CN101623101B - Application of pectin polysaccharide in preparation of antiallergic food, medicine or cosmetic - Google Patents
Application of pectin polysaccharide in preparation of antiallergic food, medicine or cosmetic Download PDFInfo
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- CN101623101B CN101623101B CN2009100131399A CN200910013139A CN101623101B CN 101623101 B CN101623101 B CN 101623101B CN 2009100131399 A CN2009100131399 A CN 2009100131399A CN 200910013139 A CN200910013139 A CN 200910013139A CN 101623101 B CN101623101 B CN 101623101B
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Abstract
The invention relates to the application of pectin polysaccharide in the preparation of antiallergic food, medicine or cosmetic. The adopted technical scheme comprises: the antiallergic food, medicine or cosmetic contains the active ingredient of pectin polysaccharide which is prepared according to the method: pectin water solution with the mass percentage concentration of 1-2% is taken, the pH value of the pectin water solution is adjusted to be 2-4, the decomposition reaction is carried out for 15-24min at 95-120 DEG C, and pectin decomposition substance can be obtained; the obtained pectin decomposition substance is separated by a hollow fiber membrane or ceramic filtering membrane, and compound with the molecular weight of 6000 daltons is recovered, so that the pectin polysaccharide can be obtained. The invention has the advantages of safe use, no toxic side effect, good antiallergic effect and easy practical operation.
Description
Technical field
The invention belongs to additive and batching field, relate to a kind of application of pectin polysaccharide in preparation antiallergic food, medicine or cosmetics particularly with antianaphylaxis function.
Background technology
In recent years, because the variation of people life style and dietary structure, and the destruction of ecological environment; Automobile exhaust pollution; Factors such as plant pollen diffusion, the sickness rate of anaphylactic disease demonstrates trend of rising year by year in worldwide, and allergic symptom also is tending towards the multiformity performance gradually.According to the prediction of WHO, anaphylactic disease might become one of common in the world epidemic diseases.Anaphylactic disease is a kind of immune disease, and clinical manifestation is symptoms such as urticaria, allergic rhinitis, asthma, dyspnea, stomachache.The effective measures of treatment allergy are to seek out irritated incitant (anaphylactogen), but will in numerous incitants, find virulence factor difficulty very exactly.At present, the existing clinically medicine that much can suppress anaphylactic disease, but the effect of these medicines also only limits to the alleviation of provisional symptom, and be difficult to fundamentally improve allergic constitution.And these medicine majorities are chemical substance, have toxic and side effects, take for a long time and can cause many bad influences to health.Therefore, safety exploitation without any side effects, that have the food composition that suppresses irritated effect will become the urgent demand and the expectation of consumer.
Summary of the invention
In order to address the above problem, the purpose of this invention is to provide a kind of safe in utilizationly, have no side effect, have the application of food composition pectin polysaccharide in preparation antiallergic food, medicine or cosmetics of antianaphylaxis function.
To achieve these goals, the technical scheme of the present invention's employing is: in antiallergic food, medicine or the cosmetics, contain the effective ingredient pectin polysaccharide.Described pectin polysaccharide prepares as follows:
1) getting mass percentage concentration is 1%～2% pectin aqueous solution, and regulating pH is 2～4, at 95～120 ℃, and decomposition reaction 15min～24h; Or to get mass percentage concentration be 1%～2% pectin aqueous solution; Add pectin hydrolase or pectin lyase in the live ratio of unit of the enzyme of every gram pectin: 0.01～1.0Unit, at 30～50 ℃, pH is 2.5～4.5; Decomposition reaction 30min～24h obtains pectin decomposer;
Said pectin can be from plant tissue or its are squeezed the juice residue after the processing, the pectin that makes by common process.The common process of preparation pectin belongs to prior art.As: can be from plant (Fructus Mali pumilae, Citrus, Fructus Crataegi, Fructus Lycopersici esculenti; Fructus Solani melongenae etc.) tissue or its squeeze the juice in the residue after the processing through water (4～100 ℃, 3h), or acid (pH2～6,4～90 ℃; 3h), or saline solution (NaCl, EDTA, oxalates; Citrates etc. 3h) wait extraction, filter, and reclaim with ethanol precipitation and obtain pectin.Also can adopt various commercially available commercial pectin.
