CN101580817A - 含有细胞因子诱导杀伤细胞的细胞群的制造方法 - Google Patents

含有细胞因子诱导杀伤细胞的细胞群的制造方法 Download PDF

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CN101580817A
CN101580817A CNA2008101007055A CN200810100705A CN101580817A CN 101580817 A CN101580817 A CN 101580817A CN A2008101007055 A CNA2008101007055 A CN A2008101007055A CN 200810100705 A CN200810100705 A CN 200810100705A CN 101580817 A CN101580817 A CN 101580817A
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pro
val
ser
cell
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Chinese (zh)
Inventor
郝希山
任秀宝
于津浦
李慧
曹水
安秀梅
加藤郁之进
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Cancer Hospital Affiliated To Tianjin Medical University
Treasure Biological Engineering Co ltd
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Cancer Hospital Affiliated To Tianjin Medical University
Treasure Biological Engineering Co ltd
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Priority to CNA2008101007055A priority Critical patent/CN101580817A/zh
Priority to CN2009801129125A priority patent/CN102027104A/zh
Priority to PCT/JP2009/058917 priority patent/WO2009139413A1/ja
Publication of CN101580817A publication Critical patent/CN101580817A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/55Lung
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4613Natural-killer cells [NK or NK-T]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/58Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/52Fibronectin; Laminin

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNA2008101007055A 2008-05-16 2008-05-16 含有细胞因子诱导杀伤细胞的细胞群的制造方法 Pending CN101580817A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CNA2008101007055A CN101580817A (zh) 2008-05-16 2008-05-16 含有细胞因子诱导杀伤细胞的细胞群的制造方法
CN2009801129125A CN102027104A (zh) 2008-05-16 2009-05-13 含有细胞因子诱导杀伤细胞的细胞群的制造方法
PCT/JP2009/058917 WO2009139413A1 (ja) 2008-05-16 2009-05-13 サイトカイン誘導キラー細胞含有細胞集団の製造方法

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Application Number Priority Date Filing Date Title
CNA2008101007055A CN101580817A (zh) 2008-05-16 2008-05-16 含有细胞因子诱导杀伤细胞的细胞群的制造方法

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CN101580817A true CN101580817A (zh) 2009-11-18

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CNA2008101007055A Pending CN101580817A (zh) 2008-05-16 2008-05-16 含有细胞因子诱导杀伤细胞的细胞群的制造方法
CN2009801129125A Pending CN102027104A (zh) 2008-05-16 2009-05-13 含有细胞因子诱导杀伤细胞的细胞群的制造方法

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WO (1) WO2009139413A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102191219A (zh) * 2011-03-29 2011-09-21 上海复仁生物科技有限公司 一种高效制备cik细胞的方法
CN103483454A (zh) * 2012-06-13 2014-01-01 深圳市阳溪生物科技有限公司 一种用于制备人细胞因子诱导的杀伤细胞的融合蛋白
CN107812013A (zh) * 2017-10-20 2018-03-20 胥萍 一种治疗耐药结核的新型生物制剂及其制备方法
CN109762785A (zh) * 2018-12-10 2019-05-17 吴江近岸蛋白质科技有限公司 一种高效应用于人nk细胞非滋养层体外培养的方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102575231B (zh) * 2009-10-28 2013-09-11 宝生物工程株式会社 制备细胞因子诱导的杀伤细胞的方法
WO2012096376A1 (ja) * 2011-01-14 2012-07-19 タカラバイオ株式会社 制御性t細胞の製造方法
DE102011106914B4 (de) 2011-07-08 2015-08-27 Zellwerk Gmbh Mäander- Bioreaktor und Verfahren zu dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen
CN105154398A (zh) * 2015-07-17 2015-12-16 深圳爱生再生医学科技有限公司 Cik及其制备方法
CN114717187B (zh) * 2022-03-09 2023-11-07 中科东方细胞科技有限公司 一种cik细胞及其制备方法与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2028266A4 (en) * 2006-06-09 2010-08-11 Takara Bio Inc PROCESS FOR PRODUCING LYMPHOCYTES

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102191219A (zh) * 2011-03-29 2011-09-21 上海复仁生物科技有限公司 一种高效制备cik细胞的方法
CN103483454A (zh) * 2012-06-13 2014-01-01 深圳市阳溪生物科技有限公司 一种用于制备人细胞因子诱导的杀伤细胞的融合蛋白
CN103483454B (zh) * 2012-06-13 2015-05-27 深圳市阳溪生物科技有限公司 一种用于制备人细胞因子诱导的杀伤细胞的融合蛋白
CN107812013A (zh) * 2017-10-20 2018-03-20 胥萍 一种治疗耐药结核的新型生物制剂及其制备方法
CN107812013B (zh) * 2017-10-20 2020-07-28 胥萍 一种治疗耐药结核的生物制剂及其制备方法
CN109762785A (zh) * 2018-12-10 2019-05-17 吴江近岸蛋白质科技有限公司 一种高效应用于人nk细胞非滋养层体外培养的方法
CN109762785B (zh) * 2018-12-10 2022-06-24 苏州近岸蛋白质科技股份有限公司 一种高效应用于人nk细胞非滋养层体外培养的方法

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CN102027104A (zh) 2011-04-20
WO2009139413A1 (ja) 2009-11-19

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