CN101584475A - 抽烟者营养保健天然生物组合物 - Google Patents
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Abstract
本发明涉及一种抽烟者营养保健天然生物组合物，是适合抽烟人群保健强体，预防肿瘤的保健品。本组合物由维生素C等复合维生素、矿物质、多种草本植物和核酸等成分组成，加入药用辅料制成片剂或胶囊剂。可有效清除多种香烟中的有害成分，提高免疫系统健康。本发明提供了详细的配方。
Description
技术领域
本发明涉及一种保健品，特别是适合抽烟人群强体防病、预防肿瘤、营养保健的天然生物组合物。
背景技术
抽烟是一种不健康的生活习惯，是一种能导致多种慢性、致死性疾病的不良行为。香烟，雪茄及烟斗的烟雾中，含有许多不同的致癌物质，可使呼吸道纤毛变短、脱落，纤毛运动障碍，粘液痰干燥，排痰机能减弱，从而使呼吸道发生炎症反应、抵抗力下降，为细菌及其它病原微生物的侵袭打开了“方便之门”。烟雾中的有害物质，可在几年和几十年里缓慢破坏机体组织，引起支气管炎、肺气肿、和肺癌等疾病。除了呼吸道疾病以外，抽烟还可以引起其他组织器官的疾病，如胃溃疡、十二指肠溃疡等消化道慢性疾病、膀胱癌、直肠癌等消化道肿瘤、冠心病等心血管疾病。抽烟对于人体健康的损害是通过多种途径实现的，肺癌等癌症患者中基因组不稳定性出现频率非常高。基因组不稳定性在癌症的发生过程中起很大的作用，通过增加致癌基因或肿瘤抑制基因的突变率，引起后续的诱发肿瘤的突变和遗传损伤。抽烟引起的各种癌症与基因表达密切相关，有研究报告称，某些特定基因变种更容易使当前烟民或过去的烟民患上肺癌，带有上述基因变体的烟民罹患肺癌的比率为28％，带有两种基因变体的烟民罹患肺癌的比率为81％。
PTEN是人类肿瘤中突变率最高的基因之一，位于10q 23.3，传统观点认为PTEN基因突变使其失去了对细胞生长的负调控，导致肿瘤发生。最新研究表明，细胞核内PTEN表达异常与细胞基因组稳定性也有密切的关系，PTEN基因可能是一个与抽烟者癌症发生密切相关的基因。
香烟的成瘾性极大，戒断比较困难，戒断时往往由于抽烟时间较久而对呼吸道、消化道、心血管系统造成不同程度的炎症发生、氧化反应、基因突变、自由基升高等损害。此类损害中很重要的一部分是经由破坏人体所必需的多种微量元素实现的，所以，人们都十分渴望能有一种有效的营养补剂，以及时有效地补充各类受迫害的营养元素，从根源减少抽烟者的痛苦和消除香烟烟雾对人体的损害，确保人们的健康。
经常抽烟的人体内维生素破坏程度较高，各种维生素代谢与正常人不同，且有潜在的癌变风险，服用普通维生素补剂难以达到补充维生素、防癌抗癌的目的。目前市场上仅有少量针对烟民的维生素制剂，多为单一维生素(如维生素C)，不能达到全面补充的效果。
发明内容
本发明的目的是提供一种抽烟者营养保健天然生物组合物，用于防止抽烟人群因烟致病，特别是降低癌症发生率。
抽烟者营养保健天然生物组合物，包含以下组分，以重量份计：维生素C 450-550份，维生素D3 0.009～0.011份，维生素E 135～165份，维生素B1 0.45-0.55份，维生素B2 0.45-0.55份，维生素B6 11.8-13.2份，叶酸0.086～0.11份；硒0.09～0.11份，锌13.5-15.5份，核酸13.5-15.5份；欧车前草粉90-110份，嗜酸乳杆菌45-55份，黑曲霉酶6.5-8.份，米曲霉酶6.5-8.5份，螺旋藻粉27-33份，蔓越莓汁11.5-13.5份，大麦草粉13.5-16.5份，北美黄莲粉22-27份，牛蒡粉4.5-5.5份，紫锥花根粉112-137份，洋菝契粉2.2-2.7份。
本组合物可以是片剂或胶囊剂。