Preferably, pectin is pectin or the commercially available extensive stock pectin that fruit extracts in hawthorn pectin, apple pectin, the Citrus plant.
2) pectin decomposer that obtains is carried out separating treatment with hollow-fibre membrane or ceramic filter membrane, reclaim the above chemical compound of molecular weight 6000 dalton, promptly make the above pectin polysaccharide of molecular weight 6000 dalton.
The experiment of experimental example pectin polysaccharide hyaluronidase inhibitor:
Hyaluronidase extensively is present in the animal tissue, induces the decomposition as the hyaluronidase of animal tissue's constituent, can bring out inflammation.Numerous researchs show that the allergy of hyaluronidase and human body or inflammation have close dependency relation (Kakegawa et al., inflammation, 4,437-438,1984).Therefore, hyaluronidase is usually as the important targeting index (Kakegawa et al., J Phamacobio Dyn., 7s-96,1984) of screening Claritin or food.
This experimental example adopts pectin polysaccharide to suppress the antiallergic effect that the matter phytase activity is investigated pectin polysaccharide.
(1) sample preparation:
1) getting mass percentage concentration is 1% hawthorn pectin aqueous solution, and regulating pH is 3, and at 110 ℃, decomposition reaction 3h obtains the hawthorn pectin analyte;
Certainly pectin is not limited to hawthorn pectin, can adopt any commercially available pectin or from the residue after plant tissue or its processing of squeezing the juice, the pectin that makes by common process.Hawthorn pectin is adopted in this experiment.
2) the above-mentioned hawthorn pectin analyte that obtains is carried out separating treatment with hollow-fibre membrane, reclaim the chemical compound of molecular weight 6000 dalton above (sample P G I) and (sample P GII) below 6000 dalton respectively.Further use ultrafilter membrane (Pall Life Science) to be classified as the product of Mw 3000-6000 dalton (sample P GIII), Mw 1000-3000 (sample P GIV) and Mw＜three molecular weight sections of 1000 dalton (sample P GV) chemical compound below molecular weight 6000 dalton that reclaim again.Pectin, proto is as contrast (sample P G).
(2) experiment
(pH3.5,0.1M) hyaluronic acid potassium solution and the hyaluronic acid enzymatic solution of modulation 5.0mg/ml are respectively as the substrate and the enzyme liquid that react with acetate buffer solution.Get the sample solution 0.2ml that each supplies examination concentration, hyaluronic acid enzymatic solution 0.2ml, 37 ℃ of reaction 20min.After reactant liquor cools off, add 1.4ml hyaluronic acid potassium solution and 25ml CaCl in ice bath
2(25mM), fully behind the mix homogeneously, react 40min down at 37 ℃.Add 20 μ l NaOH (4.0M) cessation reactions, with the Morgan-Elson method N-acetylglucosamine content that detection reaction dissociates out at the 585nm place.
(3) result
Suppress the activity of hyaluronidase and use computes:
Suppression ratio %=(contrast absorbance one sample absorbance)/contrast absorbance * 100
Potassium hyaluronate, hyaluronidase and N-acetylglucosamine are the Sigma product.
