CN101555212A - 能输送生物活性物质的合成小分子化合物及其应用 - Google Patents
能输送生物活性物质的合成小分子化合物及其应用 Download PDFInfo
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- CN101555212A CN101555212A CNA2009100434940A CN200910043494A CN101555212A CN 101555212 A CN101555212 A CN 101555212A CN A2009100434940 A CNA2009100434940 A CN A2009100434940A CN 200910043494 A CN200910043494 A CN 200910043494A CN 101555212 A CN101555212 A CN 101555212A
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Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
化合物序号 | 化合物量毫克/公斤 | 肝素量毫克/公斤 | 平均APTT(秒) |
1 | 200 | 100 | +++ |
3 | 200 | 100 | +++ |
5 | 200 | 100 | ++++ |
8 | 200 | 100 | ++++ |
13 | 200 | 100 | + |
16 | 200 | 100 | ++ |
26 | 200 | 100 | ++ |
化合物序号 | 化合物量毫克/公斤 | 胰岛素量毫克/公斤 | 血糖降低 |
1 | 100 | 0.5 | ++++ |
2 | 100 | 0.5 | ++++ |
3 | 100 | 0.5 | ++ |
4 | 100 | 0.5 | +++ |
5 | 100 | 0.5 | ++ |
6 | 100 | 0.5 | + |
7 | 100 | 0.5 | ++++ |
8 | 100 | 0.5 | +++ |
9 | 100 | 0.5 | +++ |
10 | 100 | 0.5 | +++ |
11 | 100 | 0.5 | + |
12 | 100 | 0.5 | + |
13 | 100 | 0.5 | ++ |
14 | 100 | 0.5 | +++ |
15 | 100 | 0.5 | ++ |
16 | 100 | 0.5 | ++++ |
17 | 100 | 0.5 | ++++ |
18 | 100 | 0.5 | +++ |
19 | 100 | 0.5 | ++++ |
20 | 100 | 0.5 | +++ |
21 | 100 | 0.5 | +++ |
22 | 100 | 0.5 | + |
23 | 100 | 0.5 | + |
24 | 100 | 0.5 | +++ |
25 | 100 | 0.5 | ++++ |
26 | 100 | 0.5 | + |
时间(分钟) | 0 | 15 | 30 | 45 | 60 |
血糖毫克/分升(参照组) | 85±8 | 88±6 | 83±5 | 79±4 | 80±10 |
血糖毫克/分升(配方B) | 90±5 | 91±9 | 80±9 | 78±8 | 72±8 |
血糖毫克/分升(配方C) | 75±8 | 68±5 | 63±8 | 58±9 | 44±8 |
血糖毫克/分升(配方A) | 80±9 | 71±8 | 53±9 | 45±10 | 37±9 |
化合物序号 | 血清中色甘酸峰值(纳克/毫升) |
4 | 650±50 |
8 | 490±75 |
13 | 420±35 |
25 | 220±10 |
色甘酸钠浓度摩尔/公斤 | 血清中色甘酸峰值(纳克/毫升) |
0.01 | 100±9 |
0.1 | 650±50 |
1 | 4550±700 |
10 | 527300±5000 |
100 | --- |
Claims (10)
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CN 201010279024 Division CN101962319B (zh) | 2009-05-22 | 2009-05-22 | 能输送生物活性物质的合成小分子化合物及其应用 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101797385A (zh) * | 2010-04-12 | 2010-08-11 | 戴立忠 | 一种口服钙药物组合物 |
US8362023B2 (en) | 2011-01-19 | 2013-01-29 | Hoffmann-La Roche Inc. | Pyrazolo pyrimidines |
CN103717206A (zh) * | 2011-07-27 | 2014-04-09 | 波利皮得有限公司 | 用于肽分子和多肽分子的受控释放的基质组合物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1660811A (zh) * | 2004-02-27 | 2005-08-31 | 中国科学院上海药物研究所 | 1,4-二取代苯类化合物及其制备方法和用途 |
-
2009
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101797385A (zh) * | 2010-04-12 | 2010-08-11 | 戴立忠 | 一种口服钙药物组合物 |
CN101797385B (zh) * | 2010-04-12 | 2011-02-16 | 戴立忠 | 一种口服钙药物组合物 |
US8362023B2 (en) | 2011-01-19 | 2013-01-29 | Hoffmann-La Roche Inc. | Pyrazolo pyrimidines |
CN103717206A (zh) * | 2011-07-27 | 2014-04-09 | 波利皮得有限公司 | 用于肽分子和多肽分子的受控释放的基质组合物 |
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