每片或每胶囊中各组分的优选含量为：
维生素C 500mg，维生素D3 10μg，维生素E 150mg，维生素B1 0.5mg，维生素B2 0.5mg，维生素B6 12mg，叶酸96.2μg；硒100μg，锌15mg，核酸5mg；欧车前草粉100mg，嗜酸乳杆菌50mg，黑曲霉酶78.5mg，米曲霉酶7.5mg，螺旋藻粉30mg，蔓越莓汁12.5mg，大麦草粉15mg，北美黄莲粉25mg，牛蒡粉5mg，紫锥花根粉125mg，洋菝契粉2.5mg。
片剂或胶囊剂含有以下辅料：硬脂酸、硬脂酸镁、微晶纤维素、交联羧甲基纤维素钠、二氧化硅和/或磷酸氢钙。
本组合物中维生素C的含量特别高，这是因为维生素C参与体内物质代谢，增加机体抗毒、解毒功能，有良好的抗癌作用，而在抽烟者血液中，维生素C的含量会由于摄入减少、炎性反应等原因而降低。另外，尼古丁的作用下，人体中的其他维生素可以转化为一种毒素，而充足的维生素C，使已经毒化了的维生素迅速恢复到其正常状态。因此，补充足够的维生素C，才能使烟民在血液抗氧化方面的能力保持正常水平。B族维生素特别是维生素B2和B6可防止与抽烟有关的肺癌，如非小细胞肺癌的发生。
针对抽烟者血浆中硒浓度较非抽烟者普遍降低，本组合物添加的硒是普通维生素补剂的1-4.5倍。硒能抵抗自由基、抗氧化、抗衰老，提高免疫力，对各种癌症有抑制作用；流行病学研究及动物实验表明，硒有不同程度的抑制肿瘤作用。本组合物添加的核酸成分能有效防止细胞在香烟烟雾所含的多种致癌物作用下可能发生的基因突变，起到抗癌防癌作用。选用的天然草本植物均系北美原产草本，针对抽烟者容易出现的临床症状，如气管、支气管炎、心血管疾病、肺癌之等，选用多种有抗炎、抗癌、提高免疫力的草本成分，可以对抽烟者起到全面调理的作用，有效改善由于抽烟引起的亚健康状态。
本组合物的配方遵循“循证医学”理念，提高了维生素C和硒的含量，使烟民在血液抗氧化方面的能力与那些不吸烟的人保持相同水平，从而起到抗炎抗癌等效果，达到保护人体内的其它器官的目的，添加了表达抑癌基因从而维持基因组稳定性的核酸分子成分和多种原产地为北美的名贵草本植物，有很好的保健作用。本组合物营养价值高，易于服用，便于携带，可作为抽烟患者的症状缓解剂，可在抽烟前后服用，及时有效的消除烟雾中致癌物对多种组织器官的损伤作用，起到预防炎症的的作用，提高体内多种维生素的浓度，降低过氧化物歧化酶破坏，实现保健目的。长时间服用，可防治香烟源性的癌症、血脂异常、神经系统病变等疾病。
附图说明
图1(1)表示本营养保健组合物在不同浓度下对肺癌细胞A549增殖率的影响。
图1(2)表示本营养保健组合物在不同浓度下对肺正常细胞WI-38增殖率的影响。
图2(1)表示在本营养保健组合物溶液作用下，A549细胞中的bcl-2蛋白表达量。
图2(2)表示在本营养保健组合物溶液作用下，HBE细胞中的bcl-2蛋白表达量。
具体实施方式
本品中所采用的十一种植物的名称及原产地如下：
欧车前草
英文名：Psyllium
产地：印度、伊朗、法国、西班牙。
功能：
欧车前草的种子，有效成分是种子外壳中的多醣分子，叫Arabynoxylan，能很快吸收水，形成透明的糊状物质。在小肠中吸水形成糊状团块，可润肠排便，使重金属和其他有害化学毒素被吸附在粪便团块内，从而降低致癌物或有害物质之浓度；可溶性欧车前草纤维具有降低血胆固醇的功效。在结肠内益生菌的作用下，欧车前草纤维中的糖类物质经发酵分解为短链脂肪酸，从而阻止胆固醇的合成。
嗜酸乳杆菌
英文名：Lactobacillus acidophilus Blend
产地：美国
功能：
属于乳杆菌属，革兰氏阳性杆菌，杆的末端呈圆形。能分泌抗生物素类物质(嗜酸乳菌素、嗜酸杆菌素、乳酸菌素)，对致病微生物具有拈抗作用，因此能抑制肠道不良微生物的增殖，调整肠道菌群平衡，具有很好的营养保健作用。