The product sample of the variant molecular weight section that makes after pectin and the decomposition thereof is as shown in Figure 1 to the inhibition effect of hyaluronidase activity.Visible from Fig. 1; Pectin, proto is after pectase decomposes; The macromolecule that classification obtains (Mw＞6000) pectin polysaccharide has very strong inhibitory action to hyaluronidase; And along with the reducing of pectin oligosaccharide molecular amount, its inhibitory action weakens to some extent, and molecular weight is higher than 6000 daltonian pectin polysaccharides the inhibition activity of the hyaluronidase activity than Pectin, proto is also slightly raise simultaneously.That is to say that pectin and enzymatic hydrolysate thereof have certain inhibitory action to the anaphylaxis of human body, but, be unfavorable for using operation because pectin viscosity is high, and dissolubility is little.And pectin is through the molecular weight that decomposes and further reclaim low, the soluble in water characteristics that have viscosity greater than the chemical compound more than 6000 dalton.Molecular weight is higher than 6000 daltonian pectin polysaccharides hyaluronidase is had very strong inhibitory action, can be used as the antiallergic food composition with important physiological function.
The invention has the beneficial effects as follows: adopt method of the present invention, the pectin catabolite that pectin obtains after decomposing has viscosity hardly.The above pectin polysaccharide of molecular weight 6000 dalton that reclaimed has fine solubility equally, and its aqueous solution do not have viscosity equally, is easy to actual manipulating.
The above pectin polysaccharide of molecular weight 6000 dalton of the present invention's preparation can use separately, or uses with other batch mixes, or mixes use with other materials with anti-allergic effects, preparation antiallergic food, medicine or cosmetics.
When the above pectin polysaccharide of molecular weight 6000 dalton of the present invention's preparation is used, join in the food preparation antiallergic food as food ingredient in the preparation antiallergic food.The recommendation use amount of pectin polysaccharide in food: be 0.01～1.0% by mass percentage.When pectin polysaccharide joins in the food, the food classification is had no particular limits, its food can be solid type body, also can be fluid.For example can be beverage, cake, various Flour product, meat products, egg products etc.In order to regulate character such as flavours in food products, mouthfeel, stability, shelf-life, nutritive peculiarity, in containing the food of pectin polysaccharide, also can add corresponding flavoring agent, antistaling agent, stabilizing agent, coloring agent, food additives such as nutritional auxiliary.When making food, by mass percentage pectin polysaccharide is added in the routine batching of making beverage, cake, various Flour product, meat products or egg products, mix homogeneously is processed by its conventional processing technology then, makes various antiallergic foods.Not only improved allergic constitution crowd's recipe, scope is taken in the nutrition that has also increased these crowds.
The health product that pectin polysaccharide also can be processed into various forms use, like health beverage, electuary, tablet, capsule etc.Can also pectin polysaccharide be processed capsule separately, or make tablet, antianaphylactic health product such as electuary with mixed with excipients commonly used.
When the above pectin polysaccharide of molecular weight 6000 dalton of the present invention preparation is used in preparation antiallergic medicine, can use separately or unite use, add in the medicine, prepare the antiallergic medicine as antiallergic synergist and other Claritins.Pectin polysaccharide as effective ingredient in preparation during Claritin; Can process shapes such as various tablets, electuary, capsule, oral liquid by the method for the generally acknowledged routine of industry together with the conventional excipient of pharmaceutical purpose, the content of pectin polysaccharide in medicine is advisable with mass percent 2～5%.
When the above pectin polysaccharide of molecular weight 6000 dalton of the present invention's preparation is used in preparation antiallergic cosmetics; Can use separately or unite use with material with antianaphylaxis components; Add in the cosmetics, behind the mix homogeneously, preparation has the cosmetics of antiallergic effect.The content of pectin polysaccharide in cosmetics is advisable with mass percent 0.01-0.1%.As in cream, emollient cream, sunscreen cream, essence cream or the emulsion etc. bought on the market, add pectin polysaccharide by mass percentage by the inventive method preparation, mix homogeneously is the cosmetics with antiallergic effect.Because pectin polysaccharide can not cause damage to skin matter, has satisfied the crowd demand of anaphylaxis skin matter.
Description of drawings
Fig. 1 is pectin and analyte thereof the inhibition design sketch to hyaluronidase activity.
The specific embodiment
Embodiment 1 contains the antiallergic food of pectin polysaccharide
(1) preparation of pectin polysaccharide
1) with Fructus Crataegi or the residue after squeezing the juice through water (50～100 ℃), extracted 3 hours, by the pectin recovery method of routine, use ethanol precipitation, reclaim hawthorn pectin.
