CN101573369A - α-半乳糖神经酰胺衍生物、其药物可接受的盐、制备方法和含有其作为活性成分的用于免疫佐剂的药物组合物 - Google Patents

α-半乳糖神经酰胺衍生物、其药物可接受的盐、制备方法和含有其作为活性成分的用于免疫佐剂的药物组合物 Download PDF

Info

Publication number
CN101573369A
CN101573369A CNA2007800486889A CN200780048688A CN101573369A CN 101573369 A CN101573369 A CN 101573369A CN A2007800486889 A CNA2007800486889 A CN A2007800486889A CN 200780048688 A CN200780048688 A CN 200780048688A CN 101573369 A CN101573369 A CN 101573369A
Authority
CN
China
Prior art keywords
group
pyran
tetrahydro
substituent
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800486889A
Other languages
English (en)
Chinese (zh)
Inventor
姜昌律
金相熙
尹显埈
李允淑
李圭娥
李泰浩
白东宰
赵珉在
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SNU R&DB Foundation
Original Assignee
SNU R&DB Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SNU R&DB Foundation filed Critical SNU R&DB Foundation
Publication of CN101573369A publication Critical patent/CN101573369A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
CNA2007800486889A 2006-12-30 2007-12-27 α-半乳糖神经酰胺衍生物、其药物可接受的盐、制备方法和含有其作为活性成分的用于免疫佐剂的药物组合物 Pending CN101573369A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020060139200A KR100868959B1 (ko) 2006-12-30 2006-12-30 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물
KR1020060139200 2006-12-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201210275308.8A Division CN102816189B (zh) 2006-12-30 2007-12-27 α-半乳糖神经酰胺衍生物、其药物可接受的盐、制备方法和含有其作为活性成分的用于免疫佐剂的药物组合物

Publications (1)

Publication Number Publication Date
CN101573369A true CN101573369A (zh) 2009-11-04

Family

ID=39588766

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2007800486889A Pending CN101573369A (zh) 2006-12-30 2007-12-27 α-半乳糖神经酰胺衍生物、其药物可接受的盐、制备方法和含有其作为活性成分的用于免疫佐剂的药物组合物
CN201210275308.8A Active CN102816189B (zh) 2006-12-30 2007-12-27 α-半乳糖神经酰胺衍生物、其药物可接受的盐、制备方法和含有其作为活性成分的用于免疫佐剂的药物组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201210275308.8A Active CN102816189B (zh) 2006-12-30 2007-12-27 α-半乳糖神经酰胺衍生物、其药物可接受的盐、制备方法和含有其作为活性成分的用于免疫佐剂的药物组合物

Country Status (6)