黑曲霉酶、米曲霉酶
英文名：Aspergillus niger Enzyme，Aspergillus oryzae Enzyme
产地：美国
功能：
黑曲霉酶和米曲霉酶是特异性分解黑曲霉和米曲霉的酶类，可以有效地减少曲霉毒素的产生，预防正常细胞癌变。
螺旋藻
英文名：Spirulina
产地：美国
有效成分：藻蓝蛋白γ-亚麻酸螺旋藻多糖螺旋藻多胺螺旋藻叶绿素等
功能：
优秀的纯天然蛋白质食品源，蛋白质含量高达60～70％，且消化吸收率高达95％以上。其特有的藻蓝蛋白，能够提高淋巴细胞活性，增强人体免疫力，因此对胃肠疾病及肝病患者康复具有特殊意义。其中维生素及矿物质含量极为丰富，含有大量的γ-亚麻酸，这是一种人体必需的不饱和脂肪酸，是健脑益智、清除血脂、调节血压、降低胆固醇的理想物质。在降低胆固醇和血脂，抗癌，减肥，养胃护胃，治疗贫血及微量元素缺乏，护肝，增进免疫，调整代谢机能等方面都有积极作用。
蔓越莓
产地：美国
英文名：Cranberry Concentrate，
有效成分：单宁酸
功能：
是一种表皮鲜红，生长在矮藤上的小圆果，生长在寒冷的北美湿地，蔓越莓含有化合物浓缩单宁酸，除了普通被认为具有防止泌尿道感染功能外，蔓越莓还可以有效抑制幽门螺旋杆菌附着于肠胃内。
大麦草
英文名：Green Barley Grass
产地：美国
有效成分：活性酶 膳食纤维 叶绿素 生物黄酮
功能：
含有丰富的活性酶，包括可以帮助消化的淀粉酶、蛋白酶，还有具抗氧化能力的SOD酶、过氧化氢酶、麸胺酸酶等可促进新陈代谢，帮助营养素的吸收，调节生理机能、滋补强身。还含有超氧化物歧化酶(SOD)等生物活性物质，有增强免疫力、延缓衰老、抗疲劳、促进微循环作用；大麦草粉中富含有的麦绿素，具有强力消炎、解毒排毒、抗癌作用，可以清除体内垃圾，麦绿素中含有大量的矿物质和碱性物质，帮助机体调节体内酸碱平衡。大麦草的营养素都在其汁液中，而非外表粗糙的纤维，因此本品采用能保留各种完整活性营养素的新鲜麦苗汁浓缩粉。
北美黄莲
英文名：Goldenseal
产地：北美
功能：
北美洲东部特有的草本植物，其根与茎都用于草本医学上。具抗炎性抑制细菌活动力，舒缓过敏性粘膜，可减轻喉咙发炎以及粘膜发炎引起的充血。也是最好的通便剂，能减轻痔疮所引起的不适。
牛蒡
英文名：Burdock
别名：牛菜、大力子、恶实、牛蒡子、蝙蝠刺、东洋萝卜、东洋参、牛鞭菜等。
产地：日本
有效成分：牛蒡苦素 牛蒡苷 菊糖 粗纤维 胡萝卜素
功能：
有丰富的营养物质和膳食纤维，抗菌和抗真菌，可降低体内胆固醇，减少毒素、废物在体内积存，抑制肿瘤生长，有预防中风和防治肿瘤的功效。
紫锥花
英文名：Echinacea angustifolia
产地：北美
有效成分：烷酰胺 多糖类 糖蛋白等
功能：
增强免疫能力，对抗细菌或病毒。通过润养骨髓细胞，紫锥花能增强及刺激人体免疫系统，促使人体增加T细胞的数目，抑制前癌细胞生长，保护正常细胞，增强免疫力，预防上呼吸道的感染，有助消炎杀菌，抵抗病毒。
洋菝契
英文名：Sarsaparilla
产地：北美
有效成分：洋菝契苷、菝契皂质等
功能：
可与体内毒素结合，促进毒素排出体外，达到净化血液，防细胞恶变的作用的作用；能选择性地抑制活动过度的免疫细胞，作为免疫调节剂和免疫增强剂，调节机体整体状态，平衡机体激素水平，增强体力，在抗细胞诱变方面具有一定作用。
实施例1：
将原料各成分按比例混合成粉状组合物，加入辅料，以常规方法制成片剂或胶囊剂，每片(或胶囊)中含有：维生素C 500mg，维生素D 10μg，维生素E 150mg，维生素B1 0.5mg，维生素B2 0.5mg，维生素B6 12mg，叶酸96.2μg；硒100ug，锌15mg，核酸：5mg；欧车前草粉100mg，嗜酸乳杆菌混合物50mg，黑曲霉酶7.5mg，米曲霉酶7.5mg，螺旋藻粉30mg，蔓越莓汁12.5mg，大麦草粉15mg，北美黄莲粉25m，牛蒡粉5mg，紫锥花根粉125mg，洋菝契粉2.5mg。