2) getting mass percentage concentration is 1% hawthorn pectin aqueous solution, and regulating pH is 4, and at 120 ℃, decomposition reaction 3h obtains the hawthorn pectin analyte;
3) the hawthorn pectin analyte that obtains is carried out separating treatment with hollow-fibre membrane or ceramic filter membrane, reclaim the above chemical compound of molecular weight 6000 dalton, promptly obtain the above pectin polysaccharide of molecular weight 6000 dalton.
(2) contain the preparation of the antiallergic food of pectin polysaccharide
With the pectin polysaccharide of above-mentioned preparation, as batching, when making cake; 0.01～1.0% amount and flour by mass percentage; Egg, the conventional batch mixes when milk and sugar etc. are made cake is even, by the making cake technology of routine; Toast, make the antiallergic cake that contains pectin polysaccharide.
For the local flavor of regulating cake, mouthfeel, stability, shelf-life, nutritive peculiarity etc., also can add corresponding flavoring agent, antistaling agent, stabilizing agent, coloring agent, food additives such as nutritional auxiliary are like Rhizoma et radix valerianae, pigment, vitamin or trace element etc.
Can certainly be with the pectin polysaccharide of above-mentioned preparation as antianaphylactic effective ingredient, 0.01～1.0% amount joins in the routine batching of beverage by mass percentage, makes the antiallergic beverage; Join in the routine batching of various wheaten food, make various antiallergic wheaten food; Join in the batching of meat products or egg products, make antianaphylactic meat products or egg products.
(1) preparation of pectin polysaccharide
1) Fructus Mali pumilae is squeezed the juice after the processing, the residue of squeezing the juice extracts after 3 hours through oxalic acid solution (pH2～6,50～90 ℃), filters, and filtrating is used ethanol precipitation by the pectin recovery method of routine, and recovery obtains apple pectin.
2) getting mass percentage concentration is 2% apple pectin aqueous solution, and regulating pH is 2, and at 95 ℃, decomposition reaction 3h obtains the apple pectin analyte;
3) the apple pectin analyte that obtains is carried out separating treatment with hollow-fibre membrane, reclaim the above chemical compound of molecular weight 6000 dalton, promptly obtain the above pectin polysaccharide of molecular weight 6000 dalton.
(2) contain the preparation of the antiallergic health product of pectin polysaccharide
With the pectin polysaccharide of above-mentioned preparation, as effective ingredient, when making oral liquid, 0.01～1.0% amount with agar oligosaccharide, Folium perillae extract and pure water mix homogeneously, is made the antiallergic oral liquid by prior art by mass percentage.
Certainly, also can be with pectin polysaccharide and other food or its composition of above-mentioned preparation with antianaphylaxis function, as: agar oligosaccharide, beta-carotene; Tea polyphenols, Fructus Jujubae extract, Folium perillae extract; Sweet tea extract, propolis extract, one or more of Herba Alii fistulosi, Bulbus Allii extract etc.; And/or excipient, as starch, dextrin, lactose one or more etc. mix homogeneously, be made into antiallergic health product such as electuary, tablet, capsule.Or use pectin polysaccharide and mixed with excipients even separately, or use pectin polysaccharide separately, be made into antiallergic health product such as electuary, tablet, capsule.
Embodiment 3 contains the antiallergic medicine of pectin polysaccharide
(1) preparation of pectin polysaccharide
1) with the mandarin orange leather bag through hydrochloric acid (pH2～6,50～90 ℃), extracts after 3 hours, filter, filtrating is used ethanol precipitation by the pectin recovery method of routine, recovery obtains citrus pectin.
