CN101589061B - 结合il-17a和il-17f的抗体分子 - Google Patents

结合il-17a和il-17f的抗体分子 Download PDF

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CN101589061B
CN101589061B CN200780043116.1A CN200780043116A CN101589061B CN 101589061 B CN101589061 B CN 101589061B CN 200780043116 A CN200780043116 A CN 200780043116A CN 101589061 B CN101589061 B CN 101589061B
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antibody
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CN101589061A (zh
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R·亚当斯
A·G·波普尔韦尔
S·E·拉佩奇
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UCB SA
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    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/244—Interleukins [IL]
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
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CN200780043116.1A 2006-10-18 2007-10-18 结合il-17a和il-17f的抗体分子 Active CN101589061B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0620729.4A GB0620729D0 (en) 2006-10-18 2006-10-18 Biological products
GB0620729.4 2006-10-18
PCT/GB2007/003983 WO2008047134A2 (en) 2006-10-18 2007-10-18 Antibody molecules which bind il-17a and il-17f

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CN101589061A CN101589061A (zh) 2009-11-25
CN101589061B true CN101589061B (zh) 2014-09-17

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US (6) US8303953B2 (https=)
EP (3) EP2076539B1 (https=)
JP (4) JP2010506580A (https=)
KR (1) KR20090078355A (https=)
CN (1) CN101589061B (https=)
AU (1) AU2007311689B2 (https=)
BR (1) BRPI0717768B8 (https=)
CA (1) CA2666458C (https=)
CO (1) CO6180467A2 (https=)
CY (2) CY1117963T1 (https=)
DK (2) DK2514764T3 (https=)
EA (1) EA029953B1 (https=)
ES (2) ES2588596T3 (https=)
GB (1) GB0620729D0 (https=)
HR (2) HRP20161069T1 (https=)
HU (2) HUE043667T2 (https=)
IL (1) IL198061B (https=)
LT (1) LT2514764T (https=)
MX (1) MX2009003973A (https=)
PL (2) PL2076539T3 (https=)
PT (2) PT2514764T (https=)
RS (1) RS55031B1 (https=)
SG (1) SG175652A1 (https=)
SI (2) SI2076539T1 (https=)
TR (1) TR201907599T4 (https=)
WO (1) WO2008047134A2 (https=)
ZA (1) ZA200902460B (https=)

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US7790163B2 (en) 2006-03-10 2010-09-07 Zymogenetics, Inc. Antibodies that bind both IL-17A and IL-17F and methods of using the same
EP1996622A2 (en) 2006-03-10 2008-12-03 Zymogenetics, Inc. Antibodies that bind both il-17a and il-17f and methods of using the same
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
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UA117218C2 (uk) * 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
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CN104231080B (zh) * 2013-03-15 2019-07-02 中国医学科学院药物研究所 全人源抗人白介素17a单链抗体
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