CN101595389A - 用于变应原活性测定的标准血清混合物的制备方法及其用途 - Google Patents

用于变应原活性测定的标准血清混合物的制备方法及其用途 Download PDF

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CN101595389A
CN101595389A CNA200780046311XA CN200780046311A CN101595389A CN 101595389 A CN101595389 A CN 101595389A CN A200780046311X A CNA200780046311X A CN A200780046311XA CN 200780046311 A CN200780046311 A CN 200780046311A CN 101595389 A CN101595389 A CN 101595389A
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serum
slge
allergen
mixture
deviation
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CN101595389B (zh
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胡赓熙
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Zhejiang Wolwo Biotech Co ltd
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Zhejiang Wolwo Biotech Co ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
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  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
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  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
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Abstract

一种制备用于变应原活性测定的标准血清混合物的方法以及该血清混合物的应用，所述方法包括如下步骤：1)提供多份针对所述变应原中等程度过敏的患者的血清；2)测定每份血清中针对所述变应原的sIgE相对含量，获得所述每份血清的sIgE相对含量的平均值，以及每份血清sIgE相对含量相对于该平均值的偏差值；3)除去偏差值最大和偏差值最小的各至少5％份数的血清，将剩余血清等体积混合。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN200780046311XA 2006-12-14 2007-12-14 用于变应原活性测定的标准血清混合物的制备方法及其用途 Active CN101595389B (zh)

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Application Number Priority Date Filing Date Title
CN200780046311XA CN101595389B (zh) 2006-12-14 2007-12-14 用于变应原活性测定的标准血清混合物的制备方法及其用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN200610147239.7 2006-12-14
CN200610147239 2006-12-14
CN200780046311XA CN101595389B (zh) 2006-12-14 2007-12-14 用于变应原活性测定的标准血清混合物的制备方法及其用途
PCT/CN2007/071230 WO2008086721A1 (fr) 2006-12-14 2007-12-14 Procédé de préparation d'un mélange de sérum ordinaire en vue de déterminer l'activité d'un allergène et application du mélange de sérum

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CN101595389A true CN101595389A (zh) 2009-12-02
CN101595389B CN101595389B (zh) 2012-10-10

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US (1) US8263345B2 (zh)
EP (1) EP2124064B1 (zh)
JP (1) JP5033195B2 (zh)
CN (1) CN101595389B (zh)
AT (1) ATE552506T1 (zh)
DK (1) DK2124064T3 (zh)
WO (1) WO2008086721A1 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101915850A (zh) * 2010-07-28 2010-12-15 中国兽医药品监察所 猪瘟阴、阳性血清标准物质及其制备方法
CN109142742A (zh) * 2018-07-19 2019-01-04 江苏浩欧博生物医药股份有限公司 一种过敏原特异性IgE抗体质控品及其制备方法
CN113125744A (zh) * 2019-12-31 2021-07-16 江苏众红生物工程创药研究院有限公司 脱敏治疗药物的活性检测方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102539748A (zh) * 2011-12-30 2012-07-04 苏州浩欧博生物医药有限公司 一种利用酶联板进行多指标酶联免疫吸附检测的方法
WO2016058237A1 (zh) * 2014-10-17 2016-04-21 苏州浩欧博生物医药有限公司 一种过敏原阳性血清的纯化制备方法
CN111175512A (zh) * 2018-11-09 2020-05-19 北京新华联协和药业有限责任公司 一种蒿属花粉特异性IgE抗体标准血清的制备和检验

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4528267A (en) * 1982-11-26 1985-07-09 Axionics, Inc. Fluorometirc enzyme inhibition immunoassay for measuring potency of allergen extracts
JPH05113443A (ja) * 1991-04-26 1993-05-07 Toray Ind Inc 酵素免疫測定方法
DE4133945A1 (de) * 1991-10-14 1993-04-15 Behringwerke Ag Kuenstliche standard- und kontrollseren, verfahren zu ihrer herstellung und ihre verwendung
BE1012448A3 (fr) * 1998-12-07 2000-11-07 S C R L Dept Central De Fracti Standard utilise dans des tests de diagnostic et/ou de quantification.
US6548646B1 (en) * 2001-08-23 2003-04-15 Bio-Rad Laboratories, Inc. Reference control for high-sensitivity C-reactive protein testing
US7786264B2 (en) * 2001-11-08 2010-08-31 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd Monoclonal antibody against hepatitis E virus or its fragment with binding activity and use thereof
CN1208089C (zh) * 2002-10-24 2005-06-29 胡赓熙 用于治疗过敏性疾病的药物及其制备方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101915850A (zh) * 2010-07-28 2010-12-15 中国兽医药品监察所 猪瘟阴、阳性血清标准物质及其制备方法
CN109142742A (zh) * 2018-07-19 2019-01-04 江苏浩欧博生物医药股份有限公司 一种过敏原特异性IgE抗体质控品及其制备方法
CN113125744A (zh) * 2019-12-31 2021-07-16 江苏众红生物工程创药研究院有限公司 脱敏治疗药物的活性检测方法

Also Published As

Publication number Publication date
US8263345B2 (en) 2012-09-11
EP2124064A4 (en) 2010-07-21
JP2010512520A (ja) 2010-04-22
CN101595389B (zh) 2012-10-10
WO2008086721A1 (fr) 2008-07-24
EP2124064A1 (en) 2009-11-25
EP2124064B1 (en) 2012-04-04
DK2124064T3 (da) 2012-07-09
US20100021946A1 (en) 2010-01-28
JP5033195B2 (ja) 2012-09-26
ATE552506T1 (de) 2012-04-15

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