2) getting mass percentage concentration is 1% citrus pectin solution, adds pectin hydrolase in the live ratio of unit of the enzyme of every gram pectin: 0.01Unit, and at 30 ℃, pH is 2.5, and decomposition reaction 3h obtains the citrus pectin analyte;
3) the citrus pectin analyte that obtains is carried out separating treatment with ceramic filter membrane, reclaim the above chemical compound of molecular weight 6000 dalton, promptly obtain the above pectin polysaccharide of molecular weight 6000 dalton.
(2) contain the preparation of the antiallergic medicine of pectin polysaccharide
With the pectin polysaccharide of above-mentioned preparation, as the antiallergic synergist, 2～5% amount by mass percentage, with mass percent be 1～3% Semen Ginkgo extrac, and starch and lactose mix homogeneously are by prior art making antiallergic medicine.Empirical tests adopts the antiallergic medicine that has added pectin polysaccharide, than using the Claritin that only contains Semen Ginkgo extrac to have antiallergic effect preferably.
Certainly, pectin polysaccharide also can with existing Claritin such as piperazines, amino ethers, LEVO CITRAZINE, Fexofenadine fourth, Desloratadine, Efletirizine, one or more of Claritin compositions such as this fourth of imidazoles; And/or Radix Tripterygii Wilfordii extract, Semen Ginkgo extrac, Radix Scutellariae extract; Folium Engelhardia roxburghina extrat, Rhizoma Anemones flaccidae general glycoside, Rhizoma Menispermi total bases; Sodium ferulate, GEGEN TANG, XIAOQINGLONG TANG; The Zhengchaihuyin granule, wind-repellent itching-relieving granules, one or more of the Chinese medicine compound of the rash that disappears capsule etc. or Chinese medicine extract are united use; Or use pectin polysaccharide separately, process various tablets, electuary, capsule, oral liquid or medicine for external use such as external smears, medicines such as dropping liquid with the conventional excipient of pharmaceutical purpose by the method for the generally acknowledged routine of industry.
Embodiment 4 contains the antiallergic cosmetics of pectin polysaccharide
(1) preparation of pectin polysaccharide
1) getting mass percentage concentration is 2% hawthorn pectin aqueous solution, adds pectin hydrolase in the live ratio of unit of the enzyme of every gram pectin: 1.0Unit, and at 40 ℃, pH is 3.5, and decomposition reaction 3h obtains the hawthorn pectin analyte;
2) the hawthorn pectin analyte that obtains is carried out separating treatment with ceramic filter membrane, reclaim the above chemical compound of molecular weight 6000 dalton, promptly obtain the above pectin polysaccharide of molecular weight 6000 dalton.
(2) contain the preparation of the antiallergic cosmetics of pectin polysaccharide
With the pectin polysaccharide of above-mentioned preparation, 0.05% amount and commercial emollient cream mix homogeneously prepare the emollient cream with antiallergic effect by mass percentage.
Certainly; Crowd with anaphylaxis skin matter; Can be with the cosmetics of buying arbitrarily, like emulsion, essence cream, cream, foundation emulsion or emollient cream etc., 0.01～0.1% amount by mass percentage; Add pectin polysaccharide, promptly make corresponding cosmetics with antiallergic effect by method preparation of the present invention.Because pectin polysaccharide is a food composition, chafe can not damage skin, has therefore satisfied anaphylaxis skin matter crowd's demand.
The embodiment that provides above, they just realize reliable illustration of the present invention, the purpose of enumerating the foregoing description is to specify the present invention, and and unrestricted interest field of the present invention.The present invention can have various ways in the scope that does not exceed its technical thought.Employed pectin in the foregoing description is not limited to given pectin, can use other pectin or commercially available pectin.Batching such as flavoring agent when making food, medicine and cosmetics, antistaling agent, stabilizing agent; Coloring agent, nutritional auxiliary, excipient etc., these all are materials commonly used in the prior art; Claritin can adopt in the prior art, the medicine of clinical public use and checking.Inventive point of the present invention is pectin polysaccharide to add in the batching as antianaphylactic effective ingredient or antiallergic synergist, makes antiallergic food, medicine and cosmetics.