所用的辅料包括硬脂酸、硬脂酸镁、微晶纤维素、交联羧甲基纤维素钠、二氧化硅和磷酸氢钙等常用辅料
本营养保健天然生物组合物每天服用剂量1-2片，可直接服用或添加于饮料中服用，例如加入饮料如柚子汁或桔子汁中，使每500ml饮料含有每天有效剂量。
抽烟者按上述剂量服用，一个月后，抽烟引起的症状明显改善，长期服用可增强体质，预防肿瘤。
实施例2：天然生物因子对人类肺癌细胞杀伤作用的试验
取人肺癌细胞系A549、人胎肺成纤维细胞WI-38，分别用不同浓度的本保健组合物溶液进行处理，以MTT比色法检测本保健组合物溶液对细胞增殖的影响。从图1(1)可见，本保健组合物溶液对A549细胞增殖具有明显的抑制作用，而且随着作用时间的延长，对A549细胞增殖的抑制率也升高，呈现时间效应关系，图1(2)表示，本保健组合物溶液对肺正常细胞WI-38无明显影响。
用不同浓度的本保健组合物溶液处理A549细胞和人正常支气管上皮细胞系HBE，从图2(1)可观察到本组合物溶液使A549的bcl-2表达减弱，且该作用呈浓度依赖性，而从图2(2)可见，本组合物溶液对正常细胞HBE的bcl-2表达无明显影响，说明本组合物能抑制肺腺癌A549细胞增生，促进细胞凋具有促进该细胞凋亡的作用。图2(1)和图2(2)中，GAPDH表示用于对照的内参蛋白量。
哺乳动物的细胞凋亡主要由两条通路构成，其中之一为线粒体通路，bcl-2蛋白家族在其中起了主要作用。bcl-2主要功能就是直接抑制线粒体膜的渗透性，从而减少促凋亡因子的释放，进而发挥抗凋亡作用。
试验结果为本品能提高抽烟人群生活质量提供了科学依据，并可望在临床抗肺癌治疗中发挥重要作用。
Claims (4)
1.抽烟者营养保健天然生物组合物，其特征在于包含以下组分，以重量份计：维生素C 450-550份，维生素D30.009～0.011份，维生素E 135～165份，维生素B10.45-0.55份，维生素B20.45-0.55份，维生素B611.8-13.2份，叶酸0.086～0.11份；硒0.09～0.11份，锌13.5-15.5份，核酸13.5-15.5份；欧车前草粉90-110份，嗜酸乳杆菌45-55份，黑曲霉酶6.5-8.份，米曲霉酶6.5-8.5份，螺旋藻粉27-33份，蔓越莓汁11.5-13.5份，大麦草粉13.5-16.5份，北美黄莲粉22-27份，牛蒡粉4.5-5.5份，紫锥花根粉112-137份，洋菝契粉2.2-2.7份。
2.根据权利要求1所述的抽烟者营养保健天然生物组合物，其特征在于该组合物是片剂或胶囊剂。
3.根据权利要求2所述的抽烟者营养保健天然生物组合物，其特征在于所说该组合物在每片或每胶囊中的各组分含量为：
维生素C 500mg，维生素D310μg，维生素E 150mg，维生素B10.5mg，维生素B20.5mg，维生素B612mg，叶酸96.2μg；硒100μg，锌15mg，核酸5mg；欧车前草粉100mg，嗜酸乳杆菌50mg，黑曲霉酶78.5mg，米曲霉酶7.5mg，螺旋藻粉30mg，蔓越莓汁12.5mg，大麦草粉15mg，北美黄莲粉25mg，牛蒡粉5mg，紫锥花根粉125mg，洋菝契粉2.5mg。
4.根据权利要求2或3所述的抽烟者营养保健天然生物组合物，其特征在于，含有以下辅料：硬脂酸、硬脂酸镁、微晶纤维素、交联羧甲基纤维素钠、二氧化硅和/或磷酸氢钙。
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