006-03-14 2012-06-27 Merck Sharp & Dohme METHOD AND DEVICE FOR PREPARING CRYSTALLINE ORGANIC MICROPARTICLE COMPOSITIONS USING MICROMATES AND CRYSTALLIZING MICROSAMEN AND THEIR USE
US20080075777A1 (en) * 2006-07-31 2008-03-27 Kennedy Michael T Apparatus and methods for preparing solid particles
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0711680D0 (en) * 2007-06-18 2007-07-25 Prosonix Ltd Process
EP2360147A1 (en) * 2010-02-22 2011-08-24 CHIESI FARMACEUTICI S.p.A. Process for preparing crystalline particles of a salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino] ethyl]-2(1H)-quinolinone (carmoterol)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1620333A (zh) * 2002-01-22 2005-05-25 葛兰素集团有限公司 制备结晶颗粒的设备和方法
WO2006108572A2 (en) * 2005-04-08 2006-10-19 Glaxo Group Limited Novel crystalline pharmaceutical product

Also Published As

Publication number Publication date
EP2134457A1 (en) 2009-12-23
CA2680105C (en) 2016-05-17
US20100018853A1 (en) 2010-01-28
JP5808830B2 (ja) 2015-11-10
CA2680105A1 (en) 2008-09-25
US20160001252A1 (en) 2016-01-07
US10143991B2 (en) 2018-12-04
JP2014094965A (ja) 2014-05-22
ES2701728T3 (es) 2019-02-25
IL200802A (en) 2013-04-30
RU2456066C2 (ru) 2012-07-20
US9162160B2 (en) 2015-10-20
GB2447761B (en) 2012-02-29
WO2008114052A1 (en) 2008-09-25
RU2009138325A (ru) 2011-04-27
GB0705159D0 (en) 2007-04-25
GB2447761A (en) 2008-09-24
IL200802A0 (en) 2010-05-17
EP2134457B1 (en) 2018-09-12
GB0804995D0 (en) 2008-04-16
CN101636223A (zh) 2010-01-27
JP2010522154A (ja) 2010-07-01
BRPI0809275A2 (pt) 2014-10-14

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