Claims (5)
1. the application of pectin polysaccharide in preparation antiallergic food, medicine or cosmetics is characterized in that: in antiallergic food, medicine or the cosmetics, contain the effective ingredient pectin polysaccharide;
Wherein, described pectin polysaccharide prepares as follows:
1) getting mass percentage concentration is 1%～2% pectin aqueous solution, and regulating pH is 2～4, at 95～120 ℃, and decomposition reaction 15min～24h; Or to get mass percentage concentration be 1%～2% pectin aqueous solution; Add pectin hydrolase or pectin lyase in the live ratio of unit of the enzyme of every gram pectin: 0.01～1.0Unit, at 30～50 ℃, pH is 2.5～4.5; Decomposition reaction 30min～24h obtains pectin decomposer;
2) pectin decomposer that obtains is carried out separating treatment with hollow-fibre membrane or ceramic filter membrane, reclaim the above chemical compound of molecular weight 6000 dalton, make the above pectin polysaccharide of molecular weight 6000 dalton;
Described pectin is hawthorn pectin, apple pectin or citrus pectin.
2. according to the application of the described pectin polysaccharide of claim 1 in preparation antiallergic food, medicine or cosmetics; It is characterized in that using separately pectin polysaccharide; Or pectin polysaccharide and material with anti-allergic effects are united use; Add in food, medicine or the cosmetics preparation antiallergic food, medicine or cosmetics to.
3. according to the application of the described pectin polysaccharide of claim 2 in preparation antiallergic food, medicine or cosmetics, it is characterized in that the content of pectin polysaccharide in antiallergic food is: be 0.01～1.0% by mass percentage.
4. according to the application of the described pectin polysaccharide of claim 2 in preparation antiallergic food, medicine or cosmetics, it is characterized in that the content of pectin polysaccharide in the antiallergic medicine is: be 2～5% by mass percentage.
5. according to the application of the described pectin polysaccharide of claim 2 in preparation antiallergic food, medicine or cosmetics, it is characterized in that the content of pectin polysaccharide in the antiallergic cosmetics is: be 0.01～0.1% by mass percentage.
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| CN102907671B (en) * | 2012-10-23 | 2013-12-11 | 浙江大学 | Preparation method and application of pectin enzymatic hydrolysis product having functions of dispelling effects of alcohol and resisting drunk |
| CN104522455A (en) * | 2014-12-26 | 2015-04-22 | 北京蜜蜂堂生物医药股份有限公司 | Saussurea involucrate culture honey cream and preparation method thereof |
| CN104522450A (en) * | 2014-12-26 | 2015-04-22 | 北京蜜蜂堂生物医药股份有限公司 | Corn oligopeptide pollen and preparation method thereof |
| CN104686883A (en) * | 2015-02-13 | 2015-06-10 | 邵素英 | Bee pollen for protecting liver and enhancing human immunity and preparation method thereof |
| CN104686884A (en) * | 2015-02-13 | 2015-06-10 | 邵素英 | Bee pollen containing corn oligopeptide and preparation method of bee pollen |
| CN104686886A (en) * | 2015-02-13 | 2015-06-10 | 邵素英 | Efficient saussurea involucrate culture and honey paste and preparation method thereof |
| CN104719912A (en) * | 2015-02-13 | 2015-06-24 | 邵素英 | Snow lotus culture-honey paste with relatively high biological activity and preparation method of snow lotus culture-honey paste |
| CN104643225A (en) * | 2015-03-10 | 2015-05-27 | 邵素英 | Liquorice vegetable drink for improving gastrointestinal function and enhancing immunity and preparation method of liquorice vegetable drink |
| CN104664513A (en) * | 2015-03-11 | 2015-06-03 | 邵素英 | Licorice plant beverage and preparation method thereof |
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| CN101153304A (en) * | 2007-09-21 | 2008-04-02 | 天津农学院 | Acidity oligosaccharide of pectin and its use |
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| 石启田.银杏型果胶的提取及开发应用前景.《林业实用技术》.2008,(第1期), * |
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