CN101611012B - 环烷基胺取代的异喹啉衍生物 - Google Patents

环烷基胺取代的异喹啉衍生物 Download PDF

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Publication number
CN101611012B
CN101611012B CN200780048527XA CN200780048527A CN101611012B CN 101611012 B CN101611012 B CN 101611012B CN 200780048527X A CN200780048527X A CN 200780048527XA CN 200780048527 A CN200780048527 A CN 200780048527A CN 101611012 B CN101611012 B CN 101611012B
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alkyl
alkylene
heterocyclyl
aryl
halogen
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Expired - Fee Related
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CN101611012A (zh
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O·普来登伯格
A·霍夫迈斯特
D·卡德莱特
S·波伊克特
S·鲁夫
M·勒恩
P·莫内克
A·施弗尔
A·坎特
M·科尔曼
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Sanofi SRL
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Sanofi Aventis SpA
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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CN200780048527XA 2006-12-27 2007-12-19 环烷基胺取代的异喹啉衍生物 Expired - Fee Related CN101611012B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026894 2006-12-27
EP06026894.3 2006-12-27
PCT/EP2007/011167 WO2008077554A1 (en) 2006-12-27 2007-12-19 Cycloalkylamine substituted isoquinoline derivatives

Publications (2)

Publication Number Publication Date
CN101611012A CN101611012A (zh) 2009-12-23
CN101611012B true CN101611012B (zh) 2012-11-14

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US (1) US8710228B2 (cg-RX-API-DMAC7.html)
EP (1) EP2125746B1 (cg-RX-API-DMAC7.html)
JP (1) JP5405316B2 (cg-RX-API-DMAC7.html)
KR (1) KR20090092303A (cg-RX-API-DMAC7.html)
CN (1) CN101611012B (cg-RX-API-DMAC7.html)
AT (1) ATE554072T1 (cg-RX-API-DMAC7.html)
AU (1) AU2007338410B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0721180A2 (cg-RX-API-DMAC7.html)
CA (1) CA2673920C (cg-RX-API-DMAC7.html)
IL (1) IL199539A (cg-RX-API-DMAC7.html)
MX (1) MX2009005964A (cg-RX-API-DMAC7.html)
MY (1) MY151953A (cg-RX-API-DMAC7.html)
NO (1) NO20092432L (cg-RX-API-DMAC7.html)
SV (1) SV2009003317A (cg-RX-API-DMAC7.html)
WO (1) WO2008077554A1 (cg-RX-API-DMAC7.html)

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EP2526948A1 (en) 2006-09-20 2012-11-28 Aerie Pharmaceuticals, Inc. RHO kinase inhibitors
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
GB0719644D0 (en) 2007-10-05 2007-11-14 Cancer Rec Tech Ltd Therapeutic compounds and their use
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
GB0803018D0 (en) * 2008-02-19 2008-03-26 Cancer Rec Tech Ltd Therapeutic compounds and their use
PL2313374T3 (pl) * 2008-06-24 2014-03-31 Sanofi Sa 6-podstawione izochinoliny i izochinolinony
BRPI0914330A2 (pt) * 2008-06-24 2019-09-24 Sanofi Aventis derivados de isoquinolina e isoquinolinona substituídos bl-e policíclicos
US8541449B2 (en) * 2008-06-24 2013-09-24 Sanofi Substituted isoquinolines and isoquinolinones as Rho kinase inhibitors
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
ES2834451T3 (es) 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Inhibidores de mecanismo doble para el tratamiento de enfermedades
CA2764124C (en) 2009-06-19 2016-12-13 D. Western Therapeutics Institute, Inc. Substituted isoquinoline derivative
JP6073910B2 (ja) 2011-11-09 2017-02-01 キャンサー・リサーチ・テクノロジー・リミテッド ５−（ピリジン−２−イル−アミノ）−ピラジン−２−カルボニトリル化合物及びその治療使用
KR20210156333A (ko) 2012-05-15 2021-12-24 캔써 리서치 테크놀로지 리미티드 5-[[4-[[모르폴린-2-일]메틸아미노]-5-(트리플루오로메틸)-2-피리딜]아미노]피라진-2-카보니트릴 및 그의 치료적 용도
CN110396085B (zh) 2013-03-15 2024-11-15 爱尔康公司 联合治疗
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
WO2017086941A1 (en) 2015-11-17 2017-05-26 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
CN109640966A (zh) 2016-08-31 2019-04-16 爱瑞制药公司 眼用组合物
BR112019019555A2 (pt) 2017-03-30 2020-04-22 Hoffmann La Roche composto de fórmula i, composição farmacêutica, método de inibição de hpk1, método para melhorar uma resposta imune, método para tratar um distúrbio e uso do composto
KR20190135027A (ko) 2017-03-31 2019-12-05 에어리 파마슈티컬즈, 인코포레이티드 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물
CN108997222A (zh) * 2018-07-23 2018-12-14 山东省农药科学研究院 一种氟嘧菌酯中间体4,6-二氯-5-氟嘧啶的合成方法
CN112601584A (zh) * 2018-07-24 2021-04-02 豪夫迈·罗氏有限公司 异喹啉化合物及其用途
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
TW202024053A (zh) 2018-10-02 2020-07-01 美商建南德克公司 異喹啉化合物及其用途
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof
CN111574413B (zh) * 2020-06-08 2022-04-05 杭州尚合生物医药科技有限公司 一种2-氨甲基吡啶与dmf-dma作为胺源的磺酰脒的制备方法
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
CN115572262B (zh) * 2022-10-27 2024-08-27 厦门沃克沃德医药科技有限公司 一种异喹啉衍生物及其制备方法

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AU2007338410B2 (en) 2012-08-16
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