Country Link
US (1) US8883746B2 (enExample)
EP (1) EP2102225A4 (enExample)
JP (1) JP5167273B2 (enExample)
KR (1) KR100868959B1 (enExample)
CN (2) CN101573369A (enExample)
WO (1) WO2008082156A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8916164B2 (en) 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
PT2231145E (pt) 2007-12-05 2014-12-23 Wittycell Utilização de glicosilceramidas para aumentar a resposta imunitária a antigénios
US7928077B2 (en) * 2008-07-11 2011-04-19 Academia Sinica Alpha-galactosyl ceramide analogs and their use as immunotherapies
JP5809560B2 (ja) * 2008-10-08 2015-11-11 アビヴァックス インフルエンザに対して使用するためのワクチン組成物
KR20110045545A (ko) * 2009-10-27 2011-05-04 서울대학교산학협력단 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물
US8853173B2 (en) 2010-02-05 2014-10-07 Riken Synthetic glycolipid and use thereof
ES2654382T3 (es) 2011-01-05 2018-02-13 National Taiwan University Método para la preparación de glucoesfingolípidos
KR101307331B1 (ko) * 2012-02-01 2013-09-10 서울대학교산학협력단 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물
US10227290B2 (en) * 2012-02-07 2019-03-12 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
EP2881400A4 (en) * 2012-08-03 2016-02-24 Riken HYDROXYLATED KRN7000 ANALOGON AND USE THEREOF
KR101969129B1 (ko) * 2012-08-03 2019-04-15 (주)스파크바이오파마 알파-갈락토실세라마이드 유사체, 이의 제조방법 및 이를 포함하는 면역조절 이상으로 인한 질환의 치료 또는 예방용 약학적 조성물
US20150224129A1 (en) 2012-10-03 2015-08-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with invariant nkt cell agonists
CA2925878A1 (en) 2012-10-12 2014-04-17 The Brigham And Women's Hospital, Inc. Glycosphingolipids and methods of use thereof
WO2017163808A1 (ja) * 2016-03-22 2017-09-28 学校法人慶應義塾 化合物又はその塩、ナチュラルキラーｔ細胞活性化剤、及び医薬組成物
WO2017207040A1 (en) 2016-06-01 2017-12-07 Vib Vzw ANTI-CANCER THERAPY USING A LEPTIN ANTAGONIST AND AN iNKT-CELL ACTIVATOR
EP4174074A1 (en) 2021-10-29 2023-05-03 Consejo Superior de Investigaciones Científicas (CSIC) Multiantennary glycolipid mimetics
CN115286667B (zh) * 2022-08-02 2024-03-26 华中农业大学 一种α-半乳糖基神经酰胺类似物及其制备方法和应用
WO2025035125A1 (en) * 2023-08-10 2025-02-13 The Curators Of The University Of Missouri Suppression of type 1 diabetes by intrathymic il-4

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61502124A (ja) * 1984-05-09 1986-09-25 ジ　オ−ストラリアン　ナシヨナル　ユニヴア−シテイ− 免疫応答の調節方法
JPH0559081A (ja) * 1991-08-29 1993-03-09 Kirin Brewery Co Ltd 新規スフインゴ糖脂質、その製造法および使用
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
ES2235324T3 (es) * 1997-04-10 2005-07-01 Kirin Beer Kabushiki Kaisha Empleo de a-glicosilceramidas para la obtencion de un agente terapeutico para enfermedades autoinmunes.
EP1437358B1 (en) * 2001-08-16 2006-10-18 Daiichi Asubio Pharma Co., Ltd. Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
CA2493690C (en) * 2002-06-13 2011-11-08 New York University Synthetic c-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases
EP1784196B1 (en) * 2004-08-27 2016-12-21 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity

Also Published As

Publication number Publication date
JP5167273B2 (ja) 2013-03-21
US8883746B2 (en) 2014-11-11
EP2102225A1 (en) 2009-09-23
WO2008082156A1 (en) 2008-07-10
KR20080062973A (ko) 2008-07-03
KR100868959B1 (ko) 2008-11-17
EP2102225A4 (en) 2011-12-14
US20100104590A1 (en) 2010-04-29
CN102816189B (zh) 2015-05-20
JP2010514758A (ja) 2010-05-06
CN102816189A (zh) 2012-12-12

Similar Documents

Publication Publication Date Title
CN102816189B (zh) α-半乳糖神经酰胺衍生物、其药物可接受的盐、制备方法和含有其作为活性成分的用于免疫佐剂的药物组合物
EP2661440B1 (en) Method for the preparation of glycosphingolipids
JP3717512B2 (ja) 新規スフィンゴ糖脂質およびその使用
CA2223140C (en) Substituted liposaccharides useful in the treatment and prevention of endotoxemia
US8586051B2 (en) Glycolipids and analogues thereof as antigens for NKT cells
CN102498090A (zh) 氨基环醇化合物，获得它们的工艺以及用途
TWI595878B (zh) 製備鞘糖脂之方法及其用途
KR101307331B1 (ko) 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물
KR20110045545A (ko) 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물
JP2025144472A (ja) Ｉｌ－１７産生誘導能を有する化合物及びその用